Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:4423076 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757722 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422100 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EB2031; Specimen B867 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423076 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422100 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EB2031; Specimen B867 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423076 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422100 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EB2031; Specimen B867 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423076 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1802422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422100 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EB2031; Specimen B867 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423076 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1768022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422100 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the skull (base and vault). |
Specimen Label: |
EB2031; Specimen B867 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423076 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2672022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422100 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in whisker follicle. |
Specimen Label: |
EB2031; Specimen B867 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perez-Garcia V |
Year: |
2021 |
Journal: |
Elife |
Title: |
BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion. |
Volume: |
10 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tirado-Gonzalez I |
Year: |
2021 |
Journal: |
Cancer Discov |
Title: |
AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia. |
Volume: |
11 |
Issue: |
11 |
Pages: |
2924-2943 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki N |
Year: |
2003 |
Journal: |
DNA Res |
Title: |
Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. |
Volume: |
10 |
Issue: |
1 |
Pages: |
35-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
McGinley AL |
Year: |
2014 |
Journal: |
Genesis |
Title: |
Additional sex combs-like family genes are required for normal cardiovascular development. |
Volume: |
52 |
Issue: |
7 |
Pages: |
671-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bassett JH |
Year: |
2012 |
Journal: |
PLoS Genet |
Title: |
Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. |
Volume: |
8 |
Issue: |
8 |
Pages: |
e1002858 |
|
•
•
•
•
•
|
Publication |
First Author: |
White JK |
Year: |
2013 |
Journal: |
Cell |
Title: |
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. |
Volume: |
154 |
Issue: |
2 |
Pages: |
452-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Millien G |
Year: |
2006 |
Journal: |
BMC Dev Biol |
Title: |
Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development. |
Volume: |
6 |
|
Pages: |
35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martinez-Mayer J |
Year: |
2024 |
Journal: |
Genome Med |
Title: |
Knockout mice with pituitary malformations help identify human cases of hypopituitarism. |
Volume: |
16 |
Issue: |
1 |
Pages: |
75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tuck E |
Year: |
2015 |
Journal: |
Dis Model Mech |
Title: |
A gene expression resource generated by genome-wide lacZ profiling in the mouse. |
Volume: |
8 |
Issue: |
11 |
Pages: |
1467-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maga AM |
Year: |
2015 |
Journal: |
Front Physiol |
Title: |
Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico. |
Volume: |
6 |
|
Pages: |
92 |
|
•
•
•
•
•
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Publication |
First Author: |
Thuret S |
Year: |
2004 |
Journal: |
Mol Cell Neurosci |
Title: |
Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. |
Volume: |
25 |
Issue: |
3 |
Pages: |
394-405 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu X |
Year: |
2016 |
Journal: |
BMC Immunol |
Title: |
Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. |
Volume: |
17 |
Issue: |
1 |
Pages: |
25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from Europhenome |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP) |
Year: |
2011 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom |
Year: |
2023 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ingham NJ |
Year: |
2019 |
Journal: |
PLoS Biol |
Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
Volume: |
17 |
Issue: |
4 |
Pages: |
e3000194 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
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•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
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•
•
•
•
•
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Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
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•
•
•
•
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Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
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•
•
•
•
•
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Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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•
•
•
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•
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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•
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•
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Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
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Publication |
First Author: |
MGD Nomenclature Committee |
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1995 |
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Title: |
Nomenclature Committee Use |
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•
•
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•
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Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
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7351 |
Pages: |
337-42 |
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•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
•
•
•
•
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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•
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•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
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•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
•
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•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
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Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
|
UniProt Feature |
Begin: |
1 |
Description: |
Polycomb group protein ASXL1 |
Type: |
chain |
End: |
1514 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sui P |
Year: |
2024 |
Journal: |
Leukemia |
Title: |
SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis. |
Volume: |
38 |
Issue: |
2 |
Pages: |
408-411 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ge G |
Year: |
2024 |
Journal: |
J Clin Invest |
Title: |
Targeting lysine demethylase 6B ameliorates ASXL1 truncation-mediated myeloid malignancies in preclinical models. |
Volume: |
134 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Toshio Kitamura |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inserted expressed sequence, No functional change |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Feng-Chun Yang |
Allele Type: |
Transgenic |
Attribute String: |
Epitope tag, Inserted expressed sequence |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Vav1-Asxl1*Y588X)#Fcy/? |
Background: |
C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Bejar R |
Year: |
2014 |
Journal: |
Blood |
Title: |
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. |
Volume: |
124 |
Issue: |
17 |
Pages: |
2705-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
LaFave LM |
Year: |
2015 |
Journal: |
Nat Med |
Title: |
Loss of BAP1 function leads to EZH2-dependent transformation. |
Volume: |
21 |
Issue: |
11 |
Pages: |
1344-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muto T |
Year: |
2013 |
Journal: |
J Exp Med |
Title: |
Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. |
Volume: |
210 |
Issue: |
12 |
Pages: |
2627-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abdel-Wahab O |
Year: |
2013 |
Journal: |
Leukemia |
Title: |
The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics. |
Volume: |
27 |
Issue: |
1 |
Pages: |
10-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takeda R |
Year: |
2020 |
Journal: |
Blood |
Title: |
HHEX promotes myeloid transformation in cooperation with mutant ASXL1. |
Volume: |
136 |
Issue: |
14 |
Pages: |
1670-1684 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
258
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
215
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
114
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
324
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Sahtoe DD |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
BAP1/ASXL1 recruitment and activation for H2A deubiquitination. |
Volume: |
7 |
|
Pages: |
10292 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daou S |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. |
Volume: |
9 |
Issue: |
1 |
Pages: |
4385 |
|
•
•
•
•
•
|
Publication |
First Author: |
Foglizzo M |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes. |
Volume: |
9 |
Issue: |
1 |
Pages: |
3932 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sanchez-Pulido L |
Year: |
2012 |
Journal: |
Bioinformatics |
Title: |
A common ancestry for BAP1 and Uch37 regulators. |
Volume: |
28 |
Issue: |
15 |
Pages: |
1953-6 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Protein ubiquitination is a fundamental mechanism that affects nearly all aspects of cellular life. Deubiquitinating enzymes (DUBs) play important roles in ubiquitin (Ub) signalling by Ub cleavage from adducts. The Ub C-terminal hydrolase (UCH) family of deubiquitinases (DUBs) contains four members including UCH37 (also called ubiquitin carboxy-terminal hydrolase isozyme L5, UCHL-5) and BAP1 which share high similarity in the catalytic domain (UCH) and the C-terminal region, termed the UCH37-like domain (ULD) which is responsible for binding interaction partners and is also involved in the regulation of DUB activity. ULD from BAP1 and UCH-L5 binds the DEUBiquitinase ADaptor (DEUBAD) domain present in their interacting partners, e.g., ASXL1 for BAP1, and RPN13 (ADRM1) and INO80G (NFRKB) for UCH-L5 [, , , , ].This entry represents the DEUBAD domain which consists of eight α-helices that form a helical bundle surrounding a compact hydrophobic core []. It has a modular architecture with the core formed by helices 1-4, primarily responsible for binding to ULD, and accessory elements that lead to full activation, or inhibition, of the UCH activity [, ]. |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1296
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
De I |
Year: |
2019 |
Journal: |
Structure |
Title: |
Structural Basis for the Activation of the Deubiquitinase Calypso by the Polycomb Protein ASX. |
Volume: |
27 |
Issue: |
3 |
Pages: |
528-536.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiao L |
Year: |
2014 |
Journal: |
Protein Cell |
Title: |
Mechanism of the Rpn13-induced activation of Uch37. |
Volume: |
5 |
Issue: |
8 |
Pages: |
616-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sahtoe DD |
Year: |
2015 |
Journal: |
Mol Cell |
Title: |
Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G. |
Volume: |
57 |
Issue: |
5 |
Pages: |
887-900 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
173
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
104
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This domain, known as the HARE-HTH domain, adopts the winged helix-turn-helix fold and is predicted to bind DNA. It can be found at the N terminus of the ASXL protein. It can also be found in several other eukaryotic chromatin proteins (such as HB1 in plants), diverse restriction endonucleases and DNA glycosylases, the RNA polymerase delta subunit of Gram-positive bacteria and certain bacterial proteins that combine features of the RNA polymerase alpha-subunit and sigma factors []. The genetic interaction of the HARE-HTH containing ASXL with the methyl cytosine hydroxylating Tet2 protein is suggestive of a role for the domain in discriminating sequences with DNA modifications such as hmC []. Bacterial versions include fusions to diverse restriction endonucleases, and a DNA glycosylase where it may play a similar role in detecting modified DNA. Certain bacterial version of the HARE-HTH domain show fusions to the helix-hairpin-helix domain of the RNA polymerase alpha subunit and the HTH domains found in regions 3 and 4 of the sigma factors []. These versions are predicted to function as a novel inhibitor of the binding of RNA polymerase to transcription start sites, similar to the Bacillus delta protein [, ].This domain consists of four α-helices (helices I-II-III-IV) and an antiparallel β-sheet composed of three short β-strands at the top of a "twisted tripod"formed by helices II, III, and IV [].The Asx-like (Asxl) proteins includes Asxl1-3. They are putative Polycomb group (PcG) proteins, which act by forming multiprotein complexes that are required to maintain the transcriptionally repressive state of homeotic genes throughout development. Asxl1 is involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) [].The delta protein is a dispensable subunit of Bacillus subtilis RNA polymerase (RNAP) that has major effects on the biochemical properties of the purified enzyme. In the presence of delta, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increasedefficiency of RNA synthesis because of enhanced recycling []. The delta protein, contains two distinct regions, an N-terminal domain and a glutamate and aspartate residue-rich C-terminal region []. It participates in both the initiation and recycling phases of transcription. |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1370
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2259
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1418
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1370
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
597
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1370
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2260
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
495
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
403
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
López de Saro FJ |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Expression, abundance, and RNA polymerase binding properties of the delta factor of Bacillus subtilis. |
Volume: |
274 |
Issue: |
22 |
Pages: |
15953-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
López de Saro FJ |
Year: |
1995 |
Journal: |
J Mol Biol |
Title: |
Structural analysis of the Bacillus subtilis delta factor: a protein polyanion which displaces RNA from RNA polymerase. |
Volume: |
252 |
Issue: |
2 |
Pages: |
189-202 |
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•
•
•
•
•
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