Type |
Details |
Score |
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lawrence CL |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Regulation of Schizosaccharomyces pombe Atf1 protein levels by Sty1-mediated phosphorylation and heterodimerization with Pcr1. |
Volume: |
282 |
Issue: |
8 |
Pages: |
5160-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Udagawa T |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast. |
Volume: |
283 |
Issue: |
32 |
Pages: |
22063-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ors A |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
The transcription factor Atf1 binds and activates the APC/C ubiquitin ligase in fission yeast. |
Volume: |
284 |
Issue: |
36 |
Pages: |
23989-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao J |
Year: |
2008 |
Journal: |
Nucleic Acids Res |
Title: |
Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response. |
Volume: |
36 |
Issue: |
9 |
Pages: |
2838-51 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Pseudogene |
Type: |
pseudogene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Pseudogene |
Type: |
pseudogene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Pseudogene |
Type: |
pseudogene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Plougastel B |
Year: |
1994 |
Journal: |
Genomics |
Title: |
Cloning and chromosome localization of the mouse Ews gene. |
Volume: |
23 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ananieva O |
Year: |
2008 |
Journal: |
Nat Immunol |
Title: |
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. |
Volume: |
9 |
Issue: |
9 |
Pages: |
1028-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parlato R |
Year: |
2006 |
Journal: |
Genesis |
Title: |
Survival of DA neurons is independent of CREM upregulation in absence of CREB. |
Volume: |
44 |
Issue: |
10 |
Pages: |
454-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arthur JS |
Year: |
2000 |
Journal: |
FEBS Lett |
Title: |
MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells. |
Volume: |
482 |
Issue: |
1-2 |
Pages: |
44-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho YY |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. |
Volume: |
67 |
Issue: |
17 |
Pages: |
8104-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikner A |
Year: |
2005 |
Journal: |
Mutat Res |
Title: |
Yeast signaling pathways in the oxidative stress response. |
Volume: |
569 |
Issue: |
1-2 |
Pages: |
13-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reiter W |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Fission yeast MAP kinase Sty1 is recruited to stress-induced genes. |
Volume: |
283 |
Issue: |
15 |
Pages: |
9945-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alao JP |
Year: |
2008 |
Journal: |
Mol Microbiol |
Title: |
Rad3 and Sty1 function in Schizosaccharomyces pombe: an integrated response to DNA damage and environmental stress? |
Volume: |
68 |
Issue: |
2 |
Pages: |
246-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vivancos AP |
Year: |
2006 |
Journal: |
Mol Genet Genomics |
Title: |
Oxidative stress in Schizosaccharomyces pombe: different H2O2 levels, different response pathways. |
Volume: |
276 |
Issue: |
6 |
Pages: |
495-502 |
|
•
•
•
•
•
|
Publication |
First Author: |
Day AM |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen. |
Volume: |
7 |
Issue: |
1 |
Pages: |
14340 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bruder Nascimento AC |
Year: |
2016 |
Journal: |
Mol Microbiol |
Title: |
Mitogen activated protein kinases SakA(HOG1) and MpkC collaborate for Aspergillus fumigatus virulence. |
Volume: |
100 |
Issue: |
5 |
Pages: |
841-59 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents ribosomal protein S6 kinase II []. This enzyme acts as a serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). It plays an essential role in the control of RELA transcriptional activity in response to TNF. It directly represses transcription via phosphorylation of Ser-1 of histone H2A. It phosphorylates Ser-10 of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. It mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). It requires magnesium ions as a cofactor. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This family is composed of the mitogen-activated protein kinases (MAPKs) Sty1 from Schizosaccharomyces pombe, Hog1 from Saccharomyces cerevisiae, and similar fungal proteins. Sty1 and Hog1 are stress-activated MAPKs that participate in transcriptional regulation in response to stress [].Sty1 is activated in response to oxidative stress, osmotic stress, and UV radiation [, ]. It is regulated by the MAP2K Wis1, which is activated by the MAP3Ks Wis4 and Win1, which receive signals of the stress condition from membrane-spanning histidine kinases Mak1-3 []. Activated Sty1 stabilizes the Atf1 transcription factor and induces transcription of Atf1-dependent genes of the core environmental stress response [, ].Hog1 is the key element in the high osmolarity glycerol (HOG) pathway and is activated upon hyperosmotic stress. Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription []. The HOG pathway is mediated by two transmembrane osmosensors, Sln1 and Sho1 []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Deak M |
Year: |
1998 |
Journal: |
EMBO J |
Title: |
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. |
Volume: |
17 |
Issue: |
15 |
Pages: |
4426-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hummler E |
Year: |
1994 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. |
Volume: |
91 |
Issue: |
12 |
Pages: |
5647-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mendoza-Viveros L |
Year: |
2023 |
Journal: |
Glia |
Title: |
Astrocytic circadian clock control of energy expenditure by transcriptional stress responses in the ventromedial hypothalamus. |
Volume: |
71 |
Issue: |
7 |
Pages: |
1626-1647 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kitamura T |
Year: |
2002 |
Journal: |
Biochem J |
Title: |
Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells. |
Volume: |
366 |
Issue: |
Pt 3 |
Pages: |
737-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang D |
Year: |
1994 |
Journal: |
Mol Cell Biol |
Title: |
Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes. |
Volume: |
14 |
Issue: |
6 |
Pages: |
4233-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Satyamoorthy K |
Year: |
1997 |
Journal: |
DNA Cell Biol |
Title: |
The mouse elongation factor-2 gene: isolation and characterization of the promoter. |
Volume: |
16 |
Issue: |
4 |
Pages: |
401-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tatebayashi K |
Year: |
2006 |
Journal: |
EMBO J |
Title: |
Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway. |
Volume: |
25 |
Issue: |
13 |
Pages: |
3033-44 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
863
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
500
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
740
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
733
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
773
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
724
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
764
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
442
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
776
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
741
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
735
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
860
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
735
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
773
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
733
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
737
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
712
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
708
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
736
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
760
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
741
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
719
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
781
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
719
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
625
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|