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Search results 201 to 300 out of 309 for Atg16l1

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Type Details Score
Publication
First Author: Pirooz SD
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.
Volume: 111
Issue: 7
Pages: 2716-21
Publication
First Author: Itakura E
Year: 2011
Journal: J Cell Biol
Title: p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding.
Volume: 192
Issue: 1
Pages: 17-27
Publication
First Author: Cunha LD
Year: 2018
Journal: Cell
Title: LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance.
Volume: 175
Issue: 2
Pages: 429-441.e16
Publication
First Author: Orvedahl A
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock.
Volume: 116
Issue: 33
Pages: 16497-16506
Publication
First Author: Kapur M
Year: 2020
Journal: Neuron
Title: Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility.
Volume: 108
Issue: 1
Pages: 193-208.e9
Publication
First Author: Li M
Year: 2016
Journal: Stem Cell Reports
Title: EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy.
Volume: 6
Issue: 3
Pages: 396-410
Publication
First Author: Li H
Year: 2022
Journal: Cell Rep
Title: Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival.
Volume: 41
Issue: 1
Pages: 111435
Publication
First Author: Yan W
Year: 2024
Journal: Commun Biol
Title: Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy.
Volume: 7
Issue: 1
Pages: 94
Publication
First Author: Kannan M
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.
Volume: 114
Issue: 44
Pages: E9308-E9317
Publication
First Author: Papanicolaou KN
Year: 2012
Journal: Circ Res
Title: Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.
Volume: 111
Issue: 8
Pages: 1012-26
Publication
First Author: Martinez-Mayer J
Year: 2024
Journal: Genome Med
Title: Knockout mice with pituitary malformations help identify human cases of hypopituitarism.
Volume: 16
Issue: 1
Pages: 75
Publication      
First Author: Mouse Genome Informatics and the Consortium: Deciphering the Mechanisms of Developmental Disorders (DMDD)
Year: 2017
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Deciphering the Mechanisms of Developmental Disorders (DMDD)
Publication
First Author: Perez-Garcia V
Year: 2018
Journal: Nature
Title: Placentation defects are highly prevalent in embryonic lethal mouse mutants.
Volume: 555
Issue: 7697
Pages: 463-468
Publication      
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
Publication      
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
Publication        
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication        
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Allele
Name: autophagy related 16 like 1; endonuclease-mediated mutation 1, The Babraham Institute
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
Publication  
First Author: Li XX
Year: 2020
Journal: Mol Cell Biol
Title: Interaction between HuR and circPABPN1 Modulates Autophagy in the Intestinal Epithelium by Altering ATG16L1 Translation.
Volume: 40
Issue: 6
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
Interaction Experiment
Description: FIP200 regulates targeting of Atg16L1 to the isolation membrane.
Allele
Name: autophagy related 16 like 1; gene trap BC0122, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Attribute String: Hypomorph
Allele
Name: autophagy related 16 like 1; gene trap XR0164, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Attribute String: Hypomorph
Publication
First Author: King BC
Year: 2019
Journal: Cell Metab
Title: Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents β Cell Death via ATG16L1 Interaction and Autophagy Regulation.
Volume: 29
Issue: 1
Pages: 202-210.e6
Genotype
Symbol: Atg16l1/Atg16l1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Atg16l1/Atg16l1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
DO Term
Interaction Experiment
Description: The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium.
Publication
First Author: Song H
Year: 2015
Journal: Autophagy
Title: ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation.
Volume: 11
Issue: 8
Pages: 1308-25
Publication
First Author: Hu J
Year: 2016
Journal: Cell Death Dis
Title: TMEM166/EVA1A interacts with ATG16L1 and induces autophagosome formation and cell death.
Volume: 7
Issue: 8
Pages: e2323
Publication
First Author: Boukhalfa A
Year: 2021
Journal: Cell Rep
Title: The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium.
Volume: 35
Issue: 4
Pages: 109045
HT Experiment
Series Id: GSE49109
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Schmutz I
Year: 2011
Journal: PLoS One
Title: Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.
Volume: 6
Issue: 6
Pages: e21325
Publication
First Author: Lee JH
Year: 2010
Journal: J Biol Chem
Title: Identification and characterization of a novel human PP1 phosphatase complex.
Volume: 285
Issue: 32
Pages: 24466-76
Publication
First Author: Ito M
Year: 2004
Journal: Mol Cell Biochem
Title: Myosin phosphatase: structure, regulation and function.
Volume: 259
Issue: 1-2
Pages: 197-209
Publication
First Author: Zagórska A
Year: 2010
Journal: Sci Signal
Title: New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.
Volume: 3
Issue: 115
Pages: ra25
Publication
First Author: Tang PM
Year: 1991
Journal: J Biol Chem
Title: Molecular cloning and expression of the regulatory (RG1) subunit of the glycogen-associated protein phosphatase.
Volume: 266
Issue: 24
Pages: 15782-9
Publication
First Author: Ceulemans H
Year: 2002
Journal: J Biol Chem
Title: Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.
Volume: 277
Issue: 49
Pages: 47331-7
Publication
First Author: Connor JH
Year: 2001
Journal: Mol Cell Biol
Title: Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.
Volume: 21
Issue: 20
Pages: 6841-50
Publication
First Author: Mi J
Year: 2007
Journal: Cancer Res
Title: Protein phosphatase-1alpha regulates centrosome splitting through Nek2.
Volume: 67
Issue: 3
Pages: 1082-9
Publication
First Author: Nie H
Year: 2013
Journal: Nat Med
Title: Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis.
Volume: 19
Issue: 3
Pages: 322-8
Protein Domain
Type: Family
Description: Serine/threonine-protein phosphatase PP1 () is a complex of a catalytic subunit, either PPP1CA, PPP1CB or PPP1CC, with one or more regulatory or targeting subunits. Example targeting subunits are PPP1R12A and PPP1R12C, which mediate binding of PP1 to myosin [, , ]; PPP1R3A, which mediates binding to glycogen in the skeletal muscle []; PPP1R7, []; PPP1R15A, which mediates binding to EIF2S1 []. The phosphatase associates with any one of many other regulatory proteins to form a complex that dephosphorylates a specific target protein. For example, centrosome splitting is regulated by the association of NEK2 with PP1 via the PPP1CA subunit [], binding to ATG16L1 antagonizes casein kinase 2-mediated phosphorylation of ATG16L1 affecting the fate of cadiomyocytes []and association with TNF-a induces phosphorylation of FOXP3 which controls regulatory T cell function []. PP1 is required for the cell cycle [], cell division, glycogen metabolism [], muscle contraction []and protein synthesis. PPP1CA and PPP1CB are components of the PTW/PP1 phosphatase complex [].This entry includes the catalytic subunit gamma (PPP1CC) from mammals, Dis2 from fission yeasts and Glc7 from budding yeasts. Glc7 is also a component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB [].
Protein Domain
Type: Family
Description: Serine/threonine-protein phosphatase PP1 () is a complex of a catalytic subunit, either PPP1CA, PPP1CB or PPP1CC, with one or more regulatory or targeting subunits. Example targeting subunits are PPP1R12A and PPP1R12C, which mediate binding of PP1 to myosin [, , ]; PPP1R3A, which mediates binding to glycogen in the skeletal muscle []; PPP1R7, []; PPP1R15A, which mediates binding to EIF2S1 []. The phosphatase associates with any one of many other regulatory proteins to form a complex that dephosphorylates a specific target protein. For example, centrosome splitting is regulated by the association of NEK2 with PP1 via the PPP1CA subunit [], binding to ATG16L1 antagonizes casein kinase 2-mediated phosphorylation of ATG16L1 affecting the fate of cadiomyocytes []and association with TNF-a induces phosphorylation of FOXP3 which controls regulatory T cell function []. PP1 is required for the cell cycle [], cell division, glycogen metabolism [], muscle contraction []and protein synthesis. PPP1CA and PPP1CB are components of the PTW/PP1 phosphatase complex [].This entry includes the catalytic subunits PP1-alpha (PPP1CA).
Publication
First Author: Tan I
Year: 2001
Journal: J Biol Chem
Title: Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.
Volume: 276
Issue: 24
Pages: 21209-16
Publication
First Author: Lei Y
Year: 2012
Journal: Immunity
Title: The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.
Volume: 36
Issue: 6
Pages: 933-46
Publication
First Author: Begun J
Year: 2015
Journal: Cell Rep
Title: Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.
Volume: 11
Issue: 12
Pages: 1905-18
Publication
First Author: Kim JH
Year: 2015
Journal: Autophagy
Title: Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners.
Volume: 11
Issue: 1
Pages: 75-87
Publication
First Author: Fujita N
Year: 2013
Journal: J Cell Biol
Title: Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.
Volume: 203
Issue: 1
Pages: 115-28
Publication    
First Author: Lim J
Year: 2019
Journal: Elife
Title: Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins.
Volume: 8
Publication
First Author: DeVorkin L
Year: 2019
Journal: Cell Rep
Title: Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity.
Volume: 27
Issue: 2
Pages: 502-513.e5
Publication
First Author: Wang D
Year: 2022
Journal: Eur J Immunol
Title: ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy.
Volume: 52
Issue: 8
Pages: 1321-1334
Protein
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 273  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
Publication
First Author: Nedea E
Year: 2003
Journal: J Biol Chem
Title: Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends.
Volume: 278
Issue: 35
Pages: 33000-10
Publication
First Author: Wu S
Year: 2015
Journal: Gut
Title: Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis.
Volume: 64
Issue: 7
Pages: 1082-94
Publication  
First Author: Vianello C
Year: 2023
Journal: Int J Environ Res Public Health
Title: Increased Expression of Autophagy-Related Genes in Alzheimer's Disease-Type 2 Diabetes Mellitus Comorbidity Models in Cells.
Volume: 20
Issue: 5
Publication
First Author: Lu R
Year: 2021
Journal: Gastroenterology
Title: Paneth Cell Alertness to Pathogens Maintained by Vitamin D Receptors.
Volume: 160
Issue: 4
Pages: 1269-1283