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Search results 201 to 285 out of 285 for Atxn2

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Type Details Score
Publication
26951610 | J:233532
First Author: Scekic-Zahirovic J
Year: 2016
Journal: EMBO J
Title: Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.
Volume: 35
Issue: 10
Pages: 1077-97
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Publication
34815492 | J:314906
First Author: Khang R
Year: 2021
Journal: Sci Rep
Title: Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.
Volume: 11
Issue: 1
Pages: 22745
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Tg(ATXN2*72Q)#Plt | MGI:5697198
Name: transgene insertion, Stefan M Pulst
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Atxn2<em1Smoc> | MGI:7288408
Name: ataxin 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
33802796 | -
 
First Author: López-Juárez ZM
Year: 2021
Journal: Int J Mol Sci
Title: The ATXN2 Orthologs CID3 and CID4, Act Redundantly to In-Fluence Developmental Pathways throughout the Life Cycle of Arabidopsis thaliana.
Volume: 22
Issue: 6
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Genotype
Genotype
Symbol: Tg(ATXN2*72Q)#Plt/?
Background: FVB/N-Tg(ATXN2*72Q)#Plt
Zygosity: ot
Has Mutant Allele: true
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Interaction Experiment
Halbach MV (2015)
Description: Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.
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Strain
MGI:6428205 | C57BL/6JSmoc-Atxn2<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Tg(Pcp2-ATXN2*127Q)#Plt | MGI:5467321
Name: transgene insertion, Stefan M Pulst
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Atxn2<tm2.1Aub> | MGI:5467982
Name: ataxin 2; targeted mutation 2.1, Georg Auburger
Allele Type: Targeted
Attribute String: Humanized sequence
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DO Term
DOID:0060204 | amyotrophic lateral sclerosis type 13
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HT Experiment
E-GEOD-39640 | ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice
Series Id: GSE39640
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Transgene
MGI:5467322 | Tg(Pcp2-ATXN2*127Q)#Plt
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:5697197 | Tg(ATXN2*72Q)#Plt
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Tg(Pcp2-ATXN2*127Q)#Plt/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atxn2/Atxn2
Background: B6.129S2-Atxn2
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0050955 | spinocerebellar ataxia type 2
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HT Experiment
E-GEOD-55177 | Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth
Series Id: GSE55177
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE57998 | Ataxin-2 modulates mRNA levels of proteins in ribosomal large and small subunit and in translation initiation complex
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
28405024 | J:252524
First Author: Scoles DR
Year: 2017
Journal: Nature
Title: Antisense oligonucleotide therapy for spinocerebellar ataxia type 2.
Volume: 544
Issue: 7650
Pages: 362-366
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Strain
MGI:5697199 | FVB/N-Tg(ATXN2*72Q)#Plt
Attribute String: coisogenic, mutant strain, transgenic
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Protein Domain
IPR025852 | SM_dom_ATX
Type: Domain
Description: This SM domain is found in Ataxin-2 [, ]. This domain has been shown to interact with RNA helicase DDX6 [].Ataxin-2 has many functions, such as endocytic receptor cycling [], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein []. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [].
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Protein
J3QP59
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: true
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Publication
17392519 | -
First Author: Nonhoff U
Year: 2007
Journal: Mol Biol Cell
Title: Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.
Volume: 18
Issue: 4
Pages: 1385-96
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Protein
Q7TQH0
Organism: Mus musculus/domesticus
Length: 1049  
Fragment?: false
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Protein
A0A0U1RPL0
Organism: Mus musculus/domesticus
Length: 1096  
Fragment?: false
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Protein
E9Q5Q0
Organism: Mus musculus/domesticus
Length: 863  
Fragment?: true
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Protein
Q3TYH7
Organism: Mus musculus/domesticus
Length: 890  
Fragment?: false
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Protein
Q3TGG2
Organism: Mus musculus/domesticus
Length: 994  
Fragment?: false
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Publication
9462862 | -
First Author: Neuwald AF
Year: 1998
Journal: J Mol Med (Berl)
Title: Ataxin-2, global regulators of bacterial gene expression, and spliceosomal snRNP proteins share a conserved domain.
Volume: 76
Issue: 1
Pages: 3-5
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Publication
9819425 | -
First Author: Mangus DA
Year: 1998
Journal: Mol Cell Biol
Title: Pbp1p, a factor interacting with Saccharomyces cerevisiae poly(A)-binding protein, regulates polyadenylation.
Volume: 18
Issue: 12
Pages: 7383-96
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Publication
15121841 | -
First Author: Mangus DA
Year: 2004
Journal: Mol Cell Biol
Title: Identification of factors regulating poly(A) tail synthesis and maturation.
Volume: 24
Issue: 10
Pages: 4196-206
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Publication
30982600 | -
First Author: Yang YS
Year: 2019
Journal: Cell
Title: Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth.
Volume: 177
Issue: 3
Pages: 697-710.e17
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Publication
18981231 | -
First Author: Buchan JR
Year: 2008
Journal: J Cell Biol
Title: P bodies promote stress granule assembly in Saccharomyces cerevisiae.
Volume: 183
Issue: 3
Pages: 441-55
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Protein
A0A0U1RNZ9
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Publication
11917006 | -
First Author: Anantharaman V
Year: 2002
Journal: Nucleic Acids Res
Title: Comparative genomics and evolution of proteins involved in RNA metabolism.
Volume: 30
Issue: 7
Pages: 1427-64
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Publication
16115810 | -
First Author: Ralser M
Year: 2005
Journal: Hum Mol Genet
Title: Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.
Volume: 14
Issue: 19
Pages: 2893-909
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Protein Domain
IPR009604 | LsmAD_domain
Type: Domain
Description: This domain can be found in eukaryotic ataxin-2 []. Ataxin-2 is predicted to consist of mostly non-globular domains []. This domain has been shown to interact with RNA helicase DDX6 [].Ataxin-2 has many functions, such as endocytic receptor cycling [], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein []. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [].Proteins containing this domain also include Pbp1 from budding yeasts, Pbp1 interacts with Pab1 to regulate mRNA polyadenylation [, ]. It promotes mating-type switching in mother cells by positively regulating HO mRNA translation []and forms a condensate in response to respiratory status to regulate TORC1 signaling []. It is also involved in P-body-dependent granule assembly [].
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Protein Domain
IPR045117 | ATXN2-like
Type: Family
Description: This entry represents a group of RNA-binding proteins , including Ataxin-2 from animals, Pbp1 from fungi and Cid3/4 from Arabidopsis.Ataxin-2 has many functions, such as endocytic receptor cycling [], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein []. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [].Pbp1 interacts with Pab1 to regulate mRNA polyadenylation [, ]. It promotes mating-type switching in mother cells by positively regulating HO mRNA translation []and forms a condensate in response to respiratory status to regulate TORC1 signalling []. It is also involved in P-body-dependent granule assembly [].Cid3/4 may have a role in developmental pathways throughout the life cycle of plants [].
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Publication
29556029 | J:261673
First Author: White MA
Year: 2018
Journal: Nat Neurosci
Title: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD.
Volume: 21
Issue: 4
Pages: 552-563
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Publication
39209824 | J:353901
First Author: Vieira de Sá R
Year: 2024
Journal: Nat Commun
Title: ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes.
Volume: 15
Issue: 1
Pages: 7484
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Publication
27240544 | J:253882
First Author: Lastres-Becker I
Year: 2016
Journal: Biochim Biophys Acta
Title: Mammalian ataxin-2 modulates translation control at the pre-initiation complex via PI3K/mTOR and is induced by starvation.
Volume: 1862
Issue: 9
Pages: 1558-69
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HT Experiment
E-GEOD-54418 | Dysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue
Series Id: GSE54418
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
34618203 | J:357640
First Author: Diaz-Garcia S
Year: 2021
Journal: Acta Neuropathol
Title: Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis.
Volume: 142
Issue: 6
Pages: 985-1001
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Publication
32698485 | J:294770
 
First Author: Key J
Year: 2020
Journal: Int J Mol Sci
Title: Mid-Gestation lethality of Atxn2l-Ablated Mice.
Volume: 21
Issue: 14
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Publication
15082763 | -
First Author: Tadauchi T
Year: 2004
Journal: Mol Cell Biol
Title: Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex.
Volume: 24
Issue: 9
Pages: 3670-81
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Publication
22914732 | J:188775
First Author: Scoles DR
Year: 2012
Journal: Hum Mol Genet
Title: ETS1 regulates the expression of ATXN2.
Volume: 21
Issue: 23
Pages: 5048-65
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Publication
24659297 | J:355933
First Author: Heck MV
Year: 2014
Journal: Neurogenetics
Title: Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue.
Volume: 15
Issue: 2
Pages: 135-44
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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