Type |
Details |
Score |
Publication |
First Author: |
Shindler KS |
Year: |
1997 |
Journal: |
J Neurosci |
Title: |
Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. |
Volume: |
17 |
Issue: |
9 |
Pages: |
3112-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Einsele-Scholz S |
Year: |
2016 |
Journal: |
J Cell Sci |
Title: |
Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak. |
Volume: |
129 |
Issue: |
15 |
Pages: |
3054 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stallock J |
Year: |
2003 |
Journal: |
Development |
Title: |
The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo. |
Volume: |
130 |
Issue: |
26 |
Pages: |
6589-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karch J |
Year: |
2013 |
Journal: |
Elife |
Title: |
Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. |
Volume: |
2 |
|
Pages: |
e00772 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rundle CH |
Year: |
2008 |
Journal: |
Bone |
Title: |
Bax deficiency in mice increases cartilage production during fracture repair through a mechanism involving increased chondrocyte proliferation without changes in apoptosis. |
Volume: |
43 |
Issue: |
5 |
Pages: |
880-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Westphal D |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane. |
Volume: |
111 |
Issue: |
39 |
Pages: |
E4076-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
D'Sa-Eipper C |
Year: |
2001 |
Journal: |
Development |
Title: |
DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3. |
Volume: |
128 |
Issue: |
1 |
Pages: |
137-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Firlej V |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Pea3 transcription factor cooperates with USF-1 in regulation of the murine bax transcription without binding to an Ets-binding site. |
Volume: |
280 |
Issue: |
2 |
Pages: |
887-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krajewska M |
Year: |
2002 |
Journal: |
Cell Death Differ |
Title: |
Dynamics of expression of apoptosis-regulatory proteins Bid, Bcl-2, Bcl-X, Bax and Bak during development of murine nervous system. |
Volume: |
9 |
Issue: |
2 |
Pages: |
145-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu G |
Year: |
2010 |
Journal: |
Biol Reprod |
Title: |
BAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice. |
Volume: |
83 |
Issue: |
6 |
Pages: |
979-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gonzalvez F |
Year: |
2005 |
Journal: |
Cell Death Differ |
Title: |
tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak. |
Volume: |
12 |
Issue: |
6 |
Pages: |
614-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Narita M |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. |
Volume: |
95 |
Issue: |
25 |
Pages: |
14681-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Selimi F |
Year: |
2000 |
Journal: |
C R Acad Sci III |
Title: |
Bax and p53 are differentially involved in the regulation of caspase-3 expression and activation during neurodegeneration in Lurcher mice. |
Volume: |
323 |
Issue: |
11 |
Pages: |
967-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim WR |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Impaired migration in the rostral migratory stream but spared olfactory function after the elimination of programmed cell death in Bax knock-out mice. |
Volume: |
27 |
Issue: |
52 |
Pages: |
14392-403 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parikh N |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells. |
Volume: |
173 |
Issue: |
10 |
Pages: |
6220-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lisak D |
Year: |
2016 |
Journal: |
Cell Death Differ |
Title: |
BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival. |
Volume: |
23 |
Issue: |
2 |
Pages: |
358-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hutcheson J |
Year: |
2005 |
Journal: |
J Exp Med |
Title: |
Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis. |
Volume: |
201 |
Issue: |
12 |
Pages: |
1949-60 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
238
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Blanc M |
Year: |
2024 |
Journal: |
Cell Death Dis |
Title: |
Bax Inhibitor-1 preserves pancreatic β-cell proteostasis by limiting proinsulin misfolding and programmed cell death. |
Volume: |
15 |
Issue: |
5 |
Pages: |
334 |
|
•
•
•
•
•
|
Publication |
First Author: |
Middleton G |
Year: |
2001 |
Journal: |
Development |
Title: |
Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo. |
Volume: |
128 |
Issue: |
23 |
Pages: |
4715-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beltran E |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma. |
Volume: |
108 |
Issue: |
30 |
Pages: |
12461-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oakes SA |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. |
Volume: |
102 |
Issue: |
1 |
Pages: |
105-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu WY |
Year: |
2015 |
Journal: |
Br J Pharmacol |
Title: |
The Ca(2+) channel inhibitor 2-APB reverses β-amyloid-induced LTP deficit in hippocampus by blocking BAX and caspase-3 hyperactivation. |
Volume: |
172 |
Issue: |
9 |
Pages: |
2273-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu YP |
Year: |
2004 |
Journal: |
Cancer Res |
Title: |
Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice. |
Volume: |
64 |
Issue: |
14 |
Pages: |
5020-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chandrakanthan V |
Year: |
2006 |
Journal: |
Reprod Biol Endocrinol |
Title: |
Effects of in vitro fertilization and embryo culture on TRP53 and Bax expression in B6 mouse embryos. |
Volume: |
4 |
|
Pages: |
61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata MA |
Year: |
1999 |
Journal: |
EMBO J |
Title: |
Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage. |
Volume: |
18 |
Issue: |
10 |
Pages: |
2692-701 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ledonne F |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Targeted Inactivation of Bax Reveals a Subtype-Specific Mechanism of Cajal-Retzius Neuron Death in the Postnatal Cerebral Cortex. |
Volume: |
17 |
Issue: |
12 |
Pages: |
3133-3141 |
|
•
•
•
•
•
|
Publication |
First Author: |
Croker BA |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1. |
Volume: |
108 |
Issue: |
32 |
Pages: |
13135-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ferrer PE |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function. |
Volume: |
7 |
Issue: |
3 |
Pages: |
e31510 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim HK |
Year: |
2021 |
Journal: |
Autophagy |
Title: |
TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium. |
Volume: |
17 |
Issue: |
3 |
Pages: |
761-778 |
|
•
•
•
•
•
|
Publication |
First Author: |
Runyan C |
Year: |
2008 |
Journal: |
Int J Dev Biol |
Title: |
The distribution and behavior of extragonadal primordial germ cells in Bax mutant mice suggest a novel origin for sacrococcygeal germ cell tumors. |
Volume: |
52 |
Issue: |
4 |
Pages: |
333-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jung AR |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
Misplacement of Purkinje cells during postnatal development in Bax knock-out mice: a novel role for programmed cell death in the nervous system? |
Volume: |
28 |
Issue: |
11 |
Pages: |
2941-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nam YJ |
Year: |
2004 |
Journal: |
Mol Cell |
Title: |
Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. |
Volume: |
15 |
Issue: |
6 |
Pages: |
901-12 |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Male |
Age: |
postnatal day 56 |
Stage: |
28 |
Structure . Name: |
testis |
Notes: |
littermate control; the genotype is either +/+ or +/- |
Curation Status: |
Curated |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee GH |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Enhanced lysosomal activity is involved in Bax inhibitor-1-induced regulation of the endoplasmic reticulum (ER) stress response and cell death against ER stress: involvement of vacuolar H+-ATPase (V-ATPase). |
Volume: |
286 |
Issue: |
28 |
Pages: |
24743-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yadav RK |
Year: |
2015 |
Journal: |
Autophagy |
Title: |
TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy and reduces renal dysfunction in a cyclosporine A-induced nephrotoxicity model. |
Volume: |
11 |
Issue: |
10 |
Pages: |
1760-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deng KQ |
Year: |
2018 |
Journal: |
Circulation |
Title: |
Targeting Transmembrane BAX Inhibitor Motif Containing 1 Alleviates Pathological Cardiac Hypertrophy. |
Volume: |
137 |
Issue: |
14 |
Pages: |
1486-1504 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee MR |
Year: |
2014 |
Journal: |
Cell Death Dis |
Title: |
BAX inhibitor-1-associated V-ATPase glycosylation enhances collagen degradation in pulmonary fibrosis. |
Volume: |
5 |
|
Pages: |
e1113 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
309
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe N |
Year: |
2008 |
Journal: |
Plant Signal Behav |
Title: |
Arabidopsis Bax inhibitor-1: A rheostat for ER stress-induced programmed cell death. |
Volume: |
3 |
Issue: |
8 |
Pages: |
564-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bultynck G |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. |
Volume: |
287 |
Issue: |
4 |
Pages: |
2544-57 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Publication |
First Author: |
Hunsberger JG |
Year: |
2011 |
Journal: |
Brain Res |
Title: |
Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience. |
Volume: |
1403 |
|
Pages: |
19-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe N |
Year: |
2009 |
Journal: |
Int J Mol Sci |
Title: |
Bax Inhibitor-1, a conserved cell death suppressor, is a key molecular switch downstream from a variety of biotic and abiotic stress signals in plants. |
Volume: |
10 |
Issue: |
7 |
Pages: |
3149-67 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Bax inhibitor 1 |
Type: |
chain |
End: |
237 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Apoptosis regulator BAX |
Type: |
chain |
End: |
192 |
|
•
•
•
•
•
|
Publication |
First Author: |
Philippaert K |
Year: |
2020 |
Journal: |
J Mol Med (Berl) |
Title: |
Bax inhibitor-1 deficiency leads to obesity by increasing Ca2+-dependent insulin secretion. |
Volume: |
98 |
Issue: |
6 |
Pages: |
849-862 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jeon K |
Year: |
2012 |
Journal: |
Biochim Biophys Acta |
Title: |
Bax inhibitor-1 enhances survival and neuronal differentiation of embryonic stem cells via differential regulation of mitogen-activated protein kinases activities. |
Volume: |
1823 |
Issue: |
12 |
Pages: |
2190-200 |
|
•
•
•
•
•
|
Publication |
First Author: |
Knudson CM |
Year: |
1995 |
Journal: |
Science |
Title: |
Bax-deficient mice with lymphoid hyperplasia and male germ cell death. |
Volume: |
270 |
Issue: |
5233 |
Pages: |
96-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keeley PW |
Year: |
2014 |
Journal: |
Dev Biol |
Title: |
Programmed cell death of retinal cone bipolar cells is independent of afferent or target control. |
Volume: |
394 |
Issue: |
2 |
Pages: |
191-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang K |
Year: |
1996 |
Journal: |
Genes Dev |
Title: |
BID: a novel BH3 domain-only death agonist. |
Volume: |
10 |
Issue: |
22 |
Pages: |
2859-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
He H |
Year: |
1998 |
Journal: |
J Immunol |
Title: |
Characterization of a novel Bax-associated protein expressed in hemopoietic tissues and regulated during thymocyte apoptosis. |
Volume: |
161 |
Issue: |
3 |
Pages: |
1169-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adlaf EW |
Year: |
2017 |
Journal: |
Elife |
Title: |
Adult-born neurons modify excitatory synaptic transmission to existing neurons. |
Volume: |
6 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Simmons AB |
Year: |
2020 |
Journal: |
J Comp Neurol |
Title: |
Increased density and age-related sharing of synapses at the cone to OFF bipolar cell synapse in the mouse retina. |
Volume: |
528 |
Issue: |
7 |
Pages: |
1140-1156 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsai CJ |
Year: |
2015 |
Journal: |
Structure |
Title: |
BAX-induced apoptosis can be initiated through a conformational selection mechanism. |
Volume: |
23 |
Issue: |
1 |
Pages: |
139-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rucker EB 3rd |
Year: |
2011 |
Journal: |
Genesis |
Title: |
Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax. |
Volume: |
49 |
Issue: |
1 |
Pages: |
24-35 |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuda Y |
Year: |
1996 |
Journal: |
Cytogenet Cell Genet |
Title: |
Chromosomal assignment of the Bcl2-related genes, Bcl2l and Bax, in the mouse and rat. |
Volume: |
74 |
Issue: |
1-2 |
Pages: |
107-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ueda M |
Year: |
2014 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax. |
Volume: |
443 |
Issue: |
4 |
Pages: |
1232-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gotsiridze T |
Year: |
2007 |
Journal: |
Dev Neurobiol |
Title: |
Development of sex differences in the principal nucleus of the bed nucleus of the stria terminalis of mice: role of Bax-dependent cell death. |
Volume: |
67 |
Issue: |
3 |
Pages: |
355-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun W |
Year: |
2003 |
Journal: |
Mol Cell Neurosci |
Title: |
Response of motoneurons to neonatal sciatic nerve axotomy in Bax-knockout mice. |
Volume: |
24 |
Issue: |
4 |
Pages: |
875-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee JW |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
Disruption of dentate gyrus blocks effect of visual input on spatial firing of CA1 neurons. |
Volume: |
32 |
Issue: |
38 |
Pages: |
12999-3003 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lewis J |
Year: |
1999 |
Journal: |
Nat Med |
Title: |
Inhibition of virus-induced neuronal apoptosis by Bax. |
Volume: |
5 |
Issue: |
7 |
Pages: |
832-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Korhonen L |
Year: |
2008 |
Journal: |
Neuroscience |
Title: |
Expression of X-chromosome linked inhibitor of apoptosis protein in mature Purkinje cells and in retinal bipolar cells in transgenic mice induces neurodegeneration. |
Volume: |
156 |
Issue: |
3 |
Pages: |
515-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
White FA |
Year: |
1998 |
Journal: |
J Neurosci |
Title: |
Widespread elimination of naturally occurring neuronal death in Bax-deficient mice. |
Volume: |
18 |
Issue: |
4 |
Pages: |
1428-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perez GI |
Year: |
1999 |
Journal: |
Nat Genet |
Title: |
Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency. |
Volume: |
21 |
Issue: |
2 |
Pages: |
200-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun W |
Year: |
2004 |
Journal: |
J Neurosci |
Title: |
Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax. |
Volume: |
24 |
Issue: |
49 |
Pages: |
11205-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Britton SM |
Year: |
2018 |
Journal: |
Neuroscience |
Title: |
Neuronal Loss in the Developing Cerebral Cortex of Normal and Bax-Deficient Mice: Effects of Ethanol Exposure. |
Volume: |
369 |
|
Pages: |
278-291 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki H |
Year: |
2010 |
Journal: |
Brain Res |
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