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Search results 201 to 300 out of 340 for Blm

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Type Details Score
Allele
Blm<tm1Khor> | MGI:3620977
Name: Bloom syndrome, RecQ like helicase; targeted mutation 1, Kyoji Horie
Allele Type: Targeted
Attribute String: Hypomorph
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Publication
21325134 | -
First Author: Nimonkar AV
Year: 2011
Journal: Genes Dev
Title: BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
Volume: 25
Issue: 4
Pages: 350-62
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Publication
23509288 | -
First Author: Wan L
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.
Volume: 110
Issue: 26
Pages: 10646-51
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Protein Domain
IPR032437 | BLM_N
Type: Domain
Description: This is the very N-terminal region of chordate RecQ-like DNA helicase BLM proteins. BLM participates in DNA replication and repair [, , , , ]. This domain, together with , may play a role in regulation and oligomerization of BLM. These domains are also important in mediating interactions with partner proteins [].
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Publication
9388193 | -
First Author: Karow JK
Year: 1997
Journal: J Biol Chem
Title: The Bloom's syndrome gene product is a 3'-5' DNA helicase.
Volume: 272
Issue: 49
Pages: 30611-4
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Strain
MGI:6144848 | B6;129-Blm<tm1Khor>/KhorRbrc
Attribute String: mutant stock, targeted mutation
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Strain
MGI:6144847 | 129-Blm<tm1Khor>/KhorRbrc
Attribute String: targeted mutation, coisogenic, mutant strain
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Protein Domain
IPR012532 | BDHCT
Type: Domain
Description: This is a C-terminal domain in RecQ-like DNA helicase BLM subfamily []. The helicase participates in DNA replication and repair, exhibiting a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
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Protein Domain
IPR042470 | RMI1_N_C_sf
Type: Homologous_superfamily
Description: This entry represents the N-terminal OB-fold domain of RMI (RecQ-mediated genome instability protein) proteins []. This domain forms a stable complex with Bloom syndrome protein BLM and DNA topoisomerase 3-alpha [].
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Protein Domain
IPR013894 | RMI1_N
Type: Domain
Description: This entry represents the N-terminal domain of RMI1 (RecQ-mediated genome instability protein 1) and similar proteins []. This domain carries an oligo-nucleotide-binding domain or OB-fold, and forms a stable complex with Bloom syndrome protein BLM and DNA topoisomerase 3-alpha [].
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Protein
F6ZI20
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Publication
18923083 | -
First Author: Singh TR
Year: 2008
Journal: Genes Dev
Title: BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.
Volume: 22
Issue: 20
Pages: 2856-68
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Protein Domain
IPR032439 | BDHCT_assoc
Type: Domain
Description: This domain is found on RecQ-like DNA helicase BLM in higher eukaryotes []. It lies between the BDHCT (), and DEAD-box domains (). This domain, together with , may play a role in regulation and oligomerization of BLM. These domains are also important in mediating interactions with partner proteins [].
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Protein Domain
IPR044881 | RMI1_N_N_sf
Type: Homologous_superfamily
Description: This entry represents the N-terminal helical domain of RMI 1 (RecQ-mediated genome instability protein) proteins from metazoa []. This domain is found at the N-terminal of an oligo-nucleotide-binding domain or OB-fold, and forms a stable complex with Bloom syndrome protein BLM and DNA topoisomerase 3-alpha [, ].
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Protein Domain
IPR033472 | RMI1-like_N_hel
Type: Domain
Description: This entry represents the N-terminal helical domain of RMI 1 (RecQ-mediated genome instability protein 1) and similar proteins []. This domain is found at the N-terminal of an oligo-nucleotide-binding domain or OB-fold, and forms a stable complex with Bloom syndrome protein BLM and DNA topoisomerase 3-alpha [, ].
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Publication
7516875 | -
First Author: Dumas P
Year: 1994
Journal: EMBO J
Title: Crystal structure and site-directed mutagenesis of a bleomycin resistance protein and their significance for drug sequestering.
Volume: 13
Issue: 11
Pages: 2483-92
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Protein Domain
IPR000335 | Bleomycin-R
Type: Family
Description: Bleomycin (Blm) is a glycopeptide antibiotic produced naturally by actinomycetes. It is a strong DNA-cutting agent and thus finds use as a potent anti-cancer drug. The DNA-cutting mechanism is complex, involving concomitant oxidation of FeII and reduction of oxygen. Inaddition to iron, Blm binds other transition metals: cobalt, nickel, copper and zinc. Actinomycetes have developed a defence mechanism against this lethal compound, producing a protein that confers resistance to Blm through drug sequestering.The crystal structure of the bleomycin resistance protein reveals 2identically-folded halves, each having an alpha/beta fold but showing nosequence similarity []. Each half comprises a 4-stranded β-sheet anda short α-helix (3 turns). The sheets within each half lie roughly atright-angles and are related by an approximate 2-fold axis. The crystalpacking shows compact dimers that have a hydrophobic interface and areinvolved in mutual chain exchange.
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Protein
Q9D4G9
Organism: Mus musculus/domesticus
Length: 616  
Fragment?: false
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Publication
18923082 | -
First Author: Xu D
Year: 2008
Journal: Genes Dev
Title: RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
Volume: 22
Issue: 20
Pages: 2843-55
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Publication
25901030 | -
First Author: Newman JA
Year: 2015
Journal: Nucleic Acids Res
Title: Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.
Volume: 43
Issue: 10
Pages: 5221-35
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Publication
- | J:33327
 
First Author: Wallace ME
Year: 1971
Journal: Mouse News Lett
Title: Unco-ordinated, uc (now = ml)
Volume: 44
Pages: 18
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Publication
9397680 | -
First Author: Morozov V
Year: 1997
Journal: Trends Biochem Sci
Title: A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases.
Volume: 22
Issue: 11
Pages: 417-8
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Protein
A0A0U1RPP0
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
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Protein
A0A0U1RPS3
Organism: Mus musculus/domesticus
Length: 42  
Fragment?: true
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Protein Domain
IPR002121 | HRDC_dom
Type: Domain
Description: The HRDC (helicase and RNaseD C-terminal) domain is comprised of two orthogonally packed α-hairpin subdomains, and is involved in interactions with DNA and protein. It has been suggested that this domain plays a role dissolving double Holliday junctions efficiently [].HRDC domains are found at the C terminus of many RecQ helicases, including the human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and RecQ-like DNA helicase BLM [, ]. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed alpha-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation α-hairpin [, ].The HRDC domain has a putative role in nucleic acid binding. Mutations in the HRDC domain associated with the human BLM gene result in Bloom Syndrome (BS), an autosomal recessive disorder characterised by proportionate pre- and postnatal growth deficiency; sun-sensitive, telangiectatic, hypo- and hyperpigmented skin; predisposition to malignancy; and chromosomal instability [].
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Protein Domain
IPR044876 | HRDC_dom_sf
Type: Homologous_superfamily
Description: The HRDC (helicase and RNaseD C-terminal) domain is comprised of two orthogonally packed α-hairpin subdomains, and is involved in interactions with DNA and protein. It has been suggested that this domain plays a role dissolving double Holliday junctions efficiently [].HRDC domains are found at the C terminus of many RecQ helicases, including the human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and RecQ-like DNA helicase BLM [, ]. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed alpha-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation α-hairpin [, ].The HRDC domain has a putative role in nucleic acid binding. Mutations in the HRDC domain associated with the human BLM gene result in Bloom Syndrome (BS), an autosomal recessive disorder characterised by proportionate pre- and postnatal growth deficiency; sun-sensitive, telangiectatic, hypo- and hyperpigmented skin; predisposition to malignancy; and chromosomal instability [].
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Publication
10647186 | -
First Author: Liu Z
Year: 1999
Journal: Structure
Title: The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.
Volume: 7
Issue: 12
Pages: 1557-66
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Publication
15591044 | -
First Author: Armache KJ
Year: 2005
Journal: J Biol Chem
Title: Structures of complete RNA polymerase II and its subcomplex, Rpb4/7.
Volume: 280
Issue: 8
Pages: 7131-4
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Publication
11979727 | J:85891
First Author: Ichikawa K
Year: 2002
Journal: Nihon Yakurigaku Zasshi
Title: [Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases].
Volume: 119
Issue: 4
Pages: 219-26
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Publication
9917509 | J:52931
First Author: Kuriyama S
Year: 1999
Journal: Int J Oncol
Title: Antitumor effect of electrochemotherapy on colorectal carcinoma in an orthotopic mouse model.
Volume: 14
Issue: 2
Pages: 321-6
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Protein Domain
IPR010997 | HRDC-like_sf
Type: Homologous_superfamily
Description: This superfamily represents the HRDC (helicase and RNaseD C-terminal) domain, which comprises two orthogonally packed α-hairpin subdomains, and is involved in interactions with DNA and protein. The HRDC (helicase and RNaseD C-terminal) domain is found at the C terminus of many RecQ helicases, including the human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and RecQ-like DNA helicase BLM (previously known as Werner and Bloom syndrome proteins) []. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed α-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation α-hairpin [, ].
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Protein
Q99KY7
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: true
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Protein
Q8BWH5
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: true
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Publication
22579284 | J:222674
First Author: Vannier JB
Year: 2012
Journal: Cell
Title: RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity.
Volume: 149
Issue: 4
Pages: 795-806
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Publication
- | J:25311
 
First Author: Wallace ME
Year: 1971
Journal: Mouse News Lett
Title: Dilution-Peru
Volume: 44
Pages: 18
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Publication
19596237 | J:157331
First Author: Sfeir A
Year: 2009
Journal: Cell
Title: Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
Volume: 138
Issue: 1
Pages: 90-103
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Publication
11784117 | J:105860
First Author: Sakamoto H
Year: 2002
Journal: Exp Mol Pathol
Title: IL-12p40(-/-) mice treated with intratracheal bleomycin exhibit decreased pulmonary inflammation and increased fibrosis.
Volume: 72
Issue: 1
Pages: 1-9
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Publication
33277324 | J:314537
 
First Author: Wang Y
Year: 2021
Journal: Sci Adv
Title: MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program.
Volume: 7
Issue: 1
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Publication
28304344 | J:272001
 
First Author: Li YJ
Year: 2017
Journal: Int J Mol Sci
Title: Nrf2 Regulates the Risk of a Diesel Exhaust Inhalation-Induced Immune Response during Bleomycin Lung Injury and Fibrosis in Mice.
Volume: 18
Issue: 3
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Publication
24113622 | J:221217
 
First Author: Sunaga H
Year: 2013
Journal: Nat Commun
Title: Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice.
Volume: 4
Pages: 2563
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Publication
29203799 | J:287387
First Author: Ishida Y
Year: 2017
Journal: Sci Rep
Title: Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration.
Volume: 7
Issue: 1
Pages: 16833
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Publication
31757863 | J:282070
First Author: Nakazawa Y
Year: 2019
Journal: J Immunol
Title: Cutting Edge: Involvement of the Immunoreceptor CD300c2 on Alveolar Macrophages in Bleomycin-Induced Lung Fibrosis.
Volume: 203
Issue: 12
Pages: 3107-3111
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Publication
34977500 | J:322123
First Author: Suliman HB
Year: 2022
Journal: iScience
Title: Nuclear respiratory factor-1 negatively regulates TGF-β1 and attenuates pulmonary fibrosis.
Volume: 25
Issue: 1
Pages: 103535
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Publication
32848143 | J:295439
First Author: Lee TH
Year: 2020
Journal: Nat Commun
Title: Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
Volume: 11
Issue: 1
Pages: 4254
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Publication
32656894 | J:305351
First Author: Ng B
Year: 2020
Journal: FASEB J
Title: Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease.
Volume: 34
Issue: 9
Pages: 11802-11815
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Publication
34253720 | J:308439
First Author: Prakash R
Year: 2021
Journal: Nat Commun
Title: Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex.
Volume: 12
Issue: 1
Pages: 4255
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Publication
28805810 | J:318438
First Author: Schmutz I
Year: 2017
Journal: Nat Struct Mol Biol
Title: TRF2 binds branched DNA to safeguard telomere integrity.
Volume: 24
Issue: 9
Pages: 734-742
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Protein
A0A0J9YVE5
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: false
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Publication
12820877 | -
First Author: Antony E
Year: 2003
Journal: Biochemistry
Title: Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair.
Volume: 42
Issue: 25
Pages: 7682-93
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Protein Domain
IPR032642 | Msh2
Type: Family
Description: This entry represents the DNA mismatch repair protein Msh2 (homologous to bacterial MutS) from eukaryotes. Msh2-Msh6 complex recognises base pair mismatches and small insertion/deletions in DNA and initiates repair []. Human Msh2-Msh6 complex has been shown to regulate BLM helicase in response tothe damaged DNA forks during double-stranded break repair []. Mismatch repair (MMR) is one of five major DNA repair pathways. The mismatch repair system recognises and repairs mispaired or unpaired nucleotides that result from errors in DNA replication. The most extensively studied general MMR system is the MutHLS pathway of the bacterium Escherichia coli. In the first step of the MutHLS pathway, the MutS protein (in the form of a dimer) binds to the site of a mismatch in double-stranded DNA. Through a complex interaction between MutS, MutL and MutH, a section of the newly replicated DNA strand (and thus the strand with the replication error) at the location of the mismatch bound by MutS is targeted for removal []. Homologues of MutS have been found in many species including eukaryotes, Archaea and other bacteria, and together these proteins have been grouped into the MutS family.
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Protein
P56960
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Protein
Q9CYJ3
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: false
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Protein
Q8R2R0
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Protein
F6VYQ6
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
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Protein
Q3UNK6
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Protein
Q8K366
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Publication
11741548 | -
First Author: Todone F
Year: 2001
Journal: Mol Cell
Title: Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex.
Volume: 8
Issue: 5
Pages: 1137-43
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Protein
O88700
Organism: Mus musculus/domesticus
Length: 1416  
Fragment?: false
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Protein
E9PZ97
Organism: Mus musculus/domesticus
Length: 1419  
Fragment?: false
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Publication
27986806 | J:240633
First Author: McNairn AJ
Year: 2017
Journal: Genetics
Title: Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog.
Volume: 205
Issue: 2
Pages: 529-537
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Publication
27799315 | J:319834
First Author: Higuchi S
Year: 2016
Journal: J Immunol
Title: EP4 Receptor-Associated Protein in Macrophages Protects against Bleomycin-Induced Pulmonary Inflammation in Mice.
Volume: 197
Issue: 11
Pages: 4436-4443
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Publication
11167012 | J:67348
First Author: Ohhata T
Year: 2000
Journal: Gene
Title: Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RecQ helicase protein-like 4.
Volume: 261
Issue: 2
Pages: 251-8
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Publication
11738818 | J:73673
First Author: Ohhata T
Year: 2001
Journal: Gene
Title: Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RECQL5beta.
Volume: 280
Issue: 1-2
Pages: 59-66
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Publication
24698097 | J:312235
First Author: Böhm M
Year: 2014
Journal: Exp Dermatol
Title: Bleomycin-induced fibrosis in MC1 signalling-deficient C57BL/6J-Mc1r(e/e) mice further supports a modulating role for melanocortins in collagen synthesis of the skin.
Volume: 23
Issue: 6
Pages: 431-3
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Publication
35149532 | J:336697
First Author: Moog MT
Year: 2022
Journal: J Immunol
Title: B Cells Are Not Involved in the Regulation of Adenoviral TGF-β1- or Bleomycin-Induced Lung Fibrosis in Mice.
Volume: 208
Issue: 5
Pages: 1259-1271
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Publication
15632004 | J:95244
First Author: Arras M
Year: 2005
Journal: Am J Pathol
Title: IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins.
Volume: 166
Issue: 1
Pages: 107-15
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Publication
18096870 | J:149720
First Author: Saito F
Year: 2008
Journal: Am J Respir Cell Mol Biol
Title: Role of interleukin-6 in bleomycin-induced lung inflammatory changes in mice.
Volume: 38
Issue: 5
Pages: 566-71
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Publication
22062222 | J:180181
First Author: Kitaba S
Year: 2012
Journal: Am J Pathol
Title: Blockade of interleukin-6 receptor alleviates disease in mouse model of scleroderma.
Volume: 180
Issue: 1
Pages: 165-76
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Publication
23665346 | J:197439
First Author: Bhandary YP
Year: 2013
Journal: Am J Pathol
Title: Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1.
Volume: 183
Issue: 1
Pages: 131-43
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Publication
17322370 | J:118647
First Author: Ishida Y
Year: 2007
Journal: Am J Pathol
Title: Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration.
Volume: 170
Issue: 3
Pages: 843-54
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Publication
19218193 | J:164986
First Author: Gasse P
Year: 2009
Journal: Am J Respir Crit Care Med
Title: Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.
Volume: 179
Issue: 10
Pages: 903-13
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Publication
35247890 | J:324780
First Author: Lockwood N
Year: 2022
Journal: Cancer Res
Title: Genome-Protective Topoisomerase 2a-Dependent G2 Arrest Requires p53 in hTERT-Positive Cancer Cells.
Volume: 82
Issue: 9
Pages: 1762-1773
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Publication
33632774 | J:307164
     
First Author: DeStefano Shields CE
Year: 2021
Journal: Cancer Discov
Title: Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy.
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Publication
38893159 | J:349875
 
First Author: Ghobashi AH
Year: 2024
Journal: Cancers (Basel)
Title: Single-Cell Profiling Reveals the Impact of Genetic Alterations on the Differentiation of Inflammation-Induced Murine Colon Tumors.
Volume: 16
Issue: 11
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Publication
12851251 | J:358387
First Author: Thomson RB
Year: 2003
Journal: Am J Physiol Renal Physiol
Title: Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD.
Volume: 285
Issue: 5
Pages: F870-80
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Publication
21858022 | J:176497
First Author: Gasse P
Year: 2011
Journal: PLoS One
Title: IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis.
Volume: 6
Issue: 8
Pages: e23185
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Publication
10200322 | J:54585
First Author: Schwartz DR
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance.
Volume: 96
Issue: 8
Pages: 4680-5
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Publication
15792964 | J:104755
First Author: Nakatani-Okuda A
Year: 2005
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Protection against bleomycin-induced lung injury by IL-18 in mice.
Volume: 289
Issue: 2
Pages: L280-7
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Publication
19145458 | J:144991
First Author: Paul E
Year: 2009
Journal: Mamm Genome
Title: Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.
Volume: 20
Issue: 2
Pages: 92-108
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Publication
10946246 | J:73420
First Author: Russell LB
Year: 2000
Journal: Mutat Res
Title: Bleomycin, unlike other male-mouse mutagens, is most effective in spermatogonia, inducing primarily deletions.
Volume: 469
Issue: 1
Pages: 95-105
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Publication
28263743 | J:250621
First Author: Han X
Year: 2017
Journal: Biochem Biophys Res Commun
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