Type |
Details |
Score |
Publication |
First Author: |
Wilhelm M |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model. |
Volume: |
282 |
Issue: |
2 |
Pages: |
1288-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diwan A |
Year: |
2009 |
Journal: |
J Clin Invest |
Title: |
Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. |
Volume: |
119 |
Issue: |
1 |
Pages: |
203-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharma M |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Rhes, a striatal-enriched protein, promotes mitophagy via Nix. |
Volume: |
116 |
Issue: |
47 |
Pages: |
23760-23771 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy. |
Volume: |
107 |
Issue: |
20 |
Pages: |
9035-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu K |
Year: |
2022 |
Journal: |
Cell Death Dis |
Title: |
BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy. |
Volume: |
13 |
Issue: |
4 |
Pages: |
334 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kodali S |
Year: |
2022 |
Journal: |
J Immunol |
Title: |
Protection of Quiescence and Longevity of IgG Memory B Cells by Mitochondrial Autophagy. |
Volume: |
208 |
Issue: |
5 |
Pages: |
1085-1098 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao Y |
Year: |
2023 |
Journal: |
EMBO J |
Title: |
A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease. |
Volume: |
42 |
Issue: |
13 |
Pages: |
e113033 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujimoto K |
Year: |
2010 |
Journal: |
J Clin Invest |
Title: |
Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes. |
Volume: |
120 |
Issue: |
11 |
Pages: |
4031-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diwan A |
Year: |
2008 |
Journal: |
Circulation |
Title: |
Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation. |
Volume: |
117 |
Issue: |
3 |
Pages: |
396-404 |
|
•
•
•
•
•
|
Publication |
First Author: |
Novak I |
Year: |
2010 |
Journal: |
EMBO Rep |
Title: |
Nix is a selective autophagy receptor for mitochondrial clearance. |
Volume: |
11 |
Issue: |
1 |
Pages: |
45-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pedanou VE |
Year: |
2016 |
Journal: |
Elife |
Title: |
The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mughal W |
Year: |
2018 |
Journal: |
Cell Death Differ |
Title: |
Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition. |
Volume: |
25 |
Issue: |
10 |
Pages: |
1732-1748 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
A nucleus-targeted alternately spliced Nix/Bnip3L protein isoform modifies nuclear factor κB (NFκB)-mediated cardiac transcription. |
Volume: |
288 |
Issue: |
22 |
Pages: |
15455-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Sullivan TE |
Year: |
2015 |
Journal: |
Immunity |
Title: |
BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. |
Volume: |
43 |
Issue: |
2 |
Pages: |
331-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen G |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. |
Volume: |
274 |
Issue: |
1 |
Pages: |
7-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schweers RL |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
NIX is required for programmed mitochondrial clearance during reticulocyte maturation. |
Volume: |
104 |
Issue: |
49 |
Pages: |
19500-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao T |
Year: |
2008 |
Journal: |
Eur J Neurosci |
Title: |
Genetic mapping of Foxb1-cell lineage shows migration from caudal diencephalon to telencephalon and lateral hypothalamus. |
Volume: |
28 |
Issue: |
10 |
Pages: |
1941-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sandoval H |
Year: |
2008 |
Journal: |
Nature |
Title: |
Essential role for Nix in autophagic maturation of erythroid cells. |
Volume: |
454 |
Issue: |
7201 |
Pages: |
232-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xue W |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. |
Volume: |
109 |
Issue: |
21 |
Pages: |
8212-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ha SD |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. |
Volume: |
32 |
Issue: |
23 |
Pages: |
4846-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tracy K |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. |
Volume: |
27 |
Issue: |
17 |
Pages: |
6229-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Marta C |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Mitochondrial function and intracellular distribution is severely affected in in vitro cultured mouse embryos. |
Volume: |
12 |
Issue: |
1 |
Pages: |
16152 |
|
•
•
•
•
•
|
Publication |
First Author: |
Srivastava U |
Year: |
2012 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice. |
Volume: |
32 |
Issue: |
10 |
Pages: |
2380-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Esteban-Martínez L |
Year: |
2017 |
Journal: |
EMBO J |
Title: |
Programmed mitophagy is essential for the glycolytic switch during cell differentiation. |
Volume: |
36 |
Issue: |
12 |
Pages: |
1688-1706 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Menendez-Montes I |
Year: |
2021 |
Journal: |
iScience |
Title: |
Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice. |
Volume: |
24 |
Issue: |
2 |
Pages: |
102124 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li D |
Year: |
2011 |
Journal: |
Hum Mol Genet |
Title: |
Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. |
Volume: |
20 |
Issue: |
23 |
Pages: |
4582-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Menendez-Montes I |
Year: |
2016 |
Journal: |
Dev Cell |
Title: |
Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. |
Volume: |
39 |
Issue: |
6 |
Pages: |
724-739 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2005 |
Journal: |
Unpublished |
Title: |
Information obtained from The Jackson Laboratory, Bar Harbor, ME |
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|
|
•
•
•
•
•
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Publication |
First Author: |
Soma S |
Year: |
2024 |
Journal: |
Stem Cells |
Title: |
O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation. |
Volume: |
42 |
Issue: |
1 |
Pages: |
55-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reed JC |
Year: |
2003 |
Journal: |
Genome Res |
Title: |
Comparative analysis of apoptosis and inflammation genes of mice and humans. |
Volume: |
13 |
Issue: |
6B |
Pages: |
1376-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Copeland NG |
Year: |
1999 |
Journal: |
Database Release |
Title: |
Copeland-Jenkins (Frederick) Interspecific Backcross Mapping Data |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Neidhardt L |
Year: |
2000 |
Journal: |
Mech Dev |
Title: |
Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. |
Volume: |
98 |
Issue: |
1-2 |
Pages: |
77-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sansom SN |
Year: |
2009 |
Journal: |
PLoS Genet |
Title: |
The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. |
Volume: |
5 |
Issue: |
6 |
Pages: |
e1000511 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mootha VK |
Year: |
2003 |
Journal: |
Cell |
Title: |
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. |
Volume: |
115 |
Issue: |
5 |
Pages: |
629-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Backcross DNA Panel Mapping Resource |
Year: |
1999 |
Journal: |
Database Release |
Title: |
JAX BSS Panel Mapping Data |
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•
•
•
•
•
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Publication |
First Author: |
Blackshaw S |
Year: |
2004 |
Journal: |
PLoS Biol |
Title: |
Genomic analysis of mouse retinal development. |
Volume: |
2 |
Issue: |
9 |
Pages: |
E247 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ko MS |
Year: |
2000 |
Journal: |
Development |
Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
Volume: |
127 |
Issue: |
8 |
Pages: |
1737-49 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
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•
•
•
•
•
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Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
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•
•
•
•
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Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
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•
•
•
•
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Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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•
•
•
•
•
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Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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•
•
•
•
•
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Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
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•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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•
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
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Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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Allele |
Name: |
BCL2/adenovirus E1B interacting protein 3-like; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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•
•
•
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Allele |
Name: |
BCL2/adenovirus E1B interacting protein 3-like; endonuclease-mediated mutation 1, Joseph Gordon |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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Strain |
Attribute String: |
endonuclease-mediated mutation, mutant strain |
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Pseudogene |
Type: |
pseudogene |
Organism: |
mouse, laboratory |
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Pseudogene |
Type: |
pseudogene |
Organism: |
mouse, laboratory |
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Publication |
First Author: |
Papandreou I |
Year: |
2008 |
Journal: |
Cell Death Differ |
Title: |
Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. |
Volume: |
15 |
Issue: |
10 |
Pages: |
1572-81 |
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Publication |
First Author: |
Passantino R |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. |
Volume: |
1833 |
Issue: |
3 |
Pages: |
529-40 |
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Publication |
First Author: |
Duval N |
Year: |
2018 |
Journal: |
Front Cell Neurosci |
Title: |
The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord. |
Volume: |
12 |
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Pages: |
15 |
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Publication |
First Author: |
Shi RY |
Year: |
2014 |
Journal: |
CNS Neurosci Ther |
Title: |
BNIP3 interacting with LC3 triggers excessive mitophagy in delayed neuronal death in stroke. |
Volume: |
20 |
Issue: |
12 |
Pages: |
1045-55 |
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Publication |
First Author: |
Yap AS |
Year: |
1998 |
Journal: |
J Cell Biol |
Title: |
The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. |
Volume: |
141 |
Issue: |
3 |
Pages: |
779-89 |
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Publication |
First Author: |
Nagafuchi A |
Year: |
1988 |
Journal: |
EMBO J |
Title: |
Cell binding function of E-cadherin is regulated by the cytoplasmic domain. |
Volume: |
7 |
Issue: |
12 |
Pages: |
3679-84 |
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Publication |
First Author: |
Gugnoni M |
Year: |
2017 |
Journal: |
Oncogene |
Title: |
Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy. |
Volume: |
36 |
Issue: |
5 |
Pages: |
667-677 |
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Protein Domain |
Type: |
Domain |
Description: |
Cadherins (CADHs) are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation []. CADHs also have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumor cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR (LC3 Interacting Regions, also known as ATG8-interacting motifs, AIMs) domains, a common feature among many cadherin family members [, ]. LIRs are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. They are characterised by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type []. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members []. |
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Publication |
First Author: |
Sora V |
Year: |
2020 |
Journal: |
Front Cell Dev Biol |
Title: |
Structure and Dynamics in the ATG8 Family From Experimental to Computational Techniques. |
Volume: |
8 |
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Pages: |
420 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
113
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
216
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
353
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
313
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
794
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
788
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
781
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
785
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
886
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
896
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Fragment?: |
false |
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