Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
462
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
617
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
829
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gally F |
Year: |
2011 |
Journal: |
Am J Pathol |
Title: |
SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. |
Volume: |
178 |
Issue: |
5 |
Pages: |
2159-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thaikoottathil JV |
Year: |
2012 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
SPLUNC1 deficiency enhances airway eosinophilic inflammation in mice. |
Volume: |
47 |
Issue: |
2 |
Pages: |
253-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Donoghue LJ |
Year: |
2017 |
Journal: |
Genetics |
Title: |
Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1. |
Volume: |
207 |
Issue: |
2 |
Pages: |
801-812 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rogers TD |
Year: |
2022 |
Journal: |
Front Physiol |
Title: |
Regional Differences in Mucociliary Clearance in the Upper and Lower Airways. |
Volume: |
13 |
|
Pages: |
842592 |
|
•
•
•
•
•
|
Publication |
First Author: |
Donoghue LJ |
Year: |
2023 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Nandula SR |
Year: |
2020 |
Journal: |
Exp Physiol |
Title: |
The parotid secretory protein BPIFA2 is a salivary surfactant that affects lipopolysaccharide action. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Increased susceptibility to pulmonary Pseudomonas infection in Splunc1 knockout mice. |
Volume: |
191 |
Issue: |
8 |
Pages: |
4259-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bartlett JA |
Year: |
2015 |
Journal: |
Dis Model Mech |
Title: |
Increased susceptibility to otitis media in a Splunc1-deficient mouse model. |
Volume: |
8 |
Issue: |
5 |
Pages: |
501-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu T |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor. |
Volume: |
8 |
|
Pages: |
14118 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
486
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
482
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Strain |
Attribute String: |
outbred stock |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Mulay A |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model. |
Volume: |
8 |
Issue: |
1 |
Pages: |
3128 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bingle CD |
Year: |
2004 |
Journal: |
Trends Immunol |
Title: |
Meet the relatives: a family of BPI- and LBP-related proteins. |
Volume: |
25 |
Issue: |
2 |
Pages: |
53-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bingle CD |
Year: |
2003 |
Journal: |
Biochem Soc Trans |
Title: |
Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families. |
Volume: |
31 |
Issue: |
Pt 4 |
Pages: |
806-9 |
|
•
•
•
•
•
|
Allele |
Name: |
bactericidal permeablility increasing protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Bingle CD |
Year: |
2002 |
Journal: |
Hum Mol Genet |
Title: |
PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. |
Volume: |
11 |
Issue: |
8 |
Pages: |
937-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mulero JJ |
Year: |
2002 |
Journal: |
Immunogenetics |
Title: |
Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). |
Volume: |
54 |
Issue: |
5 |
Pages: |
293-300 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bingle CD |
Year: |
2004 |
Journal: |
Protein Sci |
Title: |
Phylogenetic and evolutionary analysis of the PLUNC gene family. |
Volume: |
13 |
Issue: |
2 |
Pages: |
422-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beamer LJ |
Year: |
1997 |
Journal: |
Science |
Title: |
Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. |
Volume: |
276 |
Issue: |
5320 |
Pages: |
1861-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Britto CJ |
Year: |
2015 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Bactericidal/Permeability-increasing protein fold-containing family member A1 in airway host protection and respiratory disease. |
Volume: |
52 |
Issue: |
5 |
Pages: |
525-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di YP |
Year: |
2011 |
Journal: |
Biochem Soc Trans |
Title: |
Functional roles of SPLUNC1 in the innate immune response against Gram-negative bacteria. |
Volume: |
39 |
Issue: |
4 |
Pages: |
1051-5 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Bactericidal/permeability-increasing protein fold-containing family member A1 (BPIFA1), formerly known as SPLUNC1, participates in host protection through its antimicrobial, surfactant, and immunomodulatory properties [, ]. Its expression is largely restricted to the respiratory tract []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
591
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
403
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Little MS |
Year: |
2018 |
Journal: |
Acta Crystallogr F Struct Biol Commun |
Title: |
Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1. |
Volume: |
74 |
Issue: |
Pt 5 |
Pages: |
268-276 |
|
•
•
•
•
•
|
Publication |
First Author: |
Poulsen K |
Year: |
1986 |
Journal: |
EMBO J |
Title: |
Coordination of murine parotid secretory protein and salivary amylase expression. |
Volume: |
5 |
Issue: |
8 |
Pages: |
1891-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mirels L |
Year: |
1998 |
Journal: |
Biochem J |
Title: |
Characterization of the rat salivary-gland B1-immunoreactive proteins. |
Volume: |
330 ( Pt 1) |
|
Pages: |
437-44 |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family C; wild type |
|
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrault JB |
Year: |
2003 |
Journal: |
Genomics |
Title: |
Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides. |
Volume: |
82 |
Issue: |
2 |
Pages: |
172-84 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
555
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 2; wild type |
|
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 1; wild type |
|
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 3; wild type |
|
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 2; wild type |
|
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 6; wild type |
|
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 6; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 9B; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 3; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 5; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 1; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 4; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 5; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 9A; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family C; endonuclease-mediated mutation 1, Jackson |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Akram KM |
Year: |
2018 |
Journal: |
Mucosal Immunol |
Title: |
An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection. |
Volume: |
11 |
Issue: |
1 |
Pages: |
71-81 |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 3; targeted mutation 1, Lexicon Genetics |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 1; targeted mutation 1, Velocigene |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 3; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 3; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 5; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 4; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 3; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 3; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 1; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 1; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 2; targeted mutation 1, Velocigene |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 5; targeted mutation 2a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 5; targeted mutation 2e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 1; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 2; targeted mutation 1, Velocigene |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 6; targeted mutation 1, Velocigene |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 6; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 6; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 2; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 6; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 6; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 1; targeted mutation 1, Lexicon Pharmaceuticals |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family A, member 1; mutation 1, Ingenium Pharmaceuticals |
Allele Type: |
Chemically induced (ENU) |
|
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 4; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 4; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 3; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
BPI fold containing family B, member 1; targeted mutation 1b, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|