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Search results 201 to 300 out of 2452 for Brca1

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Type Details Score
Publication
11181458 | J:67485
First Author: Karabinis ME
Year: 2001
Journal: Carcinogenesis
Title: Heterozygosity for a mutation in Brca1 or Atm does not increase susceptibility to ENU-induced mammary tumors in Apc(Min)/+ mice.
Volume: 22
Issue: 2
Pages: 343-6
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Publication
11420664 | J:69602
First Author: Hohenstein P
Year: 2001
Journal: Oncogene
Title: A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage.
Volume: 20
Issue: 20
Pages: 2544-50
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Publication
18461147 | J:161107
First Author: Vassilopoulos A
Year: 2008
Journal: Int J Biol Sci
Title: Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells.
Volume: 4
Issue: 3
Pages: 133-42
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Publication
30445628 | J:277844
First Author: Xu X
Year: 2019
Journal: Hum Mol Genet
Title: BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy.
Volume: 28
Issue: 5
Pages: 842-857
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Publication
19088202 | J:197744
First Author: Reid LJ
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.
Volume: 105
Issue: 52
Pages: 20876-81
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Publication
17626182 | J:126551
First Author: Liu X
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.
Volume: 104
Issue: 29
Pages: 12111-6
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Publication
9133444 | J:40064
First Author: Rajan JV
Year: 1997
Journal: Dev Biol
Title: Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues.
Volume: 184
Issue: 2
Pages: 385-401
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Publication
37697435 | J:342028
First Author: Krishnan R
Year: 2023
Journal: Nucleic Acids Res
Title: RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells.
Volume: 51
Issue: 19
Pages: 10484-10505
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Publication
25066119 | J:269823
First Author: Castillo A
Year: 2014
Journal: Cell Rep
Title: The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression.
Volume: 8
Issue: 3
Pages: 807-17
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Gene
9577 | BABAM2
Type: gene
Organism: human
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Gene
84142 | ABRAXAS1
Type: gene
Organism: human
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Gene
29086 | BABAM1
Type: gene
Organism: human
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Publication
17653086 | J:132088
First Author: Jones LP
Year: 2008
Journal: Oncogene
Title: Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer.
Volume: 27
Issue: 6
Pages: 794-802
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Publication
22617326 | J:189304
First Author: Szabova L
Year: 2012
Journal: Cancer Res
Title: Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer.
Volume: 72
Issue: 16
Pages: 4141-53
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Publication
23271346 | J:192592
First Author: Sotiropoulou PA
Year: 2013
Journal: Genes Dev
Title: BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.
Volume: 27
Issue: 1
Pages: 39-51
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Publication
23509290 | J:194229
First Author: Kass EM
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase.
Volume: 110
Issue: 14
Pages: 5564-9
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Publication
28659469 | J:244006
First Author: Chen CC
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair.
Volume: 114
Issue: 29
Pages: 7665-7670
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Publication
20028858 | J:155737
First Author: Hong H
Year: 2010
Journal: Cancer Res
Title: Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer.
Volume: 70
Issue: 1
Pages: 221-8
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Publication
20616007 | J:162412
First Author: Whitehouse CA
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity.
Volume: 107
Issue: 29
Pages: 12913-8
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Publication
19403657 | J:149563
First Author: Pulvers JN
Year: 2009
Journal: Development
Title: Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors.
Volume: 136
Issue: 11
Pages: 1859-68
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Publication
23664366 | J:197441
First Author: Nakles RE
Year: 2013
Journal: Am J Pathol
Title: The PPARγ agonist efatutazone increases the spectrum of well-differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency.
Volume: 182
Issue: 6
Pages: 1976-85
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Publication
29401626 | J:272130
First Author: Jackson KC
Year: 2018
Journal: FASEB J
Title: Induced Cre-mediated knockdown of Brca1 in skeletal muscle reduces mitochondrial respiration and prevents glucose intolerance in adult mice on a high-fat diet.
Volume: 32
Issue: 6
Pages: 3070-3084
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Publication
24829461 | J:218138
First Author: Muñoz MC
Year: 2014
Journal: Nucleic Acids Res
Title: An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells.
Volume: 42
Issue: 12
Pages: 7720-33
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Publication
26903517 | J:233720
First Author: Hodge CD
Year: 2016
Journal: J Biol Chem
Title: RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.
Volume: 291
Issue: 18
Pages: 9396-410
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Publication
30484104 | J:307676
First Author: Hollern DP
Year: 2019
Journal: Breast Cancer Res Treat
Title: A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.
Volume: 174
Issue: 1
Pages: 143-155
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Publication
23863842 | J:210404
First Author: Buckley NE
Year: 2013
Journal: Nucleic Acids Res
Title: BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers.
Volume: 41
Issue: 18
Pages: 8601-14
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Publication
34548335 | J:316877
First Author: Pulver EM
Year: 2021
Journal: Cancer Res
Title: A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair.
Volume: 81
Issue: 24
Pages: 6171-6182
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Publication
31877165 | J:283370
First Author: Park D
Year: 2019
Journal: PLoS One
Title: Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains.
Volume: 14
Issue: 12
Pages: e0226714
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Publication
12140760 | J:77948
First Author: Weaver Z
Year: 2002
Journal: Oncogene
Title: Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer.
Volume: 21
Issue: 33
Pages: 5097-107
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HT Experiment
E-GEOD-6310 | Brain BRCA1 conditional knockout
Series Id: GSE6310
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
21396117 | J:175588
First Author: Burga LN
Year: 2011
Journal: Breast Cancer Res
Title: Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice.
Volume: 13
Issue: 2
Pages: R30
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Publication
16651405 | J:319986
First Author: Kim HS
Year: 2006
Journal: Cancer Res
Title: DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex.
Volume: 66
Issue: 9
Pages: 4561-5
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Publication
15159397 | J:319994
First Author: Fabbro M
Year: 2004
Journal: J Biol Chem
Title: BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
Volume: 279
Issue: 30
Pages: 31251-8
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Publication
31916095 | J:299881
First Author: Stobezki R
Year: 2020
Journal: Reprod Sci
Title: Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate.
Volume: 27
Issue: 3
Pages: 940-953
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Protein
P97432
Organism: Mus musculus/domesticus
Length: 988  
Fragment?: false
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Publication
10881179 | J:63282
First Author: Mak TW
Year: 2000
Journal: Nat Immunol
Title: Brca1 required for T cell lineage development but not TCR loci rearrangement.
Volume: 1
Issue: 1
Pages: 77-82
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Publication
16108063 | J:101017
First Author: Henderson BR
Year: 2005
Journal: Bioessays
Title: Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking.
Volume: 27
Issue: 9
Pages: 884-93
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Protein
A2A4R0
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Publication
9798686 | J:50839
First Author: Ayi TC
Year: 1998
Journal: Oncogene
Title: Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein.
Volume: 17
Issue: 16
Pages: 2143-8
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Publication
16943438 | J:112308
First Author: Kim SS
Year: 2006
Journal: Mol Cell Biol
Title: Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Delta11 isoform.
Volume: 26
Issue: 18
Pages: 6983-92
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Publication
12485996 | J:320082
First Author: Mallery DL
Year: 2002
Journal: EMBO J
Title: Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains.
Volume: 21
Issue: 24
Pages: 6755-62
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Publication
28283467 | J:328028
First Author: Alothman SJ
Year: 2017
Journal: Cancer Prev Res (Phila)
Title: Responsiveness of Brca1 and Trp53 Deficiency-Induced Mammary Preneoplasia to Selective Estrogen Modulators versus an Aromatase Inhibitor in Mus musculus.
Volume: 10
Issue: 4
Pages: 244-254
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Publication
20656689 | J:320081
First Author: Patterson-Fortin J
Year: 2010
Journal: J Biol Chem
Title: Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex.
Volume: 285
Issue: 40
Pages: 30971-81
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Publication
24966277 | J:213861
First Author: Peng M
Year: 2014
Journal: EMBO J
Title: Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses.
Volume: 33
Issue: 15
Pages: 1698-712
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Publication
30657944 | J:319683
First Author: Mohiuddin M
Year: 2019
Journal: Nucleic Acids Res
Title: CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs.
Volume: 47
Issue: 6
Pages: 2966-2980
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Publication
18171670 | J:319979
First Author: Chen L
Year: 2008
Journal: J Biol Chem
Title: Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.
Volume: 283
Issue: 12
Pages: 7713-20
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Publication
35601919 | J:325357
First Author: Chomiak AA
Year: 2022
Journal: iScience
Title: Nde1 is required for heterochromatin compaction and stability in neocortical neurons.
Volume: 25
Issue: 6
Pages: 104354
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Publication
17138902 | J:116190
First Author: Poole AJ
Year: 2006
Journal: Science
Title: Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist.
Volume: 314
Issue: 5804
Pages: 1467-70
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Allele
Brca1<tm1Whl> | MGI:1858107
Name: breast cancer 1, early onset; targeted mutation 1, Weu-Hwa Lee
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
29709199 | J:320083
 
First Author: Syed A
Year: 2018
Journal: Annu Rev Biochem
Title: The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
Volume: 87
Pages: 263-294
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Publication
8634698 | J:30136
First Author: Sharan SK
Year: 1995
Journal: Hum Mol Genet
Title: Murine Brca1: sequence and significance for human missense mutations.
Volume: 4
Issue: 12
Pages: 2275-8
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Publication
37541454 | J:339667
 
First Author: Drake DM
Year: 2023
Journal: Free Radic Biol Med
Title: Breast cancer 1 (BRCA1) protection in altered gene expression and neurodevelopmental disorders due to physiological and ethanol-enhanced reactive oxygen species formation.
Volume: 208
Pages: 272-284
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Publication
33789929 | J:349136
First Author: Shissler SC
Year: 2021
Journal: Immunohorizons
Title: Inbred Strain Characteristics Impact the NKT Cell Repertoire.
Volume: 5
Issue: 3
Pages: 147-156
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Publication
7545954 | J:20777
First Author: Miki Y
Year: 1994
Journal: Science
Title: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.
Volume: 266
Issue: 5182
Pages: 66-71
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Publication
16522651 | J:107440
First Author: Deng CX
Year: 2006
Journal: Nucleic Acids Res
Title: BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution.
Volume: 34
Issue: 5
Pages: 1416-26
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Publication
25400280 | J:237027
First Author: Savage KI
Year: 2015
Journal: FEBS J
Title: BRCA1, a 'complex' protein involved in the maintenance of genomic stability.
Volume: 282
Issue: 4
Pages: 630-46
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Protein
F6S397
Organism: Mus musculus/domesticus
Length: 712  
Fragment?: true
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Publication
20362325 | J:240590
First Author: Bunting SF
Year: 2010
Journal: Cell
Title: 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
Volume: 141
Issue: 2
Pages: 243-54
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Publication
26629949 | J:310000
 
First Author: Shapiro AM
Year: 2016
Journal: Redox Biol
Title: Breast cancer 1 (BRCA1)-deficient embryos develop normally but are more susceptible to ethanol-initiated DNA damage and embryopathies.
Volume: 7
Pages: 30-38
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Publication
28649985 | J:249598
 
First Author: Zhang X
Year: 2017
Journal: Nat Commun
Title: Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.
Volume: 8
Pages: 15908
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Publication
27292187 | J:238241
First Author: Sau A
Year: 2016
Journal: Cell Stem Cell
Title: Persistent Activation of NF-κB in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage.
Volume: 19
Issue: 1
Pages: 52-65
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Publication
12915453 | J:85693
 
First Author: Hohenstein P
Year: 2003
Journal: Hum Mol Genet
Title: Of mice and (wo)men: genotype-phenotype correlations in BRCA1.
Volume: 12 Spec No 2
Pages: R271-7
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Publication
16585167 | J:108217
First Author: Smolen GA
Year: 2006
Journal: Cancer Res
Title: Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis.
Volume: 66
Issue: 7
Pages: 3452-5
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Publication
27220670 | J:253806
 
First Author: Nair RS
Year: 2016
Journal: Sci Rep
Title: Increased sensitivity of BRCA defective triple negative breast tumors to plumbagin through induction of DNA Double Strand Breaks (DSB).
Volume: 6
Pages: 26631
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Publication
23317938 | J:321118
First Author: Singh KK
Year: 2013
Journal: J Thorac Cardiovasc Surg
Title: Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1.
Volume: 146
Issue: 3
Pages: 702-9
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Publication
30416390 | J:309110
First Author: Baek HJ
Year: 2018
Journal: Int J Biol Sci
Title: Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation.
Volume: 14
Issue: 12
Pages: 1755-1768
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Publication
12915465 | J:85460
First Author: Yang Y
Year: 2003
Journal: Hum Mol Genet
Title: Aberrant splicing induced by missense mutations in BRCA1: clues from a humanized mouse model.
Volume: 12
Issue: 17
Pages: 2121-31
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Publication
10195418 | J:54149
First Author: Irminger-Finger I
Year: 1999
Journal: Biol Chem
Title: The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.
Volume: 380
Issue: 2
Pages: 117-28
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Publication
18588899 | J:168879
First Author: Sordet O
Year: 2008
Journal: J Mol Biol
Title: Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I.
Volume: 381
Issue: 3
Pages: 540-9
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Publication
9528852 | J:46396
First Author: Jensen DE
Year: 1998
Journal: Oncogene
Title: BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.
Volume: 16
Issue: 9
Pages: 1097-112
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Publication
35393420 | J:323627
First Author: Mateo F
Year: 2022
Journal: Nat Commun
Title: Modification of BRCA1-associated breast cancer risk by HMMR overexpression.
Volume: 13
Issue: 1
Pages: 1895
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Publication
22789542 | J:191013
First Author: Schlacher K
Year: 2012
Journal: Cancer Cell
Title: A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.
Volume: 22
Issue: 1
Pages: 106-16
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Publication
23408054 | J:194529
First Author: Titus S
Year: 2013
Journal: Sci Transl Med
Title: Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans.
Volume: 5
Issue: 172
Pages: 172ra21
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Publication
23173005 | J:194081
First Author: Kumar P
Year: 2012
Journal: PLoS Genet
Title: Cooperativity of Rb, Brca1, and p53 in malignant breast cancer evolution.
Volume: 8
Issue: 11
Pages: e1003027
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Publication
27815389 | J:238429
First Author: Li M
Year: 2017
Journal: Cancer Res
Title: Chemopreventive Effects of ROS Targeting in a Murine Model of BRCA1-Deficient Breast Cancer.
Volume: 77
Issue: 2
Pages: 448-458
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Publication
16843262 | J:110942
First Author: Furuta S
Year: 2006
Journal: Cancer Cell
Title: Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature.
Volume: 10
Issue: 1
Pages: 13-24
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Publication
25016020 | J:267154
First Author: Simhadri S
Year: 2014
Journal: J Biol Chem
Title: Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice.
Volume: 289
Issue: 35
Pages: 24617-29
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Publication
19015238 | J:145559
First Author: Wu J
Year: 2009
Journal: Mol Cell Biol
Title: Histone ubiquitination associates with BRCA1-dependent DNA damage response.
Volume: 29
Issue: 3
Pages: 849-60
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Publication
21187397 | J:169700
First Author: Goldberg MS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.
Volume: 108
Issue: 2
Pages: 745-50
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Publication
34555355 | J:315842
First Author: Paes Dias M
Year: 2021
Journal: Mol Cell
Title: Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps.
Volume: 81
Issue: 22
Pages: 4692-4708.e9
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Protein
A1L329
Organism: Mus musculus/domesticus
Length: 988  
Fragment?: false
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Publication
27670884 | J:237991
First Author: Li M
Year: 2016
Journal: EMBO Rep
Title: 53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1.
Volume: 17
Issue: 11
Pages: 1532-1541
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Publication
38537683 | J:347096
First Author: Yoshino Y
Year: 2024
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification.
Volume: 1870
Issue: 5
Pages: 167138
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Publication
20807817 | J:164207
First Author: Ibrahim N
Year: 2010
Journal: Cancer Res
Title: BRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma.
Volume: 70
Issue: 18
Pages: 7155-65
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Publication
30590041 | J:270746
First Author: Tornillo G
Year: 2018
Journal: Cell Rep
Title: Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells.
Volume: 25
Issue: 13
Pages: 3674-3692.e10
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Publication
30530501 | J:271222
First Author: Barazas M
Year: 2019
Journal: Cancer Res
Title: Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors.
Volume: 79
Issue: 3
Pages: 452-460
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Publication
30017478 | J:264231
First Author: Menghi F
Year: 2018
Journal: Cancer Cell
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