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Search results 201 to 221 out of 221 for Btbd1

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Type Details Score
Publication
20156452 | -
First Author: Sampathkumar P
Year: 2010
Journal: J Mol Biol
Title: Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1.
Volume: 397
Issue: 4
Pages: 883-92
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Protein
Q0P614
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: false
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Protein
Q6IS59
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
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Protein
Q91YK4
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: true
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Protein Domain
IPR038648 | PHR_sf
Type: Homologous_superfamily
Description: This domain is called PHR as it was originally found in the E3 ubiquitin-protein ligase proteins PAM (), highwire () and RPM-1 () [].PHR proteins are conserved, large multi-domain E3 ubiquitin ligases with modular architecture. PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptically regulate endocytosis of glutamate receptors. Dysfunction of neuronal ubiquitin-mediated proteasomal degradation is implicated in various neurodegenerative diseases. PHR proteins are characterised by the presence of two PHR domains near the N terminus, which are essential for proper localisation and function. The domain has a β-sandwich fold composed of 11 anti-parallel β-strands [].The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils [].
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Protein Domain
IPR012983 | PHR
Type: Domain
Description: This domain is called PHR as it was originally found in the E3 ubiquitin-protein ligase proteins PAM (), highwire () and RPM-1 () [].PHR proteins are conserved, large multi-domain E3 ubiquitin ligases with modular architecture. PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptically regulate endocytosis of glutamate receptors. Dysfunction of neuronal ubiquitin-mediated proteasomal degradation is implicated in various neurodegenerative diseases. PHR proteins are characterised by the presence of two PHR domains near the N terminus, which are essential for proper localisation and function. The domain has a β-sandwich fold composed of 11 anti-parallel β-strands [].The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils [].
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Protein
P58545
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
P58544
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
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Protein
Q8K2J9
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
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Protein
Q14BP3
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
E9PUS2
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
Q5XJI1
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: true
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Protein
Q5M8N6
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
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Protein
Q7TNF6
Organism: Mus musculus/domesticus
Length: 392  
Fragment?: true
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Protein
Q8CHC1
Organism: Mus musculus/domesticus
Length: 547  
Fragment?: true
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Protein
G5E817
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
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Protein
Q14BP4
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
E9PY28
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
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Protein
Q3TSN9
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
Q7TPH6
Organism: Mus musculus/domesticus
Length: 4749  
Fragment?: false
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Protein
F6SMY7
Organism: Mus musculus/domesticus
Length: 4636  
Fragment?: true
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