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Search results 201 to 219 out of 219 for Capn2

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0.018s

Type

Details

Score

Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

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Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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UniProt Feature

Begin:	459
Description:	Cleavage; by CAPN2
Type:	site
End:	460

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UniProt Feature

Begin:	81
Description:	Cleavage; by CAPN2
Type:	site
End:	82

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UniProt Feature

Begin:	212
Description:	Cleavage; by CAPN2
Type:	site
End:	213

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Publication

23589330 | J:204494

First Author:	Cataldo F
Year:	2013
Journal:	Mol Cell Biol
Title:	CAPNS1 regulates USP1 stability and maintenance of genome integrity.
Volume:	33
Issue:	12
Pages:	2485-96

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Publication

15336956 | -

First Author:	Branca D
Year:	2004
Journal:	Biochem Biophys Res Commun
Title:	Calpain-related diseases.
Volume:	322
Issue:	4
Pages:	1098-104

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Publication

22496808 | -

First Author:	Bate N
Year:	2012
Journal:	PLoS One
Title:	Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics.
Volume:	7
Issue:	4
Pages:	e34461

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Publication

23940116 | -

First Author:	Saraiva N
Year:	2013
Journal:	J Cell Biol
Title:	hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2.
Volume:	202
Issue:	4
Pages:	699-713

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Publication

20094891 | -

First Author:	Magnaghi-Jaulin L
Year:	2010
Journal:	Chromosoma
Title:	Calpain 2 is required for sister chromatid cohesion.
Volume:	119
Issue:	3
Pages:	267-74

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Publication

26907807 | -

First Author:	Liu Y
Year:	2016
Journal:	Neuropharmacology
Title:	A calpain-2 selective inhibitor enhances learning & memory by prolonging ERK activation.
Volume:	105

Pages:	471-477

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Publication

22435971 | -

First Author:	Storr SJ
Year:	2012
Journal:	J Cell Mol Med
Title:	Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.
Volume:	16
Issue:	10
Pages:	2422-8

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Publication

16054132 | -

First Author:	Shih M
Year:	2006
Journal:	Exp Eye Res
Title:	Biochemical properties of lens-specific calpain Lp85.
Volume:	82
Issue:	1
Pages:	146-52

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Publication

22427650 | -

First Author:	Ho WC
Year:	2012
Journal:	J Biol Chem
Title:	Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Volume:	287
Issue:	19
Pages:	15458-65

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Protein Domain

IPR042736 | EFh_PEF_CAPN2

Type:

Domain

Description:

This entry represents the Ca2 -binding penta-EF-hand (PEF) domain found in CAPN2 (also known as Calpain 2). CAPN2 is a ubiquitously expressed Ca2 -dependent intracellular cysteine protease that contains a short N-terminal anchor helix, followed by a calpain cysteine protease (CysPc) domain, a C2-domain-like (C2L) domain, and a C-terminal Ca2 -binding penta-EF-hand (PEF) domain []. The catalytic subunit CAPN2 in complex with a regulatory subunit encoded by CAPNS1 forms an m-calpain heterodimer[]. CAPN2 acts as the key protease responsible for N-methyl-d-aspartic acid (NMDA)-induced cytoplasmic polyadenylation element-binding protein 3 (CPEB3) degradation in neurons []. It cleaves several components of the focal adhesion complex, such as FAK and talin, triggering disassembly of the complex at the rear of the cell []. The stimulation of CAPN2 activity is required for Golgi antiapoptotic proteins (GAAPs) to promote cleavage of FA kinase (FAK), cell spreading, and enhanced migration. calpain 2 is also involved in the onset of glial differentiation []. It regulates proliferation, survival, migration, and tumorigenesis of breast cancer cells through a PP2A-Akt-FoxO-p27(Kip1) signalling cascade []. Its expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer []. Moreover, CAPN2 may play a role in fundamental mitotic functions, such as the maintenance of sister chromatid cohesion []. The activation of CAPN2 plays an essential role in hippocampal synaptic plasticity and in learning and memory []. In the eye, CAPN2, together with a lens-specific variant of CAPN3, is responsible for proteolytic cleavages of alpha and beta-crystallin. Overactivated alpha and beta-crystallin can lead to cataract formation []. Sometimes, CAPN2 compensates for loss of CAPN1, and both calpain isoforms are involved in AngII-induced aortic aneurysm formation []. The main phosphorylation sites in m-calpain are Ser50 and Ser369/Thr370.

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Publication

16597616 | J:113722

First Author:	Tan Y
Year:	2006
Journal:	J Biol Chem
Title:	Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis.
Volume:	281
Issue:	23
Pages:	16016-24

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Publication

32348180 | J:293733

First Author:	Piper AK
Year:	2020
Journal:	Am J Physiol Cell Physiol
Title:	Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy.
Volume:	318
Issue:	6
Pages:	C1226-C1237

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Publication

24838245 | J:303288

First Author:	Singh R
Year:	2014
Journal:	J Biol Chem
Title:	Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies.
Volume:	289
Issue:	28
Pages:	19383-94

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Publication

27402795 | J:245452

First Author:	Rodríguez-Fernández L
Year:	2016
Journal:	Biochem J
Title:	Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer.
Volume:	473
Issue:	18
Pages:	2893-909

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