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Search results 201 to 300 out of 311 for Cbr3

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Type Details Score
GXD Expression      
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Specimen Label: MY205; Specimen C1176
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Specimen Label: MY205; Specimen C1176
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Specimen Label: MY205; Specimen C1176
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287022
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Specimen Label: MY205; Specimen C1176
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Image: MY205; Specimen C1176
Specimen Label: MY205; Specimen C1176
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1821522
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Specimen Label: MY205; Specimen C1176
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Specimen Label: MY205; Specimen C1176
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Image: MY205; Specimen C1176
Specimen Label: MY205; Specimen C1176
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Specimen Label: MY205; Specimen C1176
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Specimen Label: MY205; Specimen C1176
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Specimen Label: MY205; Specimen C1176
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Specimen Label: MY205; Specimen C1176
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Specimen Label: MY205; Specimen C1176
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1802422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Image: MY205; Specimen C1176
Specimen Label: MY205; Specimen C1176
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1768022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Image: MY205; Specimen C1176
Note: Expression was strong in the skull (base and vault).
Specimen Label: MY205; Specimen C1176
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5309658
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5423010
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: MY205; Specimen C1176
Detected: false
Specimen Num: 1
Publication
First Author: Galdzicki Z
Year: 2001
Journal: Brain Res Brain Res Rev
Title: On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models.
Volume: 35
Issue: 2
Pages: 115-45
Publication
First Author: Cabin DE
Year: 1998
Journal: Genome Res
Title: Physical and comparative mapping of distal mouse chromosome 16. 5 p5.
Volume: 8
Issue: 9
Pages: 940-50
Publication
First Author: Bondareva AA
Year: 2007
Journal: Free Radic Biol Med
Title: Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome.
Volume: 43
Issue: 6
Pages: 911-23
Publication
First Author: Billingsley CN
Year: 2013
Journal: Am J Med Genet A
Title: Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome.
Volume: 161A
Issue: 8
Pages: 1866-74
Publication
First Author: Pletcher MT
Year: 2001
Journal: Genomics
Title: Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21.
Volume: 74
Issue: 1
Pages: 45-54
Publication
First Author: Pereira JD
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.
Volume: 107
Issue: 36
Pages: 15957-62
Publication
First Author: Gitton Y
Year: 2002
Journal: Nature
Title: A gene expression map of human chromosome 21 orthologues in the mouse.
Volume: 420
Issue: 6915
Pages: 586-90
Publication
First Author: Reymond A
Year: 2002
Journal: Nature
Title: Human chromosome 21 gene expression atlas in the mouse.
Volume: 420
Issue: 6915
Pages: 582-6
Publication
First Author: Tamplin OJ
Year: 2011
Journal: Dev Biol
Title: Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.
Volume: 360
Issue: 2
Pages: 415-25
Publication
First Author: Lumayag S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Volume: 110
Issue: 6
Pages: E507-16
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Protein
Organism: Mus musculus/domesticus
Length: 277  
Fragment?: false
Allele
Name: transgene insertion 55, Edward M Rubin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 50, Edward M Rubin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Strain
Attribute String: coisogenic, mutant strain, transgenic
Strain
Attribute String: transgenic, mutant strain, coisogenic
Genotype
Symbol: Tg(CEPHY230E8)50Hgc/?
Background: (C57BL/6 x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(CEPHY230E8)55Hgc/?
Background: (C57BL/6 x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Terada T
Year: 2000
Journal: Eur J Biochem
Title: Cloning and bacterial expression of monomeric short-chain dehydrogenase/reductase (carbonyl reductase) from CHO-K1 cells.
Volume: 267
Issue: 23
Pages: 6849-57
Publication  
First Author: Huang J
Year: 2012
Journal: Nat Commun
Title: SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane.
Volume: 3
Pages: 911
Publication
First Author: Naguib A
Year: 2015
Journal: Mol Cell
Title: PTEN functions by recruitment to cytoplasmic vesicles.
Volume: 58
Issue: 2
Pages: 255-68
Protein Domain
Type: Domain
Description: Tensins constitute an eukaryotic family of lipid phosphatases that are defined by thepresence of two adjacent domains: a lipid phosphatase domain and a C2-like domain. The tensin-type C2 domain has a structure similar to the classical C2 domain (see ) that mediates the Ca2+-dependent membrane recruitment of several signalling proteins. However the tensin-type C2 domain lacks two of the three conserved loops that bind Ca2+, and in this respect it is similar to the C2 domains of PKC-type [, ]. The tensin-type C2 domain can bind phopholipid membranes in a Ca2+ independent manner []. In the tumour suppressor protein PTEN, the best characterised member of the family, the lipid phosphatase domain was shown to specifically dephosphorylate the D3 position of the inositol ring of the lipid second messenger, phosphatydilinositol-3-4-5-triphosphate (PIP3). The lipid phosphatase domain contains the signature motif HCXXGXXR present in the active sites of protein tyrosine phosphatases (PTPs) and dual specificity phosphatases (DSPs). Furthermore, two invariant lysines are found only in the tensin-type phosphatase motif (HCKXGKXR) and are suspected to interact with the phosphate group at position D1 and D5 of the inositol ring [, ]. The C2 domain is found at the C terminus of the tumour suppressor protein PTEN (phosphatidyl-inositol triphosphate phosphatase). This domain may include a CBR3 loop, indicating a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc suggesting that the C2 domain productively positions the catalytic part of the protein on the membrane. The crystal structure of the PTEN tumour suppressor has been solved []. The lipid phosphatase domain has a structure similar to the dual specificity phosphatase (see ). However, PTEN has a larger active site pocket that could be important to accommodate PI(3,4,5)P3. Proteins known to contain a phosphatase and a C2 tensin-type domain are listed below: Tensin, a focal-adhesion molecule that binds to actin filaments. It may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.Phosphatase and tensin homologue deleted on chromosome 10 protein (PTEN). It antagonizes PI 3-kinase signalling by dephosphorylating the 3-position of the inositol ring of PI(3,4,5)P3 and thus inactivates downstream signalling. It plays major roles both during development and in the adult to control cell size, growth, and survival.Auxilin. It binds clathrin heavy chain and promotes its assembly into regular cages.Cyclin G-associated kinase or auxilin-2. It is a potential regulator of clathrin-mediated membrane trafficking.
Publication
First Author: Smith DJ
Year: 1995
Journal: Genomics
Title: Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2.
Volume: 27
Issue: 3
Pages: 425-34
Publication
First Author: Chabert C
Year: 2004
Journal: Behav Genet
Title: Functional analysis of genes implicated in Down syndrome: 1. Cognitive abilities in mice transpolygenic for Down Syndrome Chromosomal Region-1 (DCR-1).
Volume: 34
Issue: 6
Pages: 559-69
Publication
First Author: Roubertoux PL
Year: 2006
Journal: Behav Genet
Title: Pre-weaning sensorial and motor development in mice transpolygenic for the critical region of trisomy 21.
Volume: 36
Issue: 3
Pages: 377-86
Publication
First Author: Smith DJ
Year: 1997
Journal: Nat Genet
Title: Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome.
Volume: 16
Issue: 1
Pages: 28-36
Protein
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
Publication
First Author: Roubertoux PL
Year: 2017
Journal: Behav Genet
Title: Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice.
Volume: 47
Issue: 3
Pages: 305-322
Protein
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
Publication
First Author: Lee JO
Year: 1999
Journal: Cell
Title: Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.
Volume: 99
Issue: 3
Pages: 323-34
Publication  
First Author: Maehama T
Year: 2001
Journal: Annu Rev Biochem
Title: PTEN and myotubularin: novel phosphoinositide phosphatases.
Volume: 70
Pages: 247-79
Publication
First Author: Leslie NR
Year: 2002
Journal: Cell Signal
Title: PTEN: The down side of PI 3-kinase signalling.
Volume: 14
Issue: 4
Pages: 285-95
Protein
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 938  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1305  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 664  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 664  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1038  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 664  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1305  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 645  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1305  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1400  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1440  
Fragment?: false