Type |
Details |
Score |
Publication |
First Author: |
Roos RS |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Identification of CCR8, the receptor for the human CC chemokine I-309. |
Volume: |
272 |
Issue: |
28 |
Pages: |
17251-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garlisi CG |
Year: |
1999 |
Journal: |
Eur J Immunol |
Title: |
The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. |
Volume: |
29 |
Issue: |
10 |
Pages: |
3210-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Howard OM |
Year: |
2000 |
Journal: |
Blood |
Title: |
LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. |
Volume: |
96 |
Issue: |
3 |
Pages: |
840-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dairaghi DJ |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines. |
Volume: |
274 |
Issue: |
31 |
Pages: |
21569-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bernardini G |
Year: |
1998 |
Journal: |
Eur J Immunol |
Title: |
Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. |
Volume: |
28 |
Issue: |
2 |
Pages: |
582-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haque NS |
Year: |
2004 |
Journal: |
Blood |
Title: |
Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. |
Volume: |
103 |
Issue: |
4 |
Pages: |
1296-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaplan AP |
Year: |
2001 |
Journal: |
Int Arch Allergy Immunol |
Title: |
Chemokines, chemokine receptors and allergy. |
Volume: |
124 |
Issue: |
4 |
Pages: |
423-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Napolitano M |
Year: |
1999 |
Journal: |
Forum (Genova) |
Title: |
Structure and function of the CC chemokine receptor (CCR) 8. |
Volume: |
9 |
Issue: |
4 |
Pages: |
315-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dickinson LA |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Cyclin L is an RS domain protein involved in pre-mRNA splicing. |
Volume: |
277 |
Issue: |
28 |
Pages: |
25465-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Herrmann A |
Year: |
2007 |
Journal: |
FASEB J |
Title: |
Characterization of cyclin L1 as an immobile component of the splicing factor compartment. |
Volume: |
21 |
Issue: |
12 |
Pages: |
3142-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kershnar E |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. |
Volume: |
273 |
Issue: |
51 |
Pages: |
34444-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garrett S |
Year: |
2001 |
Journal: |
Mol Cell Biol |
Title: |
Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. |
Volume: |
21 |
Issue: |
1 |
Pages: |
88-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Akoulitchev S |
Year: |
2000 |
Journal: |
Nature |
Title: |
TFIIH is negatively regulated by cdk8-containing mediator complexes. |
Volume: |
407 |
Issue: |
6800 |
Pages: |
102-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao SM |
Year: |
1995 |
Journal: |
Nature |
Title: |
A kinase-cyclin pair in the RNA polymerase II holoenzyme. |
Volume: |
374 |
Issue: |
6518 |
Pages: |
193-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hengartner CJ |
Year: |
1998 |
Journal: |
Mol Cell |
Title: |
Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. |
Volume: |
2 |
Issue: |
1 |
Pages: |
43-53 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues [, ]and has also been found in glomerular podocytes []and human umbilical vein endothelial cells (HUVECs) []. CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases [, , ]. CCR8 binds to CCL1 (also known as I-309) [, ]and to CCL16 (also known as liver expressed chemokine) []. It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I. |
|
•
•
•
•
•
|
Publication |
First Author: |
Delgado MJ |
Year: |
1995 |
Journal: |
J Bacteriol |
Title: |
Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum. |
Volume: |
177 |
Issue: |
17 |
Pages: |
4927-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schuster W |
Year: |
1993 |
Journal: |
Mol Gen Genet |
Title: |
A plant mitochondrial gene encodes a protein involved in cytochrome c biogenesis. |
Volume: |
239 |
Issue: |
1-2 |
Pages: |
49-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hussain H |
Year: |
1994 |
Journal: |
Mol Microbiol |
Title: |
A seven-gene operon essential for formate-dependent nitrite reduction to ammonia by enteric bacteria. |
Volume: |
12 |
Issue: |
1 |
Pages: |
153-63 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
724
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
723
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
250
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
178
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
253
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
335
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
150
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
146
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
320
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
311
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
184
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
723
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
191
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
173
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
314
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
282
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
266
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Thöny-Meyer L |
Year: |
1995 |
Journal: |
J Bacteriol |
Title: |
Escherichia coli genes required for cytochrome c maturation. |
Volume: |
177 |
Issue: |
15 |
Pages: |
4321-6 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
532
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
554
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
518
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
309
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
331
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
582
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
346
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
353
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
346
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
353
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
252
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
353
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Huber TB |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Expression of functional CCR and CXCR chemokine receptors in podocytes. |
Volume: |
168 |
Issue: |
12 |
Pages: |
6244-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Galderisi U |
Year: |
2003 |
Journal: |
Oncogene |
Title: |
Cell cycle regulation and neural differentiation. |
Volume: |
22 |
Issue: |
33 |
Pages: |
5208-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma Q |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. |
Volume: |
95 |
Issue: |
16 |
Pages: |
9448-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horuk R |
Year: |
2001 |
Journal: |
Cytokine Growth Factor Rev |
Title: |
Chemokine receptors. |
Volume: |
12 |
Issue: |
4 |
Pages: |
313-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Charbonnier AS |
Year: |
1999 |
Journal: |
J Exp Med |
Title: |
Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells. |
Volume: |
190 |
Issue: |
12 |
Pages: |
1755-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sallusto F |
Year: |
1998 |
Journal: |
J Exp Med |
Title: |
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. |
Volume: |
187 |
Issue: |
6 |
Pages: |
875-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strieter RM |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. |
Volume: |
270 |
Issue: |
45 |
Pages: |
27348-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zlotnik A |
Year: |
2000 |
Journal: |
Immunity |
Title: |
Chemokines: a new classification system and their role in immunity. |
Volume: |
12 |
Issue: |
2 |
Pages: |
121-7 |
|
•
•
•
•
•
|