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Search results 201 to 300 out of 413 for Ccl4

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Type Details Score
Publication
32406200 | J:309120
First Author: Ding H
Year: 2020
Journal: J Cell Mol Med
Title: Smad3 gene C-terminal phosphorylation site mutation aggravates CCl4 -induced inflammation in mice.
Volume: 24
Issue: 12
Pages: 7044-7054
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Publication
34769006 | J:315054
 
First Author: Unrau L
Year: 2021
Journal: Int J Mol Sci
Title: Smad7 Deficiency in Myeloid Cells Does Not Affect Liver Injury, Inflammation or Fibrosis after Chronic CCl4 Exposure in Mice.
Volume: 22
Issue: 21
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Publication
25548252 | -
First Author: Naegelen I
Year: 2015
Journal: J Leukoc Biol
Title: An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells.
Volume: 97
Issue: 3
Pages: 557-71
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HT Experiment
E-GEOD-3565 | Transcription profiling of spleens from dual specificity phosphatase-1 (DUSP1) deficient and wild type mice to demonstrate a specific regulatory role of DUSP1 on a subset of LPS-induced genes that control the outcome of endotoxin shock
Series Id: GSE3565
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
18439751 | -
First Author: Soria G
Year: 2008
Journal: Cancer Lett
Title: The inflammatory chemokines CCL2 and CCL5 in breast cancer.
Volume: 267
Issue: 2
Pages: 271-85
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Publication
24523569 | -
 
First Author: Aldinucci D
Year: 2014
Journal: Mediators Inflamm
Title: The inflammatory chemokine CCL5 and cancer progression.
Volume: 2014
Pages: 292376
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Publication
16791620 | -
First Author: Capoulade-Métay C
Year: 2006
Journal: Immunogenetics
Title: A natural CCL5/RANTES variant antagonist for CCR1 and CCR3.
Volume: 58
Issue: 7
Pages: 533-41
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Publication
25114130 | -
First Author: Secchi M
Year: 2014
Journal: Antimicrob Agents Chemother
Title: Combination of the CCL5-derived peptide R4.0 with different HIV-1 blockers reveals wide target compatibility and synergic cobinding to CCR5.
Volume: 58
Issue: 10
Pages: 6215-23
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Publication
18243436 | -
First Author: Vangelista L
Year: 2008
Journal: Vaccine
Title: Rational design of novel HIV-1 entry inhibitors by RANTES engineering.
Volume: 26
Issue: 24
Pages: 3008-15
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Protein Domain
IPR030595 | CCL5
Type: Family
Description: C-C chemokine ligand 5 (CCL5), also known as RANTES, is a target gene of NF-kappaB, and is expressed by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumour cells [, ]. CCL5 plays a role in recruiting a variety of leukocytes into inflammatory sites including T cells, macrophages, eosinophils, and basophils. CCL5 activity is mediated through its binding to CCR1, CCR3, and mainly CCR5 [, ].CCR5 is a G-protein-coupled receptor for CCL3, CCL4 and CCL5. CCR5 is also the major coreceptor for HIV-1 entry into target cells and is thought to be a suitable therapeutic target for HIV-1 blockade []. However, the affinity between CCR5 and natural CCL5 is low and has limited viral entry inhibiting activity. Therefore, several CCL5 derivatives with high anti-HIV-1 potency have been produced to act as entry inhibitors and CCR5 antagonists [, ].
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HT Experiment
E-GEOD-32210 | In vitro expansion of single adult Lgr5+ liver cells induced by Wnt-driven regeneration
Series Id: GSE32210
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
24815695 | J:211658
First Author: Ji L
Year: 2014
Journal: FEBS Lett
Title: Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAPK and NF-κB signaling pathways.
Volume: 588
Issue: 12
Pages: 2095-100
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Publication
38428421 | J:347746
First Author: Chen J
Year: 2024
Journal: Cell Rep
Title: Deficiency of lncRNA MERRICAL abrogates macrophage chemotaxis and diabetes-associated atherosclerosis.
Volume: 43
Issue: 3
Pages: 113815
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Publication
10534116 | J:58108
First Author: Natsume M
Year: 1999
Journal: J Leukoc Biol
Title: Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice.
Volume: 66
Issue: 4
Pages: 601-8
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Publication
32269221 | J:305851
First Author: Zhang L
Year: 2020
Journal: Cell Death Dis
Title: Imbalance in mitochondrial dynamics induced by low PGC-1α expression contributes to hepatocyte EMT and liver fibrosis.
Volume: 11
Issue: 4
Pages: 226
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Publication
25533346 | J:222820
First Author: Chang KH
Year: 2014
Journal: Cell Rep
Title: p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.
Volume: 9
Issue: 6
Pages: 2084-97
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Publication
27598994 | J:250912
First Author: Ogiso H
Year: 2016
Journal: PLoS One
Title: The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice.
Volume: 11
Issue: 9
Pages: e0162183
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Publication
30082275 | J:266690
First Author: Kang SS
Year: 2018
Journal: J Exp Med
Title: Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau.
Volume: 215
Issue: 9
Pages: 2235-2245
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Publication
28004654 | J:243446
 
First Author: Han CY
Year: 2016
Journal: Nat Commun
Title: Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt.
Volume: 7
Pages: 13817
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Publication
24043758 | J:204071
First Author: Iannello A
Year: 2013
Journal: J Exp Med
Title: p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells.
Volume: 210
Issue: 10
Pages: 2057-69
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Publication
27891208 | J:289742
 
First Author: Feng R
Year: 2016
Journal: Oxid Med Cell Longev
Title: Endogenous n-3 Fatty Acids Alleviate Carbon-Tetrachloride-Induced Acute Liver Injury in Fat-1 Transgenic Mice.
Volume: 2016
Pages: 7962948
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Publication
25568138 | J:278621
First Author: Zhang F
Year: 2015
Journal: Int J Toxicol
Title: Deficiency of BPOZ2 Decreases Liver Fibrosis After Chronic Carbon Tetrachloride Administration in Mice.
Volume: 34
Issue: 2
Pages: 204-10
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Publication
24801603 | J:242053
First Author: Li F
Year: 2014
Journal: J Cell Mol Med
Title: Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice.
Volume: 18
Issue: 6
Pages: 966-74
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Publication
31495934 | J:299805
First Author: Chang N
Year: 2020
Journal: J Cell Physiol
Title: Both HuR and miR-29s regulate expression of CB1 involved in infiltration of bone marrow monocyte/macrophage in chronic liver injury.
Volume: 235
Issue: 3
Pages: 2532-2544
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Publication
37996458 | J:342960
First Author: Shang S
Year: 2023
Journal: Nat Commun
Title: ID1 expressing macrophages support cancer cell stemness and limit CD8(+) T cell infiltration in colorectal cancer.
Volume: 14
Issue: 1
Pages: 7661
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Publication
38451818 | J:346745
First Author: Wang P
Year: 2024
Journal: Cell Rep
Title: Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice.
Volume: 43
Issue: 3
Pages: 113875
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Publication
24855645 | -
First Author: Jin J
Year: 2014
Journal: J Biol Chem
Title: Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry.
Volume: 289
Issue: 27
Pages: 19042-52
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Publication
8663314 | J:45024
First Author: Raport CJ
Year: 1996
Journal: J Biol Chem
Title: Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.
Volume: 271
Issue: 29
Pages: 17161-6
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Publication
9655467 | -
First Author: Jiang Y
Year: 1998
Journal: J Neuroimmunol
Title: Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis.
Volume: 86
Issue: 1
Pages: 1-12
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Publication
11994538 | -
First Author: Habasque C
Year: 2002
Journal: Mol Hum Reprod
Title: Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis.
Volume: 8
Issue: 5
Pages: 419-25
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Publication
12682253 | -
First Author: Ng-Cashin J
Year: 2003
Journal: J Immunol
Title: Host absence of CCR5 potentiates dendritic cell vaccination.
Volume: 170
Issue: 8
Pages: 4201-8
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Protein Domain
IPR002240 | Chemokine_CCR5
Type: Family
Description: CC chemokine receptor 5 (CCR5) is found on the surface of white blood cells, such as macrophages [], T cells []and dendritic cells [, ], and expressed in lymphoid organs []. Transfected cells expressing CCR5 receptor bind CCL5 (RANTES), CCL4 (MIP-1beta) and CCL3 (MIP-1alpha), and generate inositol phosphates in response to these chemokines. The same combination of chemokines has been shown to potently inhibit human immunodeficiency virus replication in human peripheral blood leukocytes []. CCR5 is the major coreceptor for HIV-1 entry into target cells and is thought to be a suitable therapeutic target for HIV-1 blockade [].Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.
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Publication
8765479 | J:35601
First Author: Suzuki M
Year: 1996
Journal: Biochem Pharmacol
Title: Increase in histamine synthesis by liver macrophages in CCl4-injured mast cell-deficient W/Wv mice.
Volume: 52
Issue: 5
Pages: 809-13
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Publication
24667392 | J:215056
First Author: Sato A
Year: 2014
Journal: PLoS One
Title: Involvement of the TNF and FasL produced by CD11b Kupffer cells/macrophages in CCl4-induced acute hepatic injury.
Volume: 9
Issue: 3
Pages: e92515
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Publication
18767021 | J:139664
First Author: Tramonti D
Year: 2008
Journal: J Pathol
Title: gammadeltaT cell-mediated regulation of chemokine producing macrophages during Listeria monocytogenes infection-induced inflammation.
Volume: 216
Issue: 2
Pages: 262-70
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Publication
16774739 | J:110519
First Author: Nabeshima Y
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis.
Volume: 346
Issue: 3
Pages: 658-64
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Publication
16612374 | J:107629
First Author: Castellino F
Year: 2006
Journal: Nature
Title: Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction.
Volume: 440
Issue: 7086
Pages: 890-5
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Publication
16301670 | J:122154
First Author: Gomez G
Year: 2005
Journal: J Immunol
Title: Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells.
Volume: 175
Issue: 11
Pages: 7602-10
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Publication
22622800 | J:187763
First Author: Zhou F
Year: 2012
Journal: Eur J Immunol
Title: IL-10 deficiency blocks the ability of LPS to regulate expression of tolerance-related molecules on dendritic cells.
Volume: 42
Issue: 6
Pages: 1449-58
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Publication
9828225 | J:106536
First Author: Louis H
Year: 1998
Journal: Hepatology
Title: Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice.
Volume: 28
Issue: 6
Pages: 1607-15
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Publication
15888563 | J:114369
First Author: Kitching AR
Year: 2005
Journal: J Am Soc Nephrol
Title: IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment.
Volume: 16
Issue: 7
Pages: 2023-33
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Publication
17289654 | J:118680
First Author: Sawaki J
Year: 2007
Journal: Int Immunol
Title: Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways.
Volume: 19
Issue: 3
Pages: 311-20
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Publication
20335531 | J:160480
First Author: Kroetz DN
Year: 2010
Journal: J Immunol
Title: CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection.
Volume: 184
Issue: 9
Pages: 5224-31
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Publication
21478401 | J:173093
First Author: Kroetz DN
Year: 2011
Journal: J Immunol
Title: An aberrant thymus in CCR5-/- mice is coupled with an enhanced adaptive immune response in fungal infection.
Volume: 186
Issue: 10
Pages: 5949-55
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Publication
26854929 | J:232426
First Author: Patterson SJ
Year: 2016
Journal: J Clin Invest
Title: T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression.
Volume: 126
Issue: 3
Pages: 1039-51
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Publication
24639355 | J:210001
First Author: Kohno H
Year: 2014
Journal: J Immunol
Title: CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration.
Volume: 192
Issue: 8
Pages: 3816-27
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Publication
28855570 | J:256640
First Author: Yang T
Year: 2017
Journal: Sci Rep
Title: Metabotropic glutamate receptor 5 deficiency inhibits neutrophil infiltration after traumatic brain injury in mice.
Volume: 7
Issue: 1
Pages: 9998
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Publication
25239636 | J:246166
First Author: Livingstone DE
Year: 2015
Journal: Diabetes
Title: 5α-Reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic steatosis, and liver fibrosis in rodents.
Volume: 64
Issue: 2
Pages: 447-58
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Publication
11264022 | J:125470
First Author: Morio LA
Year: 2001
Journal: Toxicol Appl Pharmacol
Title: Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute liver injury induced by carbon tetrachloride in mice.
Volume: 172
Issue: 1
Pages: 44-51
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Publication
9875305 | J:81111
First Author: Wong FW
Year: 1998
Journal: Toxicol Appl Pharmacol
Title: Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression.
Volume: 153
Issue: 1
Pages: 109-18
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Publication
26491845 | J:328778
 
First Author: Jang S
Year: 2015
Journal: Redox Biol
Title: Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury.
Volume: 6
Pages: 552-564
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Publication
24333183 | J:345271
First Author: Moles A
Year: 2014
Journal: J Hepatol
Title: A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse.
Volume: 60
Issue: 4
Pages: 782-91
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Publication
31269038 | J:277200
First Author: Pedroza M
Year: 2019
Journal: PLoS One
Title: Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride.
Volume: 14
Issue: 7
Pages: e0218971
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Publication
28412299 | J:243348
First Author: Kumar S
Year: 2017
Journal: Am J Pathol
Title: Toll-Like Receptor 4-Independent Carbon Tetrachloride-Induced Fibrosis and Lipopolysaccharide-Induced Acute Liver Injury in Mice: Role of Hepatic Stellate Cells.
Volume: 187
Issue: 6
Pages: 1356-1367
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Publication
16891300 | J:116897
First Author: Moreno C
Year: 2006
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Chemokine receptor CCR5 deficiency exacerbates cerulein-induced acute pancreatitis in mice.
Volume: 291
Issue: 6
Pages: G1089-99
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Publication
20639487 | J:162542
First Author: Sapir Y
Year: 2010
Journal: J Immunol
Title: A fusion protein encoding the second extracellular domain of CCR5 arrests chemokine-induced cosignaling and effectively suppresses ongoing experimental autoimmune encephalomyelitis.
Volume: 185
Issue: 4
Pages: 2589-99
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Publication
15210789 | J:90955
First Author: DePaolo RW
Year: 2004
Journal: J Immunol
Title: CCR5 regulates high dose oral tolerance by modulating CC chemokine ligand 2 levels in the GALT.
Volume: 173
Issue: 1
Pages: 314-20
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Publication
18941245 | J:140716
First Author: Turner JE
Year: 2008
Journal: J Immunol
Title: CCR5 deficiency aggravates crescentic glomerulonephritis in mice.
Volume: 181
Issue: 9
Pages: 6546-56
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Publication
23152559 | J:190855
First Author: Schlecker E
Year: 2012
Journal: J Immunol
Title: Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth.
Volume: 189
Issue: 12
Pages: 5602-11
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Publication
18535183 | J:137381
First Author: van Deventer HW
Year: 2008
Journal: Am J Pathol
Title: C-C chemokine receptor 5 on pulmonary fibrocytes facilitates migration and promotes metastasis via matrix metalloproteinase 9.
Volume: 173
Issue: 1
Pages: 253-64
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Publication
24415412 | J:231985
First Author: Delgado I
Year: 2014
Journal: Hepatology
Title: GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis in mice.
Volume: 59
Issue: 6
Pages: 2358-70
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Publication
12759355 | J:84930
First Author: Kwon YH
Year: 2003
Journal: J Biol Chem
Title: The Cdk inhibitor p21 is required for necrosis, but it inhibits apoptosis following toxin-induced liver injury.
Volume: 278
Issue: 32
Pages: 30348-55
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Publication
28118605 | J:274382
First Author: Kantari-Mimoun C
Year: 2017
Journal: Oncotarget
Title: Boosting the hypoxic response in myeloid cells accelerates resolution of fibrosis and regeneration of the liver in mice.
Volume: 8
Issue: 9
Pages: 15085-15100
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Publication
19488034 | J:150851
First Author: Ma X
Year: 2009
Journal: Lab Invest
Title: Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis.
Volume: 89
Issue: 8
Pages: 903-14
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Publication
37098757 | J:359642
First Author: Sharma A
Year: 2023
Journal: J Cell Physiol
Title: CD14 is not required for carbon tetrachloride-induced hepatic inflammation and fibrosis with or without lipopolysaccharide challenge.
Volume: 238
Issue: 7
Pages: 1530-1541
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Publication
30097285 | J:298059
 
First Author: Mafanda EK
Year: 2019
Journal: Cytokine
Title: Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis.
Volume: 124
Pages: 154501
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Publication
32048304 | J:307708
First Author: Zhang S
Year: 2020
Journal: Hepatology
Title: Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice.
Volume: 72
Issue: 5
Pages: 1717-1734
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Publication
29064819 | J:274143
First Author: Laflamme C
Year: 2017
Journal: Aging (Albany NY)
Title: Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A2A receptor.
Volume: 9
Issue: 10
Pages: 2083-2097
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Publication
28527913 | J:352737
 
First Author: Joshi N
Year: 2017
Journal: Toxicol Appl Pharmacol
Title: Von Willebrand factor deficiency reduces liver fibrosis in mice.
Volume: 328
Pages: 54-59
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Publication
28874739 | J:255506
First Author: Moreno-Marín N
Year: 2017
Journal: Sci Rep
Title: Dioxin Receptor Adjusts Liver Regeneration After Acute Toxic Injury and Protects Against Liver Carcinogenesis.
Volume: 7
Issue: 1
Pages: 10420
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Publication
27995603 | J:246725
First Author: McDermott AJ
Year: 2017
Journal: Immunology
Title: Role of interferon-γ and inflammatory monocytes in driving colonic inflammation during acute Clostridium difficile infection in mice.
Volume: 150
Issue: 4
Pages: 468-477
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Publication
31780259 | J:294161
First Author: Sun JC
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Depletion of β-arrestin 2 protects against CCl4-induced liver injury in mice.
Volume: 522
Issue: 2
Pages: 485-491
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Publication
32374849 | J:301391
First Author: Yu Y
Year: 2020
Journal: Blood
Title: Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis.
Volume: 136
Issue: 6
Pages: 726-739
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Publication
27586651 | J:240432
First Author: Scheving LA
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis.
Volume: 311
Issue: 5
Pages: G807-G816
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Publication
23813570 | J:264444
First Author: Lin T
Year: 2013
Journal: Hepatology
Title: A novel role of nucleostemin in maintaining the genome integrity of dividing hepatocytes during mouse liver development and regeneration.
Volume: 58
Issue: 6
Pages: 2176-87
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Publication
25132062 | J:316989
First Author: Sen S
Year: 2015
Journal: Hepatology
Title: Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice.
Volume: 61
Issue: 1
Pages: 171-83
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Publication
29138513 | J:253573
First Author: Wang W
Year: 2017
Journal: Sci Rep
Title: FOXA2 alleviates CCl4-induced liver fibrosis by protecting hepatocytes in mice.
Volume: 7
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