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Search results 201 to 300 out of 319 for Ccm2

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:7532714
Assay Type: Immunohistochemistry
Annotation Date: 2023-10-03
Strength: Strong
Sex: Female
Emaps: EMAPS:2906528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7532723
Age: postnatal day 5
Note: Nuclear expression.
Specimen Label: 3e
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
   
Probe: MGI:3639585
Assay Type: RNA in situ
Annotation Date: 2006-08-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639606
Age: postnatal adult
Specimen Label: Not Shown
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:3639585
Assay Type: RNA in situ
Annotation Date: 2006-08-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639606
Age: postnatal adult
Image: 1YY
Specimen Label: 1YY
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:1661664
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823705
Age: embryonic day 14.5
Image: euxassay_001506_08
Specimen Label: euxassay_001506_08
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:1661664
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823705
Age: embryonic day 14.5
Image: euxassay_001506_09
Specimen Label: euxassay_001506_09
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:1661664
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823705
Age: embryonic day 14.5
Image: euxassay_001506_15
Specimen Label: euxassay_001506_15
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:1661664
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823705
Age: embryonic day 14.5
Image: euxassay_001506_16
Specimen Label: euxassay_001506_16
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
Probe: MGI:5638714
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Diffuse
Stage: TS02
Assay Id: MGI:5638755
Age: embryonic day 1.0
Image: 2-cell
Note: Expression distributed diffusely throughout cytoplasm of each blastomere at all stages.
Specimen Label: 2-cell
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3639585
Assay Type: RNA in situ
Annotation Date: 2006-08-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639606
Age: postnatal day 8
Image: 1O
Note: Expression is in all neuronal layers throughout the brain.
Specimen Label: 1O
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:3639585
Assay Type: RNA in situ
Annotation Date: 2006-08-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639606
Age: postnatal day 19
Image: 1S
Note: Expression is in all neuronal layers throughout the brain.
Specimen Label: 1S
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:3639585
Assay Type: RNA in situ
Annotation Date: 2006-08-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639606
Age: postnatal adult
Image: 1YY
Note: Expression is in all neuronal layers throughout the brain.
Specimen Label: 1YY
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
Probe: MGI:3639585
Assay Type: RNA in situ
Annotation Date: 2006-08-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3520828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3639606
Age: postnatal day 8
Image: 4B
Note: Expression is in meningeal vessels.
Specimen Label: 4B
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
Probe: MGI:3639585
Assay Type: RNA in situ
Annotation Date: 2006-08-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3514627
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3639606
Age: postnatal day 0
Image: 5AA
Note: Expression is in meningeal vessels.
Specimen Label: 5AA
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
Probe: MGI:3639585
Assay Type: RNA in situ
Annotation Date: 2006-08-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3514628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3639606
Age: postnatal day 8
Image: 5CC
Note: Expression is in meningeal vessels.
Specimen Label: 5CC
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
 
Probe: MGI:3639585
Assay Type: RNA in situ
Annotation Date: 2006-08-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3514628
Stage: TS28
Assay Id: MGI:3639606
Age: postnatal day 19
Image: 5EE
Note: Expression is absent in meningeal vessels.
Specimen Label: 5EE
Detected: false
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:3639585
Assay Type: RNA in situ
Annotation Date: 2006-08-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3514628
Stage: TS28
Assay Id: MGI:3639606
Age: postnatal adult
Image: 5GG
Note: Expression is absent in meningeal vessels.
Specimen Label: 5GG
Detected: false
Specimen Num: 19
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GXD Expression
GXD Expression
 
Probe: MGI:3639585
Assay Type: RNA in situ
Annotation Date: 2006-08-02
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1758122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3639606
Age: embryonic day 14.5
Image: 1K
Specimen Label: 1K
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3639585
Assay Type: RNA in situ
Annotation Date: 2006-08-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3561128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639606
Age: postnatal adult
Specimen Label: Not Shown
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:7532714
Assay Type: Immunohistochemistry
Annotation Date: 2023-10-03
Strength: Absent
Sex: Female
Emaps: EMAPS:3819728
Stage: TS28
Assay Id: MGI:7532723
Age: postnatal week 12
Note: Not expressed in grown oocytes in further-developed follicles.
Specimen Label: 3i
Detected: false
Specimen Num: 16
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Gene
311550 | Ccm2l
Type: gene
Organism: rat
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Gene
609856 | CCM2L
Type: gene
Organism: dog, domestic
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Gene
525479 | CCM2L
Type: gene
Organism: cattle
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Gene
419279 | CCM2L
Type: gene
Organism: chicken
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Gene
568661 | ccm2l
Type: gene
Organism: zebrafish
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Gene
100498237 | ccm2l
Type: gene
Organism: frog, western clawed
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Gene
104003554 | CCM2L
Type: gene
Organism: chimpanzee
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Gene
107000439 | CCM2L
Type: gene
Organism: macaque, rhesus
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Publication
25625207 | J:238896
First Author: Renz M
Year: 2015
Journal: Dev Cell
Title: Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins.
Volume: 32
Issue: 2
Pages: 181-90
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Publication
28489816 | J:252526
First Author: Tang AT
Year: 2017
Journal: Nature
Title: Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.
Volume: 545
Issue: 7654
Pages: 305-310
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Publication
26612856 | J:229602
First Author: Cuttano R
Year: 2016
Journal: EMBO Mol Med
Title: KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.
Volume: 8
Issue: 1
Pages: 6-24
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Publication
31776290 | J:283508
 
First Author: Tang AT
Year: 2019
Journal: Sci Transl Med
Title: Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.
Volume: 11
Issue: 520
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Publication
21712438 | J:174387
First Author: Zhou X
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Rac1/osmosensing scaffold for MEKK3 contributes via phospholipase C-gamma1 to activation of the osmoprotective transcription factor NFAT5.
Volume: 108
Issue: 29
Pages: 12155-60
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Publication
26061019 | J:265042
First Author: Han R
Year: 2015
Journal: Organogenesis
Title: Endothelial Erg expression is required for embryogenesis and vascular integrity.
Volume: 11
Issue: 2
Pages: 75-86
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Publication
34156031 | J:324862
 
First Author: Wang R
Year: 2021
Journal: JCI Insight
Title: Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting.
Volume: 6
Issue: 12
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Publication
23918940 | J:201629
First Author: Faurobert E
Year: 2013
Journal: J Cell Biol
Title: CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling.
Volume: 202
Issue: 3
Pages: 545-61
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Publication
32648916 | J:298707
 
First Author: Hong CC
Year: 2020
Journal: J Exp Med
Title: Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
Volume: 217
Issue: 10
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Publication
20371769 | J:171969
First Author: He Y
Year: 2010
Journal: Sci Signal
Title: Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development.
Volume: 3
Issue: 116
Pages: ra26
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Publication
21795542 | J:174607
First Author: Lu CC
Year: 2011
Journal: J Neurosci
Title: Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly.
Volume: 31
Issue: 30
Pages: 10903-18
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Gene
108718459 | ccm2.L
Type: gene
Organism: frog, African clawed
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Gene
108719796 | ccm2.S
Type: gene
Organism: frog, African clawed
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Gene
108700965 | ccm2l.L
Type: gene
Organism: frog, African clawed
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Allele
Ccm2<em1Smoc> | MGI:7288943
Name: cerebral cavernous malformation 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Ccm2<tm1Kwhi> | MGI:3817969
Name: cerebral cavernous malformation 2; targeted mutation 1, Kevin Whitehead
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Ccm2<tm1.1Kwhi> | MGI:3817970
Name: cerebral cavernous malformation 2; targeted mutation 1.1, Kevin Whitehead
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ccm2<tm1Etl> | MGI:3837678
Name: cerebral cavernous malformation 2; targeted mutation 1, Elisabeth Tournier-Lasserve
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Ccm2<tm2.1Sbn> | MGI:5085315
Name: cerebral cavernous malformation 2; targeted mutation 2.1, Ulrich Siebenlist
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Ccm2<tm1Mlkn> | MGI:5439490
Name: cerebral cavernous malformation 2; targeted mutation 1, Mark L Kahn
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:6474920 | C57BL/6JSmoc-Ccm2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Ccm2/Ccm2 Tg(Nes-cre)1Kln/?
Background: B6.Cg-Ccm2 Tg(Nes-cre)1Kln
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ccm2/Ccm2 Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ccm2/Ccm2 Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ccm2/Ccm2 Tg(Tek-cre)1Ywa/?
Background: involves: C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ccm2/Ccm2 Tg(Cdh5-cre/ERT2)1Rha/?
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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DO Term
DOID:0060670 | cerebral cavernous malformation 2
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Genotype
Genotype
Symbol: Ccm2/Ccm2 Tg(Cdh5-cre/ERT2)1Rha/?
Background: involves: 129
Zygosity: cn
Has Mutant Allele: true
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Publication
23665169 | -
First Author: Xu X
Year: 2013
Journal: Structure
Title: Structural basis for the unique heterodimeric assembly between cerebral cavernous malformation 3 and germinal center kinase III.
Volume: 21
Issue: 6
Pages: 1059-66
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Publication
23541896 | -
First Author: Zhang M
Year: 2013
Journal: Structure
Title: Structural mechanism of CCM3 heterodimerization with GCKIII kinases.
Volume: 21
Issue: 4
Pages: 680-8
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Protein Domain
IPR046409 | PDC10_dimerisation_sf
Type: Homologous_superfamily
Description: Programmed cell death 10 protein (PDCD10/CCM3) is part of the CCM complex and is required for neuronal migration []. Outside of this complex, it is crucial in vascularization and in angiogenesis as it functions in vessel permeability and stability []. This protein plays an essential role in early embryonic angiogenesis and cardiovascular development. PDCD10/CCM3 interacts with a variety of proteins, including paxillin, membrane receptor vascular epidermal growth factor receptor 2, CCM complex component CCM2 and germinal centre kinase III proteins (GCKIII). PDCD10/CCM3 contains an N-terminal dimerisation domain and a C-terminal focal adhesion targeting-homology (FAT-H) domain [, , ].This entry represents the N-terminal dimerisation domain of PDC10/CCM3, consisting of four α-helices. This domain is also found at the C-terminal of GCKIIIs (STK24/MST3, STK25, STK26/MST4), which adopts a closely related fold. GCKIIIs are involved in the regulation of apoptosis, cell proliferation, polarity, migration, and cytoskeleton remodelling. This domain mediates homo and heterodimerization. PDCD10/CCM3 forms a heterodimer with GCKIIIs analogous to CCM3 homodimer [, ].
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Publication
24990152 | J:215458
First Author: Mleynek TM
Year: 2014
Journal: Hum Mol Genet
Title: Lack of CCM1 induces hypersprouting and impairs response to flow.
Volume: 23
Issue: 23
Pages: 6223-34
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Protein
Q8VE70
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
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Protein
Q3TVB4
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: true
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Protein
E0CY82
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
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Publication
24595293 | J:208651
First Author: Louvi A
Year: 2014
Journal: Development
Title: Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration.
Volume: 141
Issue: 6
Pages: 1404-15
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Publication
24481819 | -
First Author: Draheim KM
Year: 2014
Journal: J Cell Sci
Title: Cerebral cavernous malformation proteins at a glance.
Volume: 127
Issue: Pt 4
Pages: 701-7
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Publication
26490252 | -
 
First Author: Lambertz N
Year: 2015
Journal: BMC Cancer
Title: Downregulation of programmed cell death 10 is associated with tumor cell proliferation, hyperangiogenesis and peritumoral edema in human glioblastoma.
Volume: 15
Pages: 759
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Protein
F8WI55
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: false
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Publication
20229348 | -
First Author: Wang Y
Year: 1999
Journal: Sci China C Life Sci
Title: cDNA cloning and expression of an apoptosis-related gene, humanTFAR15 gene.
Volume: 42
Issue: 3
Pages: 323-9
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Protein Domain
IPR009652 | PDCD10
Type: Family
Description: Programmed cell death 10 protein (PDCD10/CCM3) is part of the CCM complex and is required for neuronal migration []. It also has roles outside of this complex [], it is crucial in vascularization and in angiogenesis as it functions in vessel permeability and stability []. PDCD10/CCM3 was originally discovered to be upregulated during granulocyte apoptosis and is thought to play a role in cell death []. However, a specific role for PDCD10 in cell survival is not clear as both pro-survival and pro-apoptotic effects have been reported [, ]. PDCD10/CCM3 contains an N-terminal dimerisation domain and a C-terminal focal adhesion targeting-homology (FAT-H) domain [].There are three CCM proteins: CCM1 (also known as KRIT1), CCM2 (also known as OSM and malcavernin) and CCM3 (also known as PDCD10). Mutations in the genes encoding CCM proteins cause cerebral cavernous malformations (CCMs), a disease characterised by dilated leaky blood vessels, especially in the neurovasculature, that result in increased risk of stroke, focal neurological defects and seizures. The CCM proteins can form a trimeric complex. They can also interact with a range of signaling, cytoskeletal and adaptor proteins that may account for their roles in a range of basic cellular processes including cell adhesion, migration, polarity and apoptosis [].
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Publication
20007487 | J:157670
First Author: Glading AJ
Year: 2010
Journal: Dis Model Mech
Title: Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling.
Volume: 3
Issue: 1-2
Pages: 73-83
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