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Search results 201 to 300 out of 393 for Cd27

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Type Details Score
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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DO Term
DOID:0060708 | lymphoproliferative syndrome 2
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Allele
Cd27<tm2(CD27)Smoc> | MGI:7288795
Name: CD27 antigen; targeted mutation 2, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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GO Term
GO:0005175 | CD27 receptor binding
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GO Term
GO:0042614 | CD70 receptor binding
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Allele
Cd27<em2Smoc> | MGI:7288794
Name: CD27 antigen; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Cd27<tm3(CD27)Smoc> | MGI:7288796
Name: CD27 antigen; targeted mutation 3, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
1334106 | J:3424
First Author: Loenen WA
Year: 1992
Journal: J Immunol
Title: Genomic organization and chromosomal localization of the human CD27 gene.
Volume: 149
Issue: 12
Pages: 3937-43
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Strain
MGI:6428050 | BALB/c-Cd27<tm2(CD27)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Allele
Cd27<em1Smoc> | MGI:7288793
Name: CD27 antigen; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6354617 | C57BL/6JSmoc-Cd27<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
26179759 | J:233044
First Author: Burchill MA
Year: 2015
Journal: Eur J Immunol
Title: T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs.
Volume: 45
Issue: 11
Pages: 3140-9
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Publication
35288635 | J:322858
First Author: Heckel F
Year: 2022
Journal: Commun Biol
Title: Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering.
Volume: 5
Issue: 1
Pages: 229
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Publication
24026078 | J:206282
First Author: He LZ
Year: 2013
Journal: J Immunol
Title: Agonist anti-human CD27 monoclonal antibody induces T cell activation and tumor immunity in human CD27-transgenic mice.
Volume: 191
Issue: 8
Pages: 4174-83
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Strain
MGI:6354618 | C57BL/6JSmoc-Cd27<tm3(CD27)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
8387892 | J:4742
First Author: Goodwin RG
Year: 1993
Journal: Cell
Title: Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor.
Volume: 73
Issue: 3
Pages: 447-56
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Publication
21781225 | J:310763
First Author: Hayakawa Y
Year: 2011
Journal: Cancer Sci
Title: Early activation and interferon-γ production of tumor-infiltrating mature CD27 high natural killer cells.
Volume: 102
Issue: 11
Pages: 1967-71
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Allele
Cd27<+> | MGI:2437059
   
Name: CD27 antigen; wild type
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Strain
MGI:7751766 | BALB/cAnSmoc-Pdcd1<em2(PDCD1)Smoc> Cd27<tm2(CD27)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7751767 | BALB/cAnSmoc-Cd27<tm2(CD27)Smoc> Cd274<em5(CD274)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Cd27<tm1Jbo> | MGI:2385835
Name: CD27 antigen; targeted mutation 1, Jannie Borst
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Cd27<Gt(OST33464)Lex> | MGI:4152625
 
Name: CD27 antigen; gene trap OST33464, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Cd27<tm1(KOMP)Vlcg> | MGI:4881222
Name: CD27 antigen; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Cd27<tm1.1Ivo> | MGI:7525735
Name: CD27 antigen; targeted mutation 1.1, Isabel Vogel
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Cd27<tm1(CD27)Gpt> | MGI:7572971
Name: CD27 antigen; targeted mutation 1, GemPharmatech
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Cd27<em1Cya> | MGI:7582838
Name: CD27 antigen; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Cd27<em2Cya> | MGI:7582839
Name: CD27 antigen; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:7751734 | C57BL/6JSmoc-Cd274<em1(CD274)Smoc> Cd27<tm3(CD27)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6475969 | C57BL/6JSmoc-Pdcd1<em1(PDCD1)Smoc> Cd27<tm3(CD27)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
23263849 | -
First Author: Kamazani FM
Year: 2013
Journal: Med Oncol
Title: CD44 and CD27 expression pattern in B cell precursor acute lymphoblastic leukemia and its clinical significance.
Volume: 30
Issue: 1
Pages: 359
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Protein
O55237
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: false
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Interaction Experiment
Gravestein LA (1998)
Description: The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.
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Interaction Experiment
Satpathy S (2010)
Description: Inhibition of terminal differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK.
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Strain
MGI:7751741 | C57BL/6JSmoc-Fcgrt2b<em3(FCGRT2B)Smoc> Cd27<tm3(CD27)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:3621445 | B6.129P2-Cd27<tm1Jbo>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5654398 | either: B6.129P2-CD27<tm1Jbo> or 129P2/OlaHsd-Tnfrsf7<tm1Jbo>
Attribute String: Not specified
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Strain
MGI:5564828 | B6.129P2(FVB)-Cd27<tm1Jbo>/J
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Cd27<tm2e(EUCOMM)Hmgu> | MGI:5511514
Name: CD27 antigen; targeted mutation 2e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Cd27<em6Gpt> | MGI:7376323
Name: CD27 antigen; endonuclease-mediated mutation 6, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Cd27<em1(CD27)Gpt> | MGI:7377547
Name: CD27 antigen; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Inserted expressed sequence
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Allele
Cd27<em1(IMPC)Ccpcz> | MGI:7425569
Name: CD27 antigen; endonuclease-mediated mutation 1, Institute of Molecular Genetics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7591744 | C57BL/6J-Cd27<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7589180 | C57BL/6J-Cd27<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Cd27<em3Smoc> | MGI:7750457
Name: CD27 antigen; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Cd27/Cd27
Background: either: B6.129P2-CD27 or 129P2/OlaHsd-Tnfrsf7
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd27/Cd27
Background: B6.129P2-Cd27
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:7381335 | C57BL/6JGpt-Cd27<em6Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7572771 | BALB/cJGpt-Cd27<em1(CD27)Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7471631 | C57BL/6NCrl-Cd27<em1(IMPC)Ccpcz>/Ccpcz
Attribute String: coisogenic
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Strain
MGI:7853144 | C57BL/6NCrl-Cd27<em1(IMPC)Ccpcz>/Ph
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7764327 | C57BL/6JSmoc-Cd27<em3Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Cd27/Cd27
Background: C57BL/6NCrl-Cd27/Ccpcz
Zygosity: hm
Has Mutant Allele: true
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Publication
9826574 | -
First Author: Loenen WA
Year: 1998
Journal: Semin Immunol
Title: CD27 and (TNFR) relatives in the immune system: their role in health and disease.
Volume: 10
Issue: 6
Pages: 417-22
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Publication
20974987 | -
First Author: Satpathy S
Year: 2010
Journal: J Immunol
Title: Inhibition of terminal differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK.
Volume: 185
Issue: 11
Pages: 6499-507
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Protein Coding Gene
MGI:1353606 | Siva1
Type: protein_coding_gene
Organism: mouse, laboratory
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Strain
MGI:6349658 | C57BL/6JGpt-Pdcd1<em1(PDCD1)Gpt> Cd27<tm1(CD27)Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Cd27/Cd27 Tg(CD19-Tnfsf7)#Rvl/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI:1195273 | Cd70
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9177220 | J:117434
First Author: Prasad KV
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.
Volume: 94
Issue: 12
Pages: 6346-51
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Strain
MGI:7382578 | BALB/cJGpt-Pdcd1<em2(PDCD1)Gpt> Cd27<em1(CD27)Gpt> Cd274<tm2(CD274)Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
12011449 | J:127189
First Author: Xue L
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis.
Volume: 99
Issue: 10
Pages: 6925-30
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Publication
10803880 | -
First Author: Jacquot S
Year: 2000
Journal: Immunol Res
Title: CD27/CD70 interactions regulate T dependent B cell differentiation.
Volume: 21
Issue: 1
Pages: 23-30
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Protein Domain
IPR042374 | CD70
Type: Family
Description: CD70 is a ligand of CD27 and is a TNF related transmembrane protein induced upon activation on T and B cells []. The CD27/CD70 interaction plays a key role in T dependent B cell responses and is responsible for plasma cell differentiation []. The CD27/CD70 pathway has been shown to contribute to the pathophysiology of autoimmunity [].
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Publication
26359318 | -
First Author: Han BK
Year: 2016
Journal: Semin Arthritis Rheum
Title: The CD27-CD70 pathway and pathogenesis of autoimmune disease.
Volume: 45
Issue: 4
Pages: 496-501
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Publication
20699361 | -
First Author: Denoeud J
Year: 2011
Journal: J Leukoc Biol
Title: Role of CD27/CD70 pathway of activation in immunity and tolerance.
Volume: 89
Issue: 2
Pages: 195-203
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Protein Domain
IPR034000 | TNFRSF7_N
Type: Domain
Description: Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27, T14, S152, Tp55, S152 or LPFS2, has a key role in the generation of immunological memory via effects on T-cell expansion and survival, and B cell development [, ]. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. CD27 transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK, and mediates the signaling process through adaptor proteins TRAF2 and TRAF5. CD27-binding protein (SIVA), a pro-apoptotic protein, can bind to CD27 and may play an important role in the apoptosis induced by this receptor []. The potential role of the CD27/CD70 pathway in the course of inflammatory diseases, such as arthritis, and inflammatory bowel disease, suggests that CD70 may be a target for immune intervention. The expression of CD27 and CD44 molecules correlates with the differentiation stage of B cell precursors and has been shown to have a biological significance in acute lymphoblastic leukemia [].This entry represents the N-terminal domain of TNFRSF7. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].
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Protein Coding Gene
MGI:101835 | Traf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96055 | Ptpn6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O54926
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
Q3TFC3
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein Domain
IPR022773 | Siva
Type: Family
Description: Siva binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an important role for Siva in the CD27-transduced apoptotic pathway []. Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. Indeed, the unique amphipathic helical region (SAH) present in Siva-1 is required for its binding to BCL-X(L) and sensitising cells to UV radiation. Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis [].
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Protein Coding Gene
MGP_CAROLIEiJ_G0018154 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020155 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020111 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020086 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019898 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1353606 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020541 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019438 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019865 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019982 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019967 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020056 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020005 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020570 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019200 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019498 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029911 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019003 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11601913 | J:118811
First Author: Henke A
Year: 2001
Journal: Virology
Title: The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva.
Volume: 289
Issue: 1
Pages: 15-22
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Publication
21768358 | J:176024
First Author: Li N
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules.
Volume: 108
Issue: 31
Pages: 12851-6
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GXD Expression
GXD Expression
     
Probe: MGI:1510754
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354920
Age: embryonic day 14.5
Specimen Label: Table S5 - Siva
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_1366716
Note: kidney
Specimen Label: HMGU_1366716
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_692931
Note: kidney
Specimen Label: HMGU_692931
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1706828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_1366710
Specimen Label: HMGU_1366710
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_692919
Specimen Label: HMGU_692919
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:1510754
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3271122
Stage: TS22
Assay Id: MGI:4354920
Age: embryonic day 14.5
Note: There is no expression in either the upper or lower cortical plate.
Specimen Label: Table S5 - Siva
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1510754
Assay Type: RNA in situ
Annotation Date: 2023-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7526629
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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