Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
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|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
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•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cabrero JG |
Year: |
1993 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Identification, by protein sequencing and gene transfection, of sgp-60 as the murine homologue of CD48. |
Volume: |
90 |
Issue: |
8 |
Pages: |
3418-22 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Munitz A |
Year: |
2007 |
Journal: |
Am J Respir Crit Care Med |
Title: |
CD48 is critically involved in allergic eosinophilic airway inflammation. |
Volume: |
175 |
Issue: |
9 |
Pages: |
911-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaplan AJ |
Year: |
1993 |
Journal: |
J Immunol |
Title: |
Production and characterization of soluble and transmembrane murine CD2. Demonstration that CD48 is a ligand for CD2 and that CD48 adhesion is regulated by CD2. |
Volume: |
151 |
Issue: |
8 |
Pages: |
4022-32 |
|
•
•
•
•
•
|
Allele |
Name: |
CD48 antigen; wild type |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Fortenbery NR |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
SHIP influences signals from CD48 and MHC class I ligands that regulate NK cell homeostasis, effector function, and repertoire formation. |
Volume: |
184 |
Issue: |
9 |
Pages: |
5065-74 |
|
•
•
•
•
•
|
Allele |
Name: |
CD48 antigen; targeted mutation 1, Hans Reiser |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
CD48 antigen; targeted mutation 1.1, Andre Veillette |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
CD48 antigen; endonuclease-mediated mutation 1, Cyagen Biosciences |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
CD48 antigen; endonuclease-mediated mutation 2, Cyagen Biosciences |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
CD48 antigen; targeted mutation 1, Mouse Biology Program, UC Davis |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
CD48 antigen; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
CD48 antigen; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
CD48 antigen; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd48/Cd48 |
Background: |
B6.129S4-Cd48 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee KM |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells. |
Volume: |
170 |
Issue: |
10 |
Pages: |
4881-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ames JB |
Year: |
2005 |
Journal: |
Biochemistry |
Title: |
NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition. |
Volume: |
44 |
Issue: |
17 |
Pages: |
6416-23 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
2B4 is a transmembrane receptor which is expressed primarily on natural killer (NK) cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells []. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two β-sheets. One of the β-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function [].This entry represents the 2B4 immunoglobulin domain. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
2B4 is a transmembrane receptor which is expressed primarily on natural killer (NK) cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells []. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two β-sheets. One of the β-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The CD2 adhesion molecule is a cell surface protein expressed by T cells and natural killer cells. CD2's extracellular domain contains immunoglobulin-like domains that are glycosylated at two sites and can mediate homodimerisation []. Ligation of CD2 by CD58 in humans or CD48 in mice helps T cells adhere to antigen-presenting cells, and initiates signal transduction pathways that enhance signalling through the T cell receptor for antigen. CD2 knockout mice exhibit essentially normal immune function [], and it is thought that CD2 is somewhat functionally redundant with other T cell co-stimulatory receptors such as CD28 []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The LFA-3 (CD2) adhesion molecule is a cell surface protein expressed by T cells and natural killer cells. LFA-3's extracellular region contains immunoglobulin-like domains that are glycosylated at two sites and can mediate homodimerisation []. Ligation of LFA3 by CD58 in humans or CD48 in mice helps T cells adhere to antigen-presenting cells, and initiates signal transduction pathways that enhance signalling through the T cell receptor for antigen. LFA-3 knockout mice exhibit essentially normal immune function [], and it is thought that LFA-3 is somewhat functionally redundant with other T cell co-stimulatory receptors such as CD28 []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang J |
Year: |
1997 |
Journal: |
J Exp Med |
Title: |
Essential lymphocyte function associated 1 (LFA-1): intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95. |
Volume: |
186 |
Issue: |
7 |
Pages: |
1171-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Latchman Y |
Year: |
1998 |
Journal: |
J Immunol |
Title: |
Identification of the 2B4 molecule as a counter-receptor for CD48. |
Volume: |
161 |
Issue: |
11 |
Pages: |
5809-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen HA |
Year: |
2002 |
Journal: |
Biochemistry |
Title: |
The pH dependence of CD2 domain 1 self-association and 15N chemical exchange broadening is correlated with the anomalous pKa of Glu41. |
Volume: |
41 |
Issue: |
50 |
Pages: |
14680-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Killeen N |
Year: |
1992 |
Journal: |
EMBO J |
Title: |
Development and function of T cells in mice with a disrupted CD2 gene. |
Volume: |
11 |
Issue: |
12 |
Pages: |
4329-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hutchcroft JE |
Year: |
1998 |
Journal: |
J Immunol |
Title: |
Uncoupling activation-dependent HS1 phosphorylation from nuclear factor of activated T cells transcriptional activation in Jurkat T cells: differential signaling through CD3 and the costimulatory receptors CD2 and CD28. |
Volume: |
161 |
Issue: |
9 |
Pages: |
4506-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kambayashi T |
Year: |
2001 |
Journal: |
J Immunol |
Title: |
Cutting edge: Regulation of CD8(+) T cell proliferation by 2B4/CD48 interactions. |
Volume: |
167 |
Issue: |
12 |
Pages: |
6706-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stepp SE |
Year: |
1999 |
Journal: |
Eur J Immunol |
Title: |
Gene structure of the murine NK cell receptor 2B4: presence of two alternatively spliced isoforms with distinct cytoplasmic domains. |
Volume: |
29 |
Issue: |
8 |
Pages: |
2392-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
McKinney-Freeman SL |
Year: |
2009 |
Journal: |
Blood |
Title: |
Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells. |
Volume: |
114 |
Issue: |
2 |
Pages: |
268-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mathew PA |
Year: |
1993 |
Journal: |
J Immunol |
Title: |
Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. |
Volume: |
151 |
Issue: |
10 |
Pages: |
5328-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bloch-Queyrat C |
Year: |
2005 |
Journal: |
J Exp Med |
Title: |
Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn. |
Volume: |
202 |
Issue: |
1 |
Pages: |
181-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peck SR |
Year: |
2000 |
Journal: |
Immunogenetics |
Title: |
Ly108: a new member of the mouse CD2 family of cell surface proteins. |
Volume: |
52 |
Issue: |
1-2 |
Pages: |
63-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao N |
Year: |
2008 |
Journal: |
Int Immunol |
Title: |
Requirements for the natural killer cell-mediated induction of IgG1 and IgG2a expression in B lymphocytes. |
Volume: |
20 |
Issue: |
5 |
Pages: |
645-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alari-Pahissa E |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Activation by SLAM Family Receptors Contributes to NK Cell Mediated "Missing-Self" Recognition. |
Volume: |
11 |
Issue: |
4 |
Pages: |
e0153236 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao N |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
B cell induction of IL-13 expression in NK cells: role of CD244 and SLAM-associated protein. |
Volume: |
176 |
Issue: |
5 |
Pages: |
2758-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gonzalez Roldan N |
Year: |
2016 |
Journal: |
Eur J Immunol |
Title: |
CD252 regulates mast cell mediated, CD1d-restricted NKT-cell activation in mice. |
Volume: |
46 |
Issue: |
2 |
Pages: |
432-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mooney JM |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
The murine NK receptor 2B4 (CD244) exhibits inhibitory function independent of signaling lymphocytic activation molecule-associated protein expression. |
Volume: |
173 |
Issue: |
6 |
Pages: |
3953-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaidya SV |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells. |
Volume: |
174 |
Issue: |
2 |
Pages: |
800-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boles KS |
Year: |
2001 |
Journal: |
Immunol Rev |
Title: |
2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes. |
Volume: |
181 |
|
Pages: |
234-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Niethammer AG |
Year: |
2001 |
Journal: |
Cancer Res |
Title: |
Targeted interleukin 2 therapy enhances protective immunity induced by an autologous oral DNA vaccine against murine melanoma. |
Volume: |
61 |
Issue: |
16 |
Pages: |
6178-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boles KS |
Year: |
1999 |
Journal: |
Tissue Antigens |
Title: |
Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4. |
Volume: |
54 |
Issue: |
1 |
Pages: |
27-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gordy C |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Visualization of antigen presentation by actin-mediated targeting of glycolipid-enriched membrane domains to the immune synapse of B cell APCs. |
Volume: |
172 |
Issue: |
4 |
Pages: |
2030-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chlewicki LK |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Molecular basis of the dual functions of 2B4 (CD244). |
Volume: |
180 |
Issue: |
12 |
Pages: |
8159-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clarkson NG |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1. |
Volume: |
284 |
Issue: |
37 |
Pages: |
24725-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Noda S |
Year: |
2008 |
Journal: |
Stem Cells |
Title: |
Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48-c-Kit+Sca-1+lineage marker- cell population. |
Volume: |
26 |
Issue: |
3 |
Pages: |
646-55 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
397
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
398
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
344
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
398
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
399
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
398
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
341
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
205
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
397
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
312
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Chuang SS |
Year: |
1999 |
Journal: |
Biochim Biophys Acta |
Title: |
Molecular cloning and characterization of the promoter region of murine natural killer cell receptor 2B4. |
Volume: |
1447 |
Issue: |
2-3 |
Pages: |
244-50 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
199
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
267
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Maltais LJ |
Year: |
1994 |
Journal: |
Mouse Genome |
Title: |
Locus Map of mouse |
Volume: |
92 |
|
Pages: |
62-85 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
344
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
344
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
344
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|