Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
213
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
CD8 subunit beta 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Allele |
Name: |
CD4 antigen; targeted mutation 1, Alfred Singer |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence, Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 3, Ellen Robey |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
CD8 subunit beta 1; mutation 2, Bruce Beutler |
Allele Type: |
Chemically induced (ENU) |
Attribute String: |
Not Specified |
|
•
•
•
•
•
|
Strain |
Attribute String: |
chemically induced mutation, coisogenic, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd8b1/Cd8b1 |
Background: |
C57BL/6J-Cd8b1 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Robey E |
Year: |
1994 |
Journal: |
J Exp Med |
Title: |
Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice. |
Volume: |
179 |
Issue: |
6 |
Pages: |
1997-2004 |
|
•
•
•
•
•
|
Publication |
First Author: |
Golde WT |
Year: |
1994 |
Journal: |
Infect Immun |
Title: |
Tick transmission of Borrelia burgdorferi to inbred strains of mice induces an antibody response to P39 but not to outer surface protein A. |
Volume: |
62 |
Issue: |
6 |
Pages: |
2625-7 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 46, Ellen Robey |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Cd8aCd8b)3Erob/? |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Itano A |
Year: |
1994 |
Journal: |
Immunity |
Title: |
A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection. |
Volume: |
1 |
Issue: |
4 |
Pages: |
287-90 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Cd8b1)46Erob/? |
Background: |
involves: 129S4/SvJae * C57BL/6 * CBA |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Hassan H |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cd8 enhancer E8I and Runx factors regulate CD8α expression in activated CD8+ T cells. |
Volume: |
108 |
Issue: |
45 |
Pages: |
18330-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scully T |
Year: |
2018 |
Journal: |
Endocr Relat Cancer |
Title: |
Enhancement of mammary tumour growth by IGFBP-3 involves impaired T cell accumulation. |
Volume: |
25 |
Issue: |
2 |
Pages: |
111-122 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd8b1/Cd8b1<+> Tg(Cd8b1)46Erob/? |
Background: |
involves: 129S4/SvJae * C57BL/6 * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Engel I |
Year: |
2010 |
Journal: |
J Exp Med |
Title: |
Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection. |
Volume: |
207 |
Issue: |
5 |
Pages: |
1015-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Robey EA |
Year: |
1991 |
Journal: |
Cell |
Title: |
Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. |
Volume: |
64 |
Issue: |
1 |
Pages: |
99-107 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wack A |
Year: |
2000 |
Journal: |
J Immunol |
Title: |
Early onset of CD8 transgene expression inhibits the transition from DN3 to DP thymocytes. |
Volume: |
165 |
Issue: |
3 |
Pages: |
1236-42 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Cd8aCd8b)3Erob/? Tg(TcraH-Y,TcrbH-Y)71Vbo/? |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ali M |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
Differential regulation of peripheral CD4+ T cell tolerance induced by deletion and TCR revision. |
Volume: |
171 |
Issue: |
11 |
Pages: |
6290-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shinzawa M |
Year: |
2022 |
Journal: |
Nat Immunol |
Title: |
Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus. |
Volume: |
23 |
Issue: |
5 |
Pages: |
731-742 |
|
•
•
•
•
•
|