| Type |
Details |
Score |
| Publication |
| First Author: |
Pirone DM |
| Year: |
2000 |
| Journal: |
J Biol Chem |
| Title: |
SPECs, small binding proteins for Cdc42. |
| Volume: |
275 |
| Issue: |
30 |
| Pages: |
22650-6 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
52
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
550
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gomes ER |
| Year: |
2005 |
| Journal: |
Cell |
| Title: |
Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. |
| Volume: |
121 |
| Issue: |
3 |
| Pages: |
451-63 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
84
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
80
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
52
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rossman KL |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. |
| Volume: |
278 |
| Issue: |
20 |
| Pages: |
18393-400 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chavrier P |
| Year: |
1992 |
| Journal: |
Gene |
| Title: |
The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. |
| Volume: |
112 |
| Issue: |
2 |
| Pages: |
261-4 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
62
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The Rho-type GTPase Cdc42 regulates cell morphology and signal transduction in eukaryotic cells. The Cdc42 effector (CEP) or binder of Rho GTPase (BORG) proteins are involved in the organisation of the actin cytoskeleton []. They may function as negative regulators of Rho GTPase signaling [].This family consists of Cdc42 effector proteins, including CEP1-5 from humans. |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peng J |
| Year: |
2003 |
| Journal: |
Curr Biol |
| Title: |
Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42. |
| Volume: |
13 |
| Issue: |
7 |
| Pages: |
534-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Joberty G |
| Year: |
2000 |
| Journal: |
Nat Cell Biol |
| Title: |
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. |
| Volume: |
2 |
| Issue: |
8 |
| Pages: |
531-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ladinsky MS |
| Year: |
2019 |
| Journal: |
Science |
| Title: |
Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. |
| Volume: |
363 |
| Issue: |
6431 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chavali M |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Anttonen T |
| Year: |
2012 |
| Journal: |
Sci Rep |
| Title: |
Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood. |
| Volume: |
2 |
|
| Pages: |
978 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marks PW |
| Year: |
1996 |
| Journal: |
Genomics |
| Title: |
Genomic organization and chromosomal location of murine Cdc42. |
| Volume: |
38 |
| Issue: |
1 |
| Pages: |
13-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Natale DR |
| Year: |
2002 |
| Journal: |
Mech Dev |
| Title: |
Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development. |
| Volume: |
119 Suppl 1 |
|
| Pages: |
S21-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sakabe I |
| Year: |
2012 |
| Journal: |
Immun Ageing |
| Title: |
Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells. |
| Volume: |
9 |
|
| Pages: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zheng C |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
10407 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo F |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis. |
| Volume: |
107 |
| Issue: |
43 |
| Pages: |
18505-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Heib T |
| Year: |
2021 |
| Journal: |
Cell Rep |
| Title: |
RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes. |
| Volume: |
35 |
| Issue: |
6 |
| Pages: |
109102 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Simionescu-Bankston A |
| Year: |
2013 |
| Journal: |
Dev Biol |
| Title: |
The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis. |
| Volume: |
382 |
| Issue: |
1 |
| Pages: |
160-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Calvo F |
| Year: |
2011 |
| Journal: |
Nat Cell Biol |
| Title: |
RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation. |
| Volume: |
13 |
| Issue: |
7 |
| Pages: |
819-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Plutoni C |
| Year: |
2016 |
| Journal: |
J Cell Biol |
| Title: |
P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces. |
| Volume: |
212 |
| Issue: |
2 |
| Pages: |
199-217 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mammoto T |
| Year: |
2019 |
| Journal: |
Aging (Albany NY) |
| Title: |
Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1. |
| Volume: |
11 |
| Issue: |
17 |
| Pages: |
7051-7069 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miki T |
| Year: |
1993 |
| Journal: |
Nature |
| Title: |
Oncogene ect2 is related to regulators of small GTP-binding proteins. |
| Volume: |
362 |
| Issue: |
6419 |
| Pages: |
462-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Prakash SK |
| Year: |
2000 |
| Journal: |
Hum Mol Genet |
| Title: |
Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. |
| Volume: |
9 |
| Issue: |
4 |
| Pages: |
477-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo X |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. |
| Volume: |
278 |
| Issue: |
15 |
| Pages: |
13207-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ryan MA |
| Year: |
2010 |
| Journal: |
Nat Med |
| Title: |
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. |
| Volume: |
16 |
| Issue: |
10 |
| Pages: |
1141-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lämmermann T |
| Year: |
2009 |
| Journal: |
Blood |
| Title: |
Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration. |
| Volume: |
113 |
| Issue: |
23 |
| Pages: |
5703-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
van Hengel J |
| Year: |
2008 |
| Journal: |
Gastroenterology |
| Title: |
Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver. |
| Volume: |
134 |
| Issue: |
3 |
| Pages: |
781-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sinai P |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42. |
| Volume: |
107 |
| Issue: |
26 |
| Pages: |
11912-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schulz AM |
| Year: |
2015 |
| Journal: |
J Cell Biol |
| Title: |
Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells. |
| Volume: |
211 |
| Issue: |
3 |
| Pages: |
553-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Karaczyn A |
| Year: |
2010 |
| Journal: |
Neural Dev |
| Title: |
Two novel human NUMB isoforms provide a potential link between development and cancer. |
| Volume: |
5 |
|
| Pages: |
31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Friesland A |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. |
| Volume: |
110 |
| Issue: |
4 |
| Pages: |
1261-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ciolli Mattioli C |
| Year: |
2019 |
| Journal: |
Nucleic Acids Res |
| Title: |
Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments. |
| Volume: |
47 |
| Issue: |
5 |
| Pages: |
2560-2573 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dong LM |
| Year: |
2019 |
| Journal: |
Artif Cells Nanomed Biotechnol |
| Title: |
Cell division cycle protein 42 regulates the inflammatory response in mice bearing inflammatory bowel disease. |
| Volume: |
47 |
| Issue: |
1 |
| Pages: |
1833-1838 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kostenko EV |
| Year: |
2006 |
| Journal: |
Mol Cell Biol |
| Title: |
Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. |
| Volume: |
26 |
| Issue: |
23 |
| Pages: |
8964-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chiang SH |
| Year: |
2003 |
| Journal: |
EMBO J |
| Title: |
TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. |
| Volume: |
22 |
| Issue: |
11 |
| Pages: |
2679-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carvalho JR |
| Year: |
2019 |
| Journal: |
Elife |
| Title: |
Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration. |
| Volume: |
8 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Montenegro-Venegas C |
| Year: |
2010 |
| Journal: |
Mol Biol Cell |
| Title: |
MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity. |
| Volume: |
21 |
| Issue: |
20 |
| Pages: |
3518-28 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lengfeld J |
| Year: |
2012 |
| Journal: |
Mol Biol Cell |
| Title: |
Protein kinase C δ regulates the release of collagen type I from vascular smooth muscle cells via regulation of Cdc42. |
| Volume: |
23 |
| Issue: |
10 |
| Pages: |
1955-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Holst K |
| Year: |
2015 |
| Journal: |
J Cell Sci |
| Title: |
The serotonin receptor 5-HT₇R regulates the morphology and migratory properties of dendritic cells. |
| Volume: |
128 |
| Issue: |
15 |
| Pages: |
2866-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Du H |
| Year: |
2021 |
| Journal: |
Front Cell Dev Biol |
| Title: |
The Rho GTPase Cell Division Cycle 42 Regulates Stereocilia Development in Cochlear Hair Cells. |
| Volume: |
9 |
|
| Pages: |
765559 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rittmeyer EN |
| Year: |
2008 |
| Journal: |
J Cell Sci |
| Title: |
A dual role for IQGAP1 in regulating exocytosis. |
| Volume: |
121 |
| Issue: |
Pt 3 |
| Pages: |
391-403 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zheng P |
| Year: |
2013 |
| Journal: |
J Cell Sci |
| Title: |
PtdIns(3,4,5)P3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes. |
| Volume: |
126 |
| Issue: |
Pt 3 |
| Pages: |
715-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matsuda C |
| Year: |
2008 |
| Journal: |
FEBS Lett |
| Title: |
Affixin activates Rac1 via betaPIX in C2C12 myoblast. |
| Volume: |
582 |
| Issue: |
8 |
| Pages: |
1189-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alberts AS |
| Year: |
1998 |
| Journal: |
J Biol Chem |
| Title: |
Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. |
| Volume: |
273 |
| Issue: |
15 |
| Pages: |
8616-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dütting S |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. |
| Volume: |
8 |
|
| Pages: |
15838 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Sakabe M |
| Year: |
2017 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
YAP/TAZ-CDC42 signaling regulates vascular tip cell migration. |
| Volume: |
114 |
| Issue: |
41 |
| Pages: |
10918-10923 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Trost M |
| Year: |
2009 |
| Journal: |
Immunity |
| Title: |
The phagosomal proteome in interferon-gamma-activated macrophages. |
| Volume: |
30 |
| Issue: |
1 |
| Pages: |
143-54 |
|
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•
•
•
•
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| GO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu X |
| Year: |
2017 |
| Journal: |
J Exp Med |
| Title: |
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. |
| Volume: |
214 |
| Issue: |
1 |
| Pages: |
209-226 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pleines I |
| Year: |
2013 |
| Journal: |
Blood |
| Title: |
Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42. |
| Volume: |
122 |
| Issue: |
18 |
| Pages: |
3178-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kalim KW |
| Year: |
2018 |
| Journal: |
J Immunol |
| Title: |
Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42. |
| Volume: |
200 |
| Issue: |
7 |
| Pages: |
2313-2326 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Burbage M |
| Year: |
2017 |
| Journal: |
J Immunol |
| Title: |
The Small Rho GTPase TC10 Modulates B Cell Immune Responses. |
| Volume: |
199 |
| Issue: |
5 |
| Pages: |
1682-1695 |
|
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•
•
•
•
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| First Author: |
Clayton L |
| Year: |
1999 |
| Journal: |
Dev Biol |
| Title: |
A role for Rho-like GTPases in the polarisation of mouse eight-cell blastomeres. |
| Volume: |
205 |
| Issue: |
2 |
| Pages: |
322-31 |
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•
•
•
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| First Author: |
Kawakatsu T |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac. |
| Volume: |
280 |
| Issue: |
6 |
| Pages: |
4940-7 |
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•
•
•
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| First Author: |
GarcÃa Z |
| Year: |
2006 |
| Journal: |
EMBO J |
| Title: |
A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis. |
| Volume: |
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20 |
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•
•
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| First Author: |
Dovas A |
| Year: |
2009 |
| Journal: |
J Cell Sci |
| Title: |
Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages. |
| Volume: |
122 |
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Pt 21 |
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•
•
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| First Author: |
Pi J |
| Year: |
2018 |
| Journal: |
Theranostics |
| Title: |
Elevated Expression of miR302-367 in Endothelial Cells Inhibits Developmental Angiogenesis via CDC42/CCND1 Mediated Signaling Pathways. |
| Volume: |
8 |
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6 |
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1511-1526 |
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•
•
•
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| First Author: |
Rolo A |
| Year: |
2016 |
| Journal: |
Elife |
| Title: |
Regulation of cell protrusions by small GTPases during fusion of the neural folds. |
| Volume: |
5 |
|
| Pages: |
e13273 |
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•
•
•
•
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| Publication |
| First Author: |
Fritsch R |
| Year: |
2013 |
| Journal: |
Cell |
| Title: |
RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. |
| Volume: |
153 |
| Issue: |
5 |
| Pages: |
1050-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smith TK |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity. |
| Volume: |
105 |
| Issue: |
24 |
| Pages: |
8298-303 |
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•
•
•
•
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| First Author: |
Oh JE |
| Year: |
2009 |
| Journal: |
FASEB J |
| Title: |
Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway. |
| Volume: |
23 |
| Issue: |
7 |
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2088-99 |
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•
•
•
•
•
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| Publication |
| First Author: |
Huber C |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. |
| Volume: |
283 |
| Issue: |
49 |
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34002-12 |
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•
•
•
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| Publication |
| First Author: |
Loebel DA |
| Year: |
2016 |
| Journal: |
Biol Open |
| Title: |
Thyroid bud morphogenesis requires CDC42- and SHROOM3-dependent apical constriction. |
| Volume: |
5 |
| Issue: |
2 |
| Pages: |
130-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hou C |
| Year: |
2024 |
| Journal: |
Neuroreport |
| Title: |
Role of LGL1 in cerebellar primordium of embryonic mice. |
| Volume: |
35 |
| Issue: |
6 |
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•
•
•
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| First Author: |
Haebig K |
| Year: |
2010 |
| Journal: |
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