|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 300 out of 300 for Cdc7

<< First    < Previous  |  Next >    Last >>
0.017s
Type Details Score
Publication
First Author: Farini D
Year: 2020
Journal: Cell Rep
Title: A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum.
Volume: 31
Issue: 9
Pages: 107703
Publication
First Author: Zhou L
Year: 2017
Journal: FASEB J
Title: Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.
Volume: 31
Issue: 1
Pages: 132-147
Publication  
First Author: Akagawa R
Year: 2021
Journal: Front Cell Dev Biol
Title: Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons.
Volume: 9
Pages: 753175
Publication        
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
Publication        
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication        
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Kurita M
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest.
Volume: 324
Issue: 2
Pages: 554-61
UniProt Feature
Begin: 40
Description: Phosphoserine; by CDC7
Type: modified residue
End: 40
UniProt Feature
Begin: 53
Description: Phosphoserine; by CDC7
Type: modified residue
End: 53
Publication
First Author: Li X
Year: 2018
Journal: Mol Cell
Title: Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication.
Volume: 72
Issue: 4
Pages: 650-660.e8
Publication
First Author: Yamashita N
Year: 2005
Journal: Genes Cells
Title: Functional analyses of mouse ASK, an activation subunit for Cdc7 kinase, using conditional ASK knockout ES cells.
Volume: 10
Issue: 6
Pages: 551-63
Publication
First Author: Duncker BP
Year: 2003
Journal: Mutat Res
Title: Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts.
Volume: 532
Issue: 1-2
Pages: 21-7
Publication
First Author: Grishina I
Year: 2005
Journal: Cell Cycle
Title: A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes.
Volume: 4
Issue: 8
Pages: 1120-6
Publication
First Author: Dowell SJ
Year: 1994
Journal: Science
Title: Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo.
Volume: 265
Issue: 5176
Pages: 1243-6
Allele
Name: transgene insertion DKO28, Hisao Masai
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Genotype
Symbol: Cdc7/Cdc7 Tg(EF1A-Cdc7)DKO28Hmas/?
Background: involves: 129S/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cdc7/Cdc7 Tg(EF1A-Cdc7)DKO28Hmas/Tg(EF1A-Cdc7)DKO28Hmas
Background: involves: 129S/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Protein Domain
Type: Homologous_superfamily
Description: In eukaryotes, initiation of DNA replication requires the assembly of pre-replication complexes (pre-RCs) on chromatin during the G1 phase. In the S phase, pre-RCs are activated by two protein kinases, Cdk2 and Cdc7, which results in the loading of replication factors and the unwinding of replication origins by the MCM helicase complex []. Cdc7 is a serine/threonine kinase that is conserved from yeast to human. It is regulated by its association with a regulatory subunit, the Dbf4 protein. This complex is often referred to as DDK (Dbf4-dependent kinase) [].DBF4 contains an N-terminal BRCT domain and a C-terminal conserved region that could potentially coordinate one zinc atom, the DBF4-type zinc finger. This entry represents the zinc finger, which is important for the interaction with Cdc7 [, ].
Protein
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: false
Protein Domain
Type: Family
Description: Cyclin-dependent kinase 2-interacting protein (CINP) is a component of theactive cyclin E/Cdk2 and cyclin A/Cdk2 complexes []. It is phopshorylated by Cdc7, but not by Cdk2 []. CINP has also been shown to bind to chromatin in a replication-dependent manner, and to associate with Origin Recognition Complex-2 (ORC2)-containing complexes and minichromosome maintenance/DNA replication licensing complex, MCM []. It has been proposed that CINP is part of the Cdc7-dependent mechanism of origin firing, and constitutes a physical link between Cdk2 and Cdc7 complexes at the origins [].
Publication
First Author: Kurita M
Year: 2007
Journal: Biochem Biophys Res Commun
Title: CR/periphilin is a transcriptional co-repressor involved in cell cycle progression.
Volume: 364
Issue: 4
Pages: 930-6
Protein
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 2498  
Fragment?: false
Publication
First Author: Nasmyth K
Year: 1996
Journal: Science
Title: Viewpoint: putting the cell cycle in order.
Volume: 274
Issue: 5293
Pages: 1643-5
Publication
First Author: Hardy CF
Year: 1996
Journal: Mol Cell Biol
Title: A novel role for Cdc5p in DNA replication.
Volume: 16
Issue: 12
Pages: 6775-82
Publication
First Author: Ishimi Y
Year: 2001
Journal: J Biol Chem
Title: Biochemical activities associated with mouse Mcm2 protein.
Volume: 276
Issue: 46
Pages: 42744-52
Publication
First Author: Guo B
Year: 2001
Journal: Gene
Title: Cloning and characterization of Chinese hamster homologue of yeast DBF4 (ChDBF4).
Volume: 264
Issue: 2
Pages: 249-56
Publication
First Author: Wang C
Year: 2019
Journal: Nature
Title: Inducing and exploiting vulnerabilities for the treatment of liver cancer.
Volume: 574
Issue: 7777
Pages: 268-272
Protein
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
Protein Domain
Type: Domain
Description: Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domainsare often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. In eukaryotes, initiation of DNA replication requires the assembly of pre-replication complexes (pre-RCs) on chromatin during the G1 phase. In the S phase, pre-RCs are activated by two protein kinases, Cdk2 and Cdc7, which results in the loading of replication factors and the unwinding of replication origins by the MCM helicase complex []. Cdc7 is a serine/threonine kinase that is conserved from yeast to human. It is regulated by its association with a regulatory subunit, the Dbf4 protein. This complex is often referred to as DDK (Dbf4-dependent kinase) [].DBF4 contains an N-terminal BRCT domain and a C-terminal conserved region that could potentially coordinate one zinc atom, the DBF4-type zinc finger. This entry represents the zinc finger, which is important for the interaction with Cdc7 [, ].
Publication
First Author: Kneissl M
Year: 2003
Journal: J Mol Biol
Title: Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.
Volume: 327
Issue: 1
Pages: 111-28
Protein
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
Protein Domain
Type: Family
Description: The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm2 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring []. MCM2-7 complex is part of the pre-replication complex (pre-RC). In G1 phase, inactive MCM2-7 complex is loaded onto origins of DNA replication [, , ]. During G1-S phase, MCM2-7 complex is activated to unwind the double stranded DNA and plays an important role in DNA replication forks elongation [].The components of the MCM2-7 complex are: DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, DNA replication licensing factor MCM5, DNA replication licensing factor MCM6, DNA replication licensing factor MCM7, In addition to its role in initiation of DNA replication, Mcm2 is able toinhibit the Mcm4,6,7 helicase. Studies on murine Mcm2 indicate that itsC terminus is required for interaction with MCM4, as well as for inhibitionof the DNA helicase activity of the Mcm4,6,7 complex. The N-terminal region,which contains an H3-binding domain and a region required for nuclear localisation, is required for the phosphorylation by CDC7 kinase.
Protein
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
Publication
First Author: Krapp A
Year: 2008
Journal: J Cell Sci
Title: Homoeostasis between the GTPase Spg1p and its GAP in the regulation of cytokinesis in S. pombe.
Volume: 121
Issue: Pt 5
Pages: 601-8
Publication
First Author: Cooper JA
Year: 2006
Journal: J Cell Biol
Title: Checkpoint control of mitotic exit--do budding yeast mind the GAP?
Volume: 172
Issue: 3
Pages: 331-3
Publication
First Author: Schmidt S
Year: 1997
Journal: Genes Dev
Title: The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe.
Volume: 11
Issue: 12
Pages: 1519-34
Protein Domain
Type: Family
Description: Small GTPases form an independent superfamily within the larger class of regulatory GTP hydrolases. This superfamily contains proteins that control a vast number of important processes and possess a common, structurally preserved GTP-binding domain [, ]. Sequence comparisons of small G proteins from various species have revealed that they are conserved in primary structures at the level of 30-55% similarity [].Crystallographic analysis of various small G proteins revealed the presence of a 20kDa catalytic domain that is unique for the whole superfamily [, ]. The domain is built of five alpha helices (A1-A5), six β-strands (B1-B6) and five polypeptide loops (G1-G5). A structural comparison of the GTP- and GDP-bound form, allows one to distinguish two functional loop regions: switch I and switch II that surround the gamma-phosphate group of the nucleotide. The G1 loop (also called the P-loop) that connects the B1 strand and the A1 helix is responsible for the binding of the phosphate groups. The G3 loop provides residues for Mg2 and phosphate binding and is located at the N terminus of the A2 helix. The G1 and G3 loops are sequentially similar to Walker A and Walker B boxes that are found in other nucleotide binding motifs. The G2 loop connects the A1 helix and the B2 strand and contains a conserved Thr residue responsible for Mg2 binding. The guanine base is recognised by the G4 and G5 loops. The consensus sequence NKXD of the G4 loop contains Lys and Asp residues directly interacting with the nucleotide. Part of the G5 loop located between B6 and A5 acts as a recognition site for the guanine base [].The small GTPase superfamily can be divided into at least 8 different families, including:Arf small GTPases. GTP-binding proteins involved in protein trafficking by modulating vesicle budding and uncoating within the Golgi apparatus.Ran small GTPases. GTP-binding proteins involved in nucleocytoplasmic transport. Required for the import of proteins into the nucleus and also for RNA export.Rab small GTPases. GTP-binding proteins involved in vesicular traffic.Rho small GTPases. GTP-binding proteins that control cytoskeleton reorganisation.Ras small GTPases. GTP-binding proteins involved in signalling pathways.Sar1 small GTPases. Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).Mitochondrial Rho (Miro). Small GTPase domain found in mitochondrial proteins involved in mitochondrial trafficking.Roc small GTPases domain. Small GTPase domain always found associated with the COR domain.This entry includes Tem1 from budding yeasts and Spg1 from fission yeasts. They are GTPases involved in the regulation of the cell cycle. In Schizosaccharomyces pombe, Spg1 is required for the localisation of Cdc7 (part of the septation initiation network) to the spindle pole body (SPB) []. It is regulated negatively by a GTPase-activating protein (GAP) comprising two subunits - Byr4 and Cdc16. In anaphase B, Spg1 is localised on the new SPB []. In Saccharomyces cerevisiae, Tem1 is associated with the mitotic exit network (MEN). It is involved in termination of M phase of the cell cycle [].
Publication
First Author: Remus D
Year: 2009
Journal: Cell
Title: Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.
Volume: 139
Issue: 4
Pages: 719-30
Publication
First Author: Evrin C
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication.
Volume: 106
Issue: 48
Pages: 20240-5
Publication
First Author: Symeonidou IE
Year: 2012
Journal: FEBS Lett
Title: Control over DNA replication in time and space.
Volume: 586
Issue: 18
Pages: 2803-12
Publication  
First Author: Singleton MR
Year: 2007
Journal: Annu Rev Biochem
Title: Structure and mechanism of helicases and nucleic acid translocases.
Volume: 76
Pages: 23-50
Protein
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
Publication
First Author: Valencia A
Year: 1991
Journal: Biochemistry
Title: The ras protein family: evolutionary tree and role of conserved amino acids.
Volume: 30
Issue: 19
Pages: 4637-48
Publication
First Author: Pai EF
Year: 1990
Journal: EMBO J
Title: Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
Volume: 9
Issue: 8
Pages: 2351-9
Publication
First Author: Bourne HR
Year: 1990
Journal: Nature
Title: The GTPase superfamily: a conserved switch for diverse cell functions.
Volume: 348
Issue: 6297
Pages: 125-32
Publication
First Author: Bourne HR
Year: 1991
Journal: Nature
Title: The GTPase superfamily: conserved structure and molecular mechanism.
Volume: 349
Issue: 6305
Pages: 117-27
Publication
First Author: Paduch M
Year: 2001
Journal: Acta Biochim Pol
Title: Structure of small G proteins and their regulators.
Volume: 48
Issue: 4
Pages: 829-50
Publication
First Author: Matthews JM
Year: 2002
Journal: IUBMB Life
Title: Zinc fingers--folds for many occasions.
Volume: 54
Issue: 6
Pages: 351-5
Publication
First Author: Gamsjaeger R
Year: 2007
Journal: Trends Biochem Sci
Title: Sticky fingers: zinc-fingers as protein-recognition motifs.
Volume: 32
Issue: 2
Pages: 63-70
Publication
First Author: Hall TM
Year: 2005
Journal: Curr Opin Struct Biol
Title: Multiple modes of RNA recognition by zinc finger proteins.
Volume: 15
Issue: 3
Pages: 367-73
Publication
First Author: Brown RS
Year: 2005
Journal: Curr Opin Struct Biol
Title: Zinc finger proteins: getting a grip on RNA.
Volume: 15
Issue: 1
Pages: 94-8
Publication
First Author: Klug A
Year: 1999
Journal: J Mol Biol
Title: Zinc finger peptides for the regulation of gene expression.
Volume: 293
Issue: 2
Pages: 215-8
Publication
First Author: Laity JH
Year: 2001
Journal: Curr Opin Struct Biol
Title: Zinc finger proteins: new insights into structural and functional diversity.
Volume: 11
Issue: 1
Pages: 39-46