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Search results 201 to 215 out of 215 for Cdc73

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Type Details Score
Publication
15580289 | -
First Author: Woodard GE
Year: 2005
Journal: Oncogene
Title: Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression.
Volume: 24
Issue: 7
Pages: 1272-6
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Publication
16989776 | -
First Author: Zhang C
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Parafibromin inhibits cancer cell growth and causes G1 phase arrest.
Volume: 350
Issue: 1
Pages: 17-24
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Protein Domain
IPR032041 | Cdc73_N
Type: Domain
Description: This is the N-terminal region of Cdc73 (cell division cycle 73). Cdc73 forms part of the Paf1 post-initiation complex []. As part of the Paf1 complex, Cdc73 associates with RNA-polymerase II and is involved in several transcriptional and posttranscriptional events. In vertebrates, the protein encoded by HRPT2/CCdc73 is known as Parafibromin, and acts as a tumour suppressor [, ].
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Publication
9891041 | -
First Author: Chang M
Year: 1999
Journal: Mol Cell Biol
Title: A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling.
Volume: 19
Issue: 2
Pages: 1056-67
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Protein Domain
IPR031336 | CDC73_C
Type: Domain
Description: CDC73 is an RNA polymerase II accessory factor [], and forms part of the Paf1 complex that has roles in post-initiation events []. More specifically, crystal structure analysis shows the C terminus to be a Ras-like domain that adopts a fold that is highly similar to GTPases of the Ras superfamily. The C-terminal domain contains a large but comparatively flat surface of highly conserved residues, devoid of ligand. Deletion of the Cdc73 C-domain significantly reduces Paf1C occupancy on active genes, which means that the Cdc73 C-domain plays a role in promoting association of Paf1C with chromatin []. The canonical nucleotide binding pocket is altered in CDC73, and there is no nucleotide ligand, but it contributes to histone methylation and Paf1 complex (Paf1C) recruitment to active genes. Thus, together with Rtf1, it combines to couple Paf1C to elongating polymerase [].
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Protein Domain
IPR038103 | CDC73_C_sf
Type: Homologous_superfamily
Description: CDC73 is an RNA polymerase II accessory factor [], and forms part of the Paf1 complex that has roles in post-initiation events []. More specifically, crystal structure analysis shows the C terminus to be a Ras-like domain that adopts a fold that is highly similar to GTPases of the Ras superfamily. The C-terminal domain contains a large but comparatively flat surface of highly conserved residues, devoid of ligand. Deletion of the Cdc73 C-domain significantly reduces Paf1C occupancy on active genes, which means that the Cdc73 C-domain plays a role in promoting association of Paf1C with chromatin []. The canonical nucleotide binding pocket is altered in CDC73, and there is no nucleotide ligand, but it contributes to histone methylation and Paf1 complex (Paf1C) recruitment to active genes. Thus, together with Rtf1, it combines to couple Paf1C to elongating polymerase [].
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Publication
8812838 | -
First Author: Wade PA
Year: 1996
Journal: Protein Expr Purif
Title: A novel collection of accessory factors associated with yeast RNA polymerase II.
Volume: 8
Issue: 1
Pages: 85-90
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Publication
9032243 | -
First Author: Shi X
Year: 1997
Journal: Mol Cell Biol
Title: Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme.
Volume: 17
Issue: 3
Pages: 1160-9
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Protein
Q8JZM7
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: false
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Publication
35171666 | J:321523
First Author: Han D
Year: 2022
Journal: Sci Adv
Title: A balanced Oct4 interactome is crucial for maintaining pluripotency.
Volume: 8
Issue: 7
Pages: eabe4375
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Publication
12242279 | -
First Author: Krogan NJ
Year: 2002
Journal: Mol Cell Biol
Title: RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach.
Volume: 22
Issue: 20
Pages: 6979-92
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Publication
20363855 | -
First Author: Park S
Year: 2010
Journal: Plant Physiol
Title: PLANT HOMOLOGOUS TO PARAFIBROMIN is a component of the PAF1 complex and assists in regulating expression of genes within H3K27ME3-enriched chromatin.
Volume: 153
Issue: 2
Pages: 821-31
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Protein Domain
IPR007852 | Cdc73/Parafibromin
Type: Family
Description: This entry includes Cdc73 from budding yeasts and its animal homologue, parafibromin. They are part of the Paf1 complex involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection [].In budding yeasts, Paf1 is an RNA polymerase II-associated protein complex containing Paf1, Cdc73, Ctr9, Rtf1 and Leo1. It is required for full expression of a subset of yeast genes, particularly those responsive to signals from the Pkc1/MAP kinase cascade. The complex appears to play an essential role in RNA elongation []. Human parafibromin is a tumour suppressor that may facilitate association of 3' mRNA processing factors with actively-transcribed chromatin. It is a component of the human Paf1 complex (Paf1C), which consists of Paf1, Cdc73, Ctr9, Rtf1, Leo1 and Wdr61 (Ski8). As in yeast, the human Paf1C has a central role in co-transcriptional histone modifications []. The Arabidopsis Cdc73 (also known as PLANT HOMOLOGOUS TO PARAFIBROMIN ,PHP) assists in regulating expression of genes within H3K27ME3-enriched chromatin []and participates in the modification of FLOWERING LOCUS C (FLC) chromatin [].
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Publication
24420920 | J:209381
First Author: Yoo HS
Year: 2014
Journal: J Immunol
Title: Transcriptional regulator CTR9 inhibits Th17 differentiation via repression of IL-17 expression.
Volume: 192
Issue: 4
Pages: 1440-8
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Publication
20178742 | -
First Author: Kim J
Year: 2010
Journal: Cell
Title: The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.
Volume: 140
Issue: 4
Pages: 491-503
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