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Search results 201 to 207 out of 207 for Clstn1

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Type Details Score
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Protein Domain
IPR045588 | CLSTN_C
Type: Domain
Description: This entry represents the cytoplasmic C-terminal domain of calsyntenin (CLSTN) proteins 1, 2 and 3 (also known as alcadein-alpha, beta and gamma). These are postsynaptic Ca2-binding proteins, evolutionarily conserved type I membrane proteins. CLSTN (also known as Alc) forms a tripartite complex with APP (amyloid beta-protein precursor) and X11L (a neuron-specific adaptor protein) in brain; this complex stabilizes both APP and CLSTN proteins metabolically. Deficiencies in the X11L-mediated interaction between CLSTN and APP and/or CTFbeta enhances the production of amyloid beta-protein and have been linked to the development or progression of Alzheimer's disease []. Moreover, CLSTN1 strongly associates with kinesin-1 light chains (KLC1) and acts as a cargo that regulates kinesin-1 function. It may affect the transport of APP-containing vesicles by kinesin-1 []. This domain includes the WD motifs required for KLC1 interaction (although one WD motif is sufficient), and the NP motif [].
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Publication
31680833 | J:291923
 
First Author: Cheng K
Year: 2019
Journal: Front Neurosci
Title: Calsyntenin-1 Negatively Regulates ICAM5 Accumulation in Postsynaptic Membrane and Influences Dendritic Spine Maturation in a Mouse Model of Fragile X Syndrome.
Volume: 13
Pages: 1098
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Protein
Q99JH7
Organism: Mus musculus/domesticus
Length: 956  
Fragment?: false
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Protein
Q9EPL2
Organism: Mus musculus/domesticus
Length: 979  
Fragment?: false
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Protein
Q9ER65
Organism: Mus musculus/domesticus
Length: 966  
Fragment?: false
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Protein
D3Z601
Organism: Mus musculus/domesticus
Length: 919  
Fragment?: false
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