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Search results 201 to 290 out of 290 for Cntn5

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Hits by Pathway

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Hits by Strain

Type Details Score
Strain
MGI:6850163 | B6.FVB(Cg)-Tg(TPO-cre)1Shk/J
Attribute String: congenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(TPO-cre)1Shk/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Publication
19177518 | -
First Author: Toyoshima M
Year: 2009
Journal: J Comp Neurol
Title: Preferential localization of neural cell recognition molecule NB-2 in developing glutamatergic neurons in the rat auditory brainstem.
Volume: 513
Issue: 4
Pages: 349-62
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Protein Domain
IPR032989 | Contactin-5
Type: Family
Description: Contactin-5 (Cntn5) or neural recognition molecule NB-2 mediates cell surface interactions necessary for connectivity during nervous system development and synaptic maintenance during adulthood [, ]. Cntn5 contributes to the development of glutamatergic neurons in the rat auditory brainstem [, ].Contactins are cell adhesion molecules that belong to the immunoglobulin superfamily and are involved in neural development []. They usually consist of six N-terminal Ig domains, four fibronectin type III domains, and a C-terminal glycophosphatidylinositol (GPI)-anchor to the extracellular part of the cell membrane [].
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Genotype
Genotype
Symbol: Nkx2-1/Nkx2-1 Tg(TPO-cre)1Shk/?
Background: involves: 129X1/SvJ * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gnas/Gnas Tg(TPO-cre)1Shk/?
Background: involves: 129S6/SvEvTac * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf2/Nf2 Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Publication
19581346 | J:152193
First Author: Hoshi S
Year: 2009
Journal: Carcinogenesis
Title: Role of NKX2-1 in N-bis(2-hydroxypropyl)-nitrosamine-induced thyroid adenoma in mice.
Volume: 30
Issue: 9
Pages: 1614-9
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Publication
17283127 | J:118219
First Author: Yeager N
Year: 2007
Journal: Cancer Res
Title: Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis.
Volume: 67
Issue: 3
Pages: 959-66
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Strain
MGI:4868759 | 129S1.Cg-Cdkn1b<tm1Ako> Tg(TPO-cre)1Shk Pten<tm2.1Ppp>
Attribute String: congenic, targeted mutation, transgenic
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Publication
20676139 | J:165293
First Author: Antico-Arciuch VG
Year: 2010
Journal: Oncogene
Title: Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females.
Volume: 29
Issue: 42
Pages: 5678-86
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Strain
MGI:5897836 | 129.Cg-Tg(TPO-cre)1Shk Trp53<tm1Brn> Pten<tm2.1Ppp>
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
22190384 | J:211100
First Author: Antico Arciuch VG
Year: 2011
Journal: Oncotarget
Title: Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors.
Volume: 2
Issue: 12
Pages: 1109-26
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Publication
21383698 | J:174636
First Author: Knauf JA
Year: 2011
Journal: Oncogene
Title: Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling.
Volume: 30
Issue: 28
Pages: 3153-62
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Strain
MGI:4868761 | 129S1.Cg-Pten<tm2.1Ppp> Tg(TPO-cre)1Shk
Attribute String: transgenic, mutant strain, targeted mutation
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Publication
23796563 | J:200610
First Author: Antico Arciuch VG
Year: 2013
Journal: Cancer Res
Title: Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells.
Volume: 73
Issue: 17
Pages: 5459-72
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Publication
31331961 | J:278688
 
First Author: Jezek J
Year: 2019
Journal: J Cell Sci
Title: Synergistic repression of thyroid hyperplasia by cyclin C and Pten.
Volume: 132
Issue: 16
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Publication
18199538 | J:131418
First Author: Yeager N
Year: 2008
Journal: Cancer Res
Title: Mammalian target of rapamycin is the key effector of phosphatidylinositol-3-OH-initiated proliferative signals in the thyroid follicular epithelium.
Volume: 68
Issue: 2
Pages: 444-9
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Publication
22514108 | J:241066
First Author: Pringle DR
Year: 2012
Journal: Endocr Relat Cancer
Title: Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer.
Volume: 19
Issue: 3
Pages: 435-46
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Publication
31314096 | J:279001
First Author: Kurashige T
Year: 2019
Journal: Endocrinology
Title: Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice.
Volume: 160
Issue: 9
Pages: 2085-2092
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Publication
22136853 | J:196861
First Author: Lin CI
Year: 2011
Journal: Surgery
Title: Thyroid-specific knockout of the tumor suppressor mitogen-inducible gene 6 activates epidermal growth factor receptor signaling pathways and suppresses nuclear factor-κB activity.
Volume: 150
Issue: 6
Pages: 1295-302
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Genotype
Genotype
Symbol: Pten/Pten Tg(TPO-cre)1Shk/?
Background: 129S1.Cg-Pten Tg(TPO-cre)1Shk
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn1b/Cdkn1b Pten/Pten Tg(TPO-cre)1Shk/?
Background: 129S1.Cg-Cdkn1b Tg(TPO-cre)1Shk Pten
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn1b/Cdkn1b<+> Pten/Pten Tg(TPO-cre)1Shk/?
Background: 129S1.Cg-Cdkn1b Tg(TPO-cre)1Shk Pten
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe/? Tg(TPO-cre)1Shk/?
Background: involves: FVB/NCr * FVB/NJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pten/Pten Trp53/Trp53 Tg(TPO-cre)1Shk/?
Background: 129.Cg-Tg(TPO-cre)1Shk Trp53 Pten
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Tg(TPO-cre)1Shk/?
Background: 129.Cg-Kras Tg(Tpo-cre)1Shk
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Prkar1a/Prkar1a Tg(TPO-cre)1Shk/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pten/Pten Tg(TPO-cre)1Shk/?
Background: involves: 129 * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras Tg(TPO-cre)1Shk/?
Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6N * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tbx3/Tbx3 Tg(TPO-cre)1Shk/?
Background: involves: FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
19351816 | J:147732
First Author: Miller KA
Year: 2009
Journal: Cancer Res
Title: Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo.
Volume: 69
Issue: 8
Pages: 3689-94
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Publication
16601074 | J:111027
First Author: Kusakabe T
Year: 2006
Journal: Mol Endocrinol
Title: Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid.
Volume: 20
Issue: 8
Pages: 1796-809
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Publication
15282748 | J:92293
First Author: Kusakabe T
Year: 2004
Journal: Genesis
Title: Thyrocyte-specific expression of Cre recombinase in transgenic mice.
Volume: 39
Issue: 3
Pages: 212-6
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Publication
29990309 | J:266426
First Author: Knauf JA
Year: 2018
Journal: J Clin Invest
Title: Hgf/Met activation mediates resistance to BRAF inhibition in murine anaplastic thyroid cancers.
Volume: 128
Issue: 9
Pages: 4086-4097
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Publication
30086162 | J:264352
First Author: Shimamura M
Year: 2018
Journal: PLoS One
Title: Mouse models of sporadic thyroid cancer derived from BRAFV600E alone or in combination with PTEN haploinsufficiency under physiologic TSH levels.
Volume: 13
Issue: 8
Pages: e0201365
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Publication
19797117 | J:158236
First Author: Diallo-Krou E
Year: 2009
Journal: Endocrinology
Title: Paired box gene 8-peroxisome proliferator-activated receptor-gamma fusion protein and loss of phosphatase and tensin homolog synergistically cause thyroid hyperplasia in transgenic mice.
Volume: 150
Issue: 11
Pages: 5181-90
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Publication
21908931 | J:234597
First Author: Ock S
Year: 2011
Journal: Endocr J
Title: Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function.
Volume: 58
Issue: 11
Pages: 1013-9
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Strain
MGI:5897667 | 129.Cg-Kras<tm4Tyj> Tg(Tpo-cre)1Shk Pten<tm2.1Ppp>
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
23751876 | J:202152
First Author: Sponziello M
Year: 2013
Journal: Endocrinology
Title: Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer.
Volume: 154
Issue: 9
Pages: 3043-53
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Publication
24512487 | J:225245
First Author: Pringle DR
Year: 2014
Journal: J Clin Endocrinol Metab
Title: Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice.
Volume: 99
Issue: 5
Pages: E804-12
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Publication
31798532 | J:312029
 
First Author: Kari S
Year: 2019
Journal: Front Endocrinol (Lausanne)
Title: PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer.
Volume: 10
Pages: 769
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Publication
29289659 | J:273968
 
First Author: Russart KLG
Year: 2018
Journal: Horm Behav
Title: Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion.
Volume: 98
Pages: 121-129
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Genotype
Genotype
Symbol: Pten/Pten Tg(TPO-cre)1Shk/?
Background: involves: 129S4/SvJae * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hras/? Tg(TPO-cre)1Shk/?
Background: involves: 129S6/SvEvTac * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/? Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hras/Hras Tg(TPO-cre)1Shk/?
Background: involves: 129S6/SvEvTac * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Pten/Pten Tg(TPO-cre)1Shk/?
Background: 129.Cg-Kras Tg(Tpo-cre)1Shk Pten
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Prkar1a/Prkar1a Pten/Pten Tg(TPO-cre)1Shk/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Prkar1a/Prkar1a<+> Pten/Pten<+> Tg(TPO-cre)1Shk/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(TPO-cre)1Shk/?
Background: involves: 129S4/SvJaeSor * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
30165401 | J:320950
First Author: Ashtekar A
Year: 2018
Journal: J Clin Endocrinol Metab
Title: Alterations in Sod2-Induced Oxidative Stress Affect Endocrine Cancer Progression.
Volume: 103
Issue: 11
Pages: 4135-4145
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Publication
21512141 | J:172205
First Author: Charles RP
Year: 2011
Journal: Cancer Res
Title: Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse.
Volume: 71
Issue: 11
Pages: 3863-71
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Publication
26477313 | J:312572
First Author: Zou M
Year: 2016
Journal: Oncogene
Title: TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer.
Volume: 35
Issue: 15
Pages: 1909-18
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Publication
26359368 | J:231492
First Author: Garcia-Rendueles ME
Year: 2015
Journal: Cancer Discov
Title: NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition.
Volume: 5
Issue: 11
Pages: 1178-93
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Publication
29760048 | J:264284
First Author: Untch BR
Year: 2018
Journal: Cancer Res
Title: Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers.
Volume: 78
Issue: 16
Pages: 4642-4657
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Publication
29055016 | J:252305
First Author: Orlacchio A
Year: 2017
Journal: Cancer Res
Title: SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance.
Volume: 77
Issue: 24
Pages: 6914-6926
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Publication
25246276 | J:273044
First Author: Zhu X
Year: 2014
Journal: Neoplasia
Title: Synergistic signaling of KRAS and thyroid hormone receptor β mutants promotes undifferentiated thyroid cancer through MYC up-regulation.
Volume: 16
Issue: 9
Pages: 757-69
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Publication
21952241 | J:177181
First Author: Dobson ME
Year: 2011
Journal: Endocrinology
Title: Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPARgamma fusion protein thyroid carcinoma.
Volume: 152
Issue: 11
Pages: 4455-65
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Publication
29420754 | J:267474
First Author: Yu J
Year: 2018
Journal: Endocrinology
Title: Thyroid-Specific PPARγ Deletion Is Benign in the Mouse.
Volume: 159
Issue: 3
Pages: 1463-1468
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Publication
31998431 | J:291446
 
First Author: Wang X
Year: 2020
Journal: Oxid Med Cell Longev
Title: Thyroid Stimulating Hormone Triggers Hepatic Mitochondrial Stress through Cyclophilin D Acetylation.
Volume: 2020
Pages: 1249630
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Publication
19416908 | J:148393
First Author: Chen X
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene.
Volume: 106
Issue: 19
Pages: 7979-84
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Publication
28242615 | J:242074
First Author: Zou M
Year: 2017
Journal: Cancer Res
Title: Cyp24a1 Attenuation Limits Progression of BrafV600E -Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAFV600E Inhibitor PLX4720.
Volume: 77
Issue: 8
Pages: 2161-2172
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Publication
26146959 | J:226338
First Author: Zou M
Year: 2015
Journal: Lab Invest
Title: KRAS(G12D)-mediated oncogenic transformation of thyroid follicular cells requires long-term TSH stimulation and is regulated by SPRY1.
Volume: 95
Issue: 11
Pages: 1269-77
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Publication
26818109 | J:231632
First Author: Jolly LA
Year: 2016
Journal: Cancer Res
Title: Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss.
Volume: 76
Issue: 7
Pages: 1804-13
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Publication
29882482 | J:311903
First Author: Huk DJ
Year: 2018
Journal: Thyroid
Title: Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A-Mediated Thyroid Cancer.
Volume: 28
Issue: 9
Pages: 1153-1161
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Publication
23365119 | J:200123
First Author: Montero-Conde C
Year: 2013
Journal: Cancer Discov
Title: Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas.
Volume: 3
Issue: 5
Pages: 520-33
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Publication
25076938 | J:311978
 
First Author: Ma R
Year: 2014
Journal: Front Endocrinol (Lausanne)
Title: Stemness is Derived from Thyroid Cancer Cells.
Volume: 5
Pages: 114
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Publication
27669459 | J:239555
First Author: Nagarajah J
Year: 2016
Journal: J Clin Invest
Title: Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine.
Volume: 126
Issue: 11
Pages: 4119-4124
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Publication
26501867 | J:227855
First Author: Parhar RS
Year: 2016
Journal: Lab Invest
Title: IL-12 immunotherapy of Braf(V600E)-induced papillary thyroid cancer in a mouse model.
Volume: 96
Issue: 1
Pages: 89-97
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Genotype
Genotype
Symbol: Pten/Pten Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe/? Tg(TPO-cre)1Shk/?
Background: involves: 129S4/SvJae * FVB/NCr * FVB/NJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tshr/Tshr Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Gnas/Gnas Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hras/Hras Nf2/Nf2 Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hras/Hras Trp53/Trp53 Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hras/Hras Pten/Pten Tg(TPO-cre)1Shk/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras Thrb/Thrb Tg(TPO-cre)1Shk/?
Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6N * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Publication
21846565 | -
 
First Author: Zuko A
Year: 2011
Journal: Adv Protein Chem Struct Biol
Title: Contactins: structural aspects in relation to developmental functions in brain disease.
Volume: 84
Pages: 143-80
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Publication
37345654 | J:338857
 
First Author: Zhang X
Year: 2023
Journal: JCI Insight
Title: Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland.
Volume: 8
Issue: 12
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Publication
21220306 | J:168249
First Author: Franco AT
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.
Volume: 108
Issue: 4
Pages: 1615-20
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Publication
28584132 | J:244142
First Author: Montero-Conde C
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene.
Volume: 114
Issue: 25
Pages: E4951-E4960
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Publication
38750011 | J:348286
First Author: Zhang Z
Year: 2024
Journal: Nat Commun
Title: Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis.
Volume: 15
Issue: 1
Pages: 4108
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Publication
25300137 | -
 
First Author: Mohebiany AN
Year: 2014
Journal: Adv Neurobiol
Title: New insights into the roles of the contactin cell adhesion molecules in neural development.
Volume: 8
Pages: 165-94
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Publication
33318036 | J:305677
First Author: Saqcena M
Year: 2021
Journal: Cancer Discov
Title: SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies.
Volume: 11
Issue: 5
Pages: 1158-1175
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Publication
26123589 | J:236513
 
First Author: Kirschner LS
Year: 2016
Journal: Mol Cell Endocrinol
Title: Mouse models of thyroid cancer: A 2015 update.
Volume: 421
Pages: 18-27
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Protein
P68500
Organism: Mus musculus/domesticus
Length: 1098  
Fragment?: false
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Protein
Q3TRE5
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
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Protein
Q3UUQ8
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
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Protein
E9PYK7
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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