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Search results 201 to 300 out of 4706 for Coil

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Hits by Strain

Type Details Score
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Remmelzwaal S
Year: 2021
Journal: Curr Biol
Title: BBLN-1 is essential for intermediate filament organization and apical membrane morphology.
Volume: 31
Issue: 11
Pages: 2334-2346.e9
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_07
Specimen Label: euxassay_000206_07
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_18
Specimen Label: euxassay_000206_18
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2023-09-26
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7530856
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1857523
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_10
Specimen Label: euxassay_000206_10
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1857523
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_11
Specimen Label: euxassay_000206_11
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1857523
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_14
Specimen Label: euxassay_000206_14
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1857523
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_15
Specimen Label: euxassay_000206_15
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1857523
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_16
Specimen Label: euxassay_000206_16
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1857523
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_18
Specimen Label: euxassay_000206_18
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_06
Specimen Label: euxassay_000206_06
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_07
Specimen Label: euxassay_000206_07
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_08
Specimen Label: euxassay_000206_08
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_09
Specimen Label: euxassay_000206_09
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_11
Specimen Label: euxassay_000206_11
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_15
Specimen Label: euxassay_000206_15
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_16
Specimen Label: euxassay_000206_16
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_17
Specimen Label: euxassay_000206_17
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_18
Specimen Label: euxassay_000206_18
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_19
Specimen Label: euxassay_000206_19
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_20
Specimen Label: euxassay_000206_20
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_22
Specimen Label: euxassay_000206_22
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_23
Specimen Label: euxassay_000206_23
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_03
Specimen Label: euxassay_000206_03
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_04
Specimen Label: euxassay_000206_04
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_05
Specimen Label: euxassay_000206_05
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_06
Specimen Label: euxassay_000206_06
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_07
Specimen Label: euxassay_000206_07
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_08
Specimen Label: euxassay_000206_08
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_09
Specimen Label: euxassay_000206_09
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_18
Specimen Label: euxassay_000206_18
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_19
Specimen Label: euxassay_000206_19
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_20
Specimen Label: euxassay_000206_20
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_21
Specimen Label: euxassay_000206_21
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_22
Specimen Label: euxassay_000206_22
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_23
Specimen Label: euxassay_000206_23
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_05
Specimen Label: euxassay_000206_05
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_06
Specimen Label: euxassay_000206_06
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_21
Specimen Label: euxassay_000206_21
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_08
Specimen Label: euxassay_000206_08
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_18
Specimen Label: euxassay_000206_18
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_20
Specimen Label: euxassay_000206_20
Detected: true
Specimen Num: 17
GXD Expression
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_07
Note: reticular cells
Specimen Label: euxassay_000206_07
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_08
Specimen Label: euxassay_000206_08
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_09
Specimen Label: euxassay_000206_09
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_13
Specimen Label: euxassay_000206_13
Detected: true
Specimen Num: 10
GXD Expression
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_14
Note: reticular neurons
Specimen Label: euxassay_000206_14
Detected: true
Specimen Num: 11
GXD Expression
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_16
Note: facial motor nucleus
Specimen Label: euxassay_000206_16
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_17
Specimen Label: euxassay_000206_17
Detected: true
Specimen Num: 14
GXD Expression
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_18
Note: reticular cells
Specimen Label: euxassay_000206_18
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_06
Specimen Label: euxassay_000206_06
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_07
Specimen Label: euxassay_000206_07
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_09
Specimen Label: euxassay_000206_09
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_19
Specimen Label: euxassay_000206_19
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:1045087
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4822590
Age: embryonic day 14.5
Image: euxassay_000206_20
Specimen Label: euxassay_000206_20
Detected: true
Specimen Num: 17
Publication
First Author: Oz-Levi D
Year: 2019
Journal: Nature
Title: Noncoding deletions reveal a gene that is critical for intestinal function.
Volume: 571
Issue: 7763
Pages: 107-111
Publication
First Author: Rai S
Year: 2019
Journal: Autophagy
Title: The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis.
Volume: 15
Issue: 4
Pages: 599-612
Protein Domain
Type: Homologous_superfamily
Description: Tetrabrachion is a surface layer glycoprotein from the hyperthermophilic archaebacterium Staphylothermus marinus []. The tetrabrachion protein complex consists of four identical subunits that form an α-helical coiled coil stalk anchored to the cell membrane that branches into four arms. Two molecules of the subtilisin-like protease STABLE are noncovalently bound near the centre of the stalk. This entry represents the protease binding region of the tetrabrachion complex, for which a right-handed coiled coil structure has been proposed. The parallel right-handed coiled-coil tetramer is stabilized by a complex pattern of complementary hydrophobic interactions between neighbouring helices [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Hayano S
Year: 2015
Journal: J Mol Cell Cardiol
Title: Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction.
Volume: 88
Pages: 55-63
Publication
First Author: Enomoto A
Year: 2009
Journal: Neuron
Title: Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.
Volume: 63
Issue: 6
Pages: 774-87
Publication
First Author: Zhou Z
Year: 2012
Journal: J Biol Chem
Title: Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope.
Volume: 287
Issue: 8
Pages: 5317-26
Protein Domain
Type: Domain
Description: This entry represents the C-terminal conserved domain of coiled-coil proteins from animals. Its function is not known.
Protein Domain
Type: Homologous_superfamily
Description: The STAT protein (Signal Transducers and Activators of Transcription) family contains transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors, hence they act as signal transducers in the cytoplasm and transcription activators in the nucleus []. Binding of these factors to cell-surface receptors leads to receptor autophosphorylation at a tyrosine, the phosphotyrosine being recognised by the STAT SH2 domain, which mediates the recruitment of STAT proteins from the cytosol and their association with the activated receptor. The STAT proteins are then activated by phosphorylation via members of the JAK family of protein kinases, causing them to dimerise and translocated to the nucleus, where they bind to specific promoter sequences in target genes. In mammals, STATs comprise a family of seven structurally and functionally related proteins: Stat1, Stat2, Stat3, Stat4, Stat5a and Stat5b, Stat6. STAT proteins play a critical role in regulating innate and acquired host immune responses. Dysregulation of at least two STAT signalling cascades (i.e. Stat3 and Stat5) is associated with cellular transformation.Signalling through the JAK/STAT pathway is initiated when a cytokine binds to its corresponding receptor. This leads to conformational changes in the cytoplasmic portion of the receptor, initiating activation of receptor associated members of the JAK family of kinases. The JAKs, in turn, mediate phosphorylation at the specific receptor tyrosine residues, which then serve as docking sites for STATs and other signalling molecules. Once recruited to the receptor, STATs also become phosphorylated by JAKs, on a single tyrosine residue. Activated STATs dissociate from the receptor, dimerise, translocate to the nucleus and bind to members of the GAS (gamma activated site) family of enhancers.The seven STAT proteins identified in mammals range in size from 750 and 850 amino acids. The chromosomal distribution of these STATs, as well as the identification of STATs in more primitive eukaryotes, suggest that this family arose from a single primordial gene. STATs share 6 structurally and functionally conserved domains including: an N-terminal domain (ND) that strengthens interactions between STAT dimers on adjacent DNA-binding sites; a coiled-coil STAT domain (CCD) that is implicated in protein-protein interactions; a DNA-binding domain (DBD) with an immunoglobulin-like fold similar to p53 tumour suppressor protein; an EF-hand-like linker domain connecting the DNA-binding and SH2 domains; an SH2 domain () that acts as a phosphorylation-dependent switch to control receptor recognition and DNA-binding; and a C-terminal transactivation domain [, , ]. The crystal structure of the N terminus of Stat4 reveals a dimer. The interface of this dimer is formed by a ring-shaped element consisting of five short helices. Several studies suggest that this N-terminal dimerisation promotes cooperativity of binding to tandem GAS elements and with the transcriptional coactivator CBP/p300.This entry represents a domain consisting of four long helices that forms a bundle with a left-handed twist (coiled coil), in a right-handed superhelix.
Protein Domain
Type: Domain
Description: LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). The formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. SUN2 possesses two coiled-coil domains (CC1 and CC2). These coiled-coil domains are also believed to act as rigid spacers to delineate the distance between the ONM and INM of the NE. Furthermore, the two coiled-coil domains of SUN2 have been indicated to be able to directly modulate SUN domain activity and regulate the subsequent interactions between the SUN and KASH domains. CC2 forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component. Structure-based sequence analysis demonstrated that several Gly residues are located in the flexible linker regions between the three helices which would ideally provide the breaks/turns in CC2 for three-helix bundle formation. The last helix alpha3 of CC2 (that is immediately connected to the SUN domain) has been shown to be an essential segment for promoting SUN domain trimerization in the SUN-KASH complex structure [, ].
Protein Domain
Type: Domain
Description: The 380kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380kDa motor unit contains a concatenated chain of six AAA modules (D1-6), of which four correspond to the ATP binding sites with P-loop signatures, and two are modules in which the P loop has been lost in evolution. This domain occurs between D4 and D5 and includes the two predicted α-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component [].
Publication
First Author: Tarbouriech N
Year: 2000
Journal: Nat Struct Biol
Title: Tetrameric coiled coil domain of Sendai virus phosphoprotein.
Volume: 7
Issue: 9
Pages: 777-81
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory