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Search results 201 to 293 out of 293 for Corin

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Type Details Score
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 122
Description: Cleavage; by CORIN
Type: site
End: 123
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Publication
37636304 | J:340026
 
First Author: Niu Y
Year: 2023
Journal: Front Cardiovasc Med
Title: Corin deficiency impairs cardiac function in mouse models of heart failure.
Volume: 10
Pages: 1164524
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Publication
15192093 | -
First Author: Knappe S
Year: 2004
Journal: J Biol Chem
Title: Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide.
Volume: 279
Issue: 33
Pages: 34464-71
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Protein
Q9Z319-2
Organism: Mus musculus/domesticus
Length: 1047  
Fragment?: false
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Allele
Corin<tm2(cre)Bamo> | MGI:4457000
Name: corin, serine peptidase; targeted mutation 2, Bruce A Morgan
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Corin<tm1(cre/ERT2)Ense> | MGI:7482264
Name: corin, serine peptidase; targeted mutation 1, David Enshell-Seijffers
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Publication
21518754 | -
First Author: Qi X
Year: 2011
Journal: J Biol Chem
Title: Human corin isoforms with different cytoplasmic tails that alter cell surface targeting.
Volume: 286
Issue: 23
Pages: 20963-9
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Corin/Corin<+>
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR041762 | Corin_CRD_1
Type: Domain
Description: The cysteine-rich domain (CRD) is an essential component of corin, a type II transmembrane serine protease which functions as the convertase of the pro-atrial natriuretic peptide (pro-ANP) in the heart []. Corin contains two CRDs in its extracellular region, which play an important role in recognition of the physiological substrate, pro-ANP. This entry represents the first (N-terminal) CRD [].
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Protein Domain
IPR041763 | Corin_CRD_2
Type: Domain
Description: The cysteine-rich domain (CRD) is an essential component of corin, a type II transmembrane serine protease which functions as the convertase of the pro-atrial natriuretic peptide (pro-ANP) in the heart []. Corin contains two CRDs in its extracellular region, which play an important role in recognition of the physiological substrate, pro-ANP. This entry represents the second (C-terminal) CRD [].
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Genotype
Genotype
Symbol: Chd4/Chd4 Corin/Corin
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ctnnb1/Ctnnb1 Corin/Corin<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Corin/Corin<+> Ctnnb1/Ctnnb1 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Publication
21853097 | J:175364
First Author: Sales KU
Year: 2011
Journal: PLoS One
Title: Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT.
Volume: 6
Issue: 8
Pages: e23261
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Publication
29240788 | J:254429
First Author: Tripathi R
Year: 2017
Journal: PLoS One
Title: Enhanced heart failure, mortality and renin activation in female mice with experimental dilated cardiomyopathy.
Volume: 12
Issue: 12
Pages: e0189315
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Protein Domain
IPR020067 | Frizzled_dom
Type: Domain
Description: The frizzled (fz) domain is an extracellular domain of about 120 amino acids.It was first identified in the alpha-1 chain of type XVIII collagen and in members of the Frizzled family of seven transmembrane (7TM) proteins which act as receptors for secreted Wingless (Wg)/Wnt glycoproteins []. In addition to these proteins, one or two copies of the fz domain are also found [, , , , ]in:The Frzb family; secreted frizzled-like proteins.Smoothened; another 7TM receptor involved in hedgehog signaling.Carboxpeptidase Z (CPZ).Transmembrane serine protease corin (atrial natriuretic peptide-converting enzyme).Two receptor tyrosine kinases (RTKs) subfamilies, the Ror family and the muscle-specific kinase (MuSK) family.As the fz domain contains 10 cysteines which are largely conserved, it has also been called cysteine-rich domain (CRD) []. The fz domain also contains several other highly conserved residues, for example, a basic amino acid follows C6, and a conserved proline residues lies four residues C-terminal to C9 []. The crystal structure of a fz domain shows that it is predominantly α-helical with all cysteines forming disulphide bonds. In addition to helical regions, two short β-strands at the N terminus form a minimal β-sheet with the second beta sheet passing through a knot created by disulphide bonds [].Several fz domains have been shown to be both necessary and sufficient for Wg/Wnt ligand binding, strongly suggesting that the fz domain is a Wg/Wnt interacting domain [, ].
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Protein Domain
IPR036790 | Frizzled_dom_sf
Type: Homologous_superfamily
Description: This entry represents the frizzled domain superfamily.The frizzled (fz) domain is an extracellular domain of about 120 amino acids.It was first identified in the alpha-1 chain of type XVIII collagen and in members of the Frizzled family of seven transmembrane (7TM) proteins which act as receptors for secreted Wingless (Wg)/Wnt glycoproteins []. In addition to these proteins, one or two copies of the fz domain are also found [, , , , ]in:The Frzb family; secreted frizzled-like proteins.Smoothened; another 7TM receptor involved in hedgehog signaling.Carboxpeptidase Z (CPZ).Transmembrane serine protease corin (atrial natriuretic peptide-converting enzyme).Two receptor tyrosine kinases (RTKs) subfamilies, the Ror family and the muscle-specific kinase (MuSK) family.As the fz domain contains 10 cysteines which are largely conserved, it has also been called cysteine-rich domain (CRD) []. The fz domain also contains several other highly conserved residues, for example, a basic amino acid follows C6, and a conserved proline residues lies four residues C-terminal to C9 []. The crystal structure of a fz domain shows that it is predominantly α-helical with all cysteines forming disulphide bonds. In addition to helical regions, two short β-strands at the N terminus form a minimal β-sheet with the second beta sheet passing through a knot created by disulphide bonds [].Several fz domains have been shown to be both necessary and sufficient for Wg/Wnt ligand binding, strongly suggesting that the fz domain is a Wg/Wnt interacting domain [, ].
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Publication
7876242 | J:23590
First Author: Rehn M
Year: 1995
Journal: J Biol Chem
Title: Identification of three N-terminal ends of type XVIII collagen chains and tissue-specific differences in the expression of the corresponding transcripts. The longest form contains a novel motif homologous to rat and Drosophila frizzled proteins.
Volume: 270
Issue: 9
Pages: 4705-11
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Protein
D3YYF7
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
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Protein
A0A0U1RPV4
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
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Publication
8717036 | -
First Author: Bhanot P
Year: 1996
Journal: Nature
Title: A new member of the frizzled family from Drosophila functions as a Wingless receptor.
Volume: 382
Issue: 6588
Pages: 225-30
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Publication
9637908 | -
First Author: Xu YK
Year: 1998
Journal: Curr Biol
Title: The Frizzled CRD domain is conserved in diverse proteins including several receptor tyrosine kinases.
Volume: 8
Issue: 12
Pages: R405-6
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Publication
9852758 | -
First Author: Rehn M
Year: 1998
Journal: Trends Biochem Sci
Title: The frizzled motif: in how many different protein families does it occur?
Volume: 23
Issue: 11
Pages: 415-7
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Publication
9637909 | -
First Author: Masiakowski P
Year: 1998
Journal: Curr Biol
Title: The Wnt receptor CRD domain is also found in MuSK and related orphan receptor tyrosine kinases.
Volume: 8
Issue: 12
Pages: R407
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Publication
10082384 | -
First Author: Saldanha J
Year: 1998
Journal: Protein Sci
Title: Identification of a Frizzled-like cysteine rich domain in the extracellular region of developmental receptor tyrosine kinases.
Volume: 7
Issue: 8
Pages: 1632-5
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Publication
9326585 | -
First Author: Lin K
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling.
Volume: 94
Issue: 21
Pages: 11196-200
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Protein
Q3TUV1
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: true
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Protein
A0A172Q396
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
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Protein
P39061
Organism: Mus musculus/domesticus
Length: 1774  
Fragment?: false
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Protein
Q61086
Organism: Mus musculus/domesticus
Length: 666  
Fragment?: false
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Protein
Q9JIP6
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
Q8BKG4
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
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Protein
O70421
Organism: Mus musculus/domesticus
Length: 642  
Fragment?: false
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Protein
Q61088
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
Q9EQD0
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
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Protein
Q61089
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
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Protein
Q61090
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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Protein
Q61091
Organism: Mus musculus/domesticus
Length: 685  
Fragment?: false
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Protein
Q9R216
Organism: Mus musculus/domesticus
Length: 592  
Fragment?: false
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Protein
Q8R4V4
Organism: Mus musculus/domesticus
Length: 654  
Fragment?: false
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Protein
P56726
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Protein
Q9Z1N6
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Protein
P97401
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
Q8C4U3
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
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Protein
Q9WU66
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
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Protein
P97299
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
Q3V1B2
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
Q4VBD5
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Protein
Q8CAH7
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: false
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Protein
Q6P551
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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Protein
Q149J3
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
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Protein
Q3UUM9
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
Q3UI35
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
A0A0R4J001
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
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Protein
Q542J1
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
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Protein
Q149L3
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
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Protein
Q80VD0
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
Q71S95
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
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Protein
E9QPX1
Organism: Mus musculus/domesticus
Length: 1774  
Fragment?: false
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Protein
Q8BKS3
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
Q3UYZ0
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: true
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Protein
Q810L8
Organism: Mus musculus/domesticus
Length: 750  
Fragment?: true
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Protein
Q8R382
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
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Protein
Q8BLL2
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
A0A2I3BR53
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: false
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Protein
A0A2I3BQF8
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: false
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Protein
Q8K480
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
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Protein
Q8K0Q8
Organism: Mus musculus/domesticus
Length: 801  
Fragment?: true
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Protein
Q1XD56
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
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Protein
A0A0U1RNR7
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
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Protein
Q9Z139
Organism: Mus musculus/domesticus
Length: 937  
Fragment?: false
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Protein
Q9Z138
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
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Protein
Q61006
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
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Protein
Q497X0
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
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Protein
Q8C3W2
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
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Protein
K3W4P7
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
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Protein
J3QPS3
Organism: Mus musculus/domesticus
Length: 878  
Fragment?: false
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Protein
Q32SD4
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
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Protein
F6WVU1
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
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Protein
Q8BSP6
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
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Protein
Q3TZP9
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
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Protein
E9PUN5
Organism: Mus musculus/domesticus
Length: 932  
Fragment?: false
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Protein
Q32S49
Organism: Mus musculus/domesticus
Length: 860  
Fragment?: false
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Protein
Q32SD3
Organism: Mus musculus/domesticus
Length: 878  
Fragment?: false
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Protein
Q8BNP9
Organism: Mus musculus/domesticus
Length: 937  
Fragment?: false
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Protein
E9PVV8
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
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Protein
Q32S50
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
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Protein
I7GSQ5
Organism: Mus musculus/domesticus
Length: 860  
Fragment?: false
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Publication
11452312 | -
First Author: Dann CE
Year: 2001
Journal: Nature
Title: Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
Volume: 412
Issue: 6842
Pages: 86-90
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom