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Search results 201 to 300 out of 365 for Cpa1

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Type Details Score
Publication
11912494 | J:75811
First Author: Kim SK
Year: 2002
Journal: Nat Genet
Title: Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.
Volume: 30
Issue: 4
Pages: 430-5
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Publication
23823474 | J:199239
First Author: Magnuson MA
Year: 2013
Journal: Cell Metab
Title: Pancreas-specific Cre driver lines and considerations for their prudent use.
Volume: 18
Issue: 1
Pages: 9-20
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Publication
16472605 | J:125042
First Author: Pierreux CE
Year: 2006
Journal: Gastroenterology
Title: The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.
Volume: 130
Issue: 2
Pages: 532-41
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Publication
17400205 | J:121610
First Author: Vanhorenbeeck V
Year: 2007
Journal: Dev Biol
Title: Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation.
Volume: 305
Issue: 2
Pages: 685-94
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Publication
26657766 | J:229014
First Author: Marty-Santos L
Year: 2016
Journal: Development
Title: Pdx1 regulates pancreas tubulogenesis and E-cadherin expression.
Volume: 143
Issue: 1
Pages: 101-12
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Publication
33811703 | J:309372
First Author: Padgett LR
Year: 2021
Journal: FASEB J
Title: Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development.
Volume: 35
Issue: 5
Pages: e21473
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Publication
31201281 | J:280517
First Author: Spaeth JM
Year: 2019
Journal: Diabetes
Title: The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function.
Volume: 68
Issue: 9
Pages: 1806-1818
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Publication
38237591 | J:346123
First Author: Darrigrand JF
Year: 2024
Journal: Dev Cell
Title: Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner.
Volume: 59
Issue: 3
Pages: 326-338.e5
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Publication
31412250 | J:284608
First Author: Campbell SA
Year: 2019
Journal: Cell Rep
Title: TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation.
Volume: 28
Issue: 7
Pages: 1830-1844.e6
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Publication
32350257 | J:292264
First Author: Vinckier NK
Year: 2020
Journal: Nat Commun
Title: LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development.
Volume: 11
Issue: 1
Pages: 2082
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Publication
36017799 | J:329047
 
First Author: Rodriguez UA
Year: 2022
Journal: Development
Title: Focal adhesion kinase-mediated signaling controls the onset of pancreatic cell differentiation.
Volume: 149
Issue: 17
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Publication
23006330 | J:192746
First Author: Carrasco M
Year: 2012
Journal: J Clin Invest
Title: GATA4 and GATA6 control mouse pancreas organogenesis.
Volume: 122
Issue: 10
Pages: 3504-15
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Publication
38905124 | J:353482
First Author: Ortiz JA
Year: 2024
Journal: Diabetes
Title: Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging.
Volume: 73
Issue: 9
Pages: 1447-1461
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Publication
37172642 | J:336187
 
First Author: Barlow HR
Year: 2023
Journal: Dev Biol
Title: Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass.
Volume: 499
Pages: 59-74
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Publication
9291463 | J:42706
First Author: McGrath KE
Year: 1997
Journal: Mol Reprod Dev
Title: Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation.
Volume: 48
Issue: 2
Pages: 145-53
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Publication
22529374 | J:184814
First Author: Horn S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Mind bomb 1 is required for pancreatic β-cell formation.
Volume: 109
Issue: 19
Pages: 7356-61
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Publication
19805515 | J:154990
First Author: Kang HS
Year: 2009
Journal: Mol Cell Biol
Title: Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression.
Volume: 29
Issue: 24
Pages: 6366-79
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Publication
32059775 | J:297252
First Author: Seymour PA
Year: 2020
Journal: Dev Cell
Title: Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors.
Volume: 52
Issue: 6
Pages: 731-747.e8
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Publication
33527355 | J:306082
First Author: Quilichini E
Year: 2021
Journal: J Pathol
Title: Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease.
Volume: 254
Issue: 1
Pages: 31-45
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Publication
19914171 | J:157396
First Author: Kesavan G
Year: 2009
Journal: Cell
Title: Cdc42-mediated tubulogenesis controls cell specification.
Volume: 139
Issue: 4
Pages: 791-801
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Publication
22178591 | J:183127
First Author: Westmoreland JJ
Year: 2012
Journal: Gastroenterology
Title: Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas.
Volume: 142
Issue: 4
Pages: 999-1009.e6
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Publication
27740873 | J:240765
First Author: Arregi I
Year: 2016
Journal: Endocrinology
Title: Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling.
Volume: 157
Issue: 12
Pages: 4615-4631
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Publication
21888903 | J:178171
First Author: Magenheim J
Year: 2011
Journal: Dev Biol
Title: Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium.
Volume: 359
Issue: 1
Pages: 26-36
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Publication
23903190 | J:199284
First Author: Muñoz-Bravo JL
Year: 2013
Journal: Development
Title: GDNF is required for neural colonization of the pancreas.
Volume: 140
Issue: 17
Pages: 3669-79
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Publication
25186293 | J:218695
First Author: Soggia A
Year: 2014
Journal: Diabetologia
Title: von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation.
Volume: 57
Issue: 11
Pages: 2348-56
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Publication
26534984 | J:239946
First Author: Pan FC
Year: 2015
Journal: Development
Title: Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells.
Volume: 142
Issue: 21
Pages: 3637-48
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Publication
21281624 | J:171472
First Author: Sand FW
Year: 2011
Journal: Dev Biol
Title: Growth-limiting role of endothelial cells in endoderm development.
Volume: 352
Issue: 2
Pages: 267-77
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Publication
24163148 | J:209016
First Author: Piccand J
Year: 2014
Journal: Diabetes
Title: Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice.
Volume: 63
Issue: 1
Pages: 203-15
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Publication
25715394 | J:220325
First Author: Lemaire LA
Year: 2015
Journal: Development
Title: Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis.
Volume: 142
Issue: 5
Pages: 858-70
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Publication
30487608 | J:267771
First Author: Mamidi A
Year: 2018
Journal: Nature
Title: Mechanosignalling via integrins directs fate decisions of pancreatic progenitors.
Volume: 564
Issue: 7734
Pages: 114-118
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Publication
23454691 | J:255620
First Author: Gao T
Year: 2013
Journal: Gastroenterology
Title: Hippo signaling regulates differentiation and maintenance in the exocrine pancreas.
Volume: 144
Issue: 7
Pages: 1543-53, 1553.e1
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Publication
23071096 | J:192856
First Author: George NM
Year: 2012
Journal: Mol Cell Biol
Title: Hippo signaling regulates pancreas development through inactivation of Yap.
Volume: 32
Issue: 24
Pages: 5116-28
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Publication
23852729 | J:198781
First Author: Sugiyama T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation.
Volume: 110
Issue: 31
Pages: 12691-6
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Publication
19223466 | J:147764
First Author: Svensson P
Year: 2009
Journal: Mol Cell Biol
Title: MFng is dispensable for mouse pancreas development and function.
Volume: 29
Issue: 8
Pages: 2129-38
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Publication
37096042 | J:336513
First Author: Patzek S
Year: 2023
Journal: iScience
Title: Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia.
Volume: 26
Issue: 4
Pages: 106500
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Publication
26944677 | J:231585
First Author: Arnes L
Year: 2016
Journal: Genes Dev
Title: βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function.
Volume: 30
Issue: 5
Pages: 502-7
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Publication
34267243 | J:307816
First Author: Heymans C
Year: 2021
Journal: Sci Rep
Title: Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function.
Volume: 11
Issue: 1
Pages: 14519
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Publication
1684952 | J:3321
First Author: Bahary N
Year: 1991
Journal: Genomics
Title: Molecular genetic linkage maps of mouse chromosomes 4 and 6.
Volume: 11
Issue: 1
Pages: 33-47
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Publication
7905852 | J:16150
First Author: Klocke R
Year: 1993
Journal: Genomics
Title: Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal.
Volume: 18
Issue: 3
Pages: 568-74
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Publication
16446123 | J:105961
First Author: van Eyll JM
Year: 2006
Journal: Gene Expr Patterns
Title: Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.
Volume: 6
Issue: 4
Pages: 353-9
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Publication
25715395 | J:220324
First Author: De Vas MG
Year: 2015
Journal: Development
Title: Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors.
Volume: 142
Issue: 5
Pages: 871-82
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Publication
27736991 | J:254493
First Author: Muñoz-Bravo JL
Year: 2016
Journal: PLoS One
Title: Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.
Volume: 11
Issue: 10
Pages: e0164714
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Publication
29180572 | J:253982
 
First Author: Norlin S
Year: 2018
Journal: Development
Title: The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
Volume: 145
Issue: 1
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Publication
23175628 | J:191071
First Author: Petzold KM
Year: 2013
Journal: Development
Title: Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas.
Volume: 140
Issue: 1
Pages: 126-35
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Publication
23684747 | J:315740
First Author: Prévot PP
Year: 2013
Journal: Gastroenterology
Title: Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6.
Volume: 145
Issue: 3
Pages: 668-78.e3
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Publication
37353485 | J:337474
First Author: Cobo I
Year: 2023
Journal: Nat Commun
Title: NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.
Volume: 14
Issue: 1
Pages: 3761
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Publication
25063451 | J:214089
First Author: Hale MA
Year: 2014
Journal: Development
Title: The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.
Volume: 141
Issue: 16
Pages: 3123-33
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Publication
23177622 | J:269131
First Author: Cortijo C
Year: 2012
Journal: Cell Rep
Title: Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.
Volume: 2
Issue: 6
Pages: 1593-606
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Publication
26771085 | J:251520
 
First Author: Pujadas G
Year: 2016
Journal: Sci Rep
Title: Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas.
Volume: 6
Pages: 19223
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Publication
27930960 | J:239317
 
First Author: Bourke LM
Year: 2017
Journal: Differentiation
Title: Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.
Volume: 94
Pages: 8-20
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Publication
37829188 | J:356223
First Author: Martinez-Ramirez AS
Year: 2022
Journal: Gastro Hep Adv
Title: Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development.
Volume: 1
Issue: 5
Pages: 807-823
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Publication
29798841 | J:277787
First Author: Ikuta K
Year: 2019
Journal: Gut
Title: Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.
Volume: 68
Issue: 5
Pages: 882-892
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Publication
31323030 | J:279716
First Author: Braitsch CM
Year: 2019
Journal: PLoS Biol
Title: LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation.
Volume: 17
Issue: 7
Pages: e3000382
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Publication
30135482 | J:266255
First Author: Scavuzzo MA
Year: 2018
Journal: Nat Commun
Title: Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis.
Volume: 9
Issue: 1
Pages: 3356
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Publication
26450967 | J:239872
First Author: Larsen BM
Year: 2015
Journal: Development
Title: Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation.
Volume: 142
Issue: 22
Pages: 3859-68
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Publication
17609113 | J:123923
First Author: Zhou Q
Year: 2007
Journal: Dev Cell
Title: A multipotent progenitor domain guides pancreatic organogenesis.
Volume: 13
Issue: 1
Pages: 103-14
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Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Cpa1<tm1.1Satom> | MGI:6501733
Name: carboxypeptidase A1, pancreatic; targeted mutation 1.1, Miklos Sahin-Toth
Allele Type: Targeted
Attribute String: Not Specified
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Publication
3555844 | -
First Author: Werner M
Year: 1987
Journal: Cell
Title: The leader peptide of yeast gene CPA1 is essential for the translational repression of its expression.
Volume: 49
Issue: 6
Pages: 805-13
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Protein
A0A140LJ55
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
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Protein Domain
IPR018422 | Cation/H_exchanger_CPA1
Type: Family
Description: Sodium proton exchangers (NHEs) constitute a large family of integral membrane protein transporters that are responsible for the counter-transport of protons and sodium ions across lipid bilayers [, ]. These proteins are found in organisms across all domains of life. In archaea, bacteria, yeast and plants, these exchangers provide increased salt tolerance by removing sodium in exchanger for extracellular protons. In mammals they participate in the regulation of cell pH, volume, and intracellular sodium concentration, as well as for the reabsorption of NaCl across renal, intestinal, and other epithelia [, , , ]. Human NHE is also involved in heart disease, cell growth and in cell differentiation []. The removal of intracellular protons in exchange for extracellular sodium effectively eliminates excess acid from actively metabolising cells. In mammalian cells, NHE activity is found in both the plasma membrane and inner mitochondrial membrane. To date, nine mammalian isoforms have been identified (designated NHE1-NHE9) [, ]. These exchangers are highly-regulated (glyco)phosphoproteins, which, based on their primary structure, appear to contain 10-12 membrane-spanning regions (M) at the N terminus and a large cytoplasmic region at the C terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family. There is some evidence that the exchangers may exist in the cell membrane as homodimers, but little is currently known about the mechanism of their antiport [].This entry represents the cation:proton antiporter family 1 (CPA1), which includes Na+/H+ exchangers, K+/H+ exchangers and Na+(K+,Li+,Rb+)/H+ exchangers.
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Protein Domain
IPR004705 | Cation/H_exchanger_CPA1_bac
Type: Family
Description: Sodium proton exchangers (NHEs) constitute a large family of integral membrane protein transporters that are responsible for the counter-transport of protons and sodium ions across lipid bilayers [, ]. These proteins are found in organisms across all domains of life. In archaea, bacteria, yeast and plants, these exchangers provide increased salt tolerance by removing sodium in exchanger for extracellular protons. In mammals they participate in the regulation of cell pH, volume, and intracellular sodium concentration, as well as for the reabsorption of NaCl across renal, intestinal, and other epithelia [, , , ]. Human NHE is also involved in heart disease, cell growth and in cell differentiation []. The removal of intracellular protons in exchange for extracellular sodium effectively eliminates excess acid from actively metabolising cells. In mammalian cells, NHE activity is found in both the plasma membrane and inner mitochondrial membrane. To date, nine mammalian isoforms have been identified (designated NHE1-NHE9) [, ]. These exchangers are highly-regulated (glyco)phosphoproteins, which, based on their primary structure, appear to contain 10-12 membrane-spanning regions (M) at the N terminus and a large cytoplasmic region at the C terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family. There is some evidence that the exchangers may exist in the cell membrane as homodimers, but little is currently known about the mechanism of their antiport [].This entry represents bacterial Na+/H+ exchanger proteins such as YjcE from Escherichia coli [].
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GXD Expression
GXD Expression
 
Probe: MGI:3507094
Assay Type: RNA in situ
Annotation Date: 2025-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3564922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7852675
Age: embryonic day 14.5
Note: Expression overlaps completely with the exocrine cell marker Cpa1 staining.
Specimen Label: 2A
Detected: true
Specimen Num: 1
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Protein
Q99KF4
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Protein
A0A286YD31
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: true
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GXD Expression
GXD Expression
   
Probe: MGI:3506744
Assay Type: RNA in situ
Annotation Date: 2025-01-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3564922
Stage: TS22
Assay Id: MGI:7852705
Age: embryonic day 14.5
Note: Expression did not overlap with Cpa1 staining in the branching tips.
Specimen Label: 2D
Detected: false
Specimen Num: 1
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Protein
Q8R4D1
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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