|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 300 out of 310 for Cradd

0.034s
Type Details Score
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5524115
Age: embryonic day 11.5
Specimen Label: 4a 11.5
Detected: true
Specimen Num: 12
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5524115
Age: embryonic day 12.5
Specimen Label: Table 1 E12.5
Detected: true
Specimen Num: 10
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Diffuse
Stage: TS19
Assay Id: MGI:5524115
Age: embryonic day 11.5
Note: Expression is more concentrated around the developing optic vesicle.
Specimen Label: 3b E11.5
Detected: true
Specimen Num: 4
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Pattern: Diffuse
Stage: TS20
Assay Id: MGI:5524115
Age: embryonic day 12.5
Note: Expression is more concentrated around the developing optic vesicle.
Specimen Label: 3b E12.5
Detected: true
Specimen Num: 5
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1625513
Stage: TS13
Assay Id: MGI:5524115
Age: embryonic day 8.5
Specimen Label: Table 1 E8.5
Detected: false
Specimen Num: 6
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1625519
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5524115
Age: embryonic day 11.5
Specimen Label: Table 1 E11.5
Detected: true
Specimen Num: 9
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1625520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5524115
Age: embryonic day 12.5
Specimen Label: Table 1 E12.5
Detected: true
Specimen Num: 10
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1625515
Stage: TS15
Assay Id: MGI:5524115
Age: embryonic day 9.5
Specimen Label: Table 1 E9.5
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1625517
Stage: TS17
Assay Id: MGI:5524115
Age: embryonic day 10.5
Specimen Label: Table 1 E10.5
Detected: false
Specimen Num: 8
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657720
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5524115
Age: embryonic day 12.5
Note: Expression is in the epithelium.
Specimen Label: 4b 12.5
Detected: true
Specimen Num: 14
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657719
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5524115
Age: embryonic day 11.5
Note: Expression is in the epithelium.
Specimen Label: 4b 11.5
Detected: true
Specimen Num: 13
Publication
First Author: Jean YY
Year: 2013
Journal: Biochem J
Title: Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.
Volume: 455
Issue: 1
Pages: 15-25
Publication
First Author: Tinel A
Year: 2004
Journal: Science
Title: The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.
Volume: 304
Issue: 5672
Pages: 843-6
Publication
First Author: Kim JY
Year: 2022
Journal: Cell Metab
Title: PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis.
Volume: 34
Issue: 10
Pages: 1548-1560.e6
Publication
First Author: Braun VZ
Year: 2024
Journal: Sci Adv
Title: Extra centrosomes delay DNA damage-driven tumorigenesis.
Volume: 10
Issue: 13
Pages: eadk0564
Publication
First Author: Peintner L
Year: 2015
Journal: Cell Death Differ
Title: The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.
Volume: 22
Issue: 11
Pages: 1803-11
Publication
First Author: Manzl C
Year: 2009
Journal: J Cell Biol
Title: Caspase-2 activation in the absence of PIDDosome formation.
Volume: 185
Issue: 2
Pages: 291-303
Publication
First Author: Tu S
Year: 2006
Journal: Nat Cell Biol
Title: In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.
Volume: 8
Issue: 1
Pages: 72-7
Publication
First Author: Ando K
Year: 2017
Journal: J Cell Biol
Title: NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.
Volume: 216
Issue: 6
Pages: 1795-1810
Publication
First Author: Berube C
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.
Volume: 102
Issue: 40
Pages: 14314-20
Publication
First Author: Hofmann K
Year: 1999
Journal: Cell Mol Life Sci
Title: The modular nature of apoptotic signaling proteins.
Volume: 55
Issue: 8-9
Pages: 1113-28
Publication
First Author: Osipovich AB
Year: 2005
Journal: Genome Res
Title: Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment.
Volume: 15
Issue: 3
Pages: 428-35
Publication
First Author: Lin Q
Year: 2006
Journal: Nucleic Acids Res
Title: Mutagenesis of diploid mammalian genes by gene entrapment.
Volume: 34
Issue: 20
Pages: e139
Publication
First Author: Reed JC
Year: 2003
Journal: Genome Res
Title: Comparative analysis of apoptosis and inflammation genes of mice and humans.
Volume: 13
Issue: 6B
Pages: 1376-88
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication        
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Publication      
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
UniProt Feature
Begin: 1
Description: Death domain-containing protein CRADD
Type: chain
End: 199
Publication
First Author: Horvat S
Year: 2001
Journal: Genomics
Title: Lack of Socs2 expression causes the high-growth phenotype in mice.
Volume: 72
Issue: 2
Pages: 209-12
DO Term
Allele  
Name: suppressor of cytokine signaling 2; high growth
Allele Type: Spontaneous
Publication
First Author: Farber CR
Year: 2009
Journal: Physiol Genomics
Title: Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling.
Volume: 37
Issue: 3
Pages: 294-302
Strain
Attribute String: mutant strain
Strain
Attribute String: mutant strain, QTL, spontaneous mutation, congenic, deletion
Strain
Attribute String: mutant strain
Strain
Attribute String: congenic, deletion, mutant strain, QTL, spontaneous mutation
Strain
Attribute String: congenic, spontaneous mutation
Strain
Attribute String: spontaneous mutation
Publication
First Author: Bradford GE
Year: 1968
Journal: Genetics
Title: Selection for litter size in mice in the presence and absence of gonadotropin treatment.
Volume: 58
Issue: 2
Pages: 283-95
Publication
First Author: Corva PM
Year: 2000
Journal: Physiol Genomics
Title: Diet effects on weight gain and body composition in high growth (hg/hg) mice.
Volume: 3
Issue: 1
Pages: 17-23
Publication
First Author: Bradford GE
Year: 1971
Journal: Genetics
Title: Growth and reproduction in mice selected for rapid body weight gain.
Volume: 69
Issue: 4
Pages: 499-512
Publication
First Author: Dilts RB
Year: 1991
Journal: J Anim Sci
Title: Ovulation rate and pre- and postimplantation survival in mice with a major gene for rapid postweaning gain.
Volume: 69
Issue: 9
Pages: 3590-6
Publication
First Author: Summers PJ
Year: 1997
Journal: Proc Soc Exp Biol Med
Title: Delayed myogenesis associated with muscle fiber hyperplasia in high-growth mice.
Volume: 214
Issue: 4
Pages: 380-5
Publication
First Author: Summers PJ
Year: 1994
Journal: Growth Dev Aging
Title: Morphometric analysis of skeletal muscle growth in the high growth mouse.
Volume: 58
Issue: 3
Pages: 135-48
Publication
First Author: Medrano JF
Year: 1991
Journal: Genet Res
Title: Growth hormone and insulin-like growth factor-I measurements in high growth (hg) mice.
Volume: 58
Issue: 1
Pages: 67-74
Publication
First Author: Cargill SL
Year: 1999
Journal: Biol Reprod
Title: Infertility in a line of mice with the high growth mutation is due to luteal insufficiency resulting from disruption at the hypothalamic-pituitary axis.
Volume: 61
Issue: 1
Pages: 283-7
Publication
First Author: Cargill SL
Year: 2000
Journal: Growth Dev Aging
Title: Effects of the high growth (hg) mutation on reproduction in high growth (HG) female mice.
Volume: 64
Issue: 1-2
Pages: 21-31
Publication
First Author: Casellas J
Year: 2010
Journal: J Hered
Title: Segregation analysis of a sex ratio distortion locus in congenic mice.
Volume: 101
Issue: 3
Pages: 351-9
Publication
First Author: Bradford GE
Year: 1984
Journal: Genet Res
Title: Evidence for a major gene for rapid postweaning growth in mice.
Volume: 44
Issue: 3
Pages: 293-308
Publication
First Author: Calvert CC
Year: 1986
Journal: J Anim Sci
Title: Efficiency of growth in mice with a major gene for rapid postweaning gain.
Volume: 62
Issue: 1
Pages: 77-85
Publication
First Author: Reiser K
Year: 1996
Journal: Am J Physiol
Title: Effects of elevated circulating IGF-1 on the extracellular matrix in "high-growth" C57BL/6J mice.
Volume: 271
Issue: 3 Pt 2
Pages: R696-703
Genotype
Symbol: Mohg1/Mohg1 Socs2/Socs2
Background: involves: C57BL/6J * CAST/EiJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mohg3/Mohg3 Socs2/Socs2
Background: involves: C57BL/6J * CAST/EiJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mohg3/Mohg3 Socs2/Socs2
Background: involves: C57BL/6J * CAST/EiJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Socs2/Socs2
Background: involves: AKR/J * C3H/HeJ * C57BL/6J * DBA/2J
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Park HH
Year: 2007
Journal: Cell
Title: Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex.
Volume: 128
Issue: 3
Pages: 533-46
Protein Domain
Type: Domain
Description: This is the death domain of RAIDD (RIP-associated ICH-1 homologous protein with a death domain), also known as CRADD (Caspase and RIP adaptor). RAIDD is an adaptor protein that together with the p53-inducible protein PIDD and caspase-2, forms the PIDDosome complex, which is required for caspase-2 activation and plays a role in mediating stress-induced apoptosis. RAIDD contains an N-terminal Caspase Activation and Recruitment Domain (CARD), which interacts with the caspase-2 CARD, and a C-terminal DD, which interacts with the DD of PIDD [, ].DDs (Death domains) are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [, ].
Publication
First Author: Sheikh TI
Year: 2021
Journal: Transl Psychiatry
Title: Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability.
Volume: 11
Issue: 1
Pages: 1
Strain
Attribute String: congenic, mutant strain, spontaneous mutation, deletion
Strain
Attribute String: congenic, mutant strain, spontaneous mutation, deletion, QTL
Strain
Attribute String: congenic, mutant strain, deletion, spontaneous mutation
Publication
First Author: Wu R
Year: 2005
Journal: Genetics
Title: Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice.
Volume: 171
Issue: 1
Pages: 239-49
Publication  
First Author: Farber CR
Year: 2008
Journal: BMC Genet
Title: Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice.
Volume: 9
Pages: 34
Genotype
Symbol: Mohg1/Mohg1 Socs2/Socs2
Background: involves: C57BL/6J * CAST/EiJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mohg2/Mohg2 Socs2/Socs2
Background: involves: C57BL/6J * CAST/EiJ
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Heikaus S
Year: 2010
Journal: Cell Oncol
Title: PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs.
Volume: 32
Issue: 1-2
Pages: 29-42
Protein Domain
Type: Domain
Description: This entry represents the CARD domain found in RAIDD (RIP-associated ICH-1 homologous protein with a death domain), also known as CRADD (Caspase and RIP adapter with death domain). RAIDD is an adaptor protein that, together with the p53-inducible protein PIDD and caspase-2, forms the PIDDosome complex, which is required for caspase-2 activation and plays a role in mediating stress-induced apoptosis. RAIDD contains an N-terminal CARD, which interacts with the caspase-2 CARD, and a C-terminal Death domain (DD), which interacts with the DD of PIDD [, ].In general, CARDs are death domains (DDs) found associated with caspases []. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms []. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
Publication  
First Author: Farber CR
Year: 2006
Journal: BMC Genomics
Title: Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.
Volume: 7
Pages: 102
Publication
First Author: Farber CR
Year: 2007
Journal: Genetics
Title: Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11.
Volume: 175
Issue: 1
Pages: 349-60
Publication
First Author: Corva PM
Year: 2001
Journal: Mamm Genome
Title: Quantitative trait loci affecting growth in high growth (hg) mice.
Volume: 12
Issue: 4
Pages: 284-90
Publication  
First Author: Park HH
Year: 2007
Journal: Annu Rev Immunol
Title: The death domain superfamily in intracellular signaling of apoptosis and inflammation.
Volume: 25
Pages: 561-86