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Search results 201 to 300 out of 322 for Crkl

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:6393243
Assay Type: RNA in situ
Annotation Date: 2020-03-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1609917
Pattern: Widespread
Stage: TS17
Assay Id: MGI:6393246
Age: embryonic day 10.5
Image: S2B
Note: Expressed broadly, but not uniformly.
Specimen Label: S2B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6502128
Assay Type: Immunohistochemistry
Annotation Date: 2021-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3537526
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6502136
Age: embryonic day 18.5
Note: Expression enriched at synaptic sites.
Specimen Label: S4 Anti-Crk-L
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4885071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4944962
Age: embryonic day 15.5
Image: g00402 E15.5
Specimen Label: g00402 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5001644
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542198
Age: embryonic day 15.5
Image: GUDMAP:10685
Specimen Label: GUDMAP:10685
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001644
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542198
Age: embryonic day 15.5
Image: GUDMAP:10686
Specimen Label: GUDMAP:10686
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5001644
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2874723
Stage: TS23
Assay Id: MGI:5542198
Age: embryonic day 15.5
Image: GUDMAP:10686
Specimen Label: GUDMAP:10686
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:4885071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4944962
Age: embryonic day 15.5
Image: g00402 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00402 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4885071
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4944962
Age: postnatal day 7
Image: g00402 P7
Specimen Label: g00402 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5001644
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542198
Age: embryonic day 15.5
Image: GUDMAP:10685
Specimen Label: GUDMAP:10685
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001644
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542198
Age: embryonic day 15.5
Image: GUDMAP:10686
Specimen Label: GUDMAP:10686
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6393243
Assay Type: RNA in situ
Annotation Date: 2020-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6393246
Age: embryonic day 10.5
Image: S2B
Note: Expressed in the ventral parts. Expression extended less dorsally than Crk.
Specimen Label: S2B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001644
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:5542198
Age: embryonic day 15.5
Image: GUDMAP:10686
Specimen Label: GUDMAP:10686
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7666594
Assay Type: RNA in situ
Annotation Date: 2024-07-22
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1761819
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7666621
Age: embryonic day 11.5
Image: 1C DKO
Note: Reduced expression was observed in the mesenchymal atrioventricular cushions in the DKO embryos.
Specimen Label: 1C DKO
Detected: true
Specimen Num: 2
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Publication
22251701 | J:184498
First Author: George B
Year: 2012
Journal: J Clin Invest
Title: Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.
Volume: 122
Issue: 2
Pages: 674-92
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Publication
34163073 | J:324232
First Author: Oury J
Year: 2021
Journal: Nature
Title: Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia.
Volume: 595
Issue: 7867
Pages: 404-408
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Publication
35559672 | J:325061
First Author: Handel AE
Year: 2022
Journal: Sci Adv
Title: Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment.
Volume: 8
Issue: 19
Pages: eabm9844
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Publication
18305217 | J:137330
First Author: Huang Y
Year: 2008
Journal: Blood
Title: The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse.
Volume: 112
Issue: 1
Pages: 111-9
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Publication
30538176 | J:284369
 
First Author: Roy NH
Year: 2018
Journal: Sci Signal
Title: Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1.
Volume: 11
Issue: 560
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Publication
25621495 | J:220382
First Author: Huang Y
Year: 2015
Journal: J Clin Invest
Title: CRK proteins selectively regulate T cell migration into inflamed tissues.
Volume: 125
Issue: 3
Pages: 1019-32
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Publication
12697763 | J:84101
First Author: Zhang W
Year: 2003
Journal: J Biol Chem
Title: Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b.
Volume: 278
Issue: 26
Pages: 23978-83
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Publication
9315092 | J:43082
First Author: Oda T
Year: 1997
Journal: Oncogene
Title: Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase.
Volume: 15
Issue: 11
Pages: 1255-62
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Publication
8653787 | J:33184
First Author: Glass DJ
Year: 1996
Journal: Cell
Title: Agrin acts via a MuSK receptor complex.
Volume: 85
Issue: 4
Pages: 513-23
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Publication
18848351 | J:145446
First Author: Kim N
Year: 2008
Journal: Cell
Title: Lrp4 is a receptor for Agrin and forms a complex with MuSK.
Volume: 135
Issue: 2
Pages: 334-42
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Publication
21041412 | J:165470
First Author: Hallock PT
Year: 2010
Journal: Genes Dev
Title: Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.
Volume: 24
Issue: 21
Pages: 2451-61
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Publication
18957220 | J:144064
First Author: Zhang B
Year: 2008
Journal: Neuron
Title: LRP4 serves as a coreceptor of agrin.
Volume: 60
Issue: 2
Pages: 285-97
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Publication
15110774 | J:89358
First Author: Huang Y
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.
Volume: 318
Issue: 1
Pages: 204-12
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Publication
14622576 | J:86639
First Author: Luo ZG
Year: 2003
Journal: Neuron
Title: Implication of geranylgeranyltransferase I in synapse formation.
Volume: 40
Issue: 4
Pages: 703-17
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Publication
20884876 | J:182094
First Author: Huang ZP
Year: 2010
Journal: Arterioscler Thromb Vasc Biol
Title: Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects.
Volume: 30
Issue: 12
Pages: 2575-86
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Publication
38696583 | J:348704
First Author: Vong KI
Year: 2024
Journal: Science
Title: Risk of meningomyelocele mediated by the common 22q11.2 deletion.
Volume: 384
Issue: 6695
Pages: 584-590
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Publication
22921202 | J:188772
First Author: Voss AK
Year: 2012
Journal: Dev Cell
Title: MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome.
Volume: 23
Issue: 3
Pages: 652-63
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Publication
15778864 | J:98850
First Author: Prescott K
Year: 2005
Journal: Hum Genet
Title: Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome.
Volume: 116
Issue: 6
Pages: 486-96
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Publication
24586749 | J:213829
First Author: Bard-Chapeau EA
Year: 2014
Journal: PLoS One
Title: Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.
Volume: 9
Issue: 2
Pages: e89397
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Publication
24472646 | J:229358
 
First Author: Teo ZL
Year: 2014
Journal: Exp Eye Res
Title: Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.
Volume: 121
Pages: 130-42
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Publication
14614146 | J:86704
First Author: Maynard TM
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A comprehensive analysis of 22q11 gene expression in the developing and adult brain.
Volume: 100
Issue: 24
Pages: 14433-8
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 484
Description: Required for CrkL binding
Type: site
End: 484
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Publication
8083188 | J:44368
First Author: Oda T
Year: 1994
Journal: J Biol Chem
Title: Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia.
Volume: 269
Issue: 37
Pages: 22925-8
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Publication
16505237 | J:106850
First Author: Laloraya M
Year: 2006
Journal: Diabetes
Title: Impaired Crkl expression contributes to the defective DNA binding of Stat5b in nonobese diabetic mice.
Volume: 55
Issue: 3
Pages: 734-41
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Publication
12522101 | -
First Author: Oda A
Year: 2003
Journal: J Biol Chem
Title: CrkL directs ASAP1 to peripheral focal adhesions.
Volume: 278
Issue: 8
Pages: 6456-60
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Interaction Experiment
Heaney C (1997)
Description: Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation.
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Interaction Experiment
Uemura N (1997)
Description: The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins.
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Interaction Experiment
Seo JH (2009)
Description: Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop.
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Publication
21700719 | -
First Author: Padmanabhan RA
Year: 2011
Journal: Mol Endocrinol
Title: CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer.
Volume: 25
Issue: 9
Pages: 1499-512
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Publication
8978305 | -
First Author: Heaney C
Year: 1997
Journal: Blood
Title: Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation.
Volume: 89
Issue: 1
Pages: 297-306
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Publication
9067577 | -
First Author: Uemura N
Year: 1997
Journal: Leukemia
Title: The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins.
Volume: 11
Issue: 3
Pages: 376-85
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Publication
11443118 | -
First Author: Arai A
Year: 2001
Journal: J Biol Chem
Title: CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling.
Volume: 276
Issue: 35
Pages: 33282-90
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Publication
16781119 | -
First Author: Arai A
Year: 2006
Journal: Cell Signal
Title: CrkL plays a role in SDF-1-induced activation of the Raf-1/MEK/Erk pathway through Ras and Rac to mediate chemotactic signaling in hematopoietic cells.
Volume: 18
Issue: 12
Pages: 2162-71
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Allele
Crkl<snoopy> | MGI:5510713
Name: v-crk avian sarcoma virus CT10 oncogene homolog-like; snoopy
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Genotype
Genotype
Symbol: Crkl/Crkl
Background: involves: C3H/HeH * C57BL/6JAnu
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crkl/Crkl
Background: involves: C57BL/6JAnu
Zygosity: hm
Has Mutant Allele: true
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Publication
19861495 | J:154584
First Author: Antoku S
Year: 2009
Journal: J Cell Sci
Title: Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals.
Volume: 122
Issue: Pt 22
Pages: 4228-38
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Publication
19017632 | -
First Author: Jian X
Year: 2009
Journal: J Biol Chem
Title: Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1.
Volume: 284
Issue: 3
Pages: 1652-63
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Publication
17893324 | J:129034
First Author: Bharti S
Year: 2007
Journal: Mol Cell Biol
Title: Src-dependent phosphorylation of ASAP1 regulates podosomes.
Volume: 27
Issue: 23
Pages: 8271-83
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Protein Domain
IPR037928 | ASAP1_BAR
Type: Domain
Description: ASAP1 is an Arf GTPase activating protein (GAP) with activity towards Arf1 and Arf5 but not Arf6 However, it has been shown to bind GTP-Arf6 stably without GAP activity []. It has been implicated in cell growth, migration, and survival, as well as in tumor invasion and malignancy. It binds paxillin and cortactin, two components of invadopodia which are essential for tumor invasiveness. It also binds focal adhesion kinase (FAK) and the SH2/SH3 adaptor CrkL [, ]. ASAP1 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, an Arf GAP domain, ankyrin (ANK) repeats, and a C-terminal SH3 domain [].This entry represents the BAR domain of ASAP1. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of ASAP1 mediates membrane bending, is essential for function, and autoinhibits GAP activity by interacting with the PH and/or Arf GAP domains [].
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Publication
15982636 | J:99259
First Author: Cho YJ
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Interaction of Bcr/Abl with C3G, an exchange factor for the small GTPase Rap1, through the adapter protein Crkl.
Volume: 333
Issue: 4
Pages: 1276-83
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Publication
8361759 | J:14185
First Author: ten Hoeve J
Year: 1993
Journal: Oncogene
Title: Isolation and chromosomal localization of CRKL, a human crk-like gene.
Volume: 8
Issue: 9
Pages: 2469-74
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Publication
25982384 | J:224930
 
First Author: Cheerathodi M
Year: 2015
Journal: J Proteomics
Title: Quantitative comparison of CrkL-SH3 binding proteins from embryonic murine brain and liver: Implications for developmental signaling and the quantification of protein species variants in bottom-up proteomics.
Volume: 125
Pages: 104-11
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Publication
7735837 | -
First Author: Wu X
Year: 1995
Journal: Structure
Title: Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk.
Volume: 3
Issue: 2
Pages: 215-26
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Publication
17515907 | -
First Author: Kobashigawa Y
Year: 2007
Journal: Nat Struct Mol Biol
Title: Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.
Volume: 14
Issue: 6
Pages: 503-10
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Publication
27332121 | -
First Author: Bhatt VS
Year: 2016
Journal: Biophys J
Title: Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl.
Volume: 110
Issue: 12
Pages: 2630-2641
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Publication
12058076 | -
First Author: Liu Y
Year: 2002
Journal: Mol Biol Cell
Title: The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly.
Volume: 13
Issue: 6
Pages: 2147-56
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Publication
11062263 | -
First Author: Jackson TR
Year: 2000
Journal: J Cell Biol
Title: ACAPs are arf6 GTPase-activating proteins that function in the cell periphery.
Volume: 151
Issue: 3
Pages: 627-38
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Protein Domain
IPR035457 | CRK_SH3_N
Type: Domain
Description: This entry represents the N-terminal SH3 domain found in the CRK family members []. CRK adaptor proteins consists of SH2 and SH3 domains, which bind tyrosine-phosphorylated peptides and proline-rich motifs, respectively. They function downstream of protein tyrosine kinases in many signaling pathways started by various extracellular signals, including growth and differentiation factors. Cellular CRK (c-CRK) contains a single SH2 domain, followed by N-terminal and C-terminal SH3 domains. It is involved in the regulation of many cellular processes including cell growth, motility, adhesion, and apoptosis. CRK has been implicated in the malignancy of various human cancers [, ]. The N-terminal SH3 domain of CRK binds a number of target proteins including DOCK180, C3G, SOS, and cABL []. The CRK family includes two alternatively spliced protein forms, CRKI and CRKII, that are expressed by the CRK gene, and the CRK-like (CRKL) protein, which is expressed by a distinct gene (CRKL). CrkI lacks the regulatory phosphorylation site and C-terminal SH3 domain present in CrkII and CrkL [, ]. The N-terminal SH3 domain of CRKII has been shown to bind the recognizes proline-rich motifs (PRMs) found in cABL kinase; this interaction is involved in the regulation of cell spreading, microbial pathogenesis, and cancer metastasis [].
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Publication
22351125 | J:187338
First Author: Yip YP
Year: 2012
Journal: J Comp Neurol
Title: Migration of sympathetic preganglionic neurons in the spinal cord of a C3G-deficient mouse suggests that C3G acts in the reelin signaling pathway.
Volume: 520
Issue: 14
Pages: 3194-202
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Publication
22692505 | J:189090
First Author: Chang KH
Year: 2012
Journal: Blood
Title: Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.
Volume: 120
Issue: 4
Pages: 800-11
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Publication
18981215 | J:145031
First Author: Feng L
Year: 2009
Journal: Mol Cell Biol
Title: Dual functions of Dab1 during brain development.
Volume: 29
Issue: 2
Pages: 324-32
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Publication
11489945 | J:259938
First Author: Engels N
Year: 2001
Journal: J Exp Med
Title: Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling module.
Volume: 194
Issue: 3
Pages: 255-64
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Publication
10871282 | J:200336
First Author: Schaeper U
Year: 2000
Journal: J Cell Biol
Title: Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.
Volume: 149
Issue: 7
Pages: 1419-32
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Publication
12901872 | J:85050
First Author: Uddin S
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Role of Stat5 in type I interferon-signaling and transcriptional regulation.
Volume: 308
Issue: 2
Pages: 325-30
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