Type |
Details |
Score |
Publication |
First Author: |
Li XA |
Year: |
1998 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Serum amyloid P component associates with high density lipoprotein as well as very low density lipoprotein but not with low density lipoprotein. |
Volume: |
244 |
Issue: |
1 |
Pages: |
249-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Romero IR |
Year: |
1998 |
Journal: |
Clin Immunol Immunopathol |
Title: |
Inflammatory potential of C-reactive protein complexes compared to immune complexes. |
Volume: |
87 |
Issue: |
2 |
Pages: |
155-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Emsley J |
Year: |
1994 |
Journal: |
Nature |
Title: |
Structure of pentameric human serum amyloid P component. |
Volume: |
367 |
Issue: |
6461 |
Pages: |
338-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coe JE |
Year: |
1997 |
Journal: |
Scand J Immunol |
Title: |
Electrophoretic polymorphism of a hamster pentraxin, female protein (amyloid P component). |
Volume: |
46 |
Issue: |
2 |
Pages: |
180-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Srinivasan N |
Year: |
1994 |
Journal: |
Structure |
Title: |
Comparative analyses of pentraxins: implications for protomer assembly and ligand binding. |
Volume: |
2 |
Issue: |
11 |
Pages: |
1017-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goodman AR |
Year: |
1996 |
Journal: |
Cytokine Growth Factor Rev |
Title: |
Long pentraxins: an emerging group of proteins with diverse functions. |
Volume: |
7 |
Issue: |
2 |
Pages: |
191-202 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kirkpatrick LL |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. |
Volume: |
275 |
Issue: |
23 |
Pages: |
17786-92 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents Pentaxins and its related proteins such as CRP (C-reactive protein) and SAP (serum amyloid P component protein) []. This entry also includes adhesion G-protein coupled receptors D2 and G6 from humans.Pentraxins (or pentaxins) [, ]are a family of proteins which show, under electron microscopy, a discoid arrangement of five noncovalently bound subunits. Proteins of the pentraxin family are involved in acute immunological responses []. Three of the principal members of the pentraxin family are serum proteins and Ca2 dependent: namely, C-reactive protein (CRP) [], serum amyloid P component protein (SAP) [], and female protein (FP) []. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans.CRP is expressed during acute phase response to tissue injury or inflammation in mammals. The protein resembles antibody and performs several functions associated with host defence: it promotes agglutination, bacterial capsular swelling and phagocytosis, and activates the classical complement pathway through its calcium-dependent binding to phosphocholine. CRPs have also been sequenced in an invertebrate, Limulus polyphemus (Atlantic horseshoe crab), where they are a normal constituent of the hemolymph [].SAP is a vertebrate protein that is a precursor of amyloid component P. It is found in all types of amyloid deposits, in glomerular basement menbrane and in elastic fibres in blood vessels. SAP binds to various lipoprotein ligands in a calcium-dependent manner, and it has been suggested that, in mammals, this may have important implications in atherosclerosis and amyloidosis [].FP is a SAP homologue found in Mesocricetus auratus (golden hamster). The concentration of this plasma protein is altered by sex steroids and stimuli that elicit an acute phase response."Long"pentraxins have N-terminal extensions to the common pentraxin domain []; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers []. Pentraxin proteins expressed in the nervous system are neural pentraxin I (NPI) and II (NPII) []. NPI and NPII are homologous and can exist within one species. It is suggested that both proteins mediate the uptake of synaptic macromolecules and play a role in synaptic plasticity. Apexin, a sperm acrosomal protein, is a homologue of NPII found in Cavia porcellus (Guinea pig) [].PTX3 is a long pentraxin that provides defence against infectious agents and plays several functions in tissue repair and regulation of cancer-related inflammation []. |
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•
•
•
•
•
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Protein Domain |
Type: |
Conserved_site |
Description: |
The crp-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain of about 70-75 amino acids present in transcription regulators of the crp-fnr family, involved in the control of virulence factors, enzymes of aromatic ring degradation, nitrogen fixation, photosynthesis, and various types of respiration. The crp-fnr family is named after the first members identified in Escherichia coli: the well characterised cyclic AMP receptor protein CRP or CAP (catabolite activator protein) and the fumarate and nitrate reductase regulator Fnr. crp-type HTH domain proteins occur in most bacteria and in chloroplasts of red algae. The DNA-binding HTH domain is located in the C-terminal part; the N-terminal part of the proteins of the crp-fnr family contains a nucleotide-binding domain and a dimerisation/linker helix occurs in between. The crp-fnr regulators predominantly act as transcription activators, but can also be important repressors, and respond to diverse intracellular and exogenous signals, such as cAMP, anoxia, redox state, oxidative and nitrosative stress, carbon monoxide, nitric oxide or temperature []. The structure of the crp-type DNA-binding domain shows that the helices (H) forming the helix-turn-helix motif (H2-H3) are flanked by two β-hairpin (B) wings, in the topology H1-B1-B2-H2-H3-B3-B4. Helix 3 is termed the recognition helix, as in most wHTHs it binds the DNA major groove [, , ]. Some proteins known to contain a Crp-type HTH domain: E. coli crp (also known as cAMP receptor), a protein that complexes with cAMP and regulates the transcription of several catabolite-sensitive operons. E. coli fnr, a protein that activates genes for proteins involved in a variety of anaerobic electron transport systems. Rhizobium leguminosarum fnrN, a transcription regulator of nitrogen fixation. Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) fnrL, a transcription activator of genes for heme biosynthesis, bacteriochlorophyll synthesis and the light-harvesting complex LHII. Rhizobiacae fixK, a protein that regulates nitrogen fixation genes, both positively and negatively. Lactobacillus casei fnr-like protein flp, a putative regulatory protein linked to the trpDCFBA operon. Cyanobacteria ntcA, a regulator of the expression of genes subject to nitrogen control. Xanthomonas campestris clp, a protein involved in the regulation of phytopathogenicity. Clp controls the production of extracellular enzymes, xanthan gum and pigment, either positively or negatively. |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
381
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
403
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Hsu YC |
Year: |
1995 |
Journal: |
Genomics |
Title: |
Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization. |
Volume: |
28 |
Issue: |
2 |
Pages: |
220-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schlimgen AK |
Year: |
1995 |
Journal: |
Neuron |
Title: |
Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system. |
Volume: |
14 |
Issue: |
3 |
Pages: |
519-26 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Conserved_site |
Description: |
Pentaxins (or pentraxins) [, ]are a family of proteins which show, underelectron microscopy, a discoid arrangement of five noncovalently boundsubunits. Proteins known to belong to this family are:C-reactive protein (CRP), a protein which, in mammals,is expressed duringacute phase response to tissue injury or inflammation. CRP displays severalfunctions associated with host defense: it promotes agglutination,bacterial capsular swelling, phagocytosis and complement fixation throughits calcium-dependent binding to phosphorylcholine. CRPs have also beensequenced in an invertebrate, the Atlantic horseshoe crab, where they are anormal constituent of the hemolymph.Serum Amyloid P-component (SAP), a precursor of amyloid component P whichis found in basement membrane and is associated with amyloid deposits.Hamster female protein (FP), a plasma protein whose concentration isaltered by sex steroids and stimuli that elicit an acute phase response.A number of proteins, whose function is not yet clear, contain a C-terminalpentaxin-like domain. These proteins are:Human PTX3 (or TSG-14). PTX3 is a cytokine-induced protein.Guinea pig apexin [], a sperm acrosomal protein. Apexin seems to be theortholog of human neuronal pentraxin II (gene NPTX2) [].Rat neuronal pentaxin I [].The sequences of the different members of this family are quite conserved. This entry represents a six residue pattern which includes a cysteineknown to be involved in a disulfide bridge in CRPs and SAP. |
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•
•
•
•
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Publication |
First Author: |
Perez J |
Year: |
2016 |
Journal: |
J Immunol |
Title: |
Calpains Released by T Lymphocytes Cleave TLR2 To Control IL-17 Expression. |
Volume: |
196 |
Issue: |
1 |
Pages: |
168-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanouna G |
Year: |
2020 |
Journal: |
J Invest Dermatol |
Title: |
Preventing Calpain Externalization by Reducing ABCA1 Activity with Probenecid Limits Melanoma Angiogenesis and Development. |
Volume: |
140 |
Issue: |
2 |
Pages: |
445-454 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng H |
Year: |
1996 |
Journal: |
Anat Rec |
Title: |
CRP-ductin: a gene expressed in intestinal crypts and in pancreatic and hepatic ducts. |
Volume: |
244 |
Issue: |
3 |
Pages: |
327-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hafeez BB |
Year: |
2011 |
Journal: |
Cancer Res |
Title: |
Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma. |
Volume: |
71 |
Issue: |
6 |
Pages: |
2318-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pasquet JM |
Year: |
2000 |
Journal: |
EMBO J |
Title: |
Phosphatidylinositol 3,4,5-trisphosphate regulates Ca(2+) entry via btk in platelets and megakaryocytes without increasing phospholipase C activity. |
Volume: |
19 |
Issue: |
12 |
Pages: |
2793-802 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ivancic MM |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Conserved serum protein biomarkers associated with growing early colorectal adenomas. |
Volume: |
116 |
Issue: |
17 |
Pages: |
8471-8480 |
|
•
•
•
•
•
|
Publication |
First Author: |
Norata GD |
Year: |
2008 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells. |
Volume: |
28 |
Issue: |
5 |
Pages: |
925-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reifenberg K |
Year: |
2005 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Role of C-reactive protein in atherogenesis: can the apolipoprotein E knockout mouse provide the answer? |
Volume: |
25 |
Issue: |
8 |
Pages: |
1641-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilund KR |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Macrophages from alpha 7 nicotinic acetylcholine receptor knockout mice demonstrate increased cholesterol accumulation and decreased cellular paraoxonase expression: a possible link between the nervous system and atherosclerosis development. |
Volume: |
390 |
Issue: |
1 |
Pages: |
148-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson PG |
Year: |
2008 |
Journal: |
Am J Pathol |
Title: |
Serum amyloid A, but not C-reactive protein, stimulates vascular proteoglycan synthesis in a pro-atherogenic manner. |
Volume: |
173 |
Issue: |
6 |
Pages: |
1902-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiao Y |
Year: |
2016 |
Journal: |
Biochim Biophys Acta |
Title: |
Effect of α-linolenic acid-modified low molecular weight chondroitin sulfate on atherosclerosis in apoE-deficient mice. |
Volume: |
1860 |
Issue: |
11 Pt A |
Pages: |
2589-2597 |
|
•
•
•
•
•
|
Publication |
First Author: |
Atkinson BT |
Year: |
2003 |
Journal: |
Blood |
Title: |
Tec regulates platelet activation by GPVI in the absence of Btk. |
Volume: |
102 |
Issue: |
10 |
Pages: |
3592-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mold C |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
C-reactive protein mediates protection from lipopolysaccharide through interactions with Fc gamma R. |
Volume: |
169 |
Issue: |
12 |
Pages: |
7019-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stein MP |
Year: |
2000 |
Journal: |
J Immunol |
Title: |
C-reactive protein binding to murine leukocytes requires Fc gamma receptors. |
Volume: |
164 |
Issue: |
3 |
Pages: |
1514-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thomas-Rudolph D |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
C-reactive protein enhances immunity to Streptococcus pneumoniae by targeting uptake to Fc gamma R on dendritic cells. |
Volume: |
178 |
Issue: |
11 |
Pages: |
7283-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mold C |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors. |
Volume: |
168 |
Issue: |
12 |
Pages: |
6375-81 |
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•
•
•
•
•
|
Publication |
First Author: |
Hughan SC |
Year: |
2007 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. |
Volume: |
27 |
Issue: |
2 |
Pages: |
422-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sundgren NC |
Year: |
2015 |
Journal: |
Hypertension |
Title: |
IgG receptor FcγRIIB plays a key role in obesity-induced hypertension. |
Volume: |
65 |
Issue: |
2 |
Pages: |
456-62 |
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•
•
•
•
•
|
Publication |
First Author: |
Rodriguez W |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
C-reactive protein-mediated suppression of nephrotoxic nephritis: role of macrophages, complement, and Fcgamma receptors. |
Volume: |
178 |
Issue: |
1 |
Pages: |
530-8 |
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•
•
•
•
•
|
Publication |
First Author: |
Kovacs A |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia. |
Volume: |
104 |
Issue: |
34 |
Pages: |
13768-73 |
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•
•
•
•
•
|
Publication |
First Author: |
Foureau DM |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondii. |
Volume: |
184 |
Issue: |
12 |
Pages: |
7022-9 |
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•
•
•
•
•
|
Publication |
First Author: |
Lenis TL |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease. |
Volume: |
114 |
Issue: |
15 |
Pages: |
3987-3992 |
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•
•
•
•
•
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Publication |
First Author: |
Radu RA |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration. |
Volume: |
286 |
Issue: |
21 |
Pages: |
18593-601 |
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•
•
•
•
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Publication |
First Author: |
Pepys MB |
Year: |
2005 |
Journal: |
Circ Res |
Title: |
Proinflammatory effects of bacterial recombinant human C-reactive protein are caused by contamination with bacterial products, not by C-reactive protein itself. |
Volume: |
97 |
Issue: |
11 |
Pages: |
e97-103 |
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•
•
•
•
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Publication |
First Author: |
Watanabe N |
Year: |
2003 |
Journal: |
Blood |
Title: |
Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation. |
Volume: |
102 |
Issue: |
2 |
Pages: |
541-8 |
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•
•
•
•
•
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Publication |
First Author: |
Bowling MR |
Year: |
2014 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Estrogen effects on vascular inflammation are age dependent: role of estrogen receptors. |
Volume: |
34 |
Issue: |
7 |
Pages: |
1477-1485 |
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•
•
•
•
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Publication |
First Author: |
Akbar H |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation. |
Volume: |
6 |
Issue: |
7 |
Pages: |
e22117 |
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•
•
•
•
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Publication |
First Author: |
Hsu WL |
Year: |
2023 |
Journal: |
Dis Model Mech |
Title: |
High-fat diet induces C-reactive protein secretion, promoting lung adenocarcinoma via immune microenvironment modulation. |
Volume: |
16 |
Issue: |
11 |
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•
•
•
•
•
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Publication |
First Author: |
Koh SH |
Year: |
2017 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Long pentraxin PTX3 mediates acute inflammatory responses against pneumococcal infection. |
Volume: |
493 |
Issue: |
1 |
Pages: |
671-676 |
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•
•
•
•
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Publication |
First Author: |
Goggs R |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
RhoG protein regulates platelet granule secretion and thrombus formation in mice. |
Volume: |
288 |
Issue: |
47 |
Pages: |
34217-29 |
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•
•
•
•
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Publication |
First Author: |
Cervera A |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke. |
Volume: |
5 |
Issue: |
2 |
Pages: |
e8433 |
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•
•
•
•
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Publication |
First Author: |
Tanigaki K |
Year: |
2016 |
Journal: |
Diabetes |
Title: |
Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice. |
Volume: |
65 |
Issue: |
7 |
Pages: |
1996-2005 |
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•
•
•
•
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Publication |
First Author: |
Chen CH |
Year: |
2013 |
Journal: |
Cardiovasc Res |
Title: |
Cysteine-rich protein 2 alters p130Cas localization and inhibits vascular smooth muscle cell migration. |
Volume: |
100 |
Issue: |
3 |
Pages: |
461-71 |
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•
•
•
•
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Publication |
First Author: |
Walsh TG |
Year: |
2021 |
Journal: |
Blood Adv |
Title: |
Loss of the exocyst complex component EXOC3 promotes hemostasis and accelerates arterial thrombosis. |
Volume: |
5 |
Issue: |
3 |
Pages: |
674-686 |
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•
•
•
•
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Publication |
First Author: |
Verschuren L |
Year: |
2005 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice. |
Volume: |
25 |
Issue: |
1 |
Pages: |
161-7 |
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•
•
•
•
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Publication |
First Author: |
Ravanat C |
Year: |
2010 |
Journal: |
Blood |
Title: |
A central role of GPIb-IX in the procoagulant function of platelets that is independent of the 45-kDa GPIbalpha N-terminal extracellular domain. |
Volume: |
116 |
Issue: |
7 |
Pages: |
1157-64 |
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•
•
•
•
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Publication |
First Author: |
Alshahrani MM |
Year: |
2014 |
Journal: |
Blood |
Title: |
CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo. |
Volume: |
124 |
Issue: |
15 |
Pages: |
2431-41 |
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•
•
•
•
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Publication |
First Author: |
Harper BD |
Year: |
2000 |
Journal: |
Biochem J |
Title: |
Fine mapping of the alpha-actinin binding site within cysteine-rich protein. |
Volume: |
350 Pt 1 |
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Pages: |
269-74 |
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•
•
•
•
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Publication |
First Author: |
Du Clos TW |
Year: |
1994 |
Journal: |
Clin Immunol Immunopathol |
Title: |
Decreased autoantibody levels and enhanced survival of (NZB x NZW) F1 mice treated with C-reactive protein. |
Volume: |
70 |
Issue: |
1 |
Pages: |
22-7 |
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•
•
•
•
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Publication |
First Author: |
Karem KL |
Year: |
1995 |
Journal: |
Infect Immun |
Title: |
Differential induction of carrier antigen-specific immunity by Salmonella typhimurium live-vaccine strains after single mucosal or intravenous immunization of BALB/c mice. |
Volume: |
63 |
Issue: |
12 |
Pages: |
4557-63 |
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•
•
•
•
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Publication |
First Author: |
Karim MA |
Year: |
1996 |
Journal: |
Genomics |
Title: |
Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. |
Volume: |
31 |
Issue: |
2 |
Pages: |
167-76 |
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•
•
•
•
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Publication |
First Author: |
Jain MK |
Year: |
1998 |
Journal: |
Circ Res |
Title: |
Embryonic expression suggests an important role for CRP2/SmLIM in the developing cardiovascular system. |
Volume: |
83 |
Issue: |
10 |
Pages: |
980-5 |
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•
•
•
•
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Publication |
First Author: |
Xia D |
Year: |
1997 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Transgenic mice expressing rabbit C-reactive protein are resistant to endotoxemia. |
Volume: |
94 |
Issue: |
6 |
Pages: |
2575-80 |
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•
•
•
•
•
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Publication |
First Author: |
Lin CS |
Year: |
1995 |
Journal: |
Immunol Cell Biol |
Title: |
Expression of rabbit C-reactive protein in transgenic mice. |
Volume: |
73 |
Issue: |
6 |
Pages: |
521-31 |
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•
•
•
•
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Publication |
First Author: |
Schwartz R |
Year: |
2007 |
Journal: |
Circ Res |
Title: |
C-reactive protein downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice. |
Volume: |
100 |
Issue: |
10 |
Pages: |
1452-9 |
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•
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•
•
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Publication |
First Author: |
Procopio C |
Year: |
2009 |
Journal: |
Endocrinology |
Title: |
Leptin-stimulated endothelial nitric-oxide synthase via an adenosine 5'-monophosphate-activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein. |
Volume: |
150 |
Issue: |
8 |
Pages: |
3584-93 |
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•
•
•
•
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Publication |
First Author: |
Takahashi T |
Year: |
2010 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Increased C-reactive protein expression exacerbates left ventricular dysfunction and remodeling after myocardial infarction. |
Volume: |
299 |
Issue: |
6 |
Pages: |
H1795-804 |
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•
•
•
•
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Publication |
First Author: |
Grad E |
Year: |
2011 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Endothelial C-reactive protein increases platelet adhesion under flow conditions. |
Volume: |
301 |
Issue: |
3 |
Pages: |
H730-6 |
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•
•
•
•
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Publication |
First Author: |
Kaneko H |
Year: |
2011 |
Journal: |
Cardiovasc Res |
Title: |
Human C-reactive protein exacerbates metabolic disorders in association with adipose tissue remodelling. |
Volume: |
91 |
Issue: |
3 |
Pages: |
546-55 |
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•
•
•
•
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Publication |
First Author: |
Hu YW |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet. |
Volume: |
8 |
Issue: |
6 |
Pages: |
e66876 |
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•
•
•
•
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Publication |
First Author: |
Gang TB |
Year: |
2015 |
Journal: |
Infect Immun |
Title: |
C-reactive protein protects mice against pneumococcal infection via both phosphocholine-dependent and phosphocholine-independent mechanisms. |
Volume: |
83 |
Issue: |
5 |
Pages: |
1845-52 |
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•
•
•
•
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Publication |
First Author: |
Nadeau-Vallée M |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice. |
Volume: |
198 |
Issue: |
5 |
Pages: |
2047-2062 |
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•
•
•
•
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Publication |
First Author: |
Watanabe S |
Year: |
2020 |
Journal: |
Biochem Biophys Res Commun |
Title: |
ASC regulates platelet activation and contributes to thrombus formation independent of NLRP3 inflammasome. |
Volume: |
531 |
Issue: |
2 |
Pages: |
125-132 |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
219
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
478
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
219
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
452
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
482
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
219
 |
Fragment?: |
false |
|
•
•
•
•
•
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Publication |
First Author: |
Beckmann G |
Year: |
1998 |
Journal: |
J Mol Biol |
Title: |
Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins. |
Volume: |
275 |
Issue: |
5 |
Pages: |
725-30 |
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•
•
•
•
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Publication |
First Author: |
Huffman JL |
Year: |
2002 |
Journal: |
Curr Opin Struct Biol |
Title: |
Prokaryotic transcription regulators: more than just the helix-turn-helix motif. |
Volume: |
12 |
Issue: |
1 |
Pages: |
98-106 |
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•
•
•
•
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Publication |
First Author: |
Lanzilotta WN |
Year: |
2000 |
Journal: |
Nat Struct Biol |
Title: |
Structure of the CO sensing transcription activator CooA. |
Volume: |
7 |
Issue: |
10 |
Pages: |
876-80 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
429
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
493
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
225
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
224
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
432
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
482
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
429
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
493
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
320
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
225
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
348
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
554
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
490
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
225
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
432
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
224
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Goblet C |
Year: |
1995 |
Journal: |
Dev Biol |
Title: |
Modifications of gene expression in myotonic murine skeletal muscle are associated with abnormal expression of myogenic regulatory factors. |
Volume: |
170 |
Issue: |
2 |
Pages: |
262-73 |
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•
•
•
•
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Publication |
First Author: |
Figler RA |
Year: |
2011 |
Journal: |
Diabetes |
Title: |
Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans. |
Volume: |
60 |
Issue: |
2 |
Pages: |
669-79 |
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•
•
•
•
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Publication |
First Author: |
Friedman JE |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice. |
Volume: |
272 |
Issue: |
50 |
Pages: |
31475-81 |
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•
•
•
•
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Publication |
First Author: |
Sundgren NC |
Year: |
2011 |
Journal: |
Circ Res |
Title: |
Coupling of Fcγ receptor I to Fcγ receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function. |
Volume: |
109 |
Issue: |
10 |
Pages: |
1132-40 |
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•
•
•
•
•
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Publication |
First Author: |
Nielsen MK |
Year: |
2023 |
Journal: |
Sci Rep |
Title: |
Complement factor H Y402H polymorphism results in diminishing CD4(+) T cells and increasing C-reactive protein in plasma. |
Volume: |
13 |
Issue: |
1 |
Pages: |
19414 |
|
•
•
•
•
•
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Publication |
First Author: |
Ballak DB |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice. |
Volume: |
9 |
Issue: |
2 |
Pages: |
e89615 |
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•
•
•
•
•
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Publication |
First Author: |
Yiangou M |
Year: |
1993 |
Journal: |
Biochim Biophys Acta |
Title: |
The differential induction of alpha 1-acid glycoprotein and serum amyloid A genes by heavy metals. |
Volume: |
1174 |
Issue: |
2 |
Pages: |
123-32 |
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