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Search results 201 to 278 out of 278 for Csl

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Type Details Score
Publication
35073927 | J:319744
First Author: Poh XY
Year: 2022
Journal: J Neuroinflammation
Title: Nos2-/- mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis.
Volume: 19
Issue: 1
Pages: 21
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Publication
23571214 | J:195490
First Author: Dai Q
Year: 2013
Journal: Development
Title: BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells.
Volume: 140
Issue: 9
Pages: 1892-902
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GO Term
GO:1990433 | CSL-Notch-Mastermind transcription factor complex
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Allele
Vkorc1<L128S> | MGI:3605979
 
Name: vitamin K epoxide reductase complex, subunit 1; Leu128Ser
Allele Type: Spontaneous
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Protein Coding Gene
MGI:1922658 | Dph3
Type: protein_coding_gene
Organism: mouse, laboratory
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HT Experiment
E-MEXP-352 | Transcription profiling of gonads from E14.5 megalin+/+ and megalin-/- embryos
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Domain
IPR037496 | BEND6
Type: Family
Description: The Notch signaling pathway regulates genes involved in cell fate decision throughout development. Its activity relies notably on the CSL transcription factors. BEND6 is a BEN-solo (bears a single BEN domain) factor that binds CSL via its BEN domain and acts as a CSL co-repressor. BEND6 associates with and represses Notch target genes, antagonizing Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis [].
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Genotype
Genotype
Symbol: Vkorc1/Vkorc1
Background: involves: wild
Zygosity: hm
Has Mutant Allele: true
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Publication
29212026 | J:254931
First Author: Noh K
Year: 2017
Journal: Cell Rep
Title: Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis.
Volume: 21
Issue: 10
Pages: 2785-2795
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Publication
30127434 | J:282524
First Author: Kong XF
Year: 2018
Journal: Nat Immunol
Title: Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency.
Volume: 19
Issue: 9
Pages: 973-985
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Publication
12370315 | J:79612
First Author: Wu L
Year: 2002
Journal: Mol Cell Biol
Title: Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.
Volume: 22
Issue: 21
Pages: 7688-700
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Publication
15879509 | J:101681
First Author: Pelz HJ
Year: 2005
Journal: Genetics
Title: The genetic basis of resistance to anticoagulants in rodents.
Volume: 170
Issue: 4
Pages: 1839-47
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Publication
15288264 | -
First Author: Hayward SD
Year: 2004
Journal: Semin Cancer Biol
Title: Viral interactions with the Notch pathway.
Volume: 14
Issue: 5
Pages: 387-96
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Protein Domain
IPR040159 | CLS_fam
Type: Family
Description: The CLS family (CBF1/RBP-Jkappa/suppressor of hairless) consists of transcription factors essential for metazoan development, mainly due to their involvement in the Notch pathway []. The members of this family recognize and bind to response element (GTGA/GGAA) in the promoters of the genes they regulate []. Despite lacking the Notch pathway, CSL family members have been identified in fungal species. Schizosaccharomyces pombe has two CLS family proteins, Cbf11 and Cbf12, that bind the canonical CSL response element and play opposing roles in cell adhesion and coordination of cell and nuclear division [, ].
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Publication
11222720 | -
First Author: Zhang J
Year: 2001
Journal: J Virol
Title: Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC.
Volume: 75
Issue: 6
Pages: 2946-56
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Protein Domain
IPR040014 | CIR1
Type: Family
Description: Corepressor interacting with RBPJ 1 (CIR1, also known as recepin) interacts CBF1, which is a member of the CSL family of DNA binding factors, which mediate either transcriptional repression or transcriptional activation. CIR1 binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex []. It interacts with a variety of proteins, including Epstein-Barr virus RPMS1 []and the NKAP transcriptional repressor of notch signaling [].
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Protein
Q6PFX2
Organism: Mus musculus/domesticus
Length: 281  
Fragment?: false
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Publication
18381292 | J:137568
First Author: Friedmann DR
Year: 2008
Journal: J Biol Chem
Title: RAM-induced allostery facilitates assembly of a notch pathway active transcription complex.
Volume: 283
Issue: 21
Pages: 14781-91
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Publication
19523851 | J:150040
First Author: Zhou J
Year: 2009
Journal: Immunity
Title: Notch and wingless signaling cooperate in regulation of dendritic cell differentiation.
Volume: 30
Issue: 6
Pages: 845-59
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Publication
29977079 | J:268318
First Author: Miesfeld JB
Year: 2018
Journal: Sci Rep
Title: Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina.
Volume: 8
Issue: 1
Pages: 10195
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Publication
24290140 | J:245357
First Author: Collins KJ
Year: 2014
Journal: Structure
Title: Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of Notch signaling.
Volume: 22
Issue: 1
Pages: 70-81
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Publication
15485916 | J:131468
First Author: Liu S
Year: 2004
Journal: Mol Cell Biol
Title: Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.
Volume: 24
Issue: 21
Pages: 9487-97
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Publication
15187027 | J:92962
First Author: Maillard I
Year: 2004
Journal: Blood
Title: Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.
Volume: 104
Issue: 6
Pages: 1696-702
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Publication
15893749 | J:99656
First Author: Schindeler A
Year: 2005
Journal: Exp Cell Res
Title: Muscle costameric protein, Chisel/Smpx, associates with focal adhesion complexes and modulates cell spreading in vitro via a Rac1/p38 pathway.
Volume: 307
Issue: 2
Pages: 367-80
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Publication
8439766 | J:4577
First Author: Li WX
Year: 1993
Journal: Neurochem Int
Title: Cerebellar soluble lectin and its glycoprotein ligands in the developing brain of control and dysmyelinating mutant mice.
Volume: 22
Issue: 2
Pages: 125-33
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Publication
2076671 | J:116788
First Author: Kuchler S
Year: 1990
Journal: Dev Neurosci
Title: Endogenous cerebellar soluble lectin and its ligands in central nervous system myelin of quaking and jimpy mutant mice.
Volume: 12
Issue: 6
Pages: 382-97
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Publication
10319319 | J:83429
First Author: Zimmermann S
Year: 1999
Journal: Mol Endocrinol
Title: Targeted disruption of the Insl3 gene causes bilateral cryptorchidism.
Volume: 13
Issue: 5
Pages: 681-91
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Publication
20801121 | J:178669
First Author: Ohashi S
Year: 2010
Journal: Gastroenterology
Title: NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.
Volume: 139
Issue: 6
Pages: 2113-23
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Publication
23675446 | J:202127
First Author: Main H
Year: 2013
Journal: PLoS One
Title: Notch signaling maintains neural rosette polarity.
Volume: 8
Issue: 5
Pages: e62959
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Publication
17535917 | J:122286
First Author: Oyama T
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo.
Volume: 104
Issue: 23
Pages: 9764-9
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Publication
22069191 | J:178680
First Author: Oyama T
Year: 2011
Journal: Development
Title: Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Volume: 138
Issue: 23
Pages: 5235-46
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Publication
20123979 | J:161721
First Author: Engel ME
Year: 2010
Journal: Mol Cell Biol
Title: Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification.
Volume: 30
Issue: 7
Pages: 1852-63
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Publication
17636029 | J:125125
First Author: Kim MY
Year: 2007
Journal: Mol Cell Biol
Title: Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation.
Volume: 27
Issue: 18
Pages: 6506-19
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Publication
19001083 | J:145571
First Author: Joshi I
Year: 2009
Journal: Blood
Title: Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.
Volume: 113
Issue: 8
Pages: 1689-98
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Publication
19473993 | J:152272
First Author: Fu Y
Year: 2009
Journal: J Biol Chem
Title: Differential regulation of transforming growth factor beta signaling pathways by Notch in human endothelial cells.
Volume: 284
Issue: 29
Pages: 19452-62
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Publication
28602625 | J:260915
First Author: Zheng X
Year: 2017
Journal: Exp Cell Res
Title: A Notch-independent mechanism contributes to the induction of Hes1 gene expression in response to hypoxia in P19 cells.
Volume: 358
Issue: 2
Pages: 129-139
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Protein
Q6T264
Organism: Mus musculus/domesticus
Length: 1020  
Fragment?: false
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Protein
D4QGC2
Organism: Mus musculus/domesticus
Length: 1135  
Fragment?: false
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Protein
Q7TPU6
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
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Protein
F6U238
Organism: Mus musculus/domesticus
Length: 1170  
Fragment?: false
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Publication
16530044 | -
First Author: Nam Y
Year: 2006
Journal: Cell
Title: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Volume: 124
Issue: 5
Pages: 973-83
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Publication
18758478 | -
First Author: Kovall RA
Year: 2008
Journal: Oncogene
Title: More complicated than it looks: assembly of Notch pathway transcription complexes.
Volume: 27
Issue: 38
Pages: 5099-109
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Publication
18758483 | J:141198
First Author: McElhinny AS
Year: 2008
Journal: Oncogene
Title: Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways.
Volume: 27
Issue: 38
Pages: 5138-47
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Publication
16510869 | J:106711
First Author: Shen H
Year: 2006
Journal: Genes Dev
Title: The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
Volume: 20
Issue: 6
Pages: 675-88
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Publication
17317671 | -
First Author: Zhao Y
Year: 2007
Journal: J Biol Chem
Title: The notch regulator MAML1 interacts with p53 and functions as a coactivator.
Volume: 282
Issue: 16
Pages: 11969-81
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Publication
17875709 | -
First Author: Alves-Guerra MC
Year: 2007
Journal: Cancer Res
Title: Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival.
Volume: 67
Issue: 18
Pages: 8690-8
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Publication
16880534 | -
First Author: Chiang MY
Year: 2006
Journal: Mol Cell Biol
Title: Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.
Volume: 26
Issue: 16
Pages: 6261-71
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Publication
17699740 | J:149110
First Author: Wu L
Year: 2007
Journal: Blood
Title: The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.
Volume: 110
Issue: 10
Pages: 3618-23
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Publication
19150886 | -
First Author: Liu H
Year: 2009
Journal: Circ Res
Title: NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1.
Volume: 104
Issue: 4
Pages: 466-75
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Publication
15961999 | -
First Author: Wu L
Year: 2005
Journal: EMBO J
Title: Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.
Volume: 24
Issue: 13
Pages: 2391-402
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Publication
15546612 | -
First Author: Fryer CJ
Year: 2004
Journal: Mol Cell
Title: Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
Volume: 16
Issue: 4
Pages: 509-20
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Protein
A0A0J9YVE0
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
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Protein
Q9DA19
Organism: Mus musculus/domesticus
Length: 450  
Fragment?: false
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Protein
E9Q6E8
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q69Z97
Organism: Mus musculus/domesticus
Length: 826  
Fragment?: true
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Protein
F6UY95
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: true
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Protein
Q8BMG4
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q5U409
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
Q6ZPH8
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: true
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Protein
Q3TZA9
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: true
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Protein
Q810L0
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
E9Q7L5
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Publication
9874765 | -
First Author: Hsieh JJ
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.
Volume: 96
Issue: 1
Pages: 23-8
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Publication
12050117 | -
First Author: Fryer CJ
Year: 2002
Journal: Genes Dev
Title: Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.
Volume: 16
Issue: 11
Pages: 1397-411
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Protein Domain
IPR046370 | MAML_N_sf
Type: Homologous_superfamily
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR046369 | MAML1-3
Type: Family
Description: This family includes the neurogenic mastermind-like proteins 1-3 (MAML1-3) from chordates, which act as critical transcriptional co-activators for Notch signaling [, ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.They consist of an N-terminal domain which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors [, ]]. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR019082 | Mastermind-like_N
Type: Domain
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Publication
30094580 | J:309664
First Author: Fulop BD
Year: 2019
Journal: J Mol Neurosci
Title: Altered Notch Signaling in Developing Molar Teeth of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Deficient Mice.
Volume: 68
Issue: 3
Pages: 377-388
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Publication
21731759 | J:174429
First Author: Guo S
Year: 2011
Journal: PLoS One
Title: Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer.
Volume: 6
Issue: 6
Pages: e21467
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Publication
28487372 | J:247196
First Author: Tabaja N
Year: 2017
Journal: J Biol Chem
Title: Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.
Volume: 292
Issue: 25
Pages: 10549-10563
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Publication
19409814 | J:165961
First Author: Pajerowski AG
Year: 2009
Journal: Immunity
Title: NKAP is a transcriptional repressor of notch signaling and is required for T cell development.
Volume: 30
Issue: 5
Pages: 696-707
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Protein
O08674
Organism: Mus musculus/domesticus
Length: 515  
Fragment?: false
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Protein
P31266
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Protein
Q3V2I2
Organism: Mus musculus/domesticus
Length: 515  
Fragment?: false
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Protein
E9Q7W0
Organism: Mus musculus/domesticus
Length: 485  
Fragment?: false
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Protein
A0A0J9YTV5
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
Q3UM17
Organism: Mus musculus/domesticus
Length: 487  
Fragment?: false
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Protein
Q3U6F1
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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