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Search results 201 to 294 out of 294 for Cxcl16

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697419
Pattern: Scattered
Stage: TS19
Assay Id: MGI:4945691
Age: embryonic day 11.5
Image: g01236 E11.5
Specimen Label: g01236 E11.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945691
Age: embryonic day 15.5
Image: g01236 E15.5
Specimen Label: g01236 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716823
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945691
Age: embryonic day 15.5
Image: g01236 E15.5
Specimen Label: g01236 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945691
Age: embryonic day 15.5
Image: g01236 E15.5
Specimen Label: g01236 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778723
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945691
Age: embryonic day 15.5
Image: g01236 E15.5
Specimen Label: g01236 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267228
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267228
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Scattered
Stage: TS19
Assay Id: MGI:4945691
Age: embryonic day 11.5
Image: g01236 E11.5
Specimen Label: g01236 E11.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945691
Age: embryonic day 15.5
Image: g01236 E15.5
Specimen Label: g01236 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Note: Expression was region specific and scattered.
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Scattered
Stage: TS19
Assay Id: MGI:4945691
Age: embryonic day 11.5
Image: g01236 E11.5
Specimen Label: g01236 E11.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Scattered
Stage: TS19
Assay Id: MGI:4945691
Age: embryonic day 11.5
Image: g01236 E11.5
Specimen Label: g01236 E11.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945691
Age: embryonic day 15.5
Image: g01236 E15.5
Specimen Label: g01236 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945691
Age: embryonic day 15.5
Image: g01236 E15.5
Specimen Label: g01236 E15.5
Detected: true
Specimen Num: 2
•
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•
•
•
GXD Expression
GXD Expression
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945691
Age: embryonic day 15.5
Image: g01236 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01236 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 7
Image: g01236 P7
Specimen Label: g01236 P7
Detected: true
Specimen Num: 3
•
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885095
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945691
Age: postnatal day 42
Image: g01236 Adult
Specimen Label: g01236 Adult
Detected: true
Specimen Num: 4
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Publication
17479179 | -
First Author: Ludwig A
Year: 2007
Journal: Thromb Haemost
Title: Transmembrane chemokines: versatile 'special agents' in vascular inflammation.
Volume: 97
Issue: 5
Pages: 694-703
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Publication
12714508 | -
First Author: Hundhausen C
Year: 2003
Journal: Blood
Title: The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Volume: 102
Issue: 4
Pages: 1186-95
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Publication
11495925 | -
First Author: Garton KJ
Year: 2001
Journal: J Biol Chem
Title: Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).
Volume: 276
Issue: 41
Pages: 37993-8001
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Publication
24789099 | -
First Author: Fujita M
Year: 2014
Journal: PLoS One
Title: The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.
Volume: 9
Issue: 5
Pages: e96372
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Publication
12969992 | -
First Author: Umehara H
Year: 2004
Journal: Arterioscler Thromb Vasc Biol
Title: Fractalkine in vascular biology: from basic research to clinical disease.
Volume: 24
Issue: 1
Pages: 34-40
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Protein Domain
IPR008097 | CX3CL1
Type: Family
Description: The only CX3C chemokine identified to date is CX3C chemokine ligand 1 (CX3CL1), also known as fractalkine or neurotactin. With its unique CX3CR1 receptor [], it is involved in adherence to the endothelium of the inflammatory monocyte population [].CX3CL1 and CXCL16 represent two exceptions among the members of the chemokine family. In addition to their chemokine domain, they possess three other domains: a mucin-like stalk, a transmembrane (TM) domain, and a cytosolic tail [, ]. When interacting with their cognate receptors (CX3CR1 and CXCR6, respectively), these chemokines induce cell-cell adhesion []. CX3CL1 and CXCL16 can also be cleaved by metalloproteinases to yield a soluble form that is chemotactic [, ]. CX3CL1 also binds and activates integrins through its chemokine domain in a CX3CR1-dependent and independent manner, binding to the classical ligand-binding site (RGD-binding site, site 1) or to a second site (site 2) in integrins, respectively [].Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions,and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).
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Publication
22290877 | J:205394
First Author: Li X
Year: 2012
Journal: Mol Cancer Res
Title: Loss of TGF-β responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions.
Volume: 10
Issue: 4
Pages: 494-503
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Publication
24832098 | J:217350
First Author: Heesch K
Year: 2014
Journal: PLoS One
Title: The function of the chemokine receptor CXCR6 in the T cell response of mice against Listeria monocytogenes.
Volume: 9
Issue: 5
Pages: e97701
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Publication
32053518 | J:309360
 
First Author: El-Zaatari M
Year: 2020
Journal: JCI Insight
Title: Aim2-mediated/IFN-β-independent regulation of gastric metaplastic lesions via CD8+ T cells.
Volume: 5
Issue: 5
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Publication
23121668 | J:190984
First Author: Nakano M
Year: 2012
Journal: Clin Exp Immunol
Title: Activated natural killer T cells producing interferon-gamma elicit promoting activity to murine dendritic cell-based autoimmune hepatic inflammation.
Volume: 170
Issue: 3
Pages: 274-82
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Publication
19812206 | J:156621
First Author: Cullen R
Year: 2009
Journal: J Immunol
Title: Enhanced tumor metastasis in response to blockade of the chemokine receptor CXCR6 is overcome by NKT cell activation.
Volume: 183
Issue: 9
Pages: 5807-15
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Publication
22006569 | J:178963
First Author: Derbigny WA
Year: 2012
Journal: Infect Immun
Title: Identifying a role for Toll-like receptor 3 in the innate immune response to Chlamydia muridarum infection in murine oviduct epithelial cells.
Volume: 80
Issue: 1
Pages: 254-65
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Publication
16493056 | J:129418
First Author: Ivakine EA
Year: 2006
Journal: J Immunol
Title: Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice.
Volume: 176
Issue: 5
Pages: 2976-90
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Publication
31002999 | J:289196
 
First Author: Zhu H
Year: 2019
Journal: Int Immunopharmacol
Title: CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease.
Volume: 72
Pages: 224-234
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Publication
23596313 | J:202543
First Author: Wehr A
Year: 2013
Journal: J Immunol
Title: Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis.
Volume: 190
Issue: 10
Pages: 5226-36
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Publication
30542347 | J:269499
 
First Author: Lepore F
Year: 2018
Journal: Front Immunol
Title: CXCL16/CXCR6 Axis Drives Microglia/Macrophages Phenotype in Physiological Conditions and Plays a Crucial Role in Glioma.
Volume: 9
Pages: 2750
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Publication
18566372 | J:137250
First Author: Germanov E
Year: 2008
Journal: J Immunol
Title: Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cells.
Volume: 181
Issue: 1
Pages: 81-91
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Publication
23207180 | J:321085
First Author: Bao L
Year: 2013
Journal: Cytokine
Title: IL-4 up-regulates epidermal chemotactic, angiogenic, and pro-inflammatory genes and down-regulates antimicrobial genes in vivo and in vitro: relevant in the pathogenesis of atopic dermatitis.
Volume: 61
Issue: 2
Pages: 419-25
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Publication
18347211 | J:153303
First Author: Combadière C
Year: 2008
Journal: Circulation
Title: Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6C(hi) and Ly6C(lo) monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice.
Volume: 117
Issue: 13
Pages: 1649-57
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Publication
21628524 | J:174974
First Author: Lee LN
Year: 2011
Journal: Infect Immun
Title: CXCR6 is a marker for protective antigen-specific cells in the lungs after intranasal immunization against Mycobacterium tuberculosis.
Volume: 79
Issue: 8
Pages: 3328-37
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Publication
23142594 | J:193746
First Author: Li C
Year: 2012
Journal: Biochem Biophys Res Commun
Title: RANKL downregulates cell surface CXCR6 expression through JAK2/STAT3 signaling pathway during osteoclastogenesis.
Volume: 429
Issue: 3-4
Pages: 156-62
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Publication
24038090 | J:206276
First Author: Fairfax KC
Year: 2013
Journal: J Immunol
Title: Regulation of the development of the hepatic B cell compartment during Schistosoma mansoni infection.
Volume: 191
Issue: 8
Pages: 4202-10
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Publication
28439009 | J:242223
First Author: Wu WF
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate.
Volume: 114
Issue: 19
Pages: E3816-E3822
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Publication
28267793 | J:248026
First Author: Koenen A
Year: 2017
Journal: PLoS One
Title: The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion.
Volume: 12
Issue: 3
Pages: e0173486
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Publication
31199046 | J:286119
First Author: Tu GW
Year: 2019
Journal: J Cell Mol Med
Title: CXCL16/CXCR6 is involved in LPS-induced acute lung injury via P38 signalling.
Volume: 23
Issue: 8
Pages: 5380-5389
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Publication
39152118 | J:353451
First Author: Zhang C
Year: 2024
Journal: Nat Commun
Title: ITGB6 modulates resistance to anti-CD276 therapy in head and neck cancer by promoting PF4(+) macrophage infiltration.
Volume: 15
Issue: 1
Pages: 7077
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Publication
9166430 | -
First Author: Liao F
Year: 1997
Journal: J Exp Med
Title: STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1.
Volume: 185
Issue: 11
Pages: 2015-23
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Publication
17437534 | -
First Author: Latta M
Year: 2007
Journal: Immunology
Title: CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis.
Volume: 121
Issue: 4
Pages: 555-64
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Publication
11714623 | -
 
First Author: Clapham PR
Year: 2001
Journal: Br Med Bull
Title: HIV-1 receptors and cell tropism.
Volume: 58
Pages: 43-59
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Publication
12810688 | -
First Author: Ancuta P
Year: 2003
Journal: J Exp Med
Title: Fractalkine preferentially mediates arrest and migration of CD16+ monocytes.
Volume: 197
Issue: 12
Pages: 1701-7
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Protein Domain
IPR002235 | Chemokine_CXCR6
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.This entry represents CXC chemokine receptor 6 (CXCR6) also known as cluster of differentiation 186 and is a receptor for chemokine CXCL16. CXCL16 does not activate any other known chemokine receptor, this interaction is highly specific and unique []. Binding of CXCL16 to CXCR6 causes chemotactic migration in activated T cells [, ]however, CXCR6 is a weak mediator of chemotaxis []. The resultant chemotactic response is sensitive to pertussis toxin and results in calcium mobilisation [, ]. CXCR6 is expressed in lymphoid tissues and activated T cells and is induced in peripheral blood leukocytes []and found on natural killer cells []. A number of roles have been suggested for CXCR6 and subset-specific immune responses may be regulated by cell-cell contacts between activated subsets of T cells expressing CXCR6 and antigen presenting cells expressing CXCL16. CXCR6 may also be involved in cell-cell contacts during chronic inflammation []. Additional roles for the receptor include T cell migration in the splenic red pulp, thymocyte development and effector T cell trafficking []. It has been shown that CXCR6 acts as a coreceptor for T cell line-tropic and macrophage-tropic HIV-1 strains, and may play a role in the establishment and progression of HIV infection [, ].
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Publication
33664727 | J:336620
 
First Author: Basic M
Year: 2020
Journal: Front Immunol
Title: Lymph Node Stromal Cells From Different Draining Areas Distinctly Regulate the Development of Chronic Intestinal Inflammation.
Volume: 11
Pages: 549473
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Publication
12960320 | J:120380
First Author: Johnston B
Year: 2003
Journal: J Immunol
Title: Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets.
Volume: 171
Issue: 6
Pages: 2960-9
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Publication
30710528 | J:295269
First Author: Mossanen JC
Year: 2019
Journal: Gastroenterology
Title: CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4+ T-Cell-Dependent Control of Senescence.
Volume: 156
Issue: 6
Pages: 1877-1889.e4
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Protein
O35188
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
Q8C9Y1
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
A0A1D5RMK8
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: false
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Publication
9390561 | -
First Author: Imai T
Year: 1997
Journal: Cell
Title: Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion.
Volume: 91
Issue: 4
Pages: 521-30
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Publication
9024663 | J:42645
First Author: Bazan JF
Year: 1997
Journal: Nature
Title: A new class of membrane-bound chemokine with a CX3C motif.
Volume: 385
Issue: 6617
Pages: 640-4
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Protein
Q9EQ16
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Protein
A0A1L1SVJ3
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Publication
9689100 | J:49070
First Author: Ma Q
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume: 95
Issue: 16
Pages: 9448-53
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Publication
10601351 | -
First Author: Charbonnier AS
Year: 1999
Journal: J Exp Med
Title: Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume: 190
Issue: 12
Pages: 1755-68
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Publication
9500790 | -
First Author: Sallusto F
Year: 1998
Journal: J Exp Med
Title: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume: 187
Issue: 6
Pages: 875-83
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Publication
7592998 | -
First Author: Strieter RM
Year: 1995
Journal: J Biol Chem
Title: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume: 270
Issue: 45
Pages: 27348-57
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Publication
25077969 | J:316108
First Author: Saita S
Year: 2014
Journal: J Biol Chem
Title: Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway.
Volume: 289
Issue: 37
Pages: 25639-54
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Publication
10714678 | -
First Author: Zlotnik A
Year: 2000
Journal: Immunity
Title: Chemokines: a new classification system and their role in immunity.
Volume: 12
Issue: 2
Pages: 121-7
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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