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Search results 201 to 284 out of 284 for Cxcl5

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:5001926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:5542480
Age: embryonic day 15.5
Image: GUDMAP:11268
Specimen Label: GUDMAP:11268
Detected: false
Specimen Num: 2
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
23772036 | J:204952
First Author: Herjan T
Year: 2013
Journal: J Immunol
Title: HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization.
Volume: 191
Issue: 2
Pages: 640-9
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Publication
29111234 | J:261196
First Author: Shimoura N
Year: 2018
Journal: J Invest Dermatol
Title: Exacerbation and Prolongation of Psoriasiform Inflammation in Diabetic Obese Mice: A Synergistic Role of CXCL5 and Endoplasmic Reticulum Stress.
Volume: 138
Issue: 4
Pages: 854-863
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Allele
Cxcl5<em1Smoc> | MGI:7291765
Name: C-X-C motif chemokine ligand 5; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6428509 | C57BL/6JSmoc-Cxcl5<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
21980263 | J:184038
First Author: Toh B
Year: 2011
Journal: PLoS Biol
Title: Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor.
Volume: 9
Issue: 9
Pages: e1001162
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Publication
22408746 | J:185747
First Author: Novitskiy SV
Year: 2011
Journal: Cancer Discov
Title: TGF-β receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms.
Volume: 1
Issue: 5
Pages: 430-41
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Publication
38805014 | J:358843
 
First Author: Xue Y
Year: 2024
Journal: J Exp Med
Title: TET2-STAT3-CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition.
Volume: 221
Issue: 7
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Publication
36635337 | J:332540
First Author: Gonzalez C
Year: 2023
Journal: Commun Biol
Title: TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy.
Volume: 6
Issue: 1
Pages: 31
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Publication
30893588 | J:282435
First Author: Mathur AN
Year: 2019
Journal: Immunity
Title: Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair.
Volume: 50
Issue: 3
Pages: 655-667.e4
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Publication
33667385 | J:303521
First Author: Chen Y
Year: 2021
Journal: Cancer Cell
Title: Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer.
Volume: 39
Issue: 4
Pages: 548-565.e6
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Publication
37922327 | J:343223
First Author: Maji S
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: MDA-9/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis.
Volume: 120
Issue: 45
Pages: e2307094120
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Publication
18025225 | J:155093
First Author: Liang SC
Year: 2007
Journal: J Immunol
Title: An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment.
Volume: 179
Issue: 11
Pages: 7791-9
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Publication
35537038 | J:326290
First Author: Lee R
Year: 2022
Journal: Cancer Discov
Title: Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer.
Volume: 12
Issue: 7
Pages: 1702-1717
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Publication
37932455 | J:358285
First Author: Yaghi OK
Year: 2023
Journal: Nat Immunol
Title: A discrete 'early-responder' stromal-cell subtype orchestrates immunocyte recruitment to injured tissue.
Volume: 24
Issue: 12
Pages: 2053-2067
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Publication
25555453 | J:230272
First Author: Chen J
Year: 2015
Journal: Exp Hematol
Title: Immune-mediated bone marrow failure in C57BL/6 mice.
Volume: 43
Issue: 4
Pages: 256-67
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Publication
22290877 | J:205394
First Author: Li X
Year: 2012
Journal: Mol Cancer Res
Title: Loss of TGF-β responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions.
Volume: 10
Issue: 4
Pages: 494-503
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Publication
22566565 | J:188885
First Author: Griffin GK
Year: 2012
Journal: J Immunol
Title: IL-17 and TNF-α sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation.
Volume: 188
Issue: 12
Pages: 6287-99
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Publication
32169848 | J:287629
First Author: Sun L
Year: 2020
Journal: J Immunol
Title: IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network.
Volume: 204
Issue: 8
Pages: 2177-2191
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Publication
27030744 | J:293085
First Author: Riedel JH
Year: 2016
Journal: J Am Soc Nephrol
Title: IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases.
Volume: 27
Issue: 12
Pages: 3666-3677
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Publication
26701088 | J:232811
First Author: Wang G
Year: 2016
Journal: Cancer Discov
Title: Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression.
Volume: 6
Issue: 1
Pages: 80-95
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Publication
29965797 | J:286699
First Author: Ince LM
Year: 2019
Journal: FASEB J
Title: Circadian variation in pulmonary inflammatory responses is independent of rhythmic glucocorticoid signaling in airway epithelial cells.
Volume: 33
Issue: 1
Pages: 126-139
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Publication
28053238 | J:247655
First Author: Chen W
Year: 2017
Journal: J Immunol
Title: Steroid Receptor Coactivator 3 Contributes to Host Defense against Enteric Bacteria by Recruiting Neutrophils via Upregulation of CXCL2 Expression.
Volume: 198
Issue: 4
Pages: 1606-1615
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Publication
28691930 | J:246353
First Author: Jung K
Year: 2017
Journal: J Clin Invest
Title: Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.
Volume: 127
Issue: 8
Pages: 3039-3051
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Publication
34452925 | J:349740
 
First Author: Moreau JM
Year: 2021
Journal: Sci Immunol
Title: Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation.
Volume: 6
Issue: 62
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Publication
27288485 | J:236262
First Author: Foronjy RF
Year: 2016
Journal: Am J Physiol Lung Cell Mol Physiol
Title: TLR9 expression is required for the development of cigarette smoke-induced emphysema in mice.
Volume: 311
Issue: 1
Pages: L154-66
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Publication
31009606 | J:275924
 
First Author: Kubota A
Year: 2019
Journal: J Mol Cell Cardiol
Title: Matrix metalloproteinase-12 produced by Ly6Clow macrophages prolongs the survival after myocardial infarction by preventing neutrophil influx.
Volume: 131
Pages: 41-52
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Publication
23966625 | J:205858
First Author: Fogli LK
Year: 2013
Journal: J Immunol
Title: T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.
Volume: 191
Issue: 6
Pages: 3100-11
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Publication
22844121 | J:189861
First Author: Yamamoto K
Year: 2012
Journal: J Immunol
Title: Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia.
Volume: 189
Issue: 5
Pages: 2450-9
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Publication
31734232 | J:291011
First Author: Matoba H
Year: 2020
Journal: Am J Pathol
Title: Cecal Tumorigenesis in Aryl Hydrocarbon Receptor-Deficient Mice Depends on Cecum-Specific Mitogen-Activated Protein Kinase Pathway Activation and Inflammation.
Volume: 190
Issue: 2
Pages: 453-468
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Publication
17375198 | J:129334
First Author: Tester AM
Year: 2007
Journal: PLoS One
Title: LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity.
Volume: 2
Issue: 3
Pages: e312
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Publication
24525743 | J:210532
First Author: Ma S
Year: 2014
Journal: Cancer Res
Title: IL-17A produced by γδ T cells promotes tumor growth in hepatocellular carcinoma.
Volume: 74
Issue: 7
Pages: 1969-82
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Publication
28922428 | J:249792
First Author: Jin L
Year: 2017
Journal: PLoS Pathog
Title: Diminished neutrophil extracellular trap (NET) formation is a novel innate immune deficiency induced by acute ethanol exposure in polymicrobial sepsis, which can be rescued by CXCL1.
Volume: 13
Issue: 9
Pages: e1006637
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Publication
24010952 | J:231869
First Author: Yamamoto K
Year: 2014
Journal: Am J Respir Cell Mol Biol
Title: Roles of lung epithelium in neutrophil recruitment during pneumococcal pneumonia.
Volume: 50
Issue: 2
Pages: 253-62
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Publication
36119114 | J:329360
 
First Author: Jones SS
Year: 2022
Journal: Front Immunol
Title: Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice.
Volume: 13
Pages: 948047
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Publication
31658231 | J:292922
First Author: Martinu T
Year: 2019
Journal: Transplantation
Title: IL-17A Contributes to Lung Fibrosis in a Model of Chronic Pulmonary Graft-versus-host Disease.
Volume: 103
Issue: 11
Pages: 2264-2274
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Publication
32816906 | J:296662
First Author: Wang Q
Year: 2020
Journal: Cancer Res
Title: ARC Is a Critical Protector against Inflammatory Bowel Disease (IBD) and IBD-Associated Colorectal Tumorigenesis.
Volume: 80
Issue: 19
Pages: 4158-4171
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Publication
25080523 | J:214839
First Author: Zuk A
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: CXCRâ‚„antagonism as a therapeutic approach to prevent acute kidney injury.
Volume: 307
Issue: 7
Pages: F783-97
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Publication
25870999 | J:229694
First Author: Lin D
Year: 2015
Journal: Eur J Immunol
Title: Secreted IL-1α promotes T-cell activation and expansion of CD11b(+) Gr1(+) cells in carbon tetrachloride-induced liver injury in mice.
Volume: 45
Issue: 7
Pages: 2084-98
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Publication
29256623 | J:275723
First Author: Vanderstocken G
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: Identification of Drug Candidates to Suppress Cigarette Smoke-induced Inflammation via Connectivity Map Analyses.
Volume: 58
Issue: 6
Pages: 727-735
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Publication
32959976 | J:296942
First Author: Kawagoe Y
Year: 2020
Journal: Aging Cell
Title: CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos.
Volume: 19
Issue: 10
Pages: e13240
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Publication
27307558 | J:315452
First Author: Jia H
Year: 2016
Journal: J Immunol
Title: Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis.
Volume: 197
Issue: 3
Pages: 859-71
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Publication
27737879 | J:320226
First Author: Chao T
Year: 2016
Journal: Cancer Immunol Res
Title: CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma.
Volume: 4
Issue: 11
Pages: 968-982
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Publication
36624683 | J:338759
First Author: Cox SL
Year: 2023
Journal: FASEB J
Title: Circadian disruption in lung fibroblasts enhances NF-κB activity to exacerbate neutrophil recruitment.
Volume: 37
Issue: 2
Pages: e22753
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Publication
15967374 | -
First Author: Fu W
Year: 2005
Journal: Cytokine
Title: Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1.
Volume: 31
Issue: 1
Pages: 9-17
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Publication
8384312 | -
First Author: Cerretti DP
Year: 1993
Journal: Mol Immunol
Title: Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.
Volume: 30
Issue: 4
Pages: 359-67
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Publication
1379593 | -
First Author: Lee J
Year: 1992
Journal: J Biol Chem
Title: Characterization of two high affinity human interleukin-8 receptors.
Volume: 267
Issue: 23
Pages: 16283-7
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Publication
10878382 | -
First Author: Ludwig A
Year: 2000
Journal: J Immunol
Title: Identification of distinct surface-expressed and intracellular CXC-chemokine receptor 2 glycoforms in neutrophils: N-glycosylation is essential for maintenance of receptor surface expression.
Volume: 165
Issue: 2
Pages: 1044-52
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Publication
8955112 | J:37299
First Author: Dunstan CA
Year: 1996
Journal: J Biol Chem
Title: Identification of two rat genes orthologous to the human interleukin-8 receptors.
Volume: 271
Issue: 51
Pages: 32770-6
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Publication
12239185 | -
First Author: Doroshenko T
Year: 2002
Journal: Blood
Title: Phagocytosing neutrophils down-regulate the expression of chemokine receptors CXCR1 and CXCR2.
Volume: 100
Issue: 7
Pages: 2668-71
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Publication
7527448 | -
First Author: Chuntharapai A
Year: 1994
Journal: J Immunol
Title: Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes.
Volume: 153
Issue: 12
Pages: 5682-8
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Publication
16720046 | -
First Author: Bizzarri C
Year: 2006
Journal: Pharmacol Ther
Title: ELR+ CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets.
Volume: 112
Issue: 1
Pages: 139-49
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Publication
12496258 | -
First Author: Heidemann J
Year: 2003
Journal: J Biol Chem
Title: Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2.
Volume: 278
Issue: 10
Pages: 8508-15
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Publication
22719179 | -
 
First Author: Konrad FM
Year: 2012
Journal: Mediators Inflamm
Title: CXCR2 in acute lung injury.
Volume: 2012
Pages: 740987
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Protein Domain
IPR000174 | Chemokine_CXCR_1/2
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.CXCR1 and CXCR2, also known as interleukin 8 receptor alpha and beta, respectively [], are closely-related receptors. They act as specific receptors for the CXCL8 and CXCL6 chemokines, which have a glutamate-leucine-arginine (ELR) motif in their N-terminal domains []. CXCR2 also binds additional ELR motif-containing CXC chemokines (such as CXCL1, CXCL2, CXCL3, CXCL5 and CXCL7) with high affinity [].CXCR1 and CXCR2 are expressed on all granulocytes, monocytes, and mast cells and on some CD8+ T-cells and CD56+ natural killer (NK) cells []. Equal amounts of CXCR1 and CXCR2 are present on neutrophils [, , , , ], but it appears that monocytes and positive lymphocytes express more CXCR2 than CXCR1 [].This entry represents both CXCR1 and CXCR2.
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Protein Domain
IPR000057 | Chemokine_CXCR2
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.CXCR1 and CXCR2, also known as interleukin 8 receptor alpha and beta, respectively [], are closely-relatedreceptors. They act as specific receptors for the CXCL8 and CXCL6 chemokines, which have a glutamate-leucine-arginine (ELR) motif in their N-terminal domains []. CXCR2 also binds additional ELR motif-containing CXC chemokines (such as CXCL1, CXCL2, CXCL3, CXCL5 and CXCL7) with high affinity [].CXCR1 and CXCR2 are expressed on all granulocytes, monocytes, and mast cells and on some CD8+ T-cells and CD56+ natural killer (NK) cells []. Equal amounts of CXCR1 and CXCR2 are present on neutrophils [, , , , ], but it appears that monocytes and positive lymphocytes express more CXCR2 than CXCR1 [].This entry represents CXCR2. The angiogenic effects of CXCL8 in intestinal microvascular endothelial cells are mediated by this receptor []. It has been suggested that the receptor may be a potential theraputic target in acute lung injury [].
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Protein Domain
IPR001355 | Chemokine_CXCR1
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.CXCR1 and CXCR2, also known as interleukin 8 receptor alpha and beta, respectively [], are closely-related receptors. They act as specific receptors for the CXCL8 and CXCL6 chemokines, which have a glutamate-leucine-arginine (ELR) motif in their N-terminal domains []. CXCR2 also binds additional ELR motif-containing CXC chemokines (such as CXCL1, CXCL2, CXCL3, CXCL5 and CXCL7) with high affinity [].CXCR1 and CXCR2 are expressed on all granulocytes, monocytes, and mast cells and on some CD8+ T-cells and CD56+ natural killer (NK) cells []. Equal amounts of CXCR1 and CXCR2 are present on neutrophils [, , , , ], but it appears that monocytes and positive lymphocytes express more CXCR2 than CXCR1 [].This entry represents CXCR1
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Publication
21933390 | J:185992
 
First Author: Götz AA
Year: 2011
Journal: Part Fibre Toxicol
Title: Carbon-nanoparticle-triggered acute lung inflammation and its resolution are not altered in PPARγ-defective (P465L) mice.
Volume: 8
Pages: 28
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Publication
32483412 | J:327645
First Author: Li X
Year: 2020
Journal: Theranostics
Title: A S100A14-CCL2/CXCL5 signaling axis drives breast cancer metastasis.
Volume: 10
Issue: 13
Pages: 5687-5703
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Publication
25104800 | J:227169
First Author: Stachon P
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice.
Volume: 34
Issue: 10
Pages: 2237-45
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Publication
26204894 | J:244134
First Author: Niazi MK
Year: 2015
Journal: Dis Model Mech
Title: Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice.
Volume: 8
Issue: 9
Pages: 1141-53
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Publication
30910700 | J:291165
First Author: Suzuki K
Year: 2019
Journal: Cell Mol Gastroenterol Hepatol
Title: Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H pylori Infection.
Volume: 8
Issue: 1
Pages: 119-142
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Protein
P35343
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
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Protein
Q810W6
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Publication
9689100 | J:49070
First Author: Ma Q
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume: 95
Issue: 16
Pages: 9448-53
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Publication
11544102 | -
First Author: Horuk R
Year: 2001
Journal: Cytokine Growth Factor Rev
Title: Chemokine receptors.
Volume: 12
Issue: 4
Pages: 313-35
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Publication
10601351 | -
First Author: Charbonnier AS
Year: 1999
Journal: J Exp Med
Title: Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume: 190
Issue: 12
Pages: 1755-68
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Publication
9500790 | -
First Author: Sallusto F
Year: 1998
Journal: J Exp Med
Title: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume: 187
Issue: 6
Pages: 875-83
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Publication
7592998 | -
First Author: Strieter RM
Year: 1995
Journal: J Biol Chem
Title: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume: 270
Issue: 45
Pages: 27348-57
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Publication
10714678 | -
First Author: Zlotnik A
Year: 2000
Journal: Immunity
Title: Chemokines: a new classification system and their role in immunity.
Volume: 12
Issue: 2
Pages: 121-7
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