Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1821522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421857 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EG1888; Specimen G0583 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3557722 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421857 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EG1888; Specimen G0583 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702122 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421857 |
Age: |
embryonic day 14.5 |
Image: |
EG1888; Specimen G0583 |
|
Specimen Label: |
EG1888; Specimen G0583 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1756322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421857 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EG1888; Specimen G0583 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1668822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421857 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EG1888; Specimen G0583 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757722 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421857 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EG1888; Specimen G0583 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421857 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EG1888; Specimen G0583 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421857 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EG1888; Specimen G0583 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1859423 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824170 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010560_14 |
|
Specimen Label: |
euxassay_010560_14 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1859423 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824170 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010560_16 |
|
Specimen Label: |
euxassay_010560_16 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1859423 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824170 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010560_17 |
|
Specimen Label: |
euxassay_010560_17 |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1802422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421857 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EG1888; Specimen G0583 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1768022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421857 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the skull (base and vault). |
Specimen Label: |
EG1888; Specimen G0583 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416451 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2672022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421857 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in whisker follicle. |
Specimen Label: |
EG1888; Specimen G0583 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Powley MW |
Year: |
2001 |
Journal: |
Toxicology |
Title: |
Hepatic and pulmonary microsomal benzene metabolism in CYP2E1 knockout mice. |
Volume: |
169 |
Issue: |
3 |
Pages: |
187-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mango GW |
Year: |
1998 |
Journal: |
Am J Physiol |
Title: |
Clara cell secretory protein deficiency increases oxidant stress response in conducting airways. |
Volume: |
275 |
Issue: |
2 Pt 1 |
Pages: |
L348-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng D |
Year: |
2014 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Evidence for Scgb1a1(+) cells in the generation of p63(+) cells in the damaged lung parenchyma. |
Volume: |
50 |
Issue: |
3 |
Pages: |
595-604 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu J |
Year: |
2014 |
Journal: |
Drug Metab Dispos |
Title: |
Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene. |
Volume: |
42 |
Issue: |
1 |
Pages: |
23-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu J |
Year: |
2006 |
Journal: |
Toxicol Appl Pharmacol |
Title: |
Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver. |
Volume: |
213 |
Issue: |
3 |
Pages: |
216-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pinkerton KE |
Year: |
1996 |
Journal: |
Inhal Toxicol |
Title: |
Quantitative histology and cytochrome P-450 immunocytochemistry of the lung parenchyma following 6 months of exposure of strain A/J mice to cigarette sidestream smoke. |
Volume: |
8 |
Issue: |
9 |
Pages: |
927-945 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nebert DW |
Year: |
1987 |
Journal: |
Annu Rev Biochem |
Title: |
P450 genes: structure, evolution, and regulation. |
Volume: |
56 |
|
Pages: |
945-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nelson DR |
Year: |
1993 |
Journal: |
DNA Cell Biol |
Title: |
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. |
Volume: |
12 |
Issue: |
1 |
Pages: |
1-51 |
|
•
•
•
•
•
|
Publication |
|
Year: |
1991 |
Journal: |
Eur J Biochem |
Title: |
Nomenclature Committee of the International Union of Biochemistry (NC-IUB). Nomenclature of electron-transfer proteins. Recommendations 1989. |
Volume: |
200 |
Issue: |
3 |
Pages: |
599-611 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nelson DR |
Year: |
1998 |
Journal: |
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol |
Title: |
Metazoan cytochrome P450 evolution. |
Volume: |
121 |
Issue: |
1-3 |
Pages: |
15-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang H |
Year: |
1998 |
Journal: |
Arch Biochem Biophys |
Title: |
Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates the selective pneumotoxins 3-methylindole and naphthalene. |
Volume: |
349 |
Issue: |
2 |
Pages: |
329-40 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
P450 enzymes constitute a superfamily of haem-thiolate proteins [], widely distributed in bacteria, fungi, plants and animals. The enzymes are involved in metabolism of a plethora of both exogenous and endogenous compounds []. Usually, they act as terminal oxidases in multi-component electron-transfer chains, called P450-containing monooxygenase systems. On the basis of sequence similarity, all P450s can be categorised into 2 main classes [], the so-called B- and E-classes: P450 proteins of prokaryotic 3-component systems and fungal P450nor (CYP55) belong to the B-class; all other known P450s from distinct systems are of the E-class. E-class P450s may be further divided into 5 subclasses (groups) according to protein sequence similarities. The data suggest that divergence of the P450 superfamily into B- and E-classes, and further divergence into stable P450 groups within the E-class, must be very ancient and had occurred before the appearance of eukaryotes. Given the rapid increase in numbers of P450s, Nelson introduced the concept of a higher-order classification of P450 families into clans []based on sequence similarity. This is similar to the previous grouping into B- and E-classes; both classifications are still used. According to Nelsons system, clan 2 contains the CYP2 plus CYP1, 17, 18, 21 and 71 families, and corresponds to the E-class group I proteins []. Members of the first 4 families are of vertebrate origin, while those from CYP71 derive from plants. CYP1 and CYP2 enzymes mainly metabolise exogenous substrates, whereas CYP17 and CYP21 are involved in metabolism of endogenous physiologically-active compounds. This entry represents the CYP2 family, comprising 15 subfamilies (A-H, J-N, P and Q), is the most dominant in clan 2. Six of these subfamilies are non-mammalian: 2H derives from chicken; 2K, 2M, 2N and 2P are from fish; 2L is from lobster; and 2Q from Xenopus. The first five (A-E) are present in mammalian liver, but in differing amounts and with different inducibilities. Members of the CYP2F gene subfamily, meanwhile, are selectively expressed in lung tissues, and have been implicated as important catalysts in the formation of reactive intermediates from several pneumotoxic chemicals. Human CYP2F1 bioactivates 3-methylindole (3MI), while mouse CYP2F2 bioactivates naphthalene []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
491
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
487
 |
Fragment?: |
true |
|
•
•
•
•
•
|