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Search results 201 to 221 out of 221 for Dbf4

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Type

Details

Score

Strain

MGI:5495231 | B6N(Cg)-Dbf4<tm1b(KOMP)Wtsi>/J

Attribute String:

mutant strain, targeted mutation

•

Genotype

Symbol:	Dbf4/Dbf4
Background:	B6N(Cg)-Dbf4/J
Zygosity:	hm
Has Mutant Allele:	true

•

Strain

MGI:6344086 | C57BL/6N-A<tm1Brd> Dbf4<tm1a(KOMP)Wtsi>/JMmucd

Attribute String:

mutant strain, coisogenic, targeted mutation

•

Strain

MGI:6344087 | C57BL/6N-A<tm1Brd> Dbf4<tm1b(KOMP)Wtsi>/JMmucd

Attribute String:

mutant strain, coisogenic, targeted mutation

•

Genotype

Symbol:	Dbf4/Dbf4<+>
Background:	B6N(Cg)-Dbf4/J
Zygosity:	ht
Has Mutant Allele:	true

•

Protein Domain

IPR038545 | Znf_DBF_sf

Type:

Homologous_superfamily

Description:

In eukaryotes, initiation of DNA replication requires the assembly of pre-replication complexes (pre-RCs) on chromatin during the G1 phase. In the S phase, pre-RCs are activated by two protein kinases, Cdk2 and Cdc7, which results in the loading of replication factors and the unwinding of replication origins by the MCM helicase complex []. Cdc7 is a serine/threonine kinase that is conserved from yeast to human. It is regulated by its association with a regulatory subunit, the Dbf4 protein. This complex is often referred to as DDK (Dbf4-dependent kinase) [].DBF4 contains an N-terminal BRCT domain and a C-terminal conserved region that could potentially coordinate one zinc atom, the DBF4-type zinc finger. This entry represents the zinc finger, which is important for the interaction with Cdc7 [, ].

•

Protein

A0A6I8MWW6

Organism:	Mus musculus/domesticus
Length:	2498
Fragment?:	false

•

Publication

8984634 | -

First Author:	Nasmyth K
Year:	1996
Journal:	Science
Title:	Viewpoint: putting the cell cycle in order.
Volume:	274
Issue:	5293
Pages:	1643-5

•

Publication

14643426 | -

First Author:	Duncker BP
Year:	2003
Journal:	Mutat Res
Title:	Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts.
Volume:	532
Issue:	1-2
Pages:	21-7

•

Publication

8943332 | -

First Author:	Hardy CF
Year:	1996
Journal:	Mol Cell Biol
Title:	A novel role for Cdc5p in DNA replication.
Volume:	16
Issue:	12
Pages:	6775-82

•

Publication

8066465 | -

First Author:	Dowell SJ
Year:	1994
Journal:	Science
Title:	Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo.
Volume:	265
Issue:	5176
Pages:	1243-6

•

Protein

Q8BNI1

Organism:	Mus musculus/domesticus
Length:	180
Fragment?:	true

•

Protein Domain

IPR006572 | Znf_DBF

Type:

Domain

Description:

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domainsare often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. In eukaryotes, initiation of DNA replication requires the assembly of pre-replication complexes (pre-RCs) on chromatin during the G1 phase. In the S phase, pre-RCs are activated by two protein kinases, Cdk2 and Cdc7, which results in the loading of replication factors and the unwinding of replication origins by the MCM helicase complex []. Cdc7 is a serine/threonine kinase that is conserved from yeast to human. It is regulated by its association with a regulatory subunit, the Dbf4 protein. This complex is often referred to as DDK (Dbf4-dependent kinase) [].DBF4 contains an N-terminal BRCT domain and a C-terminal conserved region that could potentially coordinate one zinc atom, the DBF4-type zinc finger. This entry represents the zinc finger, which is important for the interaction with Cdc7 [, ].

•

Publication

12665246 | -

First Author:	Matthews JM
Year:	2002
Journal:	IUBMB Life
Title:	Zinc fingers--folds for many occasions.
Volume:	54
Issue:	6
Pages:	351-5

•

Publication

17210253 | -

First Author:	Gamsjaeger R
Year:	2007
Journal:	Trends Biochem Sci
Title:	Sticky fingers: zinc-fingers as protein-recognition motifs.
Volume:	32
Issue:	2
Pages:	63-70

•

Publication

15963892 | -

First Author:	Hall TM
Year:	2005
Journal:	Curr Opin Struct Biol
Title:	Multiple modes of RNA recognition by zinc finger proteins.
Volume:	15
Issue:	3
Pages:	367-73

•

Publication

15718139 | -

First Author:	Brown RS
Year:	2005
Journal:	Curr Opin Struct Biol
Title:	Zinc finger proteins: getting a grip on RNA.
Volume:	15
Issue:	1
Pages:	94-8

•

Publication

10529348 | -

First Author:	Klug A
Year:	1999
Journal:	J Mol Biol
Title:	Zinc finger peptides for the regulation of gene expression.
Volume:	293
Issue:	2
Pages:	215-8

•

Publication

11179890 | -

First Author:	Laity JH
Year:	2001
Journal:	Curr Opin Struct Biol
Title:	Zinc finger proteins: new insights into structural and functional diversity.
Volume:	11
Issue:	1
Pages:	39-46

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

•

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