Type |
Details |
Score |
Allele |
Name: |
DEK proto-oncogene; gene trap IST14233A2, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dek/Dek |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Yu Hou |
Allele Type: |
Transgenic |
Attribute String: |
Conditional ready, Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu Z |
Year: |
2020 |
Journal: |
Nat Cell Biol |
Title: |
Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells. |
Volume: |
22 |
Issue: |
2 |
Pages: |
175-186 |
|
•
•
•
•
•
|
Publication |
First Author: |
Devany M |
Year: |
2004 |
Journal: |
Protein Sci |
Title: |
Solution NMR structure of the C-terminal domain of the human protein DEK. |
Volume: |
13 |
Issue: |
8 |
Pages: |
2252-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meyn MS |
Year: |
1993 |
Journal: |
Am J Hum Genet |
Title: |
Expression cloning of multiple human cDNAs that complement the phenotypic defects of ataxia-telangiectasia group D fibroblasts. |
Volume: |
53 |
Issue: |
6 |
Pages: |
1206-16 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
DEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C-terminal of DEK and is of clinical importance since it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients [, ]. The structure of this domain shows it to be homologous to the E2F/DP transcription factor family []. This domain is also found in chitin synthase proteins like , and in protein phosphatases such as . |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 317, Susanne Wells |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
242
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/? Tg(tetO/CMV-Dek,-luc)317Siwe/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Mencinger M |
Year: |
1998 |
Journal: |
Biochim Biophys Acta |
Title: |
Expression analysis and chromosomal mapping of a novel human gene, APRIL, encoding an acidic protein rich in leucines. |
Volume: |
1395 |
Issue: |
2 |
Pages: |
176-80 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(KRT5-rtTA)#Glk/? Tg(tetO/CMV-Dek,-luc)317Siwe/? |
Background: |
involves: FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
138
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Delaunay S |
Year: |
2016 |
Journal: |
J Exp Med |
Title: |
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer. |
Volume: |
213 |
Issue: |
11 |
Pages: |
2503-2523 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patel Y |
Year: |
2019 |
Journal: |
Oncogene |
Title: |
Overexpression of miR-489 derails mammary hierarchy structure and inhibits HER2/neu-induced tumorigenesis. |
Volume: |
38 |
Issue: |
3 |
Pages: |
445-453 |
|
•
•
•
•
•
|
Publication |
First Author: |
von Lindern M |
Year: |
1992 |
Journal: |
Mol Cell Biol |
Title: |
Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. |
Volume: |
12 |
Issue: |
8 |
Pages: |
3346-55 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1042
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
649
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1423
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
999
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
648
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1429
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou H |
Year: |
2008 |
Journal: |
J Proteome Res |
Title: |
Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis. |
Volume: |
7 |
Issue: |
9 |
Pages: |
3957-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Villén J |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Large-scale phosphorylation analysis of mouse liver. |
Volume: |
104 |
Issue: |
5 |
Pages: |
1488-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|