Type |
Details |
Score |
Publication |
First Author: |
Kanzaki M |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Phosphatidylinositol 4,5-bisphosphate regulates adipocyte actin dynamics and GLUT4 vesicle recycling. |
Volume: |
279 |
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29 |
Pages: |
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First Author: |
Grossman GH |
Year: |
2013 |
Journal: |
Vis Neurosci |
Title: |
Protein partners of dynamin-1 in the retina. |
Volume: |
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First Author: |
Noakes PG |
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J Comp Neurol |
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Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation. |
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First Author: |
Modregger J |
Year: |
2003 |
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J Biol Chem |
Title: |
Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1. |
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Gautam M |
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Cell |
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Milesi C |
Year: |
2019 |
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Life Sci Alliance |
Title: |
Redundant and nonredundant organismal functions of EPS15 and EPS15L1. |
Volume: |
2 |
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1 |
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Publication |
First Author: |
Wu J |
Year: |
2023 |
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Blood Adv |
Title: |
EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts. |
Volume: |
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Pages: |
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First Author: |
Piccoli G |
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J Neurosci |
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Volume: |
31 |
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Publication |
First Author: |
Hämmerle B |
Year: |
2008 |
Journal: |
Eur J Neurosci |
Title: |
The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development. |
Volume: |
27 |
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5 |
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First Author: |
Liu K |
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2016 |
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Sci Rep |
Title: |
Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. |
Volume: |
6 |
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Pages: |
21019 |
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Publication |
First Author: |
Morgan-Smith M |
Year: |
2014 |
Journal: |
Elife |
Title: |
GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation. |
Volume: |
3 |
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Pages: |
e02663 |
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Publication |
First Author: |
Li Q |
Year: |
2014 |
Journal: |
Elife |
Title: |
The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. |
Volume: |
3 |
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Pages: |
e01201 |
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•
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Publication |
First Author: |
Chen H |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. |
Volume: |
106 |
Issue: |
33 |
Pages: |
13838-43 |
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Publication |
First Author: |
Bhattacharyya S |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development. |
Volume: |
6 |
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Pages: |
20727 |
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Publication |
First Author: |
Licatalosi DD |
Year: |
2012 |
Journal: |
Genes Dev |
Title: |
Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. |
Volume: |
26 |
Issue: |
14 |
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1626-42 |
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Publication |
First Author: |
Jiang CH |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The effects of aging on gene expression in the hypothalamus and cortex of mice. |
Volume: |
98 |
Issue: |
4 |
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1930-4 |
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Publication |
First Author: |
Werner HB |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. |
Volume: |
27 |
Issue: |
29 |
Pages: |
7717-30 |
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Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
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•
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•
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Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
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•
•
•
•
•
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Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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•
•
•
•
•
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Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
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Title: |
MGI Sequence Curation Reference |
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
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Title: |
Nomenclature Committee Use |
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Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
•
•
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•
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
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•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
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Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Naylor K |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Mdv1 interacts with assembled dnm1 to promote mitochondrial division. |
Volume: |
281 |
Issue: |
4 |
Pages: |
2177-83 |
|
•
•
•
•
•
|
Allele |
Name: |
dynamin 1; endonuclease-mediated mutation 1, Michael A Cousin |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Not Specified |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu HY |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme. |
Volume: |
276 |
Issue: |
10 |
Pages: |
7541-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schauss AC |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface. |
Volume: |
119 |
Issue: |
Pt 15 |
Pages: |
3098-106 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Caf4 is a WD40 repeats containing protein involved in mitochondrial fission. It displays physical interactions with CCR4-NOT complex []. It has a paralogue, Mdv1. Both Caf4 and Mdv1 act as adapter proteins, binding to Fis1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase Dnm1 to form mitochondrial fission complexes []. However, Fis1 and Caf4, but not Mdv1, determine the polar localization of Dnm1 clusters on the mitochondrial surface []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Structural basis for recruitment of mitochondrial fission complexes by Fis1. |
Volume: |
104 |
Issue: |
47 |
Pages: |
18526-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoppins S |
Year: |
2007 |
Journal: |
Annu Rev Biochem |
Title: |
The machines that divide and fuse mitochondria. |
Volume: |
76 |
|
Pages: |
751-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo Q |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent. |
Volume: |
7 |
Issue: |
12 |
Pages: |
e53523 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Fis1, along with Dnm1 and Mdv1, is an essential protein in mediating mitochondrial fission. Dnm1 and Fis1 are highly conserved, with a common mechanism in disparate species. In mutants of these proteins, mitochondrial fission is impaired, resulting in networks of undivided mitochondria. Fis1 appears to act via the recruitment of division complexes to the mitochondrial outer membrane. Dnm1 is recruited to mitochondria via interactions with the adaptor proteins Caf4 and Mdv1, which bind directly to Fis1 [, ].The Fis1 N terminus is cytosolic andtethered to the mitochondrial outer membrane via a C-terminal transmembrane domain. The cytosolic domain of Fis1 forms a six-helix bundle, in which the central four helices consist of two tandem tetratricopeptide repeat (TPR)-like motifs, known to mediate protein-protein interactions [, , , ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki M |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission. |
Volume: |
280 |
Issue: |
22 |
Pages: |
21444-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki M |
Year: |
2003 |
Journal: |
J Mol Biol |
Title: |
The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. |
Volume: |
334 |
Issue: |
3 |
Pages: |
445-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dohm JA |
Year: |
2004 |
Journal: |
Proteins |
Title: |
Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold. |
Volume: |
54 |
Issue: |
1 |
Pages: |
153-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuravi K |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. |
Volume: |
119 |
Issue: |
Pt 19 |
Pages: |
3994-4001 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Fis1 is an outer mitochondrial membrane protein that plays a role in mitochondrial membrane fission []. In Saccharomyces cerevisiae, it facilitates mitochondrial fission by forming protein complexes with Dnm1 and Mdv1 []. It contains tetratrico-peptide repeat (TPR)-like domain and a C-terminal transmembrane region [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Griffin EE |
Year: |
2005 |
Journal: |
J Cell Biol |
Title: |
The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria. |
Volume: |
170 |
Issue: |
2 |
Pages: |
237-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagotu S |
Year: |
2008 |
Journal: |
Traffic |
Title: |
Peroxisome fission in Hansenula polymorpha requires Mdv1 and Fis1, two proteins also involved in mitochondrial fission. |
Volume: |
9 |
Issue: |
9 |
Pages: |
1471-84 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents mitochondrial division protein 1 (Mdv1), which is a component of the mitochondrial fission machinery in Saccharomyces cerevisiae. The protein is also involved in peroxisome proliferation []. Mdv1 along with Fis1 is also involved in controlling Dnm-1 dependent devision, a GTPase involved in the mediation of mitochondrial division. In this role, Mdv1 is the linker between Fis1 and Dnm1. Mdv1 plays a key role in the regulation of Dnm1 self-assembly [].Mdv1 has a partially redundant function to CAF4 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division [, ]. Mdv1 interacts with CAF4, DNM1 and FIS1, components of the mitochondrial fission machinery. It interacts via its N-terminal, coiled-coil extension (NTE) with FIS1, and via its WD repeats with DNM1. Mdv1 is uniformly distributed on the cytoplasmic face of the mitochondrial outer membrane. This localisation is dependent on FIS1. It reorganises to punctate structures on mitochondria, corresponding to mitochondrial constriction sites, at a late step in mitochondrial division. This relocalisation is dependent on DNM1. |
|
•
•
•
•
•
|
Publication |
First Author: |
Koirala S |
Year: |
2010 |
Journal: |
J Cell Biol |
Title: |
Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes. |
Volume: |
191 |
Issue: |
6 |
Pages: |
1127-39 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
152
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
102
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
145
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Mozdy AD |
Year: |
2000 |
Journal: |
J Cell Biol |
Title: |
Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. |
Volume: |
151 |
Issue: |
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367-80 |
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