Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
296
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
134
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
209
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
100
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Grasberger H |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent. |
Volume: |
281 |
Issue: |
27 |
Pages: |
18269-72 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N terminus (type III) and two N-glycosylation sites []. It is conserved from nematodes to humans. |
|
•
•
•
•
•
|
Publication |
First Author: |
Chandra V |
Year: |
2024 |
Journal: |
Cancer Cell |
Title: |
Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation. |
Volume: |
42 |
Issue: |
1 |
Pages: |
85-100.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pircalabioru G |
Year: |
2016 |
Journal: |
Cell Host Microbe |
Title: |
Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection. |
Volume: |
19 |
Issue: |
5 |
Pages: |
651-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ha EM |
Year: |
2005 |
Journal: |
Science |
Title: |
A direct role for dual oxidase in Drosophila gut immunity. |
Volume: |
310 |
Issue: |
5749 |
Pages: |
847-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grasberger H |
Year: |
2012 |
Journal: |
Mol Endocrinol |
Title: |
Mice deficient in dual oxidase maturation factors are severely hypothyroid. |
Volume: |
26 |
Issue: |
3 |
Pages: |
481-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cagle L |
Year: |
2021 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Role of Dual Oxidases in Ventilator-induced Lung Injury. |
Volume: |
64 |
Issue: |
2 |
Pages: |
208-215 |
|
•
•
•
•
•
|
Publication |
First Author: |
Afink GB |
Year: |
2010 |
Journal: |
Thyroid |
Title: |
Initial characterization of C16orf89, a novel thyroid-specific gene. |
Volume: |
20 |
Issue: |
7 |
Pages: |
811-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Esworthy RS |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e44262 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim BW |
Year: |
2012 |
Journal: |
Free Radic Biol Med |
Title: |
Expression of lactoperoxidase in differentiated mouse colon epithelial cells. |
Volume: |
52 |
Issue: |
9 |
Pages: |
1569-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grasberger H |
Year: |
2013 |
Journal: |
Gastroenterology |
Title: |
Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice. |
Volume: |
145 |
Issue: |
5 |
Pages: |
1045-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cagle LA |
Year: |
2022 |
Journal: |
Front Physiol |
Title: |
Early mechanisms of neutrophil activation and transmigration in acute lung injury. |
Volume: |
13 |
|
Pages: |
1059686 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1058
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1551
 |
Fragment?: |
false |
|
•
•
•
•
•
|