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Search results 201 to 294 out of 294 for Ect2

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Type Details Score
Allele
Ect2<tm1Arte> | MGI:3763212
Name: ect2 oncogene; targeted mutation 1, TaconicArtemis
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Ect2<Gt(BGC485)Byg> | MGI:3868111
 
Name: ect2 oncogene; gene trap BGC485, BayGenomics
Allele Type: Gene trapped
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Allele
Ect2<Gt(YHD305)Byg> | MGI:3878106
 
Name: ect2 oncogene; gene trap YHD305, BayGenomics
Allele Type: Gene trapped
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Allele
Ect2<Gt(RRF146)Byg> | MGI:4127862
 
Name: ect2 oncogene; gene trap RRF146, BayGenomics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST36820)Lex> | MGI:4154750
 
Name: ect2 oncogene; gene trap OST36820, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST147039)Lex> | MGI:4204776
 
Name: ect2 oncogene; gene trap OST147039, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST196996)Lex> | MGI:4226973
 
Name: ect2 oncogene; gene trap OST196996, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST271161)Lex> | MGI:4258531
 
Name: ect2 oncogene; gene trap OST271161, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST309296)Lex> | MGI:4274406
 
Name: ect2 oncogene; gene trap OST309296, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST315160)Lex> | MGI:4277020
 
Name: ect2 oncogene; gene trap OST315160, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST316908)Lex> | MGI:4277820
 
Name: ect2 oncogene; gene trap OST316908, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST323198)Lex> | MGI:4280370
 
Name: ect2 oncogene; gene trap OST323198, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST325661)Lex> | MGI:4281174
 
Name: ect2 oncogene; gene trap OST325661, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST340794)Lex> | MGI:4286707
 
Name: ect2 oncogene; gene trap OST340794, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST377951)Lex> | MGI:4299775
 
Name: ect2 oncogene; gene trap OST377951, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST423176)Lex> | MGI:4312192
 
Name: ect2 oncogene; gene trap OST423176, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST431456)Lex> | MGI:4314857
 
Name: ect2 oncogene; gene trap OST431456, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(OST472524)Lex> | MGI:4328602
 
Name: ect2 oncogene; gene trap OST472524, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ect2<Gt(RRP143)Byg> | MGI:4329227
 
Name: ect2 oncogene; gene trap RRP143, BayGenomics
Allele Type: Gene trapped
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Allele
Ect2<Gt(RRO063)Byg> | MGI:4329441
 
Name: ect2 oncogene; gene trap RRO063, BayGenomics
Allele Type: Gene trapped
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Allele
Ect2<Gt(RRY208)Byg> | MGI:4350041
 
Name: ect2 oncogene; gene trap RRY208, BayGenomics
Allele Type: Gene trapped
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Allele
Ect2<tm1(KOMP)Vlcg> | MGI:5312390
Name: ect2 oncogene; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Ect2<Gt(AL0495)Wtsi> | MGI:3864051
 
Name: ect2 oncogene; gene trap AL0495, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Ect2<Gt(P141E08)Wrst> | MGI:3872705
 
Name: ect2 oncogene; gene trap P141E08, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Ect2<Gt(P133B09)Wrst> | MGI:3872935
 
Name: ect2 oncogene; gene trap P133B09, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Ect2<Gt(D026C04)Wrst> | MGI:3881304
 
Name: ect2 oncogene; gene trap D026C04, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Ect2<Gt(P133G02)Wrst> | MGI:3898012
 
Name: ect2 oncogene; gene trap P133G02, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Ect2<Gt(E146F04)Wrst> | MGI:3915839
 
Name: ect2 oncogene; gene trap E146F04, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Ect2<Gt(AS0138)Wtsi> | MGI:4346685
 
Name: ect2 oncogene; gene trap AS0138, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Ect2<tm1e(EUCOMM)Wtsi> | MGI:4432660
Name: ect2 oncogene; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Ect2<tm1a(EUCOMM)Wtsi> | MGI:4433090
Name: ect2 oncogene; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Ect2<tm1.1Cjd> | MGI:5433508
Name: ect2 oncogene; targeted mutation 1.1, Channing J Der
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Ect2<tm1.2Cjd> | MGI:5433509
Name: ect2 oncogene; targeted mutation 1.2, Channing J Der
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ect2<tm1b(EUCOMM)Wtsi> | MGI:5548931
Name: ect2 oncogene; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Ect2<tm1c(EUCOMM)Wtsi> | MGI:6416160
Name: ect2 oncogene; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Ect2<em17Gpt> | MGI:7298345
Name: ect2 oncogene; endonuclease-mediated mutation 17, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Ect2<em1Gpt> | MGI:7298346
Name: ect2 oncogene; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Ect2/Ect2
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
21373644 | -
First Author: Srougi MC
Year: 2011
Journal: PLoS One
Title: The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage.
Volume: 6
Issue: 2
Pages: e17108
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Allele
Ect2<Gt(GC0034)Mist> | MGI:3853614
 
Name: ect2 oncogene; gene trap GC0034, Telethon Institute of Genetics and Medicine
Allele Type: Gene trapped
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Allele
Ect2<Gt(GC0542)Mist> | MGI:3854194
 
Name: ect2 oncogene; gene trap GC0542, Telethon Institute of Genetics and Medicine
Allele Type: Gene trapped
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Strain
MGI:5557047 | C57BL/6NTac-Ect2<tm1a(EUCOMM)Wtsi>/Ics
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6122583 | C57BL/6NTac-Ect2<tm1a(EUCOMM)Wtsi>/IcsOrl
Attribute String: mutant strain, coisogenic, targeted mutation
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Allele
Ect2<Gt(IST13331A5)Tigm> | MGI:5159735
 
Name: ect2 oncogene; gene trap IST13331A5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ect2<Gt(IST13294E5)Tigm> | MGI:5161854
 
Name: ect2 oncogene; gene trap IST13294E5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ect2<Gt(IST13455B5)Tigm> | MGI:5172882
 
Name: ect2 oncogene; gene trap IST13455B5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ect2<Gt(IST13716C10)Tigm> | MGI:5192077
 
Name: ect2 oncogene; gene trap IST13716C10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ect2<Gt(IST13937B9)Tigm> | MGI:5194436
 
Name: ect2 oncogene; gene trap IST13937B9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ect2<Gt(IST14387H9)Tigm> | MGI:5229243
 
Name: ect2 oncogene; gene trap IST14387H9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ect2<Gt(IST15006E3)Tigm> | MGI:5280259
 
Name: ect2 oncogene; gene trap IST15006E3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:5433694 | C57BL/6-Ect2<tm1.1Cjd>
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:5433695 | C57BL/6-Ect2<tm1.2Cjd>
Attribute String: targeted mutation, mutant strain, coisogenic
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Strain
MGI:5630156 | C57BL/6N-Ect2<tm1b(EUCOMM)Wtsi>/Ics
Attribute String: coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Ect2/Ect2
Background: C57BL/6-Ect2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ect2/Ect2
Background: C57BL/6N-Ect2/Ics
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ect2/Ect2<+>
Background: C57BL/6N-Ect2/Ics
Zygosity: ht
Has Mutant Allele: true
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Publication
28196591 | J:239673
First Author: Baker MJ
Year: 2017
Journal: Cancer Cell
Title: Nuclear PKCι-ECT2-Rac1 and Ribosome Biogenesis: A Novel Axis in Lung Tumorigenesis.
Volume: 31
Issue: 2
Pages: 167-169
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Protein Domain
IPR032921 | PRC1
Type: Family
Description: PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone []. It is a key regulator of cytokinesis that cross-links antiparallel microtubules at an average distance of 35 nM [, ]. PRC1 is also required for KIF14 (a kinesin-3 family motor protein) localisation to the central spindle and midbody [, , ]and is required to recruit PLK1 to the spindle. It stimulates PLK1 phosphorylation of RACGAP1/HsCyk-4 to allow recruitment of ECT2 to the central spindle [].
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Publication
8134109 | J:29568
First Author: Chan AM
Year: 1994
Journal: Oncogene
Title: Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins.
Volume: 9
Issue: 4
Pages: 1057-63
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Publication
34841254 | J:303212
First Author: Limzerwala JF
Year: 2020
Journal: Nat Cancer
Title: FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer.
Volume: 1
Issue: 10
Pages: 1010-1024
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Protein
Q99K43
Organism: Mus musculus/domesticus
Length: 603  
Fragment?: false
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Protein
G3UXB1
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
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Protein
G3UW86
Organism: Mus musculus/domesticus
Length: 606  
Fragment?: false
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Protein
G3XA79
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
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Protein
G3UY19
Organism: Mus musculus/domesticus
Length: 566  
Fragment?: false
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Protein
Q91ZQ9
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: true
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Protein
G3UXT4
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
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Protein
G3UYX6
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: true
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Protein
G3UWQ7
Organism: Mus musculus/domesticus
Length: 620  
Fragment?: false
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Publication
9885575 | -
First Author: Jiang W
Year: 1998
Journal: Mol Cell
Title: PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis.
Volume: 2
Issue: 6
Pages: 877-85
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Publication
12082078 | -
First Author: Mollinari C
Year: 2002
Journal: J Cell Biol
Title: PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone.
Volume: 157
Issue: 7
Pages: 1175-86
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Publication
15297875 | -
First Author: Kurasawa Y
Year: 2004
Journal: EMBO J
Title: Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.
Volume: 23
Issue: 16
Pages: 3237-48
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Publication
15625105 | -
First Author: Zhu C
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis.
Volume: 102
Issue: 2
Pages: 343-8
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Publication
16431929 | -
First Author: Gruneberg U
Year: 2006
Journal: J Cell Biol
Title: KIF14 and citron kinase act together to promote efficient cytokinesis.
Volume: 172
Issue: 3
Pages: 363-72
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Publication
20691902 | -
First Author: Subramanian R
Year: 2010
Journal: Cell
Title: Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein.
Volume: 142
Issue: 3
Pages: 433-43
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Publication
19468300 | -
First Author: Wolfe BA
Year: 2009
Journal: PLoS Biol
Title: Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.
Volume: 7
Issue: 5
Pages: e1000110
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Publication
12591913 | -
First Author: Schuyler SC
Year: 2003
Journal: J Cell Biol
Title: The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins.
Volume: 160
Issue: 4
Pages: 517-28
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Publication
16014384 | -
First Author: Chang HY
Year: 2005
Journal: J Cell Sci
Title: Dynamic interaction of NtMAP65-1a with microtubules in vivo.
Volume: 118
Issue: Pt 14
Pages: 3195-201
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Publication
15908607 | -
First Author: Mao T
Year: 2005
Journal: Plant Physiol
Title: Two microtubule-associated proteins of the Arabidopsis MAP65 family function differently on microtubules.
Volume: 138
Issue: 2
Pages: 654-62
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Publication
16098102 | -
First Author: Mao G
Year: 2005
Journal: Plant J
Title: Modulated targeting of GFP-AtMAP65-1 to central spindle microtubules during division.
Volume: 43
Issue: 4
Pages: 469-78
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Publication
17011227 | -
First Author: Sasabe M
Year: 2006
Journal: Curr Opin Plant Biol
Title: MAP65: a bridge linking a MAP kinase to microtubule turnover.
Volume: 9
Issue: 6
Pages: 563-70
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Publication
16847052 | -
First Author: Smertenko AP
Year: 2006
Journal: J Cell Sci
Title: Control of the AtMAP65-1 interaction with microtubules through the cell cycle.
Volume: 119
Issue: Pt 15
Pages: 3227-37
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Protein Domain
IPR007145 | MAP65_Ase1_PRC1
Type: Family
Description: This is a family of microtubule associated proteins, including MAP65 (MAP65-1/2/3/4/5/6/7/8/9) from Arabidopsis, Ase1 from yeast, and PRC1 from mammals.Ase1 is required for spindle elongation and stabilisation. It is cell cycle-regulated by anaphase promoting complex []. It is a potential Cdc28p substrate []. MAP65-1 plays a role in stabilising anti-parallel microtubules in the central spindle at anaphase to early cytokinesis. MAP65-1 is cell cycle regulated by phosphorylation [, , , , ].PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone []. It is a key regulator of cytokinesis that cross-links antiparallel microtubules at an average distance of 35 nM [, ]. PRC1 is also required for KIF14 (a kinesin-3 family motor protein) localisation to the central spindle and midbody [, , ]and is required to recruit PLK1 to the spindle. It stimulates PLK1 phosphorylation of RACGAP1/HsCyk-4 to allow recruitment of ECT2 to the central spindle [].
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Publication
19129481 | J:175145
First Author: Asiedu M
Year: 2009
Journal: Mol Biol Cell
Title: Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle.
Volume: 20
Issue: 5
Pages: 1428-40
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Publication
20348415 | J:159310
First Author: Rosario CO
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Plk4 is required for cytokinesis and maintenance of chromosomal stability.
Volume: 107
Issue: 15
Pages: 6888-93
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Publication
19816943 | J:239201
First Author: Mallakin A
Year: 2010
Journal: Int J Cancer
Title: The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1.
Volume: 126
Issue: 6
Pages: 1403-16
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Publication
16905559 | J:115019
First Author: Reiter LT
Year: 2006
Journal: Hum Mol Genet
Title: Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase.
Volume: 15
Issue: 18
Pages: 2825-35
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Publication
30726115 | J:273791
First Author: Huff LP
Year: 2019
Journal: Am J Physiol Cell Physiol
Title: Polymerase-δ-interacting protein 2 activates the RhoGEF epithelial cell transforming sequence 2 in vascular smooth muscle cells.
Volume: 316
Issue: 5
Pages: C621-C631
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Publication
27231202 | J:234844
First Author: Mansour M
Year: 2016
Journal: Cancer Res
Title: The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.
Volume: 76
Issue: 14
Pages: 4236-48
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Publication
33501895 | J:305889
First Author: Li C
Year: 2021
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Epithelial cell transforming 2 is regulated by Yes-associated protein 1 and mediates pancreatic cancer progression and metastasis.
Volume: 320
Issue: 3
Pages: G380-G395
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Publication
14574415 | -
First Author: Ubersax JA
Year: 2003
Journal: Nature
Title: Targets of the cyclin-dependent kinase Cdk1.
Volume: 425
Issue: 6960
Pages: 859-64
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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