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Search results 201 to 300 out of 305 for Ehmt1

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Type Details Score
Publication
23112189 | J:191733
First Author: Chaturvedi CP
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A.
Volume: 109
Issue: 46
Pages: 18845-50
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Publication
20005824 | J:155739
First Author: Schaefer A
Year: 2009
Journal: Neuron
Title: Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex.
Volume: 64
Issue: 5
Pages: 678-91
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Publication
22430489 | J:183875
First Author: Yoo SA
Year: 2012
Journal: J Exp Med
Title: A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis.
Volume: 209
Issue: 4
Pages: 871-86
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Publication
27281218 | J:233954
First Author: Tu S
Year: 2016
Journal: Nature
Title: Co-repressor CBFA2T2 regulates pluripotency and germline development.
Volume: 534
Issue: 7607
Pages: 387-90
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Publication
19010785 | J:159133
First Author: Shirato H
Year: 2009
Journal: J Biol Chem
Title: A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9.
Volume: 284
Issue: 2
Pages: 733-9
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Publication
29745895 | J:317372
   
First Author: Zylicz JJ
Year: 2018
Journal: Elife
Title: G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst.
Volume: 7
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Publication
23284137 | J:194500
First Author: Deguchi K
Year: 2013
Journal: Biol Reprod
Title: Posttranscriptional regulation of histone lysine methyltransferase GLP in embryonic male mouse germ cells.
Volume: 88
Issue: 2
Pages: 36
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Publication
26952936 | J:251477
First Author: Han P
Year: 2016
Journal: Biochim Biophys Acta
Title: Epigenetic response to environmental stress: Assembly of BRG1-G9a/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts.
Volume: 1863
Issue: 7 Pt B
Pages: 1772-81
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Publication
24735877 | J:213416
First Author: Dan J
Year: 2014
Journal: Dev Cell
Title: Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing.
Volume: 29
Issue: 1
Pages: 7-19
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Publication
18622394 | J:138571
First Author: Yamaji M
Year: 2008
Journal: Nat Genet
Title: Critical function of Prdm14 for the establishment of the germ cell lineage in mice.
Volume: 40
Issue: 8
Pages: 1016-22
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Publication
26551560 | J:228073
   
First Author: Zylicz JJ
Year: 2015
Journal: Elife
Title: Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development.
Volume: 4
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Publication
19144645 | J:148615
First Author: Trojer P
Year: 2009
Journal: J Biol Chem
Title: Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.
Volume: 284
Issue: 13
Pages: 8395-405
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Publication
25437545 | J:321687
First Author: Lyons DB
Year: 2014
Journal: Cell Rep
Title: Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons.
Volume: 9
Issue: 3
Pages: 884-92
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Publication
29146735 | J:259618
First Author: Hatazawa Y
Year: 2018
Journal: FASEB J
Title: Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration.
Volume: 32
Issue: 3
Pages: 1452-1467
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Publication
21402781 | J:173973
First Author: Benlhabib H
Year: 2011
Journal: Mol Cell Biol
Title: Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia.
Volume: 31
Issue: 10
Pages: 1949-58
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Publication
23333759 | J:194983
First Author: Ideno H
Year: 2013
Journal: Gene Expr Patterns
Title: Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development.
Volume: 13
Issue: 3-4
Pages: 84-90
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Publication
23748610 | J:201469
First Author: Sridharan R
Year: 2013
Journal: Nat Cell Biol
Title: Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency.
Volume: 15
Issue: 7
Pages: 872-82
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Publication
28949961 | J:246359
First Author: Kuroki S
Year: 2017
Journal: PLoS Genet
Title: Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance.
Volume: 13
Issue: 9
Pages: e1007034
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Publication
17599069 | J:123269
First Author: Tachibana M
Year: 2007
Journal: EMBO J
Title: Functional dynamics of H3K9 methylation during meiotic prophase progression.
Volume: 26
Issue: 14
Pages: 3346-59
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Publication
23892084 | J:204470
First Author: Inagawa M
Year: 2013
Journal: Mech Dev
Title: Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.
Volume: 130
Issue: 11-12
Pages: 519-31
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Publication
24009519 | J:223048
First Author: Pirouz M
Year: 2013
Journal: PLoS Genet
Title: A critical function of Mad2l2 in primordial germ cell development of mice.
Volume: 9
Issue: 8
Pages: e1003712
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Publication
36551904 | J:342743
 
First Author: Meziane H
Year: 2022
Journal: Biomedicines
Title: Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.
Volume: 10
Issue: 12
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Publication
24553289 | J:208416
First Author: Holt JE
Year: 2014
Journal: Development
Title: The APC/C activator FZR1 is essential for meiotic prophase I in mice.
Volume: 141
Issue: 6
Pages: 1354-65
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Publication
28963472 | J:255491
First Author: Matsuura T
Year: 2017
Journal: Sci Rep
Title: Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.
Volume: 7
Issue: 1
Pages: 12462
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Publication
34150743 | J:308697
 
First Author: Bukova I
Year: 2021
Journal: Front Cell Dev Biol
Title: Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate.
Volume: 9
Pages: 620692
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Publication
17392792 | J:121427
First Author: Wang J
Year: 2007
Journal: Nature
Title: Opposing LSD1 complexes function in developmental gene activation and repression programmes.
Volume: 446
Issue: 7138
Pages: 882-7
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Publication
34368113 | J:313616
 
First Author: Zhang F
Year: 2021
Journal: Front Cell Dev Biol
Title: Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.
Volume: 9
Pages: 642931
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Publication
18022353 | J:126799
First Author: Allis CD
Year: 2007
Journal: Cell
Title: New nomenclature for chromatin-modifying enzymes.
Volume: 131
Issue: 4
Pages: 633-6
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Publication
- | J:175597
     
First Author: Overbeek PA
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission for Overbeek Lentiviral Transgenic Lines
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Publication
35084365 | J:326026
First Author: Prokopuk L
Year: 2022
Journal: Reproduction
Title: An essential role for Polycomb Repressive Complex 2 in the mouse ovary.
Volume: 163
Issue: 3
Pages: 167-182
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Publication
29688375 | J:250512
   
First Author: Li J
Year: 2018
Journal: Database (Oxford)
Title: CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.
Volume: 2018
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Publication
30186101 | J:266522
 
First Author: Elsen GE
Year: 2018
Journal: Front Neurosci
Title: The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.
Volume: 12
Pages: 571
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 2
Description: Histone-lysine N-methyltransferase EHMT1
Type: chain
End: 1296
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UniProt Feature
UniProt Feature
Begin: 186
Description: N6-methyllysine; by EHMT1 and EHMT2
Type: modified residue
End: 186
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Protein
Q5DW34-3
Organism: Mus musculus/domesticus
Length: 1248  
Fragment?: false
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Protein
Q5DW34-2
Organism: Mus musculus/domesticus
Length: 1243  
Fragment?: false
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Protein
A0A0A6YXA8
Organism: Mus musculus/domesticus
Length: 24  
Fragment?: true
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Protein
A0A0G2JEQ4
Organism: Mus musculus/domesticus
Length: 45  
Fragment?: false
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UniProt Feature
UniProt Feature
Begin: 370
Description: N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate
Type: modified residue
End: 370
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Allele
Ehmt1<tm1Smoc> | MGI:7289460
Name: euchromatic histone methyltransferase 1; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:6354758 | C57BL/6JSmoc-Ehmt1<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Allele
Ehmt1<tm1Yshk> | MGI:3575505
Name: euchromatic histone methyltransferase 1; targeted mutation 1, Yoichi Shinkai
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ehmt1<tm1.1Tara> | MGI:4418563
Name: euchromatic histone methyltransferase 1; targeted mutation 1.1, Alexander Tarakhovsky
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Protein Domain
IPR043550 | EHMT1/EHMT2
Type: Family
Description: Histone-lysine N-methyltransferase EHMT1, () mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin []. H3K9me is a specific tag for repression of epigenetic transcription, recruiting HP1 proteins to methylated histones. EHMT1 also methylates 'Lys-27' of histone H3 (H3K27me), but weakly []. EHMT1 also dimethylates other proteins, including 'Lys-373' of p53 []. EHMT1 forms a heterodimer with EHMT2 [], and is a component of the E2F6.com-1 complex in G0 phase []. EHMT1 contains eight ankyrin repeats which bind the monomethylated RELA subunit of NF-kappa-B, a SET domain which interacts with WIZ [], and a pre-SET domain that binds three zinc ions via cysteine residues [].
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Genotype
Genotype
Symbol: Ehmt1/Ehmt1 Tg(Camk2a-cre)2Gsc/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ehmt1/Ehmt1<+>
Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0060352 | Kleefstra syndrome 1
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HT Experiment
E-MTAB-1704 | RNA-seq of coding RNA of brown adipose tissue from Ehmt1flox/flox control mice, Ehmt1Myf5 Knockout mice and Ehmt1adipo knockout mice to study the role of euchromatic histone-lysine N-methyltransferase 1 (EHMT1)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE89010 | Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
G3UYH7
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: true
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Protein
H3BIW5
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
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Protein
A2CG77
Organism: Mus musculus/domesticus
Length: 441  
Fragment?: true
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HT Experiment
GSE171206 | Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
22387026 | J:184478
First Author: Yu Y
Year: 2012
Journal: Mol Cell
Title: Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA.
Volume: 46
Issue: 1
Pages: 7-17
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Publication
18438403 | -
First Author: Rathert P
Year: 2008
Journal: Nat Chem Biol
Title: Protein lysine methyltransferase G9a acts on non-histone targets.
Volume: 4
Issue: 6
Pages: 344-6
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Protein Domain
IPR038034 | EHMT2
Type: Family
Description: Histone-lysine N-methyltransferase EHMT2 () mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin []. H3K9me is a specific tag for repression of epigenetic transcription, recruiting HP1 proteins to methylated histones. EHMT2 also monomethylates 'Lys-56' of histone H3 (H3K56me1) during the G1 phase of the cell cycle [], and methylates 'Lys-27' of histone H3 (H3K27me) []. EHMT2 also dimethylates other proteins [], including 'Lys-373' of p53 []. EHMT2 forms a heterdimer with EHMT1 [], and is a component of the E2F6.com-1 complex in G0 phase []. EHMT2 contains seven ankyrin repeats which bind the monomethylated RELA subunit of NF-kappa-B, a SET domain which interacts with WIZ [], and a pre-SET domain that binds three zinc ions via cysteine residues [].
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Publication
22496781 | J:355894
First Author: Anderson AM
Year: 2012
Journal: PLoS One
Title: Coexpression of nuclear receptors and histone methylation modifying genes in the testis: implications for endocrine disruptor modes of action.
Volume: 7
Issue: 4
Pages: e34158
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Protein
Q9Z148
Organism: Mus musculus/domesticus
Length: 1263  
Fragment?: false
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