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Search results 201 to 293 out of 293 for Eif2ak2

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Type Details Score
Publication
27698114 | J:238493
First Author: Khoutorsky A
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: eIF2α phosphorylation controls thermal nociception.
Volume: 113
Issue: 42
Pages: 11949-11954
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Publication
12444163 | J:119320
First Author: Stockinger S
Year: 2002
Journal: J Immunol
Title: Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes.
Volume: 169
Issue: 11
Pages: 6522-9
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Publication
23990781 | J:214498
First Author: Ogolla PS
Year: 2013
Journal: PLoS Pathog
Title: The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen.
Volume: 9
Issue: 8
Pages: e1003557
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Publication
17190817 | J:118750
First Author: Akazawa T
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells.
Volume: 104
Issue: 1
Pages: 252-7
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Publication
34343497 | J:308678
     
First Author: Maurano M
Year: 2021
Journal: Immunity
Title: Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1.
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Publication
39047044 | J:354285
First Author: Zhong X
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.
Volume: 121
Issue: 31
Pages: e2409232121
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Publication
21385877 | J:171119
First Author: Peña J
Year: 2011
Journal: J Biol Chem
Title: Dengue virus modulates the unfolded protein response in a time-dependent manner.
Volume: 286
Issue: 16
Pages: 14226-36
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Publication
14729979 | J:124910
First Author: Jiang HY
Year: 2004
Journal: Mol Cell Biol
Title: Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.
Volume: 24
Issue: 3
Pages: 1365-77
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Publication
28158275 | J:291588
First Author: Kindler E
Year: 2017
Journal: PLoS Pathog
Title: Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication.
Volume: 13
Issue: 2
Pages: e1006195
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Publication
38427731 | J:347912
First Author: Luca D
Year: 2024
Journal: Sci Adv
Title: Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity.
Volume: 10
Issue: 9
Pages: eadk0820
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Publication
7519779 | J:19621
First Author: Ito T
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase.
Volume: 91
Issue: 16
Pages: 7455-9
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Publication
7736780 | J:25280
First Author: Mathew P
Year: 1995
Journal: Cytogenet Cell Genet
Title: Localization of the murine homolog of the anaplastic lymphoma kinase (AlK) gene on mouse chromosome 17.
Volume: 70
Issue: 1-2
Pages: 143-4
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9823302 | J:50945
First Author: Schmutte C
Year: 1998
Journal: Cancer Res
Title: Refined chromosomal localization of the mismatch repair and hereditary nonpolyposis colorectal cancer genes hMSH2 and hMSH6.
Volume: 58
Issue: 22
Pages: 5023-6
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Publication
19230833 | J:150390
First Author: Yoshida K
Year: 2009
Journal: Exp Cell Res
Title: PKR-mediated degradation of STAT1 regulates osteoblast differentiation.
Volume: 315
Issue: 12
Pages: 2105-14
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Publication
20924113 | J:165561
First Author: Papadakis AI
Year: 2010
Journal: Cancer Res
Title: eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}.
Volume: 70
Issue: 20
Pages: 7820-9
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Publication
28100675 | J:240737
First Author: Dalet A
Year: 2017
Journal: EMBO J
Title: Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.
Volume: 36
Issue: 6
Pages: 761-782
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Publication
15029200 | J:278692
First Author: Hsu LC
Year: 2004
Journal: Nature
Title: The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.
Volume: 428
Issue: 6980
Pages: 341-5
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Publication
33361822 | J:305864
First Author: Kalish BT
Year: 2021
Journal: Nat Neurosci
Title: Maternal immune activation in mice disrupts proteostasis in the fetal brain.
Volume: 24
Issue: 2
Pages: 204-213
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7720577 | J:23775
First Author: Oliver G
Year: 1995
Journal: Development
Title: Homeobox genes and connective tissue patterning.
Volume: 121
Issue: 3
Pages: 693-705
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23903655 | J:205017
First Author: Dorner M
Year: 2013
Journal: Nature
Title: Completion of the entire hepatitis C virus life cycle in genetically humanized mice.
Volume: 501
Issue: 7466
Pages: 237-41
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9151674 | J:40187
First Author: Miner JH
Year: 1997
Journal: J Cell Biol
Title: The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.
Volume: 137
Issue: 3
Pages: 685-701
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18268032 | J:133523
First Author: Zwaferink H
Year: 2008
Journal: Infect Immun
Title: Stimulation of inducible nitric oxide synthase expression by beta interferon increases necrotic death of macrophages upon Listeria monocytogenes infection.
Volume: 76
Issue: 4
Pages: 1649-56
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Publication
22541070 | J:186198
First Author: Tarallo V
Year: 2012
Journal: Cell
Title: DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
Volume: 149
Issue: 4
Pages: 847-59
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Publication
25456137 | J:265968
First Author: Mannion NM
Year: 2014
Journal: Cell Rep
Title: The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.
Volume: 9
Issue: 4
Pages: 1482-94
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Publication
21266579 | J:170947
First Author: Watanabe A
Year: 2011
Journal: J Biol Chem
Title: Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
Volume: 286
Issue: 12
Pages: 10702-11
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39328932 | J:354587
First Author: Nedomova M
Year: 2024
Journal: iScience
Title: DDI2 protease controls embryonic development and inflammation via TCF11/NRF1.
Volume: 27
Issue: 10
Pages: 110893
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Publication
25131634 | J:238190
First Author: Alldred MJ
Year: 2015
Journal: J Comp Neurol
Title: Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.
Volume: 523
Issue: 1
Pages: 61-74
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Publication
27480124 | J:237787
First Author: Liu X
Year: 2016
Journal: BMC Immunol
Title: Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Volume: 17
Issue: 1
Pages: 25
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Publication
16033648 | J:103446
 
First Author: McKee AE
Year: 2005
Journal: BMC Dev Biol
Title: A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
Volume: 5
Pages: 14
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Gene
311130 | Prkra
Type: gene
Organism: rat
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Gene
488423 | PRKRA
Type: gene
Organism: dog, domestic
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Gene
459776 | PRKRA
Type: gene
Organism: chimpanzee
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Gene
282875 | PRKRA
Type: gene
Organism: cattle
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Gene
703063 | PRKRA
Type: gene
Organism: macaque, rhesus
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Gene
100379994 | prkra
Type: gene
Organism: frog, western clawed
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Gene
379187 | prkra.L
Type: gene
Organism: frog, African clawed
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GO Term
GO:0039585 | PKR/eIFalpha signaling
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GO Term
GO:0039580 | symbiont-mediated suppression of host PKR/eIFalpha signaling
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Protein
Q03963
Organism: Mus musculus/domesticus
Length: 515  
Fragment?: false
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DO Term
DOID:0060940 | dystonia 33
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DO Term
DOID:0090048 | dystonia 16
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Protein Domain
IPR044452 | EIF2AK2_DSRM_1
Type: Domain
Description: Eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2), also known as PKR, is an IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection [, , , ]. It is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation [, ]. EIF2AK2 proteins contain two to three double-stranded RNA binding motifs (DSRMs).This entry represents the first DSRM of EIF2AK2.
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Protein Domain
IPR044453 | EIF2AK2_DSRM_2
Type: Domain
Description: Eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2), also known as PKR, is an IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection [, , , ]. It is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation [, ]. EIF2AK2 proteins contain two to three double-stranded RNA binding motifs (DSRMs).This entry represents the second DSRM of EIF2AK2.
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Publication
19229320 | -
First Author: Sadler AJ
Year: 2009
Journal: PLoS Pathog
Title: An antiviral response directed by PKR phosphorylation of the RNA helicase A.
Volume: 5
Issue: 2
Pages: e1000311
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Publication
22214662 | -
First Author: Bennett RL
Year: 2012
Journal: Cell Cycle
Title: The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G₁ arrest.
Volume: 11
Issue: 2
Pages: 407-17
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Publication
19189853 | -
First Author: Kang JI
Year: 2009
Journal: Virus Res
Title: PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control.
Volume: 142
Issue: 1-2
Pages: 51-6
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Publication
18835251 | -
First Author: Cardin E
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Nck-1 interacts with PKR and modulates its activation by dsRNA.
Volume: 377
Issue: 1
Pages: 231-5
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Publication
19507191 | -
First Author: Blalock WL
Year: 2009
Journal: J Cell Physiol
Title: PKR activity is required for acute leukemic cell maintenance and growth: a role for PKR-mediated phosphatase activity to regulate GSK-3 phosphorylation.
Volume: 221
Issue: 1
Pages: 232-41
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Publication
11836380 | -
First Author: Cassady KA
Year: 2002
Journal: J Virol
Title: The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain.
Volume: 76
Issue: 5
Pages: 2029-35
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Publication
35222374 | J:321607
 
First Author: Bühler M
Year: 2022
Journal: Front Immunol
Title: IFN-β Deficiency Results in Fatal or Demyelinating Disease in C57BL/6 Mice Infected With Theiler's Murine Encephalomyelitis Viruses.
Volume: 13
Pages: 786940
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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