Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang Y |
Year: |
2015 |
Journal: |
Nucleic Acids Res |
Title: |
FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. |
Volume: |
43 |
Issue: |
17 |
Pages: |
8325-39 |
|
•
•
•
•
•
|
Allele |
Name: |
Fancd2 opposite strand; targeted mutation 1, Velocigene |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Allele |
Name: |
Fancd2 opposite strand; targeted mutation 2a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
Fancd2 opposite strand; targeted mutation 2e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi Y |
Year: |
1999 |
Journal: |
J Exp Med |
Title: |
Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. |
Volume: |
190 |
Issue: |
3 |
Pages: |
399-410 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato K |
Year: |
2012 |
Journal: |
Nucleic Acids Res |
Title: |
DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI. |
Volume: |
40 |
Issue: |
10 |
Pages: |
4553-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson JB |
Year: |
2008 |
Journal: |
Oncogene |
Title: |
FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. |
Volume: |
27 |
Issue: |
26 |
Pages: |
3641-52 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
Fancd2 opposite strand; gene trap IST13579D2, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
Fancd2 opposite strand; gene trap IST14023H12, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
mTOR regulates DNA damage response through NF-B-mediated FANCD2 pathway in hematopoietic cells. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Fancd2 is required for nuclear retention of Foxo3a in hematopoietic stem cell maintenance. |
|
•
•
•
•
•
|
Publication |
First Author: |
Yuan F |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures. |
Volume: |
284 |
Issue: |
36 |
Pages: |
24443-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seki S |
Year: |
2007 |
Journal: |
Genes Cells |
Title: |
A requirement of FancL and FancD2 monoubiquitination in DNA repair. |
Volume: |
12 |
Issue: |
3 |
Pages: |
299-310 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marek LR |
Year: |
2006 |
Journal: |
DNA Repair (Amst) |
Title: |
Drosophila homologs of FANCD2 and FANCL function in DNA repair. |
Volume: |
5 |
Issue: |
11 |
Pages: |
1317-26 |
|
•
•
•
•
•
|
Allele |
Name: |
Fanconi anemia, complementation group D2; targeted mutation 1, Scott Houghtaling |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
Fanconi anemia, complementation group D2; endonuclease-mediated mutation 1, Tingting Zhang |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage. |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Fancd2/Fancd2 |
Background: |
B6.129S4-Fancd2 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Fancd2/Fancd2 |
Background: |
129S4/SvJae-Fancd2 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Fancd2/Fancd2 |
Background: |
involves: 129S4/SvJae * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Fancd2/Fancd2 Usp1/Usp1 |
Background: |
involves: 129S5/SvEvBrd * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Aldh2/Aldh2 Fancd2/Fancd2 |
Background: |
involves: 129S4/SvJae * C57BL/6J * C57BL/6N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Fancd2/Fancd2 |
Background: |
C57BL/6-Fancd2 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Alpi A |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination. |
Volume: |
27 |
Issue: |
24 |
Pages: |
8421-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smogorzewska A |
Year: |
2007 |
Journal: |
Cell |
Title: |
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. |
Volume: |
129 |
Issue: |
2 |
Pages: |
289-301 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh TR |
Year: |
2009 |
Journal: |
Blood |
Title: |
Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M. |
Volume: |
114 |
Issue: |
1 |
Pages: |
174-80 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6694992 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-11-01 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1657819 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:7544998 |
Age: |
embryonic day 11.5 |
|
Note: |
Co-localized staining of Fancd2 was shown. The proportion of Fancd2 positive cells was significantly decreased compared with the wild-type (quantified in Fig 7B). |
Specimen Label: |
7A E11.5 -/- |
Detected: |
true |
Specimen Num: |
26 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6694992 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-11-01 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1657820 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:7544998 |
Age: |
embryonic day 12.5 |
|
Note: |
Co-localized staining of Fancd2 was shown. The proportion of Fancd2 positive cells was significantly decreased compared with the wild-type (quantified in Fig 7B). |
Specimen Label: |
7A E12.5 -/- |
Detected: |
true |
Specimen Num: |
28 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Ciccia A |
Year: |
2007 |
Journal: |
Mol Cell |
Title: |
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. |
Volume: |
25 |
Issue: |
3 |
Pages: |
331-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kato Y |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis. |
Volume: |
24 |
Issue: |
18 |
Pages: |
5234-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meetei AR |
Year: |
2003 |
Journal: |
Nat Genet |
Title: |
A novel ubiquitin ligase is deficient in Fanconi anemia. |
Volume: |
35 |
Issue: |
2 |
Pages: |
165-70 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
258
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. This entry represents FANCG, which is part of the FA core complex required for the monoubiquitylation of FANCD2 and the FANCI heterodimer. The FA complex coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination []. Besides being part of the FA complex, FANCG also promotes formation of a protein complex containing BRCA2, FANCD2 and XRCC3 []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the second of three UBC-like domains found in the FANCL protein, which is the catalytic E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits encoded by the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2 [, ]. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the third of three UBC-like domains found in the FANCL protein, which is the catalytic E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits encoded by the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2 []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1330
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
148
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Hodson C |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway. |
Volume: |
286 |
Issue: |
37 |
Pages: |
32628-37 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Fanconi anemia-associated protein of 24kDa (FAAP24) plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. It regulates FANCD2 monoubiquitination upon DNA damage. When repressed, it induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents. It targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA [].Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ]. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Fanconi Anaemia (FA) is a cancer predisposition disorder characterised by chromosome fragility and hypersensitivity to genotoxic agents that suggest defects in the molecular mechanisms of DNA damage signalling and repair. In response to DNA damage, the FA core complex monoubiquitinates the FANCD2 protein. This ubiquitination targets FANCD2 to nuclear foci where it interacts with a variety of DNA repair proteins.The FA group E protein (FANCE) has an important role in DNA repair, functioning as the FANCD2-binding protein in the FA core complex []. This entry represents the C-terminal domain of FANCE, which consists predominantly of helices and does not contain any β-strands. This domain folds in a continuous right-handed solenoidal pattern from its N terminus to its C terminus. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
591
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
660
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
169
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
229
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
412
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
212
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
43
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
461
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
117
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
216
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
73
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
558
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].This entry represents FANCC []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This entry represents the solenoid 1 cap (S1-cap) domain of the Fanconi anemia complementation group I protein (FANCI). |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the solenoid 1 (S1) domain of the Fanconi anemia group I protein (FANCI). |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the helical domain 1 (HD1) of the Fanconi anemia complementation group I protein (FANCI). |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the helical domain 2 (HD2) of the Fanconi anemia complementation group I protein (FANCI). |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the solenoid 3 (S3) domain of the Fanconi anemia group I protein (FANCI). |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein (FANCI). |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the solenoid 2 (S2) domain of the Fanconi anemia group I protein (FANCI). |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].This entry represents FANCA []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
384
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
462
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
71
 |
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
484
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
151
 |
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
406
 |
Fragment?: |
false |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
412
 |
Fragment?: |
true |
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•
•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
526
 |
Fragment?: |
false |
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•
•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
355
 |
Fragment?: |
true |
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•
•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
154
 |
Fragment?: |
true |
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