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Search results 201 to 300 out of 329 for Fbxw7

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Type Details Score
Publication
10531037 | J:58149
First Author: Winston JT
Year: 1999
Journal: Curr Biol
Title: A family of mammalian F-box proteins.
Volume: 9
Issue: 20
Pages: 1180-2
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Publication
34475389 | J:311172
First Author: Schachter NF
Year: 2021
Journal: Nat Commun
Title: Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer.
Volume: 12
Issue: 1
Pages: 5238
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Publication
21827743 | J:176598
First Author: Jandke A
Year: 2011
Journal: Dev Biol
Title: The F-box protein Fbw7 is required for cerebellar development.
Volume: 358
Issue: 1
Pages: 201-12
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Publication
14766969 | J:88903
First Author: Tetzlaff MT
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.
Volume: 101
Issue: 10
Pages: 3338-45
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Publication
17141158 | J:119653
First Author: Castro DS
Year: 2006
Journal: Dev Cell
Title: Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.
Volume: 11
Issue: 6
Pages: 831-44
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Publication
22405651 | J:184206
First Author: Tron AE
Year: 2012
Journal: Mol Cell
Title: The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.
Volume: 46
Issue: 1
Pages: 67-78
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Publication
20935640 | J:166928
First Author: Hoeck JD
Year: 2010
Journal: Nat Neurosci
Title: Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.
Volume: 13
Issue: 11
Pages: 1365-72
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Publication
14672936 | J:88517
First Author: Tsunematsu R
Year: 2004
Journal: J Biol Chem
Title: Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
Volume: 279
Issue: 10
Pages: 9417-23
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Publication
18077674 | J:130568
First Author: Kurrasch DM
Year: 2007
Journal: J Neurosci
Title: The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.
Volume: 27
Issue: 50
Pages: 13624-34
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Publication
27922003 | J:243163
 
First Author: Ramasamy SK
Year: 2016
Journal: Nat Commun
Title: Blood flow controls bone vascular function and osteogenesis.
Volume: 7
Pages: 13601
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Publication
35165395 | J:338083
First Author: Hwang I
Year: 2022
Journal: Mol Psychiatry
Title: Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.
Volume: 27
Issue: 4
Pages: 2030-2041
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Publication
15520277 | J:93441
First Author: Jin J
Year: 2004
Journal: Genes Dev
Title: Systematic analysis and nomenclature of mammalian F-box proteins.
Volume: 18
Issue: 21
Pages: 2573-80
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Publication
24357321 | J:205485
First Author: Yu C
Year: 2013
Journal: Science
Title: CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
Volume: 342
Issue: 6165
Pages: 1518-21
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Publication
16964442 | J:112870
First Author: Mager J
Year: 2006
Journal: Mamm Genome
Title: Identification of candidate maternal-effect genes through comparison of multiple microarray data sets.
Volume: 17
Issue: 9
Pages: 941-9
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 76
Description: Interaction with FBXW7
Type: short sequence motif
End: 78
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HT Experiment
GSE140503 | FBXW7 coordinates postprandial muscle glucose metabolism and maintenance of skeletal muscle mass
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GXD Expression
GXD Expression
   
Probe: MGI:6119549
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685326
Stage: TS26
Assay Id: MGI:7427622
Age: embryonic day 18.5
Image: 2
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7427605
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685326
Stage: TS26
Assay Id: MGI:7427623
Age: embryonic day 18.5
Image: 2
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7427613
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685326
Stage: TS26
Assay Id: MGI:7427624
Age: embryonic day 18.5
Image: 2
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7427612
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685326
Stage: TS26
Assay Id: MGI:7427625
Age: embryonic day 18.5
Image: 2
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7427617
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685326
Stage: TS26
Assay Id: MGI:7427626
Age: embryonic day 18.5
Image: 2
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5702631
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:7427632
Age: embryonic day 17.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5702631
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:7427632
Age: embryonic day 17.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7427581
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:7427633
Age: embryonic day 17.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7427581
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:7427633
Age: embryonic day 17.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7427602
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:7427634
Age: embryonic day 17.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7427602
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:7427634
Age: embryonic day 17.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7427589
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:7427635
Age: embryonic day 17.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7427589
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:7427635
Age: embryonic day 17.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7427591
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:7427636
Age: embryonic day 17.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7427591
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:7427636
Age: embryonic day 17.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7427593
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:7427637
Age: embryonic day 17.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7427593
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:7427637
Age: embryonic day 17.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5702631
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685326
Stage: TS26
Assay Id: MGI:7427641
Age: embryonic day 18.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7427581
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685326
Stage: TS26
Assay Id: MGI:7427642
Age: embryonic day 18.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7427602
Assay Type: Western blot
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685326
Stage: TS26
Assay Id: MGI:7427643
Age: embryonic day 18.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5698950
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685323
Stage: TS23
Assay Id: MGI:7427645
Age: embryonic day 15.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7427607
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685323
Stage: TS23
Assay Id: MGI:7427644
Age: embryonic day 15.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7427616
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685323
Stage: TS23
Assay Id: MGI:7427646
Age: embryonic day 15.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7427609
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685323
Stage: TS23
Assay Id: MGI:7427647
Age: embryonic day 15.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7427614
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685323
Stage: TS23
Assay Id: MGI:7427648
Age: embryonic day 15.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4352720
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685323
Stage: TS23
Assay Id: MGI:7427649
Age: embryonic day 15.5
Image: 3
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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Publication
31940492 | J:287684
First Author: Cui D
Year: 2020
Journal: Cell Rep
Title: FBXW7 Confers Radiation Survival by Targeting p53 for Degradation.
Volume: 30
Issue: 2
Pages: 497-509.e4
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Publication
31152129 | J:276560
First Author: Lan H
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity.
Volume: 116
Issue: 25
Pages: 12311-12320
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Publication
32113998 | J:300086
First Author: Yumimoto K
Year: 2020
Journal: Semin Cancer Biol
Title: Recent insight into the role of FBXW7 as a tumor suppressor.
Volume: 67
Issue: Pt 2
Pages: 1-15
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Publication
26898828 | J:318312
First Author: Hernandez MA
Year: 2016
Journal: Cell Signal
Title: Regulation of BRAF protein stability by a negative feedback loop involving the MEK-ERK pathway but not the FBXW7 tumour suppressor.
Volume: 28
Issue: 6
Pages: 561-71
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Allele
Fbxw7<em2Smoc> | MGI:7289638
Name: F-box and WD-40 domain protein 7; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Interaction Experiment
Bengoechea-Alonso MT (2010)
Description: The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation.
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Interaction Experiment
Kwon YW (2012)
Description: Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.
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Protein
Q2QKR2
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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GXD Expression
GXD Expression
Probe: MGI:6695084
Assay Type: Immunohistochemistry
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685526
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7427631
Age: embryonic day 18.5
Image: S4C
Note: Ectopic development of luminal Trp63-Krt5+ cells persisted, similar to the Fbxw7 single mutant.
Specimen Label: S4C
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:6731029
Assay Type: Immunohistochemistry
Annotation Date: 2023-01-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1685526
Stage: TS26
Assay Id: MGI:7427627
Age: embryonic day 18.5
Image: S4F
Note: Drastic loss of positive cells persisted, similar to the Fbxw7 single mutant.
Specimen Label: S4F
Detected: false
Specimen Num: 15
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GXD Expression
GXD Expression
Probe: MGI:5308083
Assay Type: Immunohistochemistry
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685526
Pattern: Single cells
Stage: TS26
Assay Id: MGI:7427628
Age: embryonic day 18.5
Image: S4F
Note: Clear decrease of positive cells persisted, similar to the Fbxw7 single mutant.
Specimen Label: S4F
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
Probe: MGI:6695084
Assay Type: Immunohistochemistry
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685526
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7427631
Age: embryonic day 18.5
Image: 4C
Note: Ectopic development of luminal Trp63-Krt5+ cells observed in the Fbxw7 single mutant was reversed.
Specimen Label: 4C
Detected: true
Specimen Num: 5
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Strain
MGI:7623363 | C57BL/6JSmoc-Fbxw7<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Fbxw7<em1Smoc> | MGI:7289637
Name: F-box and WD-40 domain protein 7; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
18765672 | -
First Author: Kanei-Ishii C
Year: 2008
Journal: J Biol Chem
Title: Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.
Volume: 283
Issue: 45
Pages: 30540-8
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Publication
30792223 | J:272741
First Author: Rossi D
Year: 2019
Journal: Blood
Title: FBXW7 is a biologically validated cancer driver gene for CLL.
Volume: 133
Issue: 8
Pages: 774-776
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DO Term
DOID:0070420 | developmental delay, hypotonia, and impaired language
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GO Term
GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex
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Allele
Fbxw7<tm1Itom> | MGI:5007620
Name: F-box and WD-40 domain protein 7; targeted mutation 1, Ian Tomlinson
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:6475264 | C57BL/6JSmoc-Fbxw7<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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