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Search results 201 to 300 out of 341 for Fer

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:6334921 | C57BL/6N-Fer<em1(IMPC)Tcp>
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7837237 | C57BL/6JCya-Fer<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Fer/Fer
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fer/Fer
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fer/Fer
Background: C57BL/6N-Fer/Tcp
Zygosity: hm
Has Mutant Allele: true
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Publication
8405064 | J:15289
First Author: Goodwin RG
Year: 1993
Journal: Eur J Immunol
Title: Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor.
Volume: 23
Issue: 10
Pages: 2631-41
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Publication
10191088 | J:54668
First Author: Fujii T
Year: 1999
Journal: Genomics
Title: Sperizin is a murine RING zinc-finger protein specifically expressed in Haploid germ cells.
Volume: 57
Issue: 1
Pages: 94-101
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Publication
9286710 | J:37078
First Author: Heuckeroth RO
Year: 1997
Journal: Genomics
Title: Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3.
Volume: 44
Issue: 1
Pages: 137-40
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Interaction Experiment
Taler M (2003)
Description: Fer is a downstream effector of insulin and mediates the activation of signal transducer and activator of transcription 3 in myogenic cells.
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Publication
12640114 | -
First Author: Piedra J
Year: 2003
Journal: Mol Cell Biol
Title: p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
Volume: 23
Issue: 7
Pages: 2287-97
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Publication
8288218 | J:15563
First Author: Wilkie TM
Year: 1993
Journal: Genomics
Title: Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors.
Volume: 18
Issue: 2
Pages: 175-84
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Publication
9210375 | -
First Author: Aspenström P
Year: 1997
Journal: Curr Biol
Title: A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton.
Volume: 7
Issue: 7
Pages: 479-87
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Genotype
Genotype
Symbol: Fer/Fer<+>
Background: C57BL/6N-Fer/Tcp
Zygosity: ht
Has Mutant Allele: true
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Publication
15567065 | -
First Author: Salem Y
Year: 2005
Journal: Cell Signal
Title: Fer kinase sustains the activation level of ERK1/2 and increases the production of VEGF in hypoxic cells.
Volume: 17
Issue: 3
Pages: 341-53
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Publication
15467733 | -
First Author: Perry E
Year: 2004
Journal: Oncogene
Title: TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3.
Volume: 23
Issue: 55
Pages: 8908-19
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Protein Domain
IPR037452 | Fer_F-BAR
Type: Domain
Description: Fer () is a tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis [, ]. In non-small cell lung cancer cells, Fer kinase expression has been linked to cell invasion and tumour metastasis []. It also acts downstream of EGFR (EGF receptor) to promote activation of NF-kappa-B and cell proliferation [].This entry represents the F-BAR domain of Fer. F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization [, ].
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Publication
37329887 | J:341056
First Author: Zhang Y
Year: 2023
Journal: Cell Metab
Title: Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation.
Volume: 35
Issue: 8
Pages: 1457-1473.e13
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Publication
2209086 | J:10755
First Author: Morris C
Year: 1990
Journal: Cytogenet Cell Genet
Title: The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q).
Volume: 53
Issue: 4
Pages: 196-200
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Publication
- | J:24088
 
First Author: Mattei MG
Year: 1989
Journal: Cytogenet Cell Genet
Title: Angiotensin-I converting enzyme gene is on Chromosome 17
Volume: 51
Pages: 1041 (Abstr.)
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Publication
19137586 | J:146175
First Author: Bacon C
Year: 2009
Journal: J Comp Neurol
Title: Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.
Volume: 513
Issue: 2
Pages: 224-36
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Publication
17403031 | -
First Author: Bourguignon LY
Year: 2007
Journal: J Neurochem
Title: Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes.
Volume: 101
Issue: 4
Pages: 1002-17
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Publication
22297987 | -
First Author: Liu W
Year: 2012
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun
Title: Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex.
Volume: 68
Issue: Pt 2
Pages: 154-8
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Protein Domain
IPR015503 | Cortactin
Type: Family
Description: Cortactin is a key regulator of actin polymerisation in response to tyrosine kinase signalling []. It was first identified as a tyrosine-phosphorylated protein in v-Src infected fibroblasts []. It contains several domains: an N-terminal acidic (NTA) domain, a central repeat region and a C-terminal Src homology 3 (SH3) domain. The central repeat region binds to actin filaments, the NTA domain binds to the Arp2/3 complex and the SH3 domain interacts with N-WASp, Arg and WIP []. When activated, cortactin can recruit Arp2/3 complex to existing actin filaments to nucleate a new actin filament. Cortactin is involved in the regulation of cell migration, lamellipodia formation, invadopodia formation and endocytosis []. Cortactin can be phosphorylated by Src at several sites, and also binds directly to the SH2 domain of SRC. The non-receptor kinases, such as Fyn, Syk and Fer may also play a role in cortactin tyrosine phosphorylation. The structure of cortactin has been solved [].
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Publication
17627769 | J:134425
First Author: Parsons SA
Year: 2007
Journal: Immunology
Title: The Fps/Fes kinase regulates leucocyte recruitment and extravasation during inflammation.
Volume: 122
Issue: 4
Pages: 542-50
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Publication
34264955 | J:308067
First Author: Chang LS
Year: 2021
Journal: PLoS One
Title: Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.
Volume: 16
Issue: 7
Pages: e0252048
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Publication
- | J:28119
First Author: Sakurai T
Year: 1995
Journal: Dev Growth Differ
Title: The ter mutation first causes primordial germ cell deficiency in ter/ter mouse embryos at 8 days of gestation.
Volume: 37
Issue: 3
Pages: 293-302
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Publication
24177035 | J:206183
First Author: Demonbreun AR
Year: 2014
Journal: Am J Pathol
Title: Dysferlin and myoferlin regulate transverse tubule formation and glycerol sensitivity.
Volume: 184
Issue: 1
Pages: 248-59
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Publication
34354129 | J:359914
First Author: Barefield DY
Year: 2021
Journal: Sci Rep
Title: Loss of dysferlin or myoferlin results in differential defects in excitation-contraction coupling in mouse skeletal muscle.
Volume: 11
Issue: 1
Pages: 15865
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Publication
16959897 | J:116566
First Author: Parsons SA
Year: 2006
Journal: J Leukoc Biol
Title: The Fps/Fes kinase regulates the inflammatory response to endotoxin through down-regulation of TLR4, NF-kappaB activation, and TNF-alpha secretion in macrophages.
Volume: 80
Issue: 6
Pages: 1522-8
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Publication
31723081 | J:298512
First Author: Yano A
Year: 2020
Journal: Kurume Med J
Title: IL-10-Producing Potential Treg Precursor in Placenta.
Volume: 65
Issue: 4
Pages: 169-176
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Publication
15504549 | J:93227
First Author: Sangrar W
Year: 2004
Journal: Exp Hematol
Title: Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival.
Volume: 32
Issue: 10
Pages: 935-45
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Publication
15917293 | J:101581
First Author: Vultur A
Year: 2005
Journal: Mol Biol Cell
Title: Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen.
Volume: 16
Issue: 8
Pages: 3832-46
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Publication
21423209 | J:317230
First Author: Wagh PK
Year: 2011
Journal: Oncogene
Title: β-Catenin is required for Ron receptor-induced mammary tumorigenesis.
Volume: 30
Issue: 34
Pages: 3694-704
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Publication
10713100 | -
First Author: Tian L
Year: 2000
Journal: J Biol Chem
Title: Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules.
Volume: 275
Issue: 11
Pages: 7854-61
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Publication
11994747 | -
First Author: Greer P
Year: 2002
Journal: Nat Rev Mol Cell Biol
Title: Closing in on the biological functions of Fps/Fes and Fer.
Volume: 3
Issue: 4
Pages: 278-89
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Protein Domain
IPR001060 | FCH_dom
Type: Domain
Description: FCH domain is a short conserved region of around 60 amino acids first described as a region of homology between FER and CIP4 proteins []. In the CIP4 protein the FCH domain binds to microtubules []. The FCH domain is always found N-terminally and is followed by a coiled-coil region. The FCH and coiled-coil domains are structurally similar to Bin/amphiphysin/RVS (BAR) domains []. They are α-helical membrane-binding modules that function in endocytosis, regulation of the actin cytoskeleton and signalling []. Proteins containing an FCH domain can be divided in 3 classes []:A subfamily of protein kinases usually associated with an SH2 domain:Fps/fes (Fujimani poultry sarcoma/feline sarcoma) proto-oncogenes. They are non-receptor protein-tyrosine kinases preferentially expressed in myeloid lineage. The viral oncogene has an unregulated kinase activity which abrogates the need for cytokines and influences differentiation of haematopoietic progenitor cells.Fes related protein (fer). It is an ubiquitously expressed homologue of Fes.Adaptor proteins usually associated with a C-terminal SH3 domain:Schizosaccharomyces pombe CDC15 protein. It mediates cytoskeletal rearrangements required for cytokinesis. It is essential for viability.CD2 cytoplasmic domain binding protein.Mammalian Cdc42-interacting protein 4 (CIP4). It may act as a link between Cdc42 signaling and regulation of the actin cytoskeleton.Mammalian PACSIN proteins. A family of cytoplasmic phosphoproteins playing a role in vesicle formation and transport.A subfamily of Rho-GAP proteins:Mammalian RhoGAP4 proteins. They may down-regulate Rho-like GTPases in hematopoietic cells.Yeast RHO GTPase-activating protein RGD1 (also known as YBR260C).Caenorhabditis elegans hypothetical protein ZK669.1.
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Publication
19549836 | -
First Author: Wang Q
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin.
Volume: 106
Issue: 31
Pages: 12700-5
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Publication
2110361 | -
First Author: Kanner SB
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.
Volume: 87
Issue: 9
Pages: 3328-32
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Protein
E9QA76
Organism: Mus musculus/domesticus
Length: 57  
Fragment?: false
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Publication
18525024 | -
First Author: Heath RJ
Year: 2008
Journal: J Cell Sci
Title: F-BAR domains: multifunctional regulators of membrane curvature.
Volume: 121
Issue: Pt 12
Pages: 1951-4
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Protein
Q3UQN2
Organism: Mus musculus/domesticus
Length: 809  
Fragment?: false
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Protein
A0A0U1RPB9
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
Q8CGG9
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: true
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Protein
Q32MS3
Organism: Mus musculus/domesticus
Length: 450  
Fragment?: false
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Protein
Q6A091
Organism: Mus musculus/domesticus
Length: 512  
Fragment?: true
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Protein
B1AW94
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Protein
A2AQ47
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: true
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Protein
Q6A075
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: true
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Protein
D6RCG0
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
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Protein
A0A0U1RQ80
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: false
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Protein
Q3UPB8
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
Q05CX7
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: true
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Protein
B1AW92
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Protein
E9PVQ1
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
B1AW93
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
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Protein
Q8BYX6
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: true
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Protein
A0A087WRV4
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Protein
A0A286YCL2
Organism: Mus musculus/domesticus
Length: 281  
Fragment?: true
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Protein
A0A140LIU6
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Protein
F6RG68
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
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Protein
A0A087WNR5
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: true
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Protein
D3YYE9
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: true
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Protein
A6PWR1
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
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Protein
D3Z6N2
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
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Protein
A0A286YDL7
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
Q3U0A9
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: true
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Protein
A0A338P6K4
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
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Protein
E9Q363
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Protein
J3QPQ1
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
E9Q4R3
Organism: Mus musculus/domesticus
Length: 605  
Fragment?: false
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Protein
A0A0U1RNL3
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: false
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Protein
B1AW91
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
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Protein
B1AW95
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Protein
Q3U8N2
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: true
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Protein
A0A0U1RPD6
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Protein
A0A2R8W750
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
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Protein
A2AQ39
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: true
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Protein
Q3UP40
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
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Publication
17947660 | -
First Author: Cao L
Year: 2007
Journal: J Immunol
Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
Volume: 179
Issue: 9
Pages: 5864-76
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Protein
Q60780
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Protein
Q8K285
Organism: Mus musculus/domesticus
Length: 873  
Fragment?: false
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Protein
Q3TBD2
Organism: Mus musculus/domesticus
Length: 1116  
Fragment?: false
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Protein
Q99M15
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Protein
Q60598
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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Protein
D3Z7R7
Organism: Mus musculus/domesticus
Length: 1127  
Fragment?: false
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Protein
Q0VBR8
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Protein
Q921L6
Organism: Mus musculus/domesticus
Length: 509  
Fragment?: false
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Protein
G3X9Q3
Organism: Mus musculus/domesticus
Length: 1116  
Fragment?: false
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Protein
Q3U4E4
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Protein
Q8BNA5
Organism: Mus musculus/domesticus
Length: 509  
Fragment?: false
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Protein
Q4FJU4
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Protein
B1ATI9
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
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Protein
Q3U432
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
Q3USJ8
Organism: Mus musculus/domesticus
Length: 740  
Fragment?: false
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Protein
Q6WKZ7
Organism: Mus musculus/domesticus
Length: 506  
Fragment?: false
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Protein
Q99JB8
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q6PFY1
Organism: Mus musculus/domesticus
Length: 688  
Fragment?: false
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Protein
P97814
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q8CJ53
Organism: Mus musculus/domesticus
Length: 603  
Fragment?: false
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Protein
Q80Z68
Organism: Mus musculus/domesticus
Length: 955  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom