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Search results 201 to 215 out of 215 for Fermt3

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Type Details Score
Protein
A0A2I3BPQ7
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: true
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Protein
A6X940
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
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Protein Domain
IPR037837 | PH_Kindlin/fermitin
Type: Domain
Description: Fermitin, also known as Unc-112-related protein [], functions as a mediator of integrin inside-out signalling. The recruitment of Fermitin proteins and Talin to the membrane mediates the terminal event of integrin signalling, via interaction with integrin beta subunits []. Fermatin has a FERM domain interrupted with a pleckstrin homology (PH) domain []. Fermitin family homologues (Fermt1, 2, and 3, also known as Kindlins) are each encoded by a different gene. In mammalian studies, Fermt1 is generally expressed in epithelial cells, Fermt2 is expressed in muscle tissues, and Fermt3 is expressed in hematopoietic lineages. Specifically Fermt2 is expressed in smooth and striated muscle tissues in mice and in the somites (a trunk muscle precursor) and neural crest in Xenopus embryos. As such it has been proposed that Fermt2 plays a role in cardiomyocyte and neural crest differentiation. Expression of mammalian Fermt3 is associated with hematopoietic lineages: the anterior ventral blood islands, vitelline veins, and early myeloid cells. In Xenopus embryos this expression, also include the notochord and cement gland [, ].This entry represents the PH domain of fermitins.
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Protein Domain
IPR037843 | Kindlin/fermitin
Type: Family
Description: Fermitin, also known as Unc-112-related protein [], functions as a mediator of integrin inside-out signalling. The recruitment of Fermitin proteins and Talin to the membrane mediates the terminal event of integrin signalling, via interaction with integrin beta subunits []. Fermatin has a FERM domain interrupted with a pleckstrin homology (PH) domain []. Fermitin family homologues (Fermt1, 2, and 3, also known as Kindlins) are each encoded by a different gene. In mammalian studies, Fermt1 is generally expressed in epithelial cells, Fermt2 is expressed in muscle tissues, and Fermt3 is expressed in hematopoietic lineages. Specifically Fermt2 is expressed in smooth and striated muscle tissues in mice and in the somites (a trunk muscle precursor) and neural crest in Xenopus embryos. As such it has been proposed that Fermt2 plays a role in cardiomyocyte and neural crest differentiation. Expression of mammalian Fermt3 is associated with hematopoietic lineages: the anterior ventral blood islands, vitelline veins, and early myeloid cells. In Xenopus embryos this expression, also include the notochord and cement gland [, ].
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Publication
34561280 | J:360106
First Author: Guenther C
Year: 2021
Journal: Cancer Immunol Res
Title: β2-Integrin Adhesion Regulates Dendritic Cell Epigenetic and Transcriptional Landscapes to Restrict Dendritic Cell Maturation and Tumor Rejection.
Volume: 9
Issue: 11
Pages: 1354-1369
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Protein
Q8K1B8
Organism: Mus musculus/domesticus
Length: 665  
Fragment?: false
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Protein
Q8CIB5
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
P59113
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
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Protein
Q3TLE2
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
Q3TEE6
Organism: Mus musculus/domesticus
Length: 665  
Fragment?: false
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Protein
Q4W4Z0
Organism: Mus musculus/domesticus
Length: 491  
Fragment?: false
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Protein
A6X941
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
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Protein
Q3UMA4
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
A0A494B9W3
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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