|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 300 out of 381 for Fh1

<< First    < Previous  |  Next >    Last >>
0.059s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3274122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2008-02-05
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3287422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3769877
Age: embryonic day 14.5
Image: 3B
Specimen Label: 3B
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3266022
Pattern: Ubiquitous
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1624622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Note: Expression was detected in the digestive system.
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1721422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1646922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1736222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1683322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1700022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1832122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1876522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Note: Expression was weak in the immune system.
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1741222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2008-02-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3599822
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3769877
Age: embryonic day 14.5
Image: 3B
Specimen Label: 3B
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3599822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3280922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1833322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3287022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1821522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3557722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2008-02-05
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3769877
Age: embryonic day 14.5
Image: 3B
Specimen Label: 3B
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2008-02-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756322
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3769877
Age: embryonic day 14.5
Image: 3B
Specimen Label: 3B
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1668822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2008-02-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273022
Stage: TS22
Assay Id: MGI:3769877
Age: embryonic day 14.5
Image: 3B
Note: There is no expression in the axial cartilage.
Specimen Label: 3B
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2008-02-05
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3769877
Age: embryonic day 14.5
Image: 3B
Specimen Label: 3B
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1738322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Specimen Label: MH954; Specimen C1363
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1768022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Note: Expression was weak in the skull (base and vault).
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3724701
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421360
Age: embryonic day 14.5
Image: MH954; Specimen C1363
Note: Expression was detected in whisker follicle.
Specimen Label: MH954; Specimen C1363
Detected: true
Specimen Num: 1
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
24861497 | J:213503
First Author: Zhao C
Year: 2014
Journal: FEBS Lett
Title: A cooperative jack model of random coil-to-elongation transition of the FH1 domain by profilin binding explains formin motor behavior in actin polymerization.
Volume: 588
Issue: 14
Pages: 2288-93
•
•
•
•
•
Protein
P97807
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
•
•
•
•
•
Protein
P97807-2
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
•
•
•
•
•
Publication
12538772 | -
First Author: Kitayama C
Year: 2003
Journal: J Cell Sci
Title: ForC, a novel type of formin family protein lacking an FH1 domain, is involved in multicellular development in Dictyostelium discoideum.
Volume: 116
Issue: Pt 4
Pages: 711-23
•
•
•
•
•
Publication
14576350 | -
First Author: Takeya R
Year: 2003
Journal: J Cell Sci
Title: Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation.
Volume: 116
Issue: Pt 22
Pages: 4567-75
•
•
•
•
•
Allele
Fh1<tm1.1Pjp> | MGI:3711129
Name: fumarate hydratase 1; targeted mutation 1.1, Patrick J Pollard
Allele Type: Targeted
Attribute String: Null/knockout
•
•
•
•
•
Genotype
Genotype
Symbol: Fh1/Fh1
Background: involves: 129X1/SvJ * BALB/c * C57BL/6
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Allele
Fmn1<tm2Made> | MGI:3848983
Name: formin 1; targeted mutation 2, Markus Dettenhofer
Allele Type: Targeted
Attribute String: Null/knockout
•
•
•
•
•
HT Experiment
E-GEOD-10989 | Expression data of cystic renal epithelial tissue from mice deficient for fumarate hydratase
Series Id: GSE10989
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Strain
MGI:4365751 | FVB.129S6-Fmn1<tm2Made>/J
Attribute String: congenic, mutant strain, targeted mutation
•
•
•
•
•
Genotype
Genotype
Symbol: Fmn1/Fmn1
Background: involves: 129S6/SvEvTac * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Fmn1/Fmn1
Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Publication
16818491 | -
First Author: Chhabra ES
Year: 2006
Journal: J Biol Chem
Title: INF2 Is a WASP homology 2 motif-containing formin that severs actin filaments and accelerates both polymerization and depolymerization.
Volume: 281
Issue: 36
Pages: 26754-67
•
•
•
•
•
Protein Domain
IPR027649 | Inf2
Type: Family
Description: Inverted formin-2 belongs to the formin homology family. In mice, it interacts with profilin and actin at the FH1 and FH2 domains respectively. It severs actin filaments and accelerates their polymerisation and depolymerisation [].
•
•
•
•
•
Publication
18572016 | J:139152
First Author: Schwaibold EM
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Identification of Neurochondrin as a new interaction partner of the FH3 domain of the Diaphanous-related formin Dia1.
Volume: 373
Issue: 3
Pages: 366-72
•
•
•
•
•
HT Experiment
E-GEOD-29988 | The role of HIF in FH-associated renal neoplasia
Series Id: GSE29988
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Allele
Fmn2<tm1Led> | MGI:2448909
Name: formin 2; targeted mutation 1, Philip Leder
Allele Type: Targeted
Attribute String: Null/knockout
•
•
•
•
•
Publication
12775772 | J:84435
First Author: Evangelista M
Year: 2003
Journal: J Cell Sci
Title: Formins: signaling effectors for assembly and polarization of actin filaments.
Volume: 116
Issue: Pt 13
Pages: 2603-11
•
•
•
•
•
Publication
16094489 | J:103334
First Author: Cui YZ
Year: 2005
Journal: Sheng Li Xue Bao
Title: Expression of man, a formin homology domain-containing gene in the mouse limb.
Volume: 57
Issue: 4
Pages: 433-8
•
•
•
•
•
Publication
12447394 | J:81246
First Author: Leader B
Year: 2002
Journal: Nat Cell Biol
Title: Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes.
Volume: 4
Issue: 12
Pages: 921-8
•
•
•
•
•
Publication
18848445 | J:143403
First Author: Azoury J
Year: 2008
Journal: Curr Biol
Title: Spindle positioning in mouse oocytes relies on a dynamic meshwork of actin filaments.
Volume: 18
Issue: 19
Pages: 1514-9
•
•
•
•
•
Publication
19062278 | J:144718
First Author: Schuh M
Year: 2008
Journal: Curr Biol
Title: A new model for asymmetric spindle positioning in mouse oocytes.
Volume: 18
Issue: 24
Pages: 1986-92
•
•
•
•
•
Publication
21620703 | J:174016
First Author: Pfender S
Year: 2011
Journal: Curr Biol
Title: Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division.
Volume: 21
Issue: 11
Pages: 955-60
•
•
•
•
•
Strain
MGI:5427356 | 129S6-Fmn2<tm1Led>/RwwJ
Attribute String: mutant strain, targeted mutation, coisogenic
•
•
•
•
•
Publication
25480035 | J:230279
First Author: Law R
Year: 2014
Journal: Am J Hum Genet
Title: Biallelic truncating mutations in FMN2, encoding the actin-regulatory protein Formin 2, cause nonsyndromic autosomal-recessive intellectual disability.
Volume: 95
Issue: 6
Pages: 721-8
•
•
•
•
•
Publication
19008955 | J:142391
First Author: Mozhui K
Year: 2008
Journal: PLoS Genet
Title: Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression.
Volume: 4
Issue: 11
Pages: e1000260
•
•
•
•
•
Publication
31937754 | J:286667
First Author: Duan X
Year: 2020
Journal: Nat Commun
Title: Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes.
Volume: 11
Issue: 1
Pages: 277
•
•
•
•
•
Publication
23439682 | J:195195
First Author: Yi K
Year: 2013
Journal: J Cell Biol
Title: Sequential actin-based pushing forces drive meiosis I chromosome migration and symmetry breaking in oocytes.
Volume: 200
Issue: 5
Pages: 567-76
•
•
•
•
•
Publication
24722338 | J:215089
First Author: Shin H
Year: 2014
Journal: PLoS One
Title: The transcription factor Egr3 is a putative component of the microtubule organizing center in mouse oocytes.
Volume: 9
Issue: 4
Pages: e94708
•
•
•
•
•
Publication
38086376 | J:343760
First Author: Au NPB
Year: 2023
Journal: Neuron
Title: Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair.
Volume: 111
Issue: 24
Pages: 3970-3987.e8
•
•
•
•
•
Publication
31607652 | J:284138
First Author: Almonacid M
Year: 2019
Journal: Dev Cell
Title: Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes.
Volume: 51
Issue: 2
Pages: 145-157.e10
•
•
•
•
•
Publication
28839045 | J:244150
 
First Author: Mogessie B
Year: 2017
Journal: Science
Title: Actin protects mammalian eggs against chromosome segregation errors.
Volume: 357
Issue: 6353
•
•
•
•
•
Publication
32245998 | J:287308
First Author: Bennabi I
Year: 2020
Journal: Nat Commun
Title: Artificially decreasing cortical tension generates aneuploidy in mouse oocytes.
Volume: 11
Issue: 1
Pages: 1649
•
•
•
•
•
Genotype
Genotype
Symbol: Fmn2/Fmn2
Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Fmn1/Fmn1<+> Grem1/Grem1<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Publication
27991490 | J:243452
 
First Author: Cheeseman LP
Year: 2016
Journal: Nat Commun
Title: Two pathways regulate cortical granule translocation to prevent polyspermy in mouse oocytes.
Volume: 7
Pages: 13726
•
•
•
•
•
Publication
29240780 | J:254620
First Author: Lian G
Year: 2017
Journal: PLoS One
Title: FilaminA and Formin2 regulate skeletal, muscular, and intestinal formation through mesenchymal progenitor proliferation.
Volume: 12
Issue: 12
Pages: e0189285
•
•
•
•
•
Publication
27789627 | J:237533
First Author: Lian G
Year: 2016
Journal: Development
Title: Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway.
Volume: 143
Issue: 23
Pages: 4509-4520
•
•
•
•
•
HT Experiment
E-GEOD-72563 | Haploinsufficiency in bromodomain containing 2 (Brd2) gene remodels synaptic transmission in female mouse striatum in a sex-specific manner
Series Id: GSE72563
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Protein
Q3TLZ9
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: false
•
•
•
•
•
Publication
12577064 | -
First Author: Gasman S
Year: 2003
Journal: Nat Cell Biol
Title: RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase.
Volume: 5
Issue: 3
Pages: 195-204
•
•
•
•
•
Protein Domain
IPR027644 | DIAPH2
Type: Family
Description: DIAPH2 belongs to the formin homology family, Diaphanous subfamily (also known as the Diaphanous-related formins, Drfs). In addition to the FH1 and FH2 domains, Drfs contain an N-terminal GTPase-binding domain (mDiaN) and a C-terminal Diaphanous-autoregulatory domain (DAD).DIAPH2 may be involved in oogenesis and in the regulation of endosome dynamics. In humans, DIAPH2 has three isoforms produced by alternative splicing. Its isoform3, DIA2C, together with CSK are sequentially activated by GTPase RhoD to regulate the motility of early endosomes through interactions with the actin cytoskeleton [].
•
•
•
•
•
Protein Domain
IPR027654 | Formin_DIAPH3
Type: Family
Description: Protein diaphanous homologue 3 (DIAPH3) belongs to the formin homology family, Diaphanous subfamily (also known as the Diaphanous-related formins, Drfs). In addition to the FH1 and FH2 domains, Drfs contain an N-terminal GTPase-binding domain (mDiaN) and a C-terminal Diaphanous-autoregulatory domain (DAD).DIAPH3 (also known as mDia2, which can be confusing) acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerisation. It is required for cytokinesis, stress fibre formation, and transcriptional activation of the serum response factor []. It couples Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics [].
•
•
•
•
•
Publication
28768717 | J:248773
First Author: Agís-Balboa RC
Year: 2017
Journal: EMBO J
Title: Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia.
Volume: 36
Issue: 19
Pages: 2815-2828
•
•
•
•
•
Publication
10678165 | -
First Author: Tominaga T
Year: 2000
Journal: Mol Cell
Title: Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling.
Volume: 5
Issue: 1
Pages: 13-25
•
•
•
•
•
Publication
12417149 | -
First Author: Deeks MJ
Year: 2002
Journal: Trends Plant Sci
Title: Formins: intermediates in signal-transduction cascades that affect cytoskeletal reorganization.
Volume: 7
Issue: 11
Pages: 492-8
•
•
•
•
•
Publication
11104517 | -
First Author: Cvrcková F
Year: 2000
Journal: Genome Biol
Title: Are plant formins integral membrane proteins?
Volume: 1
Issue: 1
Pages: RESEARCH001
•
•
•
•
•
Publication
16495927 | -
First Author: Kim RH
Year: 2006
Journal: Br J Cancer
Title: Tumours and tremors: how PTEN regulation underlies both.
Volume: 94
Issue: 5
Pages: 620-4
•
•
•
•
•
Protein Domain
IPR027643 | Formin-like_plant
Type: Family
Description: Formins (formin homology proteins) proteins play a crucial role in the reorganisation of the actin cytoskeleton and associate with the fast-growing end (barbed end) of actin filaments [, ]. This entry represents the formin homologues from plants. Seed plants have two formin clades with numerous paralogues []. They can be classified as class I and class II formins. Class I formins includes a N-terminal membrane insertion signal, a predicted extracytoplasmic Pro-rich stretch, a transmembrane region, and C-terminal FH1 and FH2 domains []. Though class II formins usually contain a N-terminal PTEN domain related to the human PTEN protein (implied in pathogenesis of the Parkinson disease) [], the N-termini of type-II plant formins do not contain any recognisable domain that can provide a clue to their biological function.
•
•
•
•
•
Protein Domain
IPR027653 | Formin_Diaph1
Type: Family
Description: Protein diaphanous homologue 1 (Dia1) belongs to the formin homology family, Diaphanous subfamily (also known as the Diaphanous-related formins, Drfs). In addition to the FH1 and FH2 domains, Drfs contain an N-terminal GTPase-binding domain (mDiaN) and a C-terminal Diaphanous-autoregulatory domain (DAD).Dia1 contains the N-terminal RhoA-binding domain (RBD) followed by a four armadillo-repeats containing Diaphanous inhibitory domain (DID) that binds the C-terminal Diaphanous autoregulatory domain (DAD) [, ]. Dia1 nucleates actin filaments and regulate actin polymerisation and depolymerisation. The activities of Dia1 is regulated by an autoinhibitory interaction between DAD domain and the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments []. Dia1 couples Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics [].
•
•
•
•
•
Publication
16480715 | J:107893
First Author: Zhou F
Year: 2006
Journal: Exp Cell Res
Title: Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2.
Volume: 312
Issue: 7
Pages: 1119-26
•
•
•
•
•
Publication
10958683 | J:64031
First Author: Yayoshi-Yamamoto S
Year: 2000
Journal: Mol Cell Biol
Title: FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages.
Volume: 20
Issue: 18
Pages: 6872-81
•
•
•
•
•
Publication
11826110 | J:74533
First Author: Miyagi Y
Year: 2002
Journal: J Neurosci
Title: Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit.
Volume: 22
Issue: 3
Pages: 803-14
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom