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Search results 201 to 300 out of 337 for Fto

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Type Details Score
HT Experiment
GSE90687 | Functional Genomic Analyses of hepatic tissue after FTO knockout
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-65098 | Adiponectin-cre FTO flox/flox and FTO flox/flox mouse white fat tissues
Series Id: GSE65098
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Fto<em2Smoc> | MGI:7289762
Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
30991027 | J:274181
First Author: Huang Y
Year: 2019
Journal: Cancer Cell
Title: Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Volume: 35
Issue: 4
Pages: 677-691.e10
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Gene
447305 | fto.L
Type: gene
Organism: frog, African clawed
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Publication
28288181 | J:245495
First Author: Aas A
Year: 2017
Journal: PLoS One
Title: Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy.
Volume: 12
Issue: 3
Pages: e0168182
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HT Experiment
E-MTAB-2331 | Transcription profiling by array of FTO over expressing mice in order to gain more insight into the underlying mechanisms by which FTO influences body weight and adiposity
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
GSE125785 | Transcriptomics analysis of gene expression in wildtype and FTO knockout mouse liver
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-MEXP-2201 | Transcription profiling of mouse model for the metabolic effects of the human fat mass and obesity associated fto gene
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Fto<em3Smoc> | MGI:7289763
Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:7718067 | C57BL/6JSmoc-Fto<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
29486327 | J:262286
First Author: Chen A
Year: 2018
Journal: Biochim Biophys Acta
Title: FTO promotes SREBP1c maturation and enhances CIDEC transcription during lipid accumulation in HepG2 cells.
Volume: 1863
Issue: 5
Pages: 538-548
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Publication
36685533 | J:336675
 
First Author: Yang Y
Year: 2022
Journal: Front Immunol
Title: m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis.
Volume: 13
Pages: 1094556
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HT Experiment
GSE100491 | Transcriptomics analysis of gene expression in control, Prrc2a conditional knockout, and Fto transgene mouse brain sample
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
32817424 | J:295970
First Author: Xiao Y
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor.
Volume: 117
Issue: 35
Pages: 21441-21449
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Publication
20376003 | -
First Author: Han Z
Year: 2010
Journal: Nature
Title: Crystal structure of the FTO protein reveals basis for its substrate specificity.
Volume: 464
Issue: 7292
Pages: 1205-9
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Strain
MGI:6354794 | C57BL/6JSmoc-Fto<em3Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Fto<+> | MGI:2438303
   
Name: FTO alpha-ketoglutarate dependent dioxygenase; wild type
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Allele
Fto<I367F> | MGI:4356560
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; Ile 367 Phe
Allele Type: Chemically induced (ENU)
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Allele
Fto<tm1Urt> | MGI:3841156
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1, Ulrich Ruther
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Fto<Gt(RRX012)Byg> | MGI:3852732
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap RRX012, BayGenomics
Allele Type: Gene trapped
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Allele
Fto<Gt(RRZ624)Byg> | MGI:3853459
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap RRZ624, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Allele
Fto<Gt(RRF029)Byg> | MGI:4127937
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap RRF029, BayGenomics
Allele Type: Gene trapped
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Allele
Fto<Gt(RRF262)Byg> | MGI:4127744
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap RRF262, BayGenomics
Allele Type: Gene trapped
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Allele
Fto<Gt(XF485)Byg> | MGI:4128115
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap XF485, BayGenomics
Allele Type: Gene trapped
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Allele
Fto<Gt(RRG257)Byg> | MGI:4128962
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap RRG257, BayGenomics
Allele Type: Gene trapped
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Allele
Fto<Gt(RRG248)Byg> | MGI:4128983
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap RRG248, BayGenomics
Allele Type: Gene trapped
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Allele
Fto<Gt(RRM118)Byg> | MGI:4130103
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap RRM118, BayGenomics
Allele Type: Gene trapped
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Allele
Fto<Gt(OST42405)Lex> | MGI:4157958
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap OST42405, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Fto<Gt(OST61205)Lex> | MGI:4167845
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap OST61205, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Fto<Gt(OST242168)Lex> | MGI:4247386
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap OST242168, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Fto<Gt(OST327146)Lex> | MGI:4281764
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap OST327146, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Fto<Gt(OST336718)Lex> | MGI:4284843
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap OST336718, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Fto<Gt(OST351918)Lex> | MGI:4290500
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap OST351918, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Fto<Gt(OST360101)Lex> | MGI:4293688
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap OST360101, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Fto<Gt(OST364474)Lex> | MGI:4295118
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap OST364474, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Fto<Gt(OST371308)Lex> | MGI:4297250
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap OST371308, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Fto<Gt(OST432137)Lex> | MGI:4315097
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap OST432137, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Fto<Gt(RRT336)Byg> | MGI:4340553
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap RRT336, BayGenomics
Allele Type: Gene trapped
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Allele
Fto<tm1.1Pzg> | MGI:4868738
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1.1, Pumin Zhang
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Fto<tm1.2Pzg> | MGI:4868744
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1.2, Pumin Zhang
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Fto<tm1.3Pzg> | MGI:4868745
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1.3, Pumin Zhang
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Fto<tm1.1Rdc> | MGI:5494489
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1.1, Roger Cox
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Fto<tm1.2Rdc> | MGI:5494490
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1.2, Roger Cox
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Fto<em1Fmas> | MGI:6159866
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 1, Frances M Ashcroft
Allele Type: Endonuclease-mediated
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Allele
Fto<tm1Klng> | MGI:6257029
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1, Arne Klungland
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Fto<tm1Fcw> | MGI:7442521
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1, Fengchao Wang
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Fto<em1Yqt> | MGI:7718677
Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 1, Yue-Qiu Tan
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Fto<em1.1Tasun> | MGI:7539720
Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 1.1, Tao Sun
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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Allele
Fto<em1Hbgl> | MGI:7545694
Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 1, Hua-Bing Li
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Fto<em1Cya> | MGI:7573097
Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Fto<em1H> | MGI:7658874
Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 1, Harwell
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Allele
Fto<em2Cya> | MGI:7793505
Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Fto/Fto
Background: involves: C3H/HeH * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Publication
29429926 | J:260810
First Author: Zhou J
Year: 2018
Journal: Mol Cell
Title: N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
Volume: 69
Issue: 4
Pages: 636-647.e7
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Publication
28002401 | -
First Author: Mauer J
Year: 2017
Journal: Nature
Title: Reversible methylation of m6Am in the 5' cap controls mRNA stability.
Volume: 541
Issue: 7637
Pages: 371-375
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Allele
Fto<Gt(AY0125)Wtsi> | MGI:3853165
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap AY0125, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Fto<Gt(CA0159)Wtsi> | MGI:3858409
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap CA0159, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Fto<Gt(CH0551)Wtsi> | MGI:3870620
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap CH0551, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Fto<Gt(AL0554)Wtsi> | MGI:3877055
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap AL0554, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Fto<Gt(XS0073)Wtsi> | MGI:3877266
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap XS0073, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Fto<Gt(Ayu21-T95)Imeg> | MGI:3923408
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap Ayu21-T95, Institute of Molecular Embryology and Genetics
Allele Type: Gene trapped
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Allele
Fto<Gt(Ayu21-W21)Imeg> | MGI:3923681
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap Ayu21-W21, Institute of Molecular Embryology and Genetics
Allele Type: Gene trapped
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Allele
Fto<Gt(AA0361)Wtsi> | MGI:4331083
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap AA0361, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Fto<Gt(EUCE00128a08)Hmgu> | MGI:4381649
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap EUCE00128a08, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Fto<tm1a(EUCOMM)Wtsi> | MGI:4432397
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Fto<tm1e(EUCOMM)Wtsi> | MGI:4433313
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:5888986 | B6.129-Fto<tm1.1Pzg>/YxtJ
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:6386759 | B6.129(CBA)-Fto<tm1.2Pzg>/J
Attribute String: targeted mutation, mutant strain, congenic
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Allele
Fto<Gt(375D5)Cmhd> | MGI:4951451
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap 375D5, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Fto<Gt(IST13738C9)Tigm> | MGI:5186086
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap IST13738C9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Fto<Gt(IST14194F11)Tigm> | MGI:5211939
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap IST14194F11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Fto<Gt(IST14221B5)Tigm> | MGI:5217095
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap IST14221B5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Fto<Gt(IST14525H5)Tigm> | MGI:5237651
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap IST14525H5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Fto<Gt(IST15037D10)Tigm> | MGI:5278201
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap IST15037D10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Fto<Gt(IST15037E10)Tigm> | MGI:5278209
 
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap IST15037E10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:6148933 | B6.129(Cg)-Fto<tm1.1Rdc>/H
Attribute String: mutant strain, congenic, targeted mutation
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Allele
Fto<tm1c(EUCOMM)Wtsi> | MGI:5529918
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Fto<tm1d(EUCOMM)Wtsi> | MGI:5529920
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1d, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Fto<tm1(EGFP/cre/ERT2)Wtsi> | MGI:5632490
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Recombinase, Reporter
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Allele
Fto<tm1b(EUCOMM)Wtsi> | MGI:5795627
Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Fto<Gt(cre/ERT2)1Card> | MGI:7482569
Name: FTO alpha-ketoglutarate dependent dioxygenase; gene trap Ayu21-T95, Center for Animal Resources and Development
Allele Type: Gene trapped
Attribute String: Inducible, Recombinase
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Strain
MGI:7592060 | C57BL/6J-Fto<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7658875 | C57BL/6NTac-Fto<em1H>/H
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7838318 | C57BL/6N-Fto<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Fto/Fto
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fto/Fto
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fto/Fto
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fto/Fto
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fto/Fto
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fto/Fto
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Allele
Gt(ROSA)26Sor<tm1(CAG-Fto)Rdc> | MGI:4879000
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Roger D Cox
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, No functional change
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Allele
Gt(ROSA)26Sor<tm1(CAG-Fto,-GFP)Sbq> | MGI:6154621
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Shu-Bing Qian
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Protein Domain
IPR024367 | FTO_cat_dom
Type: Domain
Description: Alpha-ketoglutarate-dependent dioxygenase FTO, also known as Fat mass and obesity-associated protein, is a nucleus protein which belongs to the FTO family. This enzyme is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation []. FTO activity is highest towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. FTO has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine [], ]. FTO has no activity towards 1-methylguanine. It has no detectable activity towards double-stranded DNA. FTO requires molecular oxygen, alpha-ketoglutarate and iron. FTO contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. It contributes to the regulation of body size and body fat accumulation as well [].This domain is the catalytic AlkB-like domain from the FTO protein []. This domain catalyses a demethylase activity with a preference for 3-methylthymidine.
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Strain
MGI:5556492 | B6Brd;B6N-Tyr<c-Brd> Fto<tm1a(EUCOMM)Wtsi>/WtsiCnbc
Attribute String: mutant strain, targeted mutation, spontaneous mutation
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Strain
MGI:5781345 | B6JTyr;B6N-Fto<tm1a(EUCOMM)Wtsi>/Wtsi
Attribute String: mutant stock, targeted mutation
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Strain
MGI:5659571 | C57BL/6NTac-Fto<tm1(EGFP/Cre/ERT2)Wtsi>/WtsiH
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6146623 | B6.Cg-Fto<Gt(cre/ERT2)1Card>/CardRbrc
Attribute String: mutant strain, congenic, gene trap
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Genotype
Genotype
Symbol: Fto/Fto<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fto/Fto<+>
Background: involves: C3H/HeH * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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