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Search results 201 to 286 out of 286 for Fxn

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:1096898
Assay Type: RNA in situ
Annotation Date: 2008-12-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3586328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3818927
Age: postnatal day 14
Specimen Label: Not shown
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:1096898
Assay Type: RNA in situ
Annotation Date: 2008-12-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3818927
Age: postnatal adult
Image: 3d
Specimen Label: 3d
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1099210
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1609820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:3809640
Age: embryonic day 12.5
Note: Expression was detected in facial mesenchyme.
Specimen Label: 2b
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1099210
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1761824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3809640
Age: embryonic day 16.5
Specimen Label: 7a
Detected: true
Specimen Num: 8
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Publication
9405681 | J:74420
First Author: Oliver PM
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A.
Volume: 94
Issue: 26
Pages: 14730-5
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Publication
29853274 | J:307895
First Author: Piguet F
Year: 2018
Journal: Mol Ther
Title: Rapid and Complete Reversal of Sensory Ataxia by Gene Therapy in a Novel Model of Friedreich Ataxia.
Volume: 26
Issue: 8
Pages: 1940-1952
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Publication
11852098 | J:109164
First Author: Miranda CJ
Year: 2002
Journal: FEBS Lett
Title: Frataxin knockin mouse.
Volume: 512
Issue: 1-3
Pages: 291-7
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Publication
29259026 | J:255917
First Author: Lin H
Year: 2017
Journal: Dis Model Mech
Title: Early VGLUT1-specific parallel fiber synaptic deficits and dysregulated cerebellar circuit in the KIKO mouse model of Friedreich ataxia.
Volume: 10
Issue: 12
Pages: 1529-1538
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Publication
12880182 | J:112348
First Author: Santos MM
Year: 2003
Journal: Cerebellum
Title: Iron metabolism in mice with partial frataxin deficiency.
Volume: 2
Issue: 2
Pages: 146-53
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Publication
22394676 | J:184473
First Author: Wagner GR
Year: 2012
Journal: Hum Mol Genet
Title: Friedreich's ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase.
Volume: 21
Issue: 12
Pages: 2688-97
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Publication
23886890 | J:200077
First Author: Huang ML
Year: 2013
Journal: Am J Pathol
Title: Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets.
Volume: 183
Issue: 3
Pages: 745-57
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Publication
28724806 | J:288034
 
First Author: Martin AS
Year: 2017
Journal: JCI Insight
Title: Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.
Volume: 2
Issue: 14
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Publication
38724625 | J:351866
First Author: Southwell N
Year: 2024
Journal: EMBO Mol Med
Title: High fat diet ameliorates mitochondrial cardiomyopathy in CHCHD10 mutant mice.
Volume: 16
Issue: 6
Pages: 1352-1378
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Publication
19376812 | J:329177
First Author: Coppola G
Year: 2009
Journal: Hum Mol Genet
Title: Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia.
Volume: 18
Issue: 13
Pages: 2452-61
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Publication
26752519 | J:233150
First Author: Cloonan SM
Year: 2016
Journal: Nat Med
Title: Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.
Volume: 22
Issue: 2
Pages: 163-74
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Publication
19154341 | J:147890
First Author: Guillon B
Year: 2009
Journal: FEBS J
Title: Frataxin deficiency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe-S proteins.
Volume: 276
Issue: 4
Pages: 1036-47
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Publication
33826906 | J:314804
First Author: Brown J
Year: 2021
Journal: Neuron
Title: Spatial integration during active tactile sensation drives orientation perception.
Volume: 109
Issue: 10
Pages: 1707-1720.e7
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Publication
25597503 | J:326895
 
First Author: Parent A
Year: 2015
Journal: Nat Commun
Title: Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols.
Volume: 6
Pages: 5686
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Publication
21298097 | J:327042
First Author: Schmucker S
Year: 2011
Journal: PLoS One
Title: Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex.
Volume: 6
Issue: 1
Pages: e16199
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Publication
29097656 | J:320071
First Author: Boniecki MT
Year: 2017
Journal: Nat Commun
Title: Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Volume: 8
Issue: 1
Pages: 1287
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Publication
27519411 | J:320072
First Author: Gakh O
Year: 2016
Journal: J Biol Chem
Title: Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery.
Volume: 291
Issue: 40
Pages: 21296-21321
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
14651853 | J:86816
First Author: Mootha VK
Year: 2003
Journal: Cell
Title: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Volume: 115
Issue: 5
Pages: 629-40
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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DO Term
DOID:0111218 | Friedreich ataxia 1
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Publication
31158268 | J:276454
First Author: Jasoliya M
Year: 2019
Journal: PLoS One
Title: Dimethyl fumarate dosing in humans increases frataxin expression: A potential therapy for Friedreich's Ataxia.
Volume: 14
Issue: 6
Pages: e0217776
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Allele
Tg(FXN)Y47Pook | MGI:5585461
Name: transgene insertion Y47, Mark A Pook
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
23071719 | J:192085
First Author: Bourn RL
Year: 2012
Journal: PLoS One
Title: Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues.
Volume: 7
Issue: 10
Pages: e47085
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HT Experiment
GSE109510 | The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Tg(FXN)YG8Pook | MGI:3797739
Name: transgene insertion YG8, Mark A Pook
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(FXN)YG22Pook | MGI:4412181
Name: transgene insertion YG22, Mark A Pook
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Fxn<em10Lutzy> | MGI:7316637
Name: frataxin; endonuclease-mediated mutation 10, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Publication
22289650 | J:182296
First Author: Ezzatizadeh V
Year: 2012
Journal: Neurobiol Dis
Title: The mismatch repair system protects against intergenerational GAA repeat instability in a Friedreich ataxia mouse model.
Volume: 46
Issue: 1
Pages: 165-71
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Strain
MGI:5909979 | STOCK Tg(FXN)YG8Pook/J
Attribute String: mutant stock, transgenic
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Strain
MGI:3798080 | B6.Cg-Tg(FXN)YG8Pook
Attribute String: congenic, transgenic
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Publication
25070719 | J:232156
First Author: Jones J
Year: 2015
Journal: Mol Ther
Title: Mesenchymal stem cells improve motor functions and decrease neurodegeneration in ataxic mice.
Volume: 23
Issue: 1
Pages: 130-8
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Strain
MGI:5700051 | B6J.Cg-Tg(FXN)YG22Pook
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:5911832 | STOCK Fxn<em2.1Lutzy> Tg(FXN)Y47Pook/J
Attribute String: mutant stock, transgenic, endonuclease-mediated mutation
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Strain
MGI:7316638 | C57BL/6J-Fxn<em10Lutzy>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Tg(FXN)YG8Pook/?
Background: B6.Cg-Tg(FXN)YG8Pook
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(FXN)YG22Pook/?
Background: B6J.Cg-Tg(FXN)YG22Pook
Zygosity: ot
Has Mutant Allele: true
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Strain
MGI:5909980 | STOCK Fxn<em2.1Lutzy> Tg(FXN)YG8Pook/J
Attribute String: transgenic, mutant stock, endonuclease-mediated mutation
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Strain
MGI:6111731 | STOCK Fxn<em2.1Lutzy> Tg(FXN)YG8Pook/800J
Attribute String: endonuclease-mediated mutation, mutant stock, transgenic
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HT Experiment
GSE232826 | Loss of homeostatic functions in microglia from a murine model of Friedreichs ataxia
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
29257745 | J:254962
   
First Author: Chandran V
Year: 2017
Journal: Elife
Title: Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia.
Volume: 6
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Strain
MGI:5140697 | B6.Cg-Fxn<tm1Mkn> Tg(FXN)YG22Pook/J
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Strain
MGI:4437675 | B6.Cg-Fxn<tm1Mkn> Tg(FXN)YG8Pook/J
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Strain
MGI:5616090 | STOCK Fxn<tm1Mkn> Tg(FXN)YG8Pook/2J
Attribute String: mutant stock, targeted mutation, transgenic
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Strain
MGI:4412278 | STOCK Fxn<tm1Mkn> Tg(FXN)YG22Pook/J
Attribute String: mutant stock, targeted mutation, transgenic
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Strain
MGI:3797885 | STOCK Fxn<tm1Mkn> Tg(FXN)YG8Pook/J
Attribute String: congenic, targeted mutation, transgenic
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Strain
MGI:5585458 | STOCK Fxn<tm1Mkn> Tg(FXN)Y47Pook/J
Attribute String: mutant stock, targeted mutation, transgenic
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Genotype
Genotype
Symbol: Fxn/Fxn Tg(FXN)YG8Pook/?
Background: involves: 129/Sv * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fxn/Fxn Tg(FXN)YG22Pook/?
Background: involves: 129/Sv * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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