Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3561134 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-09-10 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3525627 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:7716443 |
Age: |
postnatal day 0 |
|
|
Specimen Label: |
6E |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3561134 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-09-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3525628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7716443 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
6F |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3561134 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-09-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3525628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7716443 |
Age: |
postnatal adult |
|
Note: |
Decreased expression compared with that of P14. |
Specimen Label: |
6G |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3561134 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-09-10 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3525627 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:7716443 |
Age: |
postnatal day 0 |
|
|
Specimen Label: |
13D |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3561134 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-09-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3525628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7716443 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
13E |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3561134 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-09-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3525628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7716443 |
Age: |
postnatal adult |
|
|
Specimen Label: |
13F |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5306749 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-02-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1618414 |
Pattern: |
Regionally restricted |
Stage: |
TS14 |
Assay Id: |
MGI:5306772 |
Age: |
embryonic day 8.75 |
Image: |
3C |
Note: |
Expression is in the first epithelial somites. |
Specimen Label: |
3C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5306749 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-02-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1618414 |
Pattern: |
Regionally restricted |
Stage: |
TS14 |
Assay Id: |
MGI:5306772 |
Age: |
embryonic day 8.75 |
Image: |
3D |
Note: |
Expression is in the first epithelial somites. |
Specimen Label: |
3D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5306749 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-02-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1618417 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:5306772 |
Age: |
embryonic day 10.5 |
Image: |
3L |
|
Specimen Label: |
3L |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5306749 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-02-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1618417 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:5306772 |
Age: |
embryonic day 10.5 |
Image: |
3N,O |
|
Specimen Label: |
3N,O |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5306749 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-02-22 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1618417 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:5306772 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Table 1 E10.5 |
Detected: |
true |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5002025 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2850023 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5542579 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:10502 |
|
Specimen Label: |
GUDMAP:10502 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5002025 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2850023 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5542579 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:10526 |
|
Specimen Label: |
GUDMAP:10526 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5002025 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796223 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5542579 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:10526 |
|
Specimen Label: |
GUDMAP:10526 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin R |
Year: |
2002 |
Journal: |
DNA Cell Biol |
Title: |
Regulation of the gadd45beta promoter by NF-kappaB. |
Volume: |
21 |
Issue: |
7 |
Pages: |
491-503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schüle KM |
Year: |
2019 |
Journal: |
Genes Dev |
Title: |
GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells. |
Volume: |
33 |
Issue: |
13-14 |
Pages: |
782-798 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu L |
Year: |
2005 |
Journal: |
J Exp Med |
Title: |
Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity. |
Volume: |
202 |
Issue: |
10 |
Pages: |
1341-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hwang JH |
Year: |
2019 |
Journal: |
Exp Mol Med |
Title: |
Gadd45β promotes regeneration after injury through TGFβ-dependent restitution in experimental colitis. |
Volume: |
51 |
Issue: |
10 |
Pages: |
1-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tian X |
Year: |
2020 |
Journal: |
JCI Insight |
Title: |
Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury. |
Volume: |
5 |
Issue: |
22 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mak SK |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress. |
Volume: |
279 |
Issue: |
37 |
Pages: |
39075-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mittal A |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
NF-kappaB-dependent regulation of the timing of activation-induced cell death of T lymphocytes. |
Volume: |
176 |
Issue: |
4 |
Pages: |
2183-9 |
|
•
•
•
•
•
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Publication |
First Author: |
Morinobu A |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. |
Volume: |
99 |
Issue: |
19 |
Pages: |
12281-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu L |
Year: |
2021 |
Journal: |
J Exp Med |
Title: |
Hepatic Gadd45β promotes hyperglycemia and glucose intolerance through DNA demethylation of PGC-1α. |
Volume: |
218 |
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5 |
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|
•
•
•
•
•
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Publication |
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Fuhrmeister J |
Year: |
2016 |
Journal: |
EMBO Mol Med |
Title: |
Fasting-induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health. |
Volume: |
8 |
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6 |
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654-69 |
|
•
•
•
•
•
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Publication |
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Year: |
2017 |
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Nat Commun |
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Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons. |
Volume: |
8 |
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1 |
Pages: |
2015 |
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•
•
•
•
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Publication |
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Smith T |
Year: |
2017 |
Journal: |
J Immunol |
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Peripheral Deletion of CD8 T Cells Requires p38 MAPK in Cross-Presenting Dendritic Cells. |
Volume: |
199 |
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8 |
Pages: |
2713-2720 |
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•
•
•
•
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Yang Q |
Year: |
2011 |
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Eur J Immunol |
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IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells. |
Volume: |
41 |
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11 |
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3351-60 |
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•
•
•
•
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Publication |
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Ijiri K |
Year: |
2005 |
Journal: |
J Biol Chem |
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A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. |
Volume: |
280 |
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46 |
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38544-55 |
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•
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Publication |
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Matsunaga E |
Year: |
2015 |
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Neuroscience |
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Comparative analysis of developmentally regulated expressions of Gadd45a, Gadd45b, and Gadd45g in the mouse and marmoset cerebral cortex. |
Volume: |
284 |
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Pages: |
566-80 |
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Publication |
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Year: |
2004 |
Journal: |
EMBO J |
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GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. |
Volume: |
23 |
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7 |
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1576-86 |
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Proc Natl Acad Sci U S A |
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Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap. |
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7563-8 |
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Birth Defects Res A Clin Mol Teratol |
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Oct4 Methylation-Mediated Silencing As an Epigenetic Barrier Preventing Müller Glia Dedifferentiation in a Murine Model of Retinal Injury. |
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MGI Direct Data Submission |
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Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Yang TC |
Year: |
2016 |
Journal: |
J Neurochem |
Title: |
Cell death caused by the synergistic effects of zinc and dopamine is mediated by a stress sensor gene Gadd45b - implication in the pathogenesis of Parkinson's disease. |
Volume: |
139 |
Issue: |
1 |
Pages: |
120-33 |
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Allele |
Name: |
growth arrest and DNA-damage-inducible 45 beta; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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Publication |
First Author: |
Fornace AJ Jr |
Year: |
1992 |
Journal: |
Ann N Y Acad Sci |
Title: |
Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrest. |
Volume: |
663 |
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Pages: |
139-53 |
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Publication |
First Author: |
Liebermann DA |
Year: |
2002 |
Journal: |
Leukemia |
Title: |
Myeloid differentiation (MyD)/growth arrest DNA damage (GADD) genes in tumor suppression, immunity and inflammation. |
Volume: |
16 |
Issue: |
4 |
Pages: |
527-41 |
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•
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Publication |
First Author: |
Smith ML |
Year: |
1994 |
Journal: |
Science |
Title: |
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. |
Volume: |
266 |
Issue: |
5189 |
Pages: |
1376-80 |
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Protein Domain |
Type: |
Family |
Description: |
The growth arrest and DNA damage GADD45 proteins, which include GADD45A, GADD45B , and GADD45G, are implicated as stress sensors that modulate the response of mammalian cells to genotoxic/physiological stress, and modulate tumor formation [, , ]. GADD45 proteins interact with a number of other proteins implicated in stress responses, including PCNA, p21, Cdc2/CyclinB1, MEKK4, and p38 kinase. GADD45 stimulates DNA excision repair in vitro and inhibits the entry of cells into S phase during the cell cycle. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
60
 |
Fragment?: |
false |
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•
•
•
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Publication |
First Author: |
Mukherjee K |
Year: |
2017 |
Journal: |
Oncotarget |
Title: |
Gadd45a deficiency accelerates BCR-ABL driven chronic myelogenous leukemia. |
Volume: |
8 |
Issue: |
7 |
Pages: |
10809-10821 |
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Publication |
First Author: |
Li CL |
Year: |
2024 |
Journal: |
Exp Neurol |
Title: |
STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells. |
Volume: |
377 |
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Pages: |
114805 |
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•
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•
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Publication |
First Author: |
Steiner AJ |
Year: |
2023 |
Journal: |
Sci Rep |
Title: |
Characterization of a rhabdomyosarcoma reveals a critical role for SMG7 in cancer cell viability and tumor growth. |
Volume: |
13 |
Issue: |
1 |
Pages: |
10152 |
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•
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•
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Publication |
First Author: |
Morin CI |
Year: |
2004 |
Journal: |
Cancer Res |
Title: |
Recent advances in stress signaling in cancer. |
Volume: |
64 |
Issue: |
5 |
Pages: |
1893-8 |
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•
•
•
•
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Publication |
First Author: |
Li Z |
Year: |
2015 |
Journal: |
Nucleic Acids Res |
Title: |
Gadd45a promotes DNA demethylation through TDG. |
Volume: |
43 |
Issue: |
8 |
Pages: |
3986-97 |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
165
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
160
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
159
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
159
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
159
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
131
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
165
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
145
 |
Fragment?: |
false |
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•
•
•
•
|