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Search results 201 to 300 out of 311 for Galt

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Type Details Score
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
DO Term
Publication
First Author: Bruns GA
Year: 1978
Journal: Cytogenet Cell Genet
Title: Expression of ACONS and GALT in man-rodent somatic cell hybrids.
Volume: 22
Issue: 1-6
Pages: 172-6
Publication
First Author: Glaysher BR
Year: 2007
Journal: J Immunol
Title: Role of the GALT in scrapie agent neuroinvasion from the intestine.
Volume: 178
Issue: 6
Pages: 3757-66
MP Term
Publication
First Author: Shimizu I
Year: 2006
Journal: Scand J Immunol
Title: Sequential analysis of anti-alpha Gal natural antibody-producing B cells in GalT knockout mice in cyclophosphamide-induced tolerance.
Volume: 63
Issue: 6
Pages: 435-43
Publication    
First Author: Shukla A
Year: 2019
Journal: JCI Insight
Title: Self-reactive B cells in the GALT are actively curtailed to prevent gut inflammation.
Volume: 5
Publication
First Author: Johansson-Lindbom B
Year: 2003
Journal: J Exp Med
Title: Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant.
Volume: 198
Issue: 6
Pages: 963-9
Publication
First Author: Bergqvist P
Year: 2010
Journal: J Immunol
Title: T cell-independent IgA class switch recombination is restricted to the GALT and occurs prior to manifest germinal center formation.
Volume: 184
Issue: 7
Pages: 3545-53
Publication  
First Author: Aitken DA
Year: 1979
Journal: Cytogenet Cell Genet
Title: Intrachromosomal assignment of the structural gene for GALT to the short arm of chromosome 9 by gene dosage studies
Volume: 25
Pages: 131 (Abstr.)
GO Term
GO Term
Allele
Name: galactose-1-phosphate uridyl transferase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Publication
First Author: Plummer NW
Year: 1998
Journal: Genomics
Title: Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A.
Volume: 54
Issue: 2
Pages: 287-96
Publication
First Author: Burgess DL
Year: 1995
Journal: Nat Genet
Title: Mutation of a new sodium channel gene, Scn8a, in the mouse mutant 'motor endplate disease'.
Volume: 10
Issue: 4
Pages: 461-5
Publication
First Author: Kolb M
Year: 2002
Journal: Am J Respir Cell Mol Biol
Title: Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains.
Volume: 27
Issue: 2
Pages: 141-50
MP Term
GO Term
Publication
First Author: Kohrman DC
Year: 1995
Journal: Genomics
Title: Insertional mutation of the motor endplate disease (med) locus on mouse chromosome 15.
Volume: 26
Issue: 2
Pages: 171-7
Publication
First Author: Bonniaud P
Year: 2004
Journal: J Immunol
Title: Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis.
Volume: 173
Issue: 3
Pages: 2099-108
GO Term
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GO Term
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Chou TF
Year: 2005
Journal: J Biol Chem
Title: 31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions.
Volume: 280
Issue: 15
Pages: 15356-61
Protein Domain
Type: Family
Description: The Histidine Triad (HIT) motif, His-x-His-x-His-x-x (x, ahydrophobic amino acid) was identified as being highly conserved in a variety of organisms [, ]. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the FHIT branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases [, ]. In budding yeast Hnt1 has been shown to have adenosine monophosphoramidase activity and function as positive regulators of Cdk7/Kin28 in vivo [, ]. FHIT plays a very important role in the development of tumours. In fact, FHIT deletions are among the earliest and most frequent genetic alterations in the development of tumours [, ]. The third branch of the HIT superfamily, which includes GalT homologues, contains a related His-X-His-X-Gln motif and transfers nucleoside monophosphate moieties to phosphorylated second substrates ratherthan hydrolysing them [].
Protein Domain
Type: Domain
Description: Galactose-1-phosphate uridyl transferase catalyses the conversion of UDP-glucose and alpha-D-galactose 1-phosphate to alpha-D-glucose 1-phosphate and UDP-galactose during galactose metabolism. The enzyme is present in prokaryotes and eukaryotes. Defects in GalT in humans is the cause of galactosemia, an inherited disorder of galactose metabolism that leads to jaundice, cataracts and mental retardation.This domain describes the C-terminal of Galactose-1-phosphate uridyl transferase. SCOP reports fold duplication of the C-terminal with the N-terminal domain. Both are involved in Zn and Fe binding
Protein Domain
Type: Domain
Description: Galactose-1-phosphate uridyl transferase catalyses the conversion of UDP-glucose and alpha-D-galactose 1-phosphate to alpha-D-glucose 1-phosphate and UDP-galactose during galactose metabolism. The enzyme is present in prokaryotes and eukaryotes. Defects in GalT in humans is the cause of galactosemia, an inherited disorder of galactose metabolism that leads to jaundice, cataracts and mental retardation.This domain describes the C-terminal of Galactose-1-phosphate uridyl transferase. SCOP reports fold duplication of the C-terminal with the N-terminal domain. Both are involved in Zn and Fe binding
Publication
First Author: Pekarsky Y
Year: 2002
Journal: Cancer Biol Ther
Title: FHIT as tumor suppressor: mechanisms and therapeutic opportunities.
Volume: 1
Issue: 3
Pages: 232-6
Publication
First Author: Lima CD
Year: 1997
Journal: Science
Title: Structure-based analysis of catalysis and substrate definition in the HIT protein family.
Volume: 278
Issue: 5336
Pages: 286-90
Publication
First Author: Pekarsky Y
Year: 2002
Journal: Lancet Oncol
Title: FHIT: from gene discovery to cancer treatment and prevention.
Volume: 3
Issue: 12
Pages: 748-54
Publication
First Author: Wedekind JE
Year: 1995
Journal: Biochemistry
Title: Three-dimensional structure of galactose-1-phosphate uridylyltransferase from Escherichia coli at 1.8 A resolution.
Volume: 34
Issue: 35
Pages: 11049-61
Publication
First Author: Cornwell TL
Year: 1987
Journal: Nucleic Acids Res
Title: The nucleotide sequence of the gal T gene of Escherichia coli.
Volume: 15
Issue: 19
Pages: 8116
Publication
First Author: Thoden JB
Year: 1997
Journal: Biochemistry
Title: Structural analysis of the H166G site-directed mutant of galactose-1-phosphate uridylyltransferase complexed with either UDP-glucose or UDP-galactose: detailed description of the nucleotide sugar binding site.
Volume: 36
Issue: 6
Pages: 1212-22
Protein Domain
Type: Family
Description: This group is related to , galactose-1-phosphate uridylyltransferases (GalT; ). is a member of the HIT domain superfamily based on structural fold []and has a signature HXHXQ. Members of this group are shorter than members by ~100 residues, but have considerable sequence similarity, including the signature. Galactose-1-phosphate uridylyltransferase is involved in the metabolism of galactose via the Leloir pathway []. GalT catalyses the transfer of a uridine 5 -phosphoryl group from UDP-galactose 1-phosphate. It consists of two identical subunits; the active site is formed by amino acid residues from both subunits of the dimer [, ].
Protein Domain
Type: Family
Description: FHIT (fragile histidine) proteins are related to the HIT family members that carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid) []. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the FHIT branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases [, , ]. FHIT plays a very important role in the development of tumours. In fact, FHIT deletions are among the earliest and most frequent genetic alterations in the development of tumours [, ].
Publication
First Author: Wagner N
Year: 1996
Journal: Nature
Title: Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue.
Volume: 382
Issue: 6589
Pages: 366-70
Publication
First Author: Obata Y
Year: 2014
Journal: EMBO Rep
Title: Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues.
Volume: 15
Issue: 12
Pages: 1297-304
Publication
First Author: Carpio RV
Year: 2004
Journal: J Biol Chem
Title: Role of the histidine triad-like motif in nucleotide hydrolysis by the rotavirus RNA-packaging protein NSP2.
Volume: 279
Issue: 11
Pages: 10624-33
Publication
First Author: Lima CD
Year: 1997
Journal: Structure
Title: MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family.
Volume: 5
Issue: 6
Pages: 763-74
Publication
First Author: Brzoska PM
Year: 1996
Journal: Genomics
Title: Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1).
Volume: 36
Issue: 1
Pages: 151-6
Protein Domain
Type: Family
Description: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified in the literature into three major branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, which consists of diadenosine polyphosphate hydrolases, and the GalT branch, consisting of specific nucleoside monophosphate transferases. Further sequence analysis reveals several new, closely related, yet uncharacterised subgroups. This group includes bacterial proteins which are members from the Hint branch of hydrolases. For additional information please see [, , , , , ].
Protein Domain
Type: Family
Description: HINT (histidine triad nucleotide-binding protein) are related to the HIT family members that carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid) []. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the FHIT branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases []. HINT family includes members from all three forms of cellular life. In budding yeast Hnt1 has been shown to have adenosine monophosphoramidase activity []. It is involved in secretion, peroxisome formation and gene expression [, ]. The bacterial and archaeal members of this family are mostly uncharacterised.
Publication  
First Author: Sun H
Year: 2021
Journal: J Exp Med
Title: Distinct integrin activation pathways for effector and regulatory T cell trafficking and function.
Volume: 218
Issue: 2
Publication
First Author: Gonnella PA
Year: 2004
Journal: J Autoimmun
Title: Induction of low dose oral tolerance in IL-10 deficient mice with experimental autoimmune encephalomyelitis.
Volume: 23
Issue: 3
Pages: 193-200
Publication
First Author: de Lau W
Year: 2012
Journal: Mol Cell Biol
Title: Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".
Volume: 32
Issue: 18
Pages: 3639-47
Publication
First Author: Proietti M
Year: 2014
Journal: Immunity
Title: ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism.
Volume: 41
Issue: 5
Pages: 789-801
Publication
First Author: Kimura S
Year: 2020
Journal: Nat Commun
Title: Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity.
Volume: 11
Issue: 1
Pages: 234
Publication
First Author: Asano M
Year: 1997
Journal: EMBO J
Title: Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells.
Volume: 16
Issue: 8
Pages: 1850-7
Publication
First Author: Lee SW
Year: 2012
Journal: J Immunol
Title: Cutting edge: 4-1BB controls regulatory activity in dendritic cells through promoting optimal expression of retinal dehydrogenase.
Volume: 189
Issue: 6
Pages: 2697-701
Publication
First Author: Canales-Herrerias P
Year: 2024
Journal: Sci Immunol
Title: Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis.
Volume: 9
Issue: 94
Pages: eadg7549
Publication
First Author: Mohandas T
Year: 1977
Journal: Proc Natl Acad Sci U S A
Title: Assignment of the human gene for galactose-1-phosphate uridyltransferase to chromosome 9: studies with Chinese hamster-human somatic cell hybrids.
Volume: 74
Issue: 12
Pages: 5628-31
Publication
First Author: Séraphin B
Year: 1992
Journal: DNA Seq
Title: The HIT protein family: a new family of proteins present in prokaryotes, yeast and mammals.
Volume: 3
Issue: 3
Pages: 177-9
Publication
First Author: Brenner C
Year: 1997
Journal: Nat Struct Biol
Title: Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins.
Volume: 4
Issue: 3
Pages: 231-8
Publication
First Author: Bieganowski P
Year: 2002
Journal: J Biol Chem
Title: Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3.
Volume: 277
Issue: 13
Pages: 10852-60
Publication
First Author: Fröhlich KU
Year: 1991
Journal: J Cell Biol
Title: Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression.
Volume: 114
Issue: 3
Pages: 443-53
Publication
First Author: Xu PA
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Function of murine adenosine deaminase in the gastrointestinal tract.
Volume: 269
Issue: 3
Pages: 749-57
Publication
First Author: Eldridge JH
Year: 1983
Journal: J Exp Med
Title: Evidence for a mature B cell subpopulation in Peyer's patches of young adult xid mice.
Volume: 157
Issue: 2
Pages: 789-94
Publication
First Author: Gonnella PA
Year: 2001
Journal: J Immunol
Title: B cell-deficient (mu MT) mice have alterations in the cytokine microenvironment of the gut-associated lymphoid tissue (GALT) and a defect in the low dose mechanism of oral tolerance.
Volume: 166
Issue: 7
Pages: 4456-64
Publication
First Author: Heidegger S
Year: 2013
Journal: J Immunol
Title: TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice.
Volume: 190
Issue: 10
Pages: 5313-20
Publication
First Author: Spahn TW
Year: 2001
Journal: Eur J Immunol
Title: Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches.
Volume: 31
Issue: 4
Pages: 1278-87
Publication
First Author: Morimoto M
Year: 2006
Journal: Scand J Immunol
Title: Nematode infection in Alymphoplasia (aly) mice: worm species-dependent differential effect of defects of the gut-associated lymphatic tissue system.
Volume: 63
Issue: 5
Pages: 365-70
Publication
First Author: Takedatsu H
Year: 2008
Journal: Gastroenterology
Title: TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.
Volume: 135
Issue: 2
Pages: 552-67
Publication
First Author: Schippers A
Year: 2012
Journal: Clin Immunol
Title: β7 integrin controls immunogenic and tolerogenic mucosal B cell responses.
Volume: 144
Issue: 2
Pages: 87-97
Publication
First Author: Uto T
Year: 2018
Journal: J Allergy Clin Immunol
Title: Critical role of plasmacytoid dendritic cells in induction of oral tolerance.
Volume: 141
Issue: 6
Pages: 2156-2167.e9
Publication
First Author: Rydström A
Year: 2007
Journal: J Immunol
Title: Monocyte recruitment, activation, and function in the gut-associated lymphoid tissue during oral Salmonella infection.
Volume: 178
Issue: 9
Pages: 5789-801
Publication
First Author: Park SS
Year: 2005
Journal: Cancer Res
Title: Insertion of Myc into Igh accelerates peritoneal plasmacytomas in mice.
Volume: 65
Issue: 17
Pages: 7644-52
Publication
First Author: Rudolphi A
Year: 1994
Journal: Eur J Immunol
Title: Gut-homing CD4+ T cell receptor alpha beta+ T cells in the pathogenesis of murine inflammatory bowel disease.
Volume: 24
Issue: 11
Pages: 2803-12
Publication
First Author: Soulié J
Year: 1983
Journal: Hum Genet
Title: New gene assignments in the rabbit (Oryctolagus cuniculus). Comparison with other species.
Volume: 63
Issue: 1
Pages: 48-52
Publication
First Author: Cheng ZY
Year: 1986
Journal: Cytogenet Cell Genet
Title: The mouse IFN-alpha (Ifa) locus: correlation of physical and linkage maps by in situ hybridization.
Volume: 41
Issue: 2
Pages: 101-6
Publication
First Author: Song F
Year: 2002
Journal: J Autoimmun
Title: Differences between two strains of myelin basic protein (MBP) TCR transgenic mice: implications for tolerance induction.
Volume: 18
Issue: 1
Pages: 27-37
Publication
First Author: Rodeheffer C
Year: 2002
Journal: Biochim Biophys Acta
Title: Targeted mutations in beta1,4-galactosyltransferase I reveal its multiple cellular functions.
Volume: 1573
Issue: 3
Pages: 258-70
Publication
First Author: Hoshino H
Year: 2011
Journal: J Histochem Cytochem
Title: An integrin alpha4beta7•IgG heterodimeric chimera binds to MAdCAM-1 on high endothelial venules in gut-associated lymphoid tissue.
Volume: 59
Issue: 6
Pages: 572-83
Publication  
First Author: Amorim A
Year: 1984
Journal: Cytogenet Cell Genet
Title: Linkage studies on the ALADH polymorphism (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping)
Volume: 37 (1-4)
Pages: 400 (Abstr.) (399-616)
Publication
First Author: Brenner C
Year: 2002
Journal: Biochemistry
Title: Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.
Volume: 41
Issue: 29
Pages: 9003-14
Protein
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: false
Publication
First Author: Bergqvist P
Year: 2006
Journal: J Immunol
Title: Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers.
Volume: 177
Issue: 11
Pages: 7772-83
Publication
First Author: Posekany KJ
Year: 2004
Journal: Anticancer Res
Title: Suppression of Lewis lung tumor development in alpha 1,3 galactosyltransferase knock-out mice.
Volume: 24
Issue: 2B
Pages: 605-12
Publication
First Author: de la Cruz L
Year: 2004
Journal: Dev Biol
Title: Apoptosis and involution in the mammary gland are altered in mice lacking a novel receptor, beta1,4-Galactosyltransferase I.
Volume: 272
Issue: 2
Pages: 286-309
Publication
First Author: Pérez-Bosque A
Year: 2016
Journal: PLoS One
Title: Oral Serum-Derived Bovine Immunoglobulin/Protein Isolate Has Immunomodulatory Effects on the Colon of Mice that Spontaneously Develop Colitis.
Volume: 11
Issue: 5
Pages: e0154823
Publication
First Author: Steffgen K
Year: 2002
Journal: Dev Biol
Title: Enhanced branching morphogenesis in mammary glands of mice lacking cell surface beta1,4-galactosyltransferase.
Volume: 244
Issue: 1
Pages: 114-33
Publication
First Author: Tang B
Year: 2014
Journal: Arthritis Res Ther
Title: Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis.
Volume: 16
Issue: 1
Pages: R7
Publication
First Author: Shinkel TA
Year: 1997
Journal: Transplantation
Title: Changes in cell surface glycosylation in alpha1,3-galactosyltransferase knockout and alpha1,2-fucosyltransferase transgenic mice.
Volume: 64
Issue: 2
Pages: 197-204
Publication
First Author: Hathaway HJ
Year: 2003
Journal: J Cell Sci
Title: Mutational analysis of the cytoplasmic domain of beta1,4-galactosyltransferase I: influence of phosphorylation on cell surface expression.
Volume: 116
Issue: Pt 21
Pages: 4319-30
Publication
First Author: Pace HC
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.
Volume: 95
Issue: 10
Pages: 5484-9
Protein
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 375  
Fragment?: false