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Search results 201 to 300 out of 330 for Ghsr

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Type Details Score
Publication
20034618 | J:281291
First Author: Perello M
Year: 2010
Journal: Biol Psychiatry
Title: Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.
Volume: 67
Issue: 9
Pages: 880-6
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Publication
29063591 | J:251820
First Author: Murtuza MI
Year: 2018
Journal: J Neurochem
Title: Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus.
Volume: 144
Issue: 1
Pages: 58-67
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Publication
31251830 | J:295404
First Author: Wu CS
Year: 2019
Journal: J Neuroendocrinol
Title: Ghrelin receptor in agouti-related peptide neurones regulates metabolic adaptation to calorie restriction.
Volume: 31
Issue: 7
Pages: e12763
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Publication
21037584 | J:166904
First Author: Xu Y
Year: 2010
Journal: Nat Neurosci
Title: 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.
Volume: 13
Issue: 12
Pages: 1457-9
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Publication
22391948 | J:184991
First Author: Xu G
Year: 2012
Journal: Diabetologia
Title: Ghrelin contributes to derangements of glucose metabolism induced by rapamycin in mice.
Volume: 55
Issue: 6
Pages: 1813-23
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Publication
31942916 | J:288317
First Author: Fan Z
Year: 2020
Journal: Acta Biochim Biophys Sin (Shanghai)
Title: Long noncoding RNA UC.98 stabilizes atherosclerotic plaques by promoting the proliferation and adhesive capacity in murine aortic endothelial cells.
Volume: 52
Issue: 2
Pages: 141-149
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Publication
18657539 | J:141985
First Author: Verhulst PJ
Year: 2008
Journal: Gastroenterology
Title: Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice.
Volume: 135
Issue: 4
Pages: 1267-76
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Publication
35239443 | J:334541
First Author: Gross JD
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Discovery of a functionally selective ghrelin receptor (GHSR(1a)) ligand for modulating brain dopamine.
Volume: 119
Issue: 10
Pages: e2112397119
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Publication
25658305 | J:229051
First Author: Xu Y
Year: 2015
Journal: PLoS One
Title: Ghrelin inhibits the differentiation of T helper 17 cells through mTOR/STAT3 signaling pathway.
Volume: 10
Issue: 2
Pages: e0117081
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Publication
24735326 | J:214261
First Author: Lin D
Year: 2014
Journal: Endocrinology
Title: Abnormal response to the anorexic effect of GHS-R inhibitors and exenatide in male Snord116 deletion mouse model for Prader-Willi syndrome.
Volume: 155
Issue: 7
Pages: 2355-62
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Publication
19666521 | J:151960
First Author: Szentirmai E
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice.
Volume: 106
Issue: 33
Pages: 14069-74
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Publication
25060361 | J:218338
First Author: Delhanty PJ
Year: 2014
Journal: Endocrinology
Title: Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling.
Volume: 155
Issue: 11
Pages: 4287-95
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Publication
18006636 | J:141558
First Author: Sun Y
Year: 2008
Journal: Endocrinology
Title: Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance.
Volume: 149
Issue: 2
Pages: 843-50
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Publication
22284186 | J:182302
First Author: Kern A
Year: 2012
Journal: Neuron
Title: Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism.
Volume: 73
Issue: 2
Pages: 317-32
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Publication
22338071 | J:186866
First Author: Chacko SK
Year: 2012
Journal: Am J Physiol Endocrinol Metab
Title: Effect of ghrelin on glucose regulation in mice.
Volume: 302
Issue: 9
Pages: E1055-62
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Publication
17823656 | J:127392
First Author: Dixit VD
Year: 2007
Journal: J Clin Invest
Title: Ghrelin promotes thymopoiesis during aging.
Volume: 117
Issue: 10
Pages: 2778-90
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Publication
21054685 | J:189724
First Author: Clifford S
Year: 2011
Journal: Addict Biol
Title: Impact of food restriction and cocaine on locomotion in ghrelin- and ghrelin-receptor knockout mice.
Volume: 16
Issue: 3
Pages: 386-92
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Publication
21298106 | J:169555
First Author: Ma X
Year: 2011
Journal: PLoS One
Title: Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging.
Volume: 6
Issue: 1
Pages: e16391
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Publication
22211783 | J:184335
First Author: Esposito M
Year: 2012
Journal: Eur J Neurosci
Title: Impaired wake-promoting mechanisms in ghrelin receptor-deficient mice.
Volume: 35
Issue: 2
Pages: 233-43
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Publication
26590421 | J:228021
First Author: Kern A
Year: 2015
Journal: Cell
Title: Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor.
Volume: 163
Issue: 5
Pages: 1176-1190
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Publication
18048479 | J:132302
First Author: Pfluger PT
Year: 2008
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure.
Volume: 294
Issue: 3
Pages: G610-8
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Publication
25447526 | J:216951
First Author: Lee JH
Year: 2014
Journal: FEBS Lett
Title: Ghrelin augments murine T-cell proliferation by activation of the phosphatidylinositol-3-kinase, extracellular signal-regulated kinase and protein kinase C signaling pathways.
Volume: 588
Issue: 24
Pages: 4708-19
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Publication
24285267 | J:213079
First Author: Tsubouchi H
Year: 2014
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner.
Volume: 306
Issue: 3
Pages: L233-45
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Publication
16491079 | J:107095
First Author: Diano S
Year: 2006
Journal: Nat Neurosci
Title: Ghrelin controls hippocampal spine synapse density and memory performance.
Volume: 9
Issue: 3
Pages: 381-8
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Publication
16601073 | J:111043
First Author: Jiang H
Year: 2006
Journal: Mol Endocrinol
Title: Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers.
Volume: 20
Issue: 8
Pages: 1772-85
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Publication
34641940 | J:311734
First Author: Li N
Year: 2021
Journal: Mol Brain
Title: Selectively increasing GHS-R1a expression in dCA1 excitatory/inhibitory neurons have opposite effects on memory encoding.
Volume: 14
Issue: 1
Pages: 157
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Publication
32128814 | J:297508
First Author: Pierre A
Year: 2020
Journal: J Neurochem
Title: Effects of ghrelin receptor activation on forebrain dopamine release, conditioned fear and fear extinction in C57BL/6J mice.
Volume: 154
Issue: 4
Pages: 389-403
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Publication
19564604 | J:150811
First Author: Jerlhag E
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Requirement of central ghrelin signaling for alcohol reward.
Volume: 106
Issue: 27
Pages: 11318-23
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Publication
21963822 | J:215868
First Author: Verhulst PJ
Year: 2012
Journal: Regul Pept
Title: Role of the AMP-activated protein kinase (AMPK) signaling pathway in the orexigenic effects of endogenous ghrelin.
Volume: 173
Issue: 1-3
Pages: 27-35
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Publication
19633195 | J:152003
First Author: LeSauter J
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Stomach ghrelin-secreting cells as food-entrainable circadian clocks.
Volume: 106
Issue: 32
Pages: 13582-7
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Publication
12746326 | J:83705
First Author: Kawamura K
Year: 2003
Journal: Endocrinology
Title: Ghrelin inhibits the development of mouse preimplantation embryos in vitro.
Volume: 144
Issue: 6
Pages: 2623-33
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Publication
20933579 | J:170171
First Author: Dickson SL
Year: 2010
Journal: Neuroscience
Title: Blockade of central nicotine acetylcholine receptor signaling attenuate ghrelin-induced food intake in rodents.
Volume: 171
Issue: 4
Pages: 1180-6
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Publication
28487437 | J:247172
First Author: Mani BK
Year: 2017
Journal: Diabetes
Title: Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade.
Volume: 66
Issue: 7
Pages: 1847-1857
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Publication
35159134 | J:324107
 
First Author: Lugilde J
Year: 2022
Journal: Cells
Title: LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner.
Volume: 11
Issue: 3
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Publication
31413143 | J:278681
 
First Author: Tian J
Year: 2019
Journal: Sci Transl Med
Title: Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer's disease.
Volume: 11
Issue: 505
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Publication
28959025 | J:253492
First Author: Srisai D
Year: 2017
Journal: Nat Commun
Title: MRAP2 regulates ghrelin receptor signaling and hunger sensing.
Volume: 8
Issue: 1
Pages: 713
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Publication
28361877 | J:275148
 
First Author: Hopkins AL
Year: 2017
Journal: Sci Rep
Title: Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R1a activity: evidence for target cell-induced acylation.
Volume: 7
Pages: 45541
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Publication
30204871 | J:270218
First Author: Lockie SH
Year: 2018
Journal: Endocrinology
Title: Glucose Availability Predicts the Feeding Response to Ghrelin in Male Mice, an Effect Dependent on AMPK in AgRP Neurons.
Volume: 159
Issue: 11
Pages: 3605-3614
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Publication
24685142 | J:345562
First Author: Aourz N
Year: 2014
Journal: CNS Neurosci Ther
Title: Cortistatin-14 mediates its anticonvulsant effects via sst2 and sst3 but not ghrelin receptors.
Volume: 20
Issue: 7
Pages: 662-70
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Publication
36317965 | J:331457
   
First Author: Pauli JL
Year: 2022
Journal: Elife
Title: Molecular and anatomical characterization of parabrachial neurons and their axonal projections.
Volume: 11
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Publication
22700774 | J:189083
First Author: van der Velde M
Year: 2012
Journal: Endocrinology
Title: An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects.
Volume: 153
Issue: 8
Pages: 3593-602
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Publication
31105045 | J:275677
First Author: Godlewski G
Year: 2019
Journal: Cell Metab
Title: Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis.
Volume: 29
Issue: 6
Pages: 1320-1333.e8
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Publication
33116243 | J:298931
First Author: Zhang W
Year: 2020
Journal: Sci Rep
Title: Functional interaction between Ghrelin and GLP-1 regulates feeding through the vagal afferent system.
Volume: 10
Issue: 1
Pages: 18415
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Publication
18668043 | J:139938
First Author: Andrews ZB
Year: 2008
Journal: Nature
Title: UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
Volume: 454
Issue: 7206
Pages: 846-51
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Publication
25329803 | J:223445
First Author: Laermans J
Year: 2014
Journal: PLoS One
Title: Shifting the circadian rhythm of feeding in mice induces gastrointestinal, metabolic and immune alterations which are influenced by ghrelin and the core clock gene Bmal1.
Volume: 9
Issue: 10
Pages: e110176
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Publication
14962995 | J:90744
First Author: Chen HY
Year: 2004
Journal: Endocrinology
Title: Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein.
Volume: 145
Issue: 6
Pages: 2607-12
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Publication
20526334 | J:161611
First Author: Perez-Tilve D
Year: 2010
Journal: Nat Neurosci
Title: Melanocortin signaling in the CNS directly regulates circulating cholesterol.
Volume: 13
Issue: 7
Pages: 877-82
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Publication
19299626 | J:149612
First Author: Yang H
Year: 2009
Journal: J Leukoc Biol
Title: Axin expression in thymic stromal cells contributes to an age-related increase in thymic adiposity and is associated with reduced thymopoiesis independently of ghrelin signaling.
Volume: 85
Issue: 6
Pages: 928-38
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Publication
26490687 | J:239858
First Author: Muniz BG
Year: 2015
Journal: Eur J Neurosci
Title: Ghrelin receptor activity amplifies hippocampal N-methyl-d-aspartate receptor-mediated postsynaptic currents and increases phosphorylation of the GluN1 subunit at Ser896 and Ser897.
Volume: 42
Issue: 12
Pages: 3045-53
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Publication
25157160 | J:216395
First Author: Li Z
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway.
Volume: 111
Issue: 36
Pages: 13163-8
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Publication
16513828 | J:129482
First Author: Luque RM
Year: 2006
Journal: Endocrinology
Title: Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function.
Volume: 147
Issue: 6
Pages: 2754-63
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Publication
33788980 | J:308824
First Author: de Guia RM
Year: 2021
Journal: FASEB J
Title: Ablation of Nampt in AgRP neurons leads to neurodegeneration and impairs fasting- and ghrelin-mediated food intake.
Volume: 35
Issue: 5
Pages: e21450
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Publication
26357899 | J:233737
First Author: Ma L
Year: 2015
Journal: Mol Endocrinol
Title: HDAC5-mTORC1 Interaction in Differential Regulation of Ghrelin and Nucleobindin 2 (NUCB2)/Nesfatin-1.
Volume: 29
Issue: 11
Pages: 1571-80
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Publication
34971379 | J:324529
 
First Author: Stallings CE
Year: 2022
Journal: Endocrinology
Title: FOXO Transcription Factors Are Required for Normal Somatotrope Function and Growth.
Volume: 163
Issue: 2
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Publication
14996723 | J:88787
First Author: Wang Y
Year: 2004
Journal: Cancer Res
Title: A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility.
Volume: 64
Issue: 5
Pages: 1647-54
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Publication
29688375 | J:250512
   
First Author: Li J
Year: 2018
Journal: Database (Oxford)
Title: CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.
Volume: 2018
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Publication
28700664 | J:246066
First Author: Sundberg JP
Year: 2017
Journal: PLoS One
Title: Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Volume: 12
Issue: 7
Pages: e0180682
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Ghsr<tm1Rgs> | MGI:3040440
Name: growth hormone secretagogue receptor; targeted mutation 1, Roy G Smith
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ghsr<tm1.1(cre)Jmz> | MGI:6759033
Name: growth hormone secretagogue receptor; targeted mutation 1.1, Jeffrey M Zigman
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Ghsr<tm2.1Jmz> | MGI:7467199
Name: growth hormone secretagogue receptor; targeted mutation 2.1, Jeffrey M Zigman
Allele Type: Targeted
Attribute String: Conditional ready
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Publication
23831041 | J:248677
 
First Author: Smith JT
Year: 2013
Journal: Peptides
Title: An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice.
Volume: 47
Pages: 45-53
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Publication
22886413 | J:255138
First Author: Callaghan B
Year: 2012
Journal: Am J Physiol Heart Circ Physiol
Title: Sites of action of ghrelin receptor ligands in cardiovascular control.
Volume: 303
Issue: 8
Pages: H1011-21
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Publication
38638279 | J:347665
 
First Author: Nie M
Year: 2024
Journal: Front Physiol
Title: Ghrelin enhances tubular magnesium absorption in the kidney.
Volume: 15
Pages: 1363708
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Allele
Tg(Ghsr-EGFP)KZ65Gsat | MGI:4847081
Name: transgene insertion KZ65, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5004042 | STOCK Tg(Ghsr-EGFP)KZ65Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
21956643 | J:251986
First Author: Venables G
Year: 2011
Journal: Cell Tissue Res
Title: Ghrelin receptors are expressed by distal tubules of the mouse kidney.
Volume: 346
Issue: 1
Pages: 135-9
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Publication
22826465 | -
First Author: Chopin LK
Year: 2012
Journal: Endocr Rev
Title: The ghrelin axis--does it have an appetite for cancer progression?
Volume: 33
Issue: 6
Pages: 849-91
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Publication
24388883 | -
First Author: Rak-Mardyla A
Year: 2013
Journal: J Physiol Pharmacol
Title: Ghrelin role in hypothalamus-pituitary-ovarian axis.
Volume: 64
Issue: 6
Pages: 695-704
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Publication
11356716 | -
First Author: Petersenn S
Year: 2001
Journal: Endocrinology
Title: Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor.
Volume: 142
Issue: 6
Pages: 2649-59
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Protein Domain
IPR039129 | 7tmA_GHSR
Type: Family
Description: The growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems [, ]. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis [].Two transcript variants of this receptor have been identified: GHS-R1a, the signal transduction form of the receptor and the biologically inactive GHS-R1b [].
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Allele
Ghsr<tm1.1Jmz> | MGI:7579167
Name: growth hormone secretagogue receptor; targeted mutation 1.1, Jeffrey M Zigman
Allele Type: Targeted
Attribute String: Humanized sequence
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